Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADM1_LEIMA

TriTrypDb:

LmjF.29.0190 , LMJLV39_290007000 , LMJSD75_290007000

Length:

1020

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.751
CLV_C14_Caspase3-7	32	36	PF00656	0.702
CLV_C14_Caspase3-7	800	804	PF00656	0.518
CLV_NRD_NRD_1	183	185	PF00675	0.755
CLV_NRD_NRD_1	511	513	PF00675	0.602
CLV_NRD_NRD_1	543	545	PF00675	0.551
CLV_NRD_NRD_1	683	685	PF00675	0.573
CLV_NRD_NRD_1	815	817	PF00675	0.600
CLV_NRD_NRD_1	854	856	PF00675	0.710
CLV_NRD_NRD_1	967	969	PF00675	0.513
CLV_NRD_NRD_1	989	991	PF00675	0.555
CLV_PCSK_FUR_1	509	513	PF00082	0.546
CLV_PCSK_KEX2_1	126	128	PF00082	0.552
CLV_PCSK_KEX2_1	183	185	PF00082	0.715
CLV_PCSK_KEX2_1	238	240	PF00082	0.779
CLV_PCSK_KEX2_1	511	513	PF00082	0.600
CLV_PCSK_KEX2_1	543	545	PF00082	0.551
CLV_PCSK_KEX2_1	587	589	PF00082	0.756
CLV_PCSK_KEX2_1	683	685	PF00082	0.573
CLV_PCSK_KEX2_1	815	817	PF00082	0.549
CLV_PCSK_KEX2_1	854	856	PF00082	0.779
CLV_PCSK_KEX2_1	966	968	PF00082	0.538
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.544
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.720
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.772
CLV_PCSK_SKI1_1	184	188	PF00082	0.589
CLV_PCSK_SKI1_1	233	237	PF00082	0.757
CLV_PCSK_SKI1_1	391	395	PF00082	0.694
CLV_PCSK_SKI1_1	451	455	PF00082	0.627
CLV_PCSK_SKI1_1	674	678	PF00082	0.524
CLV_PCSK_SKI1_1	679	683	PF00082	0.551
CLV_PCSK_SKI1_1	684	688	PF00082	0.609
CLV_PCSK_SKI1_1	705	709	PF00082	0.520
CLV_PCSK_SKI1_1	815	819	PF00082	0.567
DEG_APCC_DBOX_1	182	190	PF00400	0.701
DEG_Nend_UBRbox_2	1	3	PF02207	0.782
DEG_ODPH_VHL_1	778	789	PF01847	0.571
DEG_SCF_FBW7_1	325	331	PF00400	0.722
DEG_SCF_FBW7_1	332	339	PF00400	0.637
DEG_SCF_FBW7_1	840	847	PF00400	0.660
DEG_SCF_TRCP1_1	202	208	PF00400	0.557
DEG_SPOP_SBC_1	24	28	PF00917	0.744
DEG_SPOP_SBC_1	864	868	PF00917	0.550
DOC_ANK_TNKS_1	220	227	PF00023	0.551
DOC_ANK_TNKS_1	472	479	PF00023	0.790
DOC_ANK_TNKS_1	513	520	PF00023	0.704
DOC_CKS1_1	325	330	PF01111	0.690
DOC_CKS1_1	333	338	PF01111	0.590
DOC_CKS1_1	378	383	PF01111	0.744
DOC_CKS1_1	735	740	PF01111	0.687
DOC_CKS1_1	841	846	PF01111	0.580
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.784
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.713
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.737
DOC_CYCLIN_yCln2_LP_2	838	841	PF00134	0.641
DOC_MAPK_gen_1	183	191	PF00069	0.700
DOC_MAPK_gen_1	494	504	PF00069	0.692
DOC_PP1_RVXF_1	125	132	PF00149	0.658
DOC_PP1_RVXF_1	185	192	PF00149	0.654
DOC_PP2B_LxvP_1	355	358	PF13499	0.693
