FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADN2_LEIMA

TriTrypDb:

LmjF.29.0300 , LMJLV39_290008100 , LMJSD75_290008100

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.655
CLV_C14_Caspase3-7	415	419	PF00656	0.319
CLV_NRD_NRD_1	115	117	PF00675	0.502
CLV_NRD_NRD_1	156	158	PF00675	0.520
CLV_NRD_NRD_1	199	201	PF00675	0.432
CLV_NRD_NRD_1	273	275	PF00675	0.475
CLV_NRD_NRD_1	428	430	PF00675	0.402
CLV_PCSK_KEX2_1	115	117	PF00082	0.502
CLV_PCSK_KEX2_1	156	158	PF00082	0.520
CLV_PCSK_KEX2_1	199	201	PF00082	0.479
CLV_PCSK_KEX2_1	208	210	PF00082	0.620
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.626
CLV_PCSK_SKI1_1	125	129	PF00082	0.544
CLV_PCSK_SKI1_1	136	140	PF00082	0.510
CLV_PCSK_SKI1_1	186	190	PF00082	0.408
CLV_PCSK_SKI1_1	316	320	PF00082	0.387
CLV_PCSK_SKI1_1	357	361	PF00082	0.304
DEG_SPOP_SBC_1	169	173	PF00917	0.549
DOC_CYCLIN_RxL_1	122	132	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.443
DOC_MAPK_gen_1	115	121	PF00069	0.484
DOC_MAPK_HePTP_8	112	128	PF00069	0.476
DOC_PP1_RVXF_1	134	141	PF00149	0.550
DOC_PP2B_LxvP_1	126	129	PF13499	0.602
DOC_PP2B_LxvP_1	145	148	PF13499	0.367
DOC_PP4_FxxP_1	260	263	PF00568	0.445
DOC_USP7_MATH_1	129	133	PF00917	0.714
DOC_USP7_MATH_1	204	208	PF00917	0.480
DOC_USP7_MATH_1	251	255	PF00917	0.654
DOC_USP7_MATH_1	304	308	PF00917	0.325
DOC_USP7_MATH_1	359	363	PF00917	0.408
DOC_USP7_MATH_1	374	378	PF00917	0.272
DOC_USP7_MATH_1	93	97	PF00917	0.708
DOC_USP7_MATH_2	300	306	PF00917	0.363
DOC_USP7_UBL2_3	271	275	PF12436	0.473
DOC_WW_Pin1_4	334	339	PF00397	0.365
LIG_14-3-3_CanoR_1	209	216	PF00244	0.664
LIG_14-3-3_CanoR_1	28	37	PF00244	0.493
LIG_BIR_III_4	160	164	PF00653	0.461
LIG_BIR_III_4	51	55	PF00653	0.447
LIG_BRCT_BRCA1_1	256	260	PF00533	0.481
LIG_deltaCOP1_diTrp_1	7	11	PF00928	0.495
LIG_eIF4E_1	106	112	PF01652	0.626
LIG_FHA_1	107	113	PF00498	0.538
LIG_FHA_1	209	215	PF00498	0.615
LIG_FHA_1	227	233	PF00498	0.441
LIG_FHA_1	257	263	PF00498	0.470
LIG_FHA_1	328	334	PF00498	0.319
LIG_FHA_1	385	391	PF00498	0.389
LIG_FHA_1	412	418	PF00498	0.325
LIG_FHA_2	187	193	PF00498	0.420
LIG_FHA_2	413	419	PF00498	0.291
LIG_LIR_Apic_2	257	263	PF02991	0.477
LIG_LIR_Gen_1	183	191	PF02991	0.448
LIG_LIR_Gen_1	278	287	PF02991	0.392
LIG_LIR_Gen_1	365	375	PF02991	0.385
LIG_LIR_Gen_1	428	437	PF02991	0.349
LIG_LIR_Nem_3	183	187	PF02991	0.414
LIG_LIR_Nem_3	225	231	PF02991	0.524
LIG_LIR_Nem_3	278	282	PF02991	0.380
LIG_LIR_Nem_3	283	287	PF02991	0.365
LIG_LIR_Nem_3	365	371	PF02991	0.385
LIG_LYPXL_yS_3	141	144	PF13949	0.507
LIG_MLH1_MIPbox_1	257	261	PF16413	0.468
LIG_SH2_CRK	228	232	PF00017	0.452
LIG_SH2_CRK	265	269	PF00017	0.417
LIG_SH2_CRK	279	283	PF00017	0.447
LIG_SH2_GRB2like	279	282	PF00017	0.454
LIG_SH2_NCK_1	279	283	PF00017	0.444
LIG_SH2_SRC	279	282	PF00017	0.417
LIG_SH2_STAT5	184	187	PF00017	0.427
LIG_SH2_STAT5	228	231	PF00017	0.437
LIG_SH2_STAT5	328	331	PF00017	0.367
