SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADM9_LEIMA

TriTrypDb:

LmjF.29.0270 , LMJLV39_290007800 , LMJSD75_290007800

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005643	nuclear pore	3	2
GO:0020023	kinetoplast	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9ADM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.478
CLV_NRD_NRD_1	149	151	PF00675	0.637
CLV_NRD_NRD_1	239	241	PF00675	0.660
CLV_NRD_NRD_1	294	296	PF00675	0.635
CLV_NRD_NRD_1	303	305	PF00675	0.611
CLV_PCSK_FUR_1	292	296	PF00082	0.627
CLV_PCSK_FUR_1	99	103	PF00082	0.416
CLV_PCSK_KEX2_1	101	103	PF00082	0.481
CLV_PCSK_KEX2_1	149	151	PF00082	0.564
CLV_PCSK_KEX2_1	292	294	PF00082	0.601
CLV_PCSK_KEX2_1	303	305	PF00082	0.574
CLV_PCSK_PC7_1	299	305	PF00082	0.603
CLV_PCSK_SKI1_1	305	309	PF00082	0.780
CLV_PCSK_SKI1_1	335	339	PF00082	0.460
DEG_Nend_UBRbox_1	1	4	PF02207	0.412
DEG_SCF_FBW7_2	183	189	PF00400	0.691
DOC_CDC14_PxL_1	61	69	PF14671	0.349
DOC_CKS1_1	183	188	PF01111	0.620
DOC_MAPK_DCC_7	63	72	PF00069	0.341
DOC_MAPK_MEF2A_6	63	72	PF00069	0.341
DOC_USP7_MATH_1	207	211	PF00917	0.604
DOC_USP7_MATH_1	254	258	PF00917	0.690
DOC_USP7_MATH_1	287	291	PF00917	0.620
DOC_USP7_MATH_1	54	58	PF00917	0.412
DOC_USP7_UBL2_3	241	245	PF12436	0.631
DOC_USP7_UBL2_3	246	250	PF12436	0.570
DOC_USP7_UBL2_3	251	255	PF12436	0.563
DOC_USP7_UBL2_3	256	260	PF12436	0.567
DOC_USP7_UBL2_3	284	288	PF12436	0.620
DOC_USP7_UBL2_3	324	328	PF12436	0.465
DOC_WW_Pin1_4	161	166	PF00397	0.562
DOC_WW_Pin1_4	182	187	PF00397	0.729
DOC_WW_Pin1_4	195	200	PF00397	0.605
DOC_WW_Pin1_4	203	208	PF00397	0.562
DOC_WW_Pin1_4	217	222	PF00397	0.595
DOC_WW_Pin1_4	223	228	PF00397	0.620
DOC_WW_Pin1_4	235	240	PF00397	0.545
DOC_WW_Pin1_4	250	255	PF00397	0.554
DOC_WW_Pin1_4	260	265	PF00397	0.645
DOC_WW_Pin1_4	268	273	PF00397	0.576
DOC_WW_Pin1_4	274	279	PF00397	0.554
DOC_WW_Pin1_4	310	315	PF00397	0.477
DOC_WW_Pin1_4	93	98	PF00397	0.440
LIG_14-3-3_CanoR_1	304	310	PF00244	0.611
LIG_BRCT_BRCA1_1	24	28	PF00533	0.412
LIG_BRCT_BRCA1_1	68	72	PF00533	0.364
LIG_FHA_1	140	146	PF00498	0.511
LIG_FHA_1	17	23	PF00498	0.527
LIG_FHA_1	182	188	PF00498	0.617
LIG_FHA_1	43	49	PF00498	0.442
LIG_FHA_2	110	116	PF00498	0.477
LIG_FHA_2	337	343	PF00498	0.455
LIG_LIR_Nem_3	125	129	PF02991	0.635
LIG_LIR_Nem_3	25	31	PF02991	0.386
LIG_NRBOX	69	75	PF00104	0.354
LIG_PTB_Apo_2	9	16	PF02174	0.375
LIG_PTB_Phospho_1	9	15	PF10480	0.379
LIG_SH2_NCK_1	111	115	PF00017	0.521
LIG_SH2_STAP1	18	22	PF00017	0.388
LIG_SH2_STAT5	109	112	PF00017	0.514
LIG_SH2_STAT5	15	18	PF00017	0.383
LIG_SH3_3	1	7	PF00018	0.394
LIG_SH3_3	277	283	PF00018	0.611
LIG_SH3_3	62	68	PF00018	0.377
LIG_TRAF2_1	38	41	PF00917	0.408
MOD_CDC14_SPxK_1	198	201	PF00782	0.641
MOD_CDC14_SPxK_1	220	223	PF00782	0.646
MOD_CDC14_SPxK_1	243	246	PF00782	0.634
MOD_CDC14_SPxK_1	253	256	PF00782	0.627
MOD_CDC14_SPxK_1	263	266	PF00782	0.635
MOD_CDC14_SPxK_1	271	274	PF00782	0.589
MOD_CDC14_SPxK_1	279	282	PF00782	0.501
MOD_CDC14_SPxK_1	96	99	PF00782	0.434
MOD_CDK_SPK_2	235	240	PF00069	0.607
MOD_CDK_SPK_2	250	255	PF00069	0.554
MOD_CDK_SPK_2	260	265	PF00069	0.722
MOD_CDK_SPK_2	312	317	PF00069	0.476
MOD_CDK_SPxK_1	182	188	PF00069	0.753
MOD_CDK_SPxK_1	195	201	PF00069	0.655
MOD_CDK_SPxK_1	217	223	PF00069	0.613