DOC_PP2B_LxvP_1	360	363	PF13499	0.631
DOC_PP2B_LxvP_1	423	426	PF13499	0.652
DOC_PP2B_LxvP_1	77	80	PF13499	0.742
DOC_PP2B_LxvP_1	837	840	PF13499	0.614
DOC_PP4_FxxP_1	227	230	PF00568	0.671
DOC_PP4_FxxP_1	340	343	PF00568	0.565
DOC_PP4_FxxP_1	900	903	PF00568	0.669
DOC_USP7_MATH_1	139	143	PF00917	0.648
DOC_USP7_MATH_1	172	176	PF00917	0.769
DOC_USP7_MATH_1	179	183	PF00917	0.749
DOC_USP7_MATH_1	260	264	PF00917	0.736
DOC_USP7_MATH_1	284	288	PF00917	0.683
DOC_USP7_MATH_1	30	34	PF00917	0.628
DOC_USP7_MATH_1	315	319	PF00917	0.797
DOC_USP7_MATH_1	510	514	PF00917	0.699
DOC_USP7_MATH_1	527	531	PF00917	0.707
DOC_USP7_MATH_1	537	541	PF00917	0.702
DOC_USP7_MATH_1	591	595	PF00917	0.705
DOC_USP7_MATH_1	697	701	PF00917	0.690
DOC_USP7_MATH_1	864	868	PF00917	0.672
DOC_USP7_MATH_1	984	988	PF00917	0.646
DOC_WW_Pin1_4	226	231	PF00397	0.744
DOC_WW_Pin1_4	242	247	PF00397	0.526
DOC_WW_Pin1_4	324	329	PF00397	0.780
DOC_WW_Pin1_4	332	337	PF00397	0.710
DOC_WW_Pin1_4	343	348	PF00397	0.660
DOC_WW_Pin1_4	377	382	PF00397	0.755
DOC_WW_Pin1_4	407	412	PF00397	0.719
DOC_WW_Pin1_4	68	73	PF00397	0.682
DOC_WW_Pin1_4	734	739	PF00397	0.644
DOC_WW_Pin1_4	81	86	PF00397	0.646
DOC_WW_Pin1_4	820	825	PF00397	0.665
DOC_WW_Pin1_4	840	845	PF00397	0.593
DOC_WW_Pin1_4	93	98	PF00397	0.727
LIG_14-3-3_CanoR_1	134	138	PF00244	0.613
LIG_14-3-3_CanoR_1	145	150	PF00244	0.727
LIG_14-3-3_CanoR_1	215	220	PF00244	0.750
LIG_14-3-3_CanoR_1	497	503	PF00244	0.714
LIG_14-3-3_CanoR_1	705	713	PF00244	0.578
LIG_Actin_WH2_2	670	685	PF00022	0.582
LIG_Actin_WH2_2	806	823	PF00022	0.396
LIG_BIR_III_2	732	736	PF00653	0.699
LIG_BIR_III_4	392	396	PF00653	0.576
LIG_BRCT_BRCA1_1	285	289	PF00533	0.615
LIG_BRCT_BRCA1_1	642	646	PF00533	0.740
LIG_EVH1_2	336	340	PF00568	0.558
LIG_FHA_1	412	418	PF00498	0.659
LIG_FHA_1	437	443	PF00498	0.583
LIG_FHA_1	499	505	PF00498	0.775
LIG_FHA_1	825	831	PF00498	0.628
LIG_FHA_1	841	847	PF00498	0.573
LIG_FHA_1	916	922	PF00498	0.500
LIG_FHA_2	220	226	PF00498	0.560
LIG_FHA_2	235	241	PF00498	0.493
LIG_FHA_2	30	36	PF00498	0.706
LIG_FHA_2	410	416	PF00498	0.802
LIG_FHA_2	685	691	PF00498	0.619
LIG_FHA_2	798	804	PF00498	0.418
LIG_FHA_2	806	812	PF00498	0.438
LIG_FHA_2	935	941	PF00498	0.684
LIG_FHA_2	949	955	PF00498	0.561
LIG_GBD_Chelix_1	1006	1014	PF00786	0.599
LIG_GSK3_LRP6_1	840	845	PF00069	0.678
LIG_Integrin_RGD_1	749	751	PF01839	0.617
LIG_LIR_Apic_2	225	230	PF02991	0.681
LIG_LIR_Apic_2	339	343	PF02991	0.566
LIG_LIR_Apic_2	898	903	PF02991	0.688
LIG_LIR_Gen_1	286	296	PF02991	0.629
LIG_LIR_Gen_1	668	677	PF02991	0.466
