STI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania major

UniProt:

E9ADN3_LEIMA

TriTrypDb:

LmjF.29.0320 , LMJLV39_290008400 , LMJSD75_290008400

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADN3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0006458	'de novo' protein folding	3	2
GO:0009987	cellular process	1	2
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0061077	chaperone-mediated protein folding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.600
CLV_NRD_NRD_1	194	196	PF00675	0.526
CLV_NRD_NRD_1	200	202	PF00675	0.496
CLV_NRD_NRD_1	343	345	PF00675	0.602
CLV_PCSK_FUR_1	177	181	PF00082	0.561
CLV_PCSK_KEX2_1	179	181	PF00082	0.492
CLV_PCSK_KEX2_1	194	196	PF00082	0.519
CLV_PCSK_KEX2_1	200	202	PF00082	0.465
CLV_PCSK_KEX2_1	343	345	PF00082	0.602
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.479
CLV_PCSK_SKI1_1	111	115	PF00082	0.522
DEG_Nend_UBRbox_2	1	3	PF02207	0.574
DOC_ANK_TNKS_1	331	338	PF00023	0.623
DOC_PP2B_PxIxI_1	257	263	PF00149	0.411
DOC_PP4_FxxP_1	107	110	PF00568	0.469
DOC_USP7_MATH_1	282	286	PF00917	0.515
DOC_USP7_MATH_1	338	342	PF00917	0.702
DOC_USP7_UBL2_3	298	302	PF12436	0.485
DOC_WW_Pin1_4	9	14	PF00397	0.565
LIG_14-3-3_CanoR_1	34	42	PF00244	0.539
LIG_FHA_2	340	346	PF00498	0.654
LIG_LIR_Apic_2	106	110	PF02991	0.473
LIG_PCNA_yPIPBox_3	291	304	PF02747	0.527
LIG_SH2_STAT5	169	172	PF00017	0.550
LIG_TRAF2_1	187	190	PF00917	0.563
MOD_CK1_1	172	178	PF00069	0.472
MOD_CK1_1	339	345	PF00069	0.649
MOD_CK2_1	35	41	PF00069	0.633
MOD_GlcNHglycan	15	18	PF01048	0.686
MOD_GlcNHglycan	150	154	PF01048	0.500
MOD_GlcNHglycan	338	341	PF01048	0.806
MOD_GSK3_1	9	16	PF00069	0.636
MOD_N-GLC_1	163	168	PF02516	0.504
MOD_NEK2_2	144	149	PF00069	0.487
MOD_PIKK_1	172	178	PF00454	0.462
MOD_PKA_2	133	139	PF00069	0.378
MOD_PKA_2	172	178	PF00069	0.456
MOD_PKA_2	33	39	PF00069	0.544
MOD_Plk_1	144	150	PF00069	0.558
MOD_Plk_1	163	169	PF00069	0.520
MOD_Plk_2-3	25	31	PF00069	0.586
MOD_Plk_2-3	33	39	PF00069	0.521
MOD_Plk_4	250	256	PF00069	0.540
MOD_Plk_4	282	288	PF00069	0.563
MOD_ProDKin_1	9	15	PF00069	0.565
MOD_SUMO_for_1	63	66	PF00179	0.514
MOD_SUMO_rev_2	158	163	PF00179	0.507
MOD_SUMO_rev_2	285	292	PF00179	0.515
TRG_ENDOCYTIC_2	96	99	PF00928	0.435
TRG_ER_diArg_1	131	134	PF00400	0.385
TRG_ER_diArg_1	199	201	PF00400	0.465
TRG_NES_CRM1_1	275	289	PF08389	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I190	Leptomonas seymouri	65%	100%
A0A1X0NZI2	Trypanosomatidae	49%	94%
A0A3Q8III7	Leishmania donovani	86%	99%
A4HH33	Leishmania braziliensis	77%	100%
A4I484	Leishmania infantum	87%	99%
C4NYP8	Drosophila melanogaster	27%	92%
E9AM47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
P50502	Homo sapiens	33%	94%
P50503	Rattus norvegicus	30%	95%
Q5RF31	Pongo abelii	32%	94%
Q5ZLF0	Gallus gallus	34%	96%
Q86DS1	Drosophila melanogaster	27%	92%
Q8NFI4	Homo sapiens	34%	94%
Q99L47	Mus musculus	31%	94%
V5BUJ8	Trypanosoma cruzi	45%	91%