MOD_CDK_SPxK_1	235	241	PF00069	0.586
MOD_CDK_SPxK_1	250	256	PF00069	0.515
MOD_CDK_SPxK_1	260	266	PF00069	0.647
MOD_CDK_SPxK_1	268	274	PF00069	0.579
MOD_CDK_SPxK_1	276	282	PF00069	0.521
MOD_CDK_SPxK_1	93	99	PF00069	0.439
MOD_CDK_SPxxK_3	310	317	PF00069	0.566
MOD_CK1_1	151	157	PF00069	0.656
MOD_CK1_1	234	240	PF00069	0.651
MOD_CK1_1	259	265	PF00069	0.676
MOD_CK1_1	35	41	PF00069	0.447
MOD_CK1_1	66	72	PF00069	0.398
MOD_CK2_1	109	115	PF00069	0.484
MOD_CK2_1	35	41	PF00069	0.405
MOD_DYRK1A_RPxSP_1	223	227	PF00069	0.733
MOD_DYRK1A_RPxSP_1	274	278	PF00069	0.686
MOD_GlcNHglycan	157	160	PF01048	0.623
MOD_GlcNHglycan	233	236	PF01048	0.635
MOD_GlcNHglycan	24	27	PF01048	0.409
MOD_GlcNHglycan	284	287	PF01048	0.659
MOD_GlcNHglycan	289	292	PF01048	0.637
MOD_GSK3_1	139	146	PF00069	0.452
MOD_GSK3_1	148	155	PF00069	0.551
MOD_GSK3_1	16	23	PF00069	0.488
MOD_GSK3_1	161	168	PF00069	0.552
MOD_GSK3_1	171	178	PF00069	0.514
MOD_GSK3_1	193	200	PF00069	0.669
MOD_GSK3_1	203	210	PF00069	0.558
MOD_GSK3_1	230	237	PF00069	0.623
MOD_GSK3_1	250	257	PF00069	0.656
MOD_GSK3_1	274	281	PF00069	0.669
MOD_GSK3_1	282	289	PF00069	0.641
MOD_GSK3_1	293	300	PF00069	0.580
MOD_GSK3_1	308	315	PF00069	0.460
MOD_GSK3_1	32	39	PF00069	0.409
MOD_GSK3_1	59	66	PF00069	0.425
MOD_N-GLC_1	54	59	PF02516	0.447
MOD_N-GLC_1	81	86	PF02516	0.352
MOD_NEK2_1	143	148	PF00069	0.476
MOD_NEK2_1	175	180	PF00069	0.571
MOD_NEK2_1	22	27	PF00069	0.384
MOD_NEK2_1	231	236	PF00069	0.523
MOD_NEK2_1	59	64	PF00069	0.445
MOD_NEK2_1	74	79	PF00069	0.329
MOD_NEK2_2	29	34	PF00069	0.394
MOD_NEK2_2	54	59	PF00069	0.410
MOD_PIKK_1	165	171	PF00454	0.572
MOD_PIKK_1	74	80	PF00454	0.343
MOD_PK_1	328	334	PF00069	0.517
MOD_PKA_1	149	155	PF00069	0.576
MOD_PKA_1	255	261	PF00069	0.644
MOD_PKA_1	293	299	PF00069	0.702
MOD_PKA_2	148	154	PF00069	0.587
MOD_PKA_2	293	299	PF00069	0.653
MOD_PKB_1	293	301	PF00069	0.596
MOD_Plk_1	328	334	PF00069	0.544
MOD_Plk_1	42	48	PF00069	0.437
MOD_Plk_1	59	65	PF00069	0.457
MOD_Plk_1	81	87	PF00069	0.355
MOD_Plk_4	171	177	PF00069	0.561
MOD_Plk_4	5	11	PF00069	0.370
MOD_Plk_4	54	60	PF00069	0.542
MOD_Plk_4	66	72	PF00069	0.376
MOD_Plk_4	81	87	PF00069	0.337
MOD_ProDKin_1	161	167	PF00069	0.558
MOD_ProDKin_1	182	188	PF00069	0.733
MOD_ProDKin_1	195	201	PF00069	0.608
MOD_ProDKin_1	203	209	PF00069	0.561
MOD_ProDKin_1	217	223	PF00069	0.599
MOD_ProDKin_1	235	241	PF00069	0.546
MOD_ProDKin_1	250	256	PF00069	0.538
MOD_ProDKin_1	260	266	PF00069	0.647
MOD_ProDKin_1	268	274	PF00069	0.579
MOD_ProDKin_1	276	282	PF00069	0.521
MOD_ProDKin_1	310	316	PF00069	0.474
MOD_ProDKin_1	93	99	PF00069	0.439
MOD_SUMO_rev_2	189	195	PF00179	0.594
TRG_ENDOCYTIC_2	126	129	PF00928	0.607
TRG_ER_diArg_1	148	150	PF00400	0.556
TRG_ER_diArg_1	292	295	PF00400	0.712
TRG_ER_diArg_1	44	47	PF00400	0.448
TRG_ER_diArg_1	50	53	PF00400	0.441
TRG_ER_diArg_1	99	102	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS3	Leptomonas seymouri	48%	100%
A0A1X0NZQ5	Trypanosomatidae	32%	100%
A0A3S5H7K5	Leishmania donovani	93%	100%
A4HH60	Leishmania braziliensis	73%	100%
A4I480	Leishmania infantum	93%	81%
C9ZKP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AM51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DLD7	Trypanosoma cruzi	33%	100%