LIG_LIR_Gen_1	73	83	PF02991	0.692
LIG_LIR_Nem_3	286	292	PF02991	0.622
LIG_LIR_Nem_3	577	583	PF02991	0.561
LIG_LIR_Nem_3	668	673	PF02991	0.476
LIG_LIR_Nem_3	73	79	PF02991	0.696
LIG_LIR_Nem_3	739	745	PF02991	0.558
LIG_LIR_Nem_3	939	944	PF02991	0.610
LIG_LYPXL_S_1	741	745	PF13949	0.602
LIG_LYPXL_yS_3	742	745	PF13949	0.589
LIG_LYPXL_yS_3	941	944	PF13949	0.626
LIG_MYND_1	308	312	PF01753	0.586
LIG_MYND_1	358	362	PF01753	0.691
LIG_MYND_1	421	425	PF01753	0.716
LIG_MYND_1	93	97	PF01753	0.560
LIG_PCNA_APIM_2	677	683	PF02747	0.538
LIG_SH2_CRK	670	674	PF00017	0.493
LIG_SH2_GRB2like	639	642	PF00017	0.707
LIG_SH2_NCK_1	602	606	PF00017	0.721
LIG_SH2_NCK_1	731	735	PF00017	0.635
LIG_SH2_SRC	4	7	PF00017	0.651
LIG_SH2_SRC	427	430	PF00017	0.806
LIG_SH2_STAP1	4	8	PF00017	0.656
LIG_SH2_STAT5	639	642	PF00017	0.746
LIG_SH2_STAT5	680	683	PF00017	0.448
LIG_SH2_STAT5	76	79	PF00017	0.704
LIG_SH3_3	308	314	PF00018	0.692
LIG_SH3_3	317	323	PF00018	0.675
LIG_SH3_3	330	336	PF00018	0.728
LIG_SH3_3	355	361	PF00018	0.705
LIG_SH3_3	418	424	PF00018	0.680
LIG_SH3_3	512	518	PF00018	0.695
LIG_SH3_3	531	537	PF00018	0.462
LIG_SH3_3	696	702	PF00018	0.764
LIG_SH3_3	732	738	PF00018	0.678
LIG_SH3_3	79	85	PF00018	0.619
LIG_SH3_3	838	844	PF00018	0.621
LIG_SH3_3	87	93	PF00018	0.638
LIG_SH3_4	300	307	PF00018	0.819
LIG_Sin3_3	712	719	PF02671	0.466
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.553
LIG_SUMO_SIM_par_1	380	386	PF11976	0.553
LIG_SUMO_SIM_par_1	59	66	PF11976	0.694
LIG_TRAF2_1	753	756	PF00917	0.588
LIG_WW_1	424	427	PF00397	0.718
LIG_WW_2	421	424	PF00397	0.695
MOD_CDK_SPK_2	242	247	PF00069	0.659
MOD_CDK_SPxxK_3	226	233	PF00069	0.677
MOD_CDK_SPxxK_3	68	75	PF00069	0.684
MOD_CK1_1	115	121	PF00069	0.653
MOD_CK1_1	23	29	PF00069	0.589
MOD_CK1_1	258	264	PF00069	0.739
MOD_CK1_1	287	293	PF00069	0.624
MOD_CK1_1	324	330	PF00069	0.791
MOD_CK1_1	33	39	PF00069	0.674
MOD_CK1_1	366	372	PF00069	0.758
MOD_CK1_1	522	528	PF00069	0.701
MOD_CK1_1	623	629	PF00069	0.716
MOD_CK1_1	66	72	PF00069	0.703
MOD_CK1_1	7	13	PF00069	0.682
MOD_CK1_1	915	921	PF00069	0.498
MOD_CK1_1	923	929	PF00069	0.553
MOD_CK1_1	934	940	PF00069	0.429
MOD_CK1_1	98	104	PF00069	0.792
MOD_CK2_1	219	225	PF00069	0.736
MOD_CK2_1	234	240	PF00069	0.649
MOD_CK2_1	242	248	PF00069	0.650
MOD_CK2_1	409	415	PF00069	0.800
MOD_CK2_1	546	552	PF00069	0.646
MOD_CK2_1	571	577	PF00069	0.792
MOD_CK2_1	684	690	PF00069	0.658
MOD_CK2_1	805	811	PF00069	0.522
MOD_CK2_1	948	954	PF00069	0.604
MOD_Cter_Amidation	852	855	PF01082	0.695
MOD_GlcNHglycan	100	103	PF01048	0.765