LIG_SH2_STAT5	431	434	PF00017	0.330
LIG_SH3_3	118	124	PF00018	0.637
LIG_SH3_3	17	23	PF00018	0.495
LIG_SH3_3	213	219	PF00018	0.483
LIG_SH3_3	335	341	PF00018	0.336
LIG_SH3_3	58	64	PF00018	0.434
LIG_SH3_3	71	77	PF00018	0.433
LIG_SUMO_SIM_par_1	391	398	PF11976	0.291
LIG_TRAF2_2	148	153	PF00917	0.470
LIG_TYR_ITIM	182	187	PF00017	0.437
LIG_UBA3_1	267	275	PF00899	0.457
LIG_WRC_WIRS_1	360	365	PF05994	0.222
LIG_WRC_WIRS_1	65	70	PF05994	0.492
MOD_CK1_1	132	138	PF00069	0.603
MOD_CK1_1	143	149	PF00069	0.366
MOD_CK1_1	174	180	PF00069	0.497
MOD_CK1_1	207	213	PF00069	0.587
MOD_CK1_1	241	247	PF00069	0.650
MOD_CK1_1	254	260	PF00069	0.526
MOD_CK1_1	362	368	PF00069	0.367
MOD_CK2_1	186	192	PF00069	0.408
MOD_CMANNOS	198	201	PF00535	0.435
MOD_GlcNHglycan	131	134	PF01048	0.571
MOD_GlcNHglycan	224	227	PF01048	0.436
MOD_GlcNHglycan	240	243	PF01048	0.522
MOD_GlcNHglycan	247	250	PF01048	0.592
MOD_GlcNHglycan	306	309	PF01048	0.270
MOD_GlcNHglycan	345	348	PF01048	0.370
MOD_GlcNHglycan	376	379	PF01048	0.377
MOD_GlcNHglycan	61	64	PF01048	0.429
MOD_GlcNHglycan	89	92	PF01048	0.573
MOD_GSK3_1	106	113	PF00069	0.629
MOD_GSK3_1	128	135	PF00069	0.489
MOD_GSK3_1	169	176	PF00069	0.656
MOD_GSK3_1	204	211	PF00069	0.523
MOD_GSK3_1	222	229	PF00069	0.544
MOD_GSK3_1	241	248	PF00069	0.454
MOD_GSK3_1	251	258	PF00069	0.612
MOD_GSK3_1	380	387	PF00069	0.396
MOD_GSK3_1	394	401	PF00069	0.291
MOD_GSK3_1	412	419	PF00069	0.291
MOD_N-GLC_1	280	285	PF02516	0.464
MOD_N-GLC_1	398	403	PF02516	0.291
MOD_NEK2_1	111	116	PF00069	0.604
MOD_NEK2_1	353	358	PF00069	0.367
MOD_NEK2_1	395	400	PF00069	0.291
MOD_NEK2_1	411	416	PF00069	0.291
MOD_NEK2_1	424	429	PF00069	0.265
MOD_PKA_1	208	214	PF00069	0.538
MOD_PKA_2	208	214	PF00069	0.641
MOD_PKB_1	26	34	PF00069	0.503
MOD_Plk_1	280	286	PF00069	0.438
MOD_Plk_1	380	386	PF00069	0.273
MOD_Plk_1	411	417	PF00069	0.367
MOD_Plk_2-3	412	418	PF00069	0.325
MOD_Plk_4	140	146	PF00069	0.419
MOD_Plk_4	177	183	PF00069	0.480
MOD_Plk_4	256	262	PF00069	0.493
MOD_Plk_4	380	386	PF00069	0.254
MOD_Plk_4	412	418	PF00069	0.291
MOD_ProDKin_1	334	340	PF00069	0.365
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.739
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.431
TRG_ENDOCYTIC_2	141	144	PF00928	0.507
TRG_ENDOCYTIC_2	184	187	PF00928	0.385
TRG_ENDOCYTIC_2	228	231	PF00928	0.455
TRG_ENDOCYTIC_2	265	268	PF00928	0.421
TRG_ENDOCYTIC_2	279	282	PF00928	0.454
TRG_ENDOCYTIC_2	431	434	PF00928	0.330
TRG_ER_diArg_1	123	126	PF00400	0.605
TRG_ER_diArg_1	155	157	PF00400	0.504
TRG_ER_diArg_1	198	200	PF00400	0.473
TRG_ER_diArg_1	25	28	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9L3	Leptomonas seymouri	57%	100%
A0A3S7X221	Leishmania donovani	93%	100%
A4HH57	Leishmania braziliensis	78%	100%
A4I483	Leishmania infantum	93%	100%
C9ZKP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AM48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BPX7	Trypanosoma cruzi	34%	100%