MOD_GlcNHglycan	117	120	PF01048	0.657
MOD_GlcNHglycan	122	125	PF01048	0.480
MOD_GlcNHglycan	143	148	PF01048	0.747
MOD_GlcNHglycan	151	154	PF01048	0.736
MOD_GlcNHglycan	202	205	PF01048	0.662
MOD_GlcNHglycan	264	267	PF01048	0.682
MOD_GlcNHglycan	317	320	PF01048	0.753
MOD_GlcNHglycan	32	35	PF01048	0.765
MOD_GlcNHglycan	385	388	PF01048	0.653
MOD_GlcNHglycan	491	494	PF01048	0.741
MOD_GlcNHglycan	52	55	PF01048	0.494
MOD_GlcNHglycan	521	524	PF01048	0.722
MOD_GlcNHglycan	529	532	PF01048	0.663
MOD_GlcNHglycan	539	542	PF01048	0.699
MOD_GlcNHglycan	630	633	PF01048	0.771
MOD_GlcNHglycan	643	646	PF01048	0.695
MOD_GlcNHglycan	65	68	PF01048	0.636
MOD_GlcNHglycan	664	667	PF01048	0.551
MOD_GlcNHglycan	699	702	PF01048	0.673
MOD_GlcNHglycan	738	741	PF01048	0.680
MOD_GlcNHglycan	772	775	PF01048	0.664
MOD_GlcNHglycan	891	894	PF01048	0.741
MOD_GlcNHglycan	9	12	PF01048	0.667
MOD_GlcNHglycan	932	936	PF01048	0.637
MOD_GSK3_1	111	118	PF00069	0.669
MOD_GSK3_1	139	146	PF00069	0.759
MOD_GSK3_1	157	164	PF00069	0.536
MOD_GSK3_1	20	27	PF00069	0.758
MOD_GSK3_1	200	207	PF00069	0.641
MOD_GSK3_1	210	217	PF00069	0.667
MOD_GSK3_1	258	265	PF00069	0.776
MOD_GSK3_1	275	282	PF00069	0.566
MOD_GSK3_1	283	290	PF00069	0.612
MOD_GSK3_1	29	36	PF00069	0.713
MOD_GSK3_1	324	331	PF00069	0.720
MOD_GSK3_1	332	339	PF00069	0.707
MOD_GSK3_1	407	414	PF00069	0.701
MOD_GSK3_1	522	529	PF00069	0.677
MOD_GSK3_1	56	63	PF00069	0.763
MOD_GSK3_1	567	574	PF00069	0.754
MOD_GSK3_1	583	590	PF00069	0.655
MOD_GSK3_1	66	73	PF00069	0.697
MOD_GSK3_1	770	777	PF00069	0.627
MOD_GSK3_1	820	827	PF00069	0.565
MOD_GSK3_1	840	847	PF00069	0.666
MOD_GSK3_1	865	872	PF00069	0.702
MOD_GSK3_1	91	98	PF00069	0.777
MOD_GSK3_1	912	919	PF00069	0.464
MOD_GSK3_1	920	927	PF00069	0.519
MOD_GSK3_1	946	953	PF00069	0.555
MOD_N-GLC_1	120	125	PF02516	0.657
MOD_N-GLC_1	173	178	PF02516	0.643
MOD_N-GLC_1	204	209	PF02516	0.678
MOD_N-GLC_1	372	377	PF02516	0.760
MOD_N-GLC_1	640	645	PF02516	0.625
MOD_N-GLC_2	721	723	PF02516	0.442
MOD_NEK2_1	111	116	PF00069	0.714
MOD_NEK2_1	149	154	PF00069	0.750
MOD_NEK2_1	161	166	PF00069	0.763
MOD_NEK2_1	200	205	PF00069	0.677
MOD_NEK2_1	234	239	PF00069	0.752
MOD_NEK2_1	401	406	PF00069	0.628
MOD_NEK2_1	526	531	PF00069	0.688
MOD_NEK2_1	62	67	PF00069	0.697
MOD_NEK2_1	640	645	PF00069	0.699
MOD_NEK2_1	650	655	PF00069	0.710
MOD_NEK2_1	770	775	PF00069	0.622
MOD_NEK2_1	805	810	PF00069	0.427
MOD_NEK2_1	983	988	PF00069	0.566
MOD_NEK2_2	284	289	PF00069	0.700
MOD_NEK2_2	783	788	PF00069	0.523
MOD_NEK2_2	844	849	PF00069	0.556
MOD_PIKK_1	258	264	PF00454	0.762
MOD_PIKK_1	290	296	PF00454	0.638
MOD_PIKK_1	393	399	PF00454	0.580
MOD_PIKK_1	633	639	PF00454	0.710
MOD_PIKK_1	791	797	PF00454	0.523
MOD_PIKK_1	973	979	PF00454	0.517
MOD_PK_1	215	221	PF00069	0.765
MOD_PK_1	279	285	PF00069	0.725
MOD_PK_1	703	709	PF00069	0.525
MOD_PKA_1	587	593	PF00069	0.712
MOD_PKA_2	133	139	PF00069	0.577
MOD_PKA_2	214	220	PF00069	0.700
MOD_PKA_2	24	30	PF00069	0.746
MOD_PKA_2	252	258	PF00069	0.644
MOD_PKA_2	437	443	PF00069	0.591
MOD_PKA_2	504	510	PF00069	0.691
MOD_PKA_2	567	573	PF00069	0.683
MOD_PKA_2	583	589	PF00069	0.509
MOD_PKA_2	620	626	PF00069	0.686
MOD_PKB_1	703	711	PF00069	0.513
MOD_Plk_1	161	167	PF00069	0.692
MOD_Plk_1	4	10	PF00069	0.659
MOD_Plk_1	931	937	PF00069	0.599
MOD_Plk_1	957	963	PF00069	0.616
MOD_Plk_2-3	41	47	PF00069	0.586
MOD_Plk_2-3	546	552	PF00069	0.689
MOD_Plk_4	112	118	PF00069	0.753
MOD_Plk_4	215	221	PF00069	0.738
MOD_Plk_4	284	290	PF00069	0.622
MOD_Plk_4	306	312	PF00069	0.586
MOD_Plk_4	380	386	PF00069	0.592
MOD_Plk_4	912	918	PF00069	0.543
MOD_ProDKin_1	226	232	PF00069	0.741
MOD_ProDKin_1	242	248	PF00069	0.532
MOD_ProDKin_1	324	330	PF00069	0.782
MOD_ProDKin_1	332	338	PF00069	0.710
MOD_ProDKin_1	343	349	PF00069	0.660
MOD_ProDKin_1	377	383	PF00069	0.755
MOD_ProDKin_1	407	413	PF00069	0.721
MOD_ProDKin_1	68	74	PF00069	0.680
MOD_ProDKin_1	734	740	PF00069	0.644
MOD_ProDKin_1	81	87	PF00069	0.648
MOD_ProDKin_1	820	826	PF00069	0.665
MOD_ProDKin_1	840	846	PF00069	0.581
MOD_ProDKin_1	93	99	PF00069	0.723
TRG_DiLeu_BaLyEn_6	833	838	PF01217	0.575
TRG_ENDOCYTIC_2	462	465	PF00928	0.678
TRG_ENDOCYTIC_2	602	605	PF00928	0.726
TRG_ENDOCYTIC_2	670	673	PF00928	0.498
TRG_ENDOCYTIC_2	742	745	PF00928	0.589
TRG_ENDOCYTIC_2	76	79	PF00928	0.704
TRG_ENDOCYTIC_2	822	825	PF00928	0.547
TRG_ENDOCYTIC_2	941	944	PF00928	0.604
TRG_ER_diArg_1	471	474	PF00400	0.745
TRG_ER_diArg_1	508	511	PF00400	0.706
TRG_ER_diArg_1	512	515	PF00400	0.664
TRG_ER_diArg_1	542	544	PF00400	0.538
TRG_ER_diArg_1	682	684	PF00400	0.562
TRG_ER_diArg_1	702	705	PF00400	0.664
TRG_ER_diArg_1	814	816	PF00400	0.545
TRG_ER_diArg_1	965	968	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.793

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C6	Leptomonas seymouri	45%	100%
A0A1X0NZF9	Trypanosomatidae	27%	100%
A0A3S7X251	Leishmania donovani	89%	100%
A0A422NUW5	Trypanosoma rangeli	29%	100%
A4HH27	Leishmania braziliensis	64%	99%
A4I472	Leishmania infantum	89%	100%
E9AM60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BPW9	Trypanosoma cruzi	27%	100%