RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADM0_LEIMA

TriTrypDb:

LmjF.29.0180 , LMJLV39_290006900 , LMJSD75_290006900

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADM0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.540
CLV_NRD_NRD_1	264	266	PF00675	0.683
CLV_NRD_NRD_1	414	416	PF00675	0.578
CLV_NRD_NRD_1	61	63	PF00675	0.694
CLV_PCSK_KEX2_1	195	197	PF00082	0.540
CLV_PCSK_KEX2_1	333	335	PF00082	0.423
CLV_PCSK_KEX2_1	410	412	PF00082	0.538
CLV_PCSK_KEX2_1	61	63	PF00082	0.693
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.509
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.538
CLV_PCSK_SKI1_1	315	319	PF00082	0.560
CLV_PCSK_SKI1_1	341	345	PF00082	0.501
DEG_SCF_TRCP1_1	19	25	PF00400	0.686
DEG_SPOP_SBC_1	102	106	PF00917	0.719
DEG_SPOP_SBC_1	384	388	PF00917	0.755
DEG_SPOP_SBC_1	47	51	PF00917	0.727
DOC_CKS1_1	134	139	PF01111	0.572
DOC_CKS1_1	389	394	PF01111	0.720
DOC_CKS1_1	475	480	PF01111	0.703
DOC_CYCLIN_RxL_1	339	347	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.745
DOC_CYCLIN_yCln2_LP_2	520	523	PF00134	0.590
DOC_MAPK_DCC_7	505	514	PF00069	0.679
DOC_MAPK_MEF2A_6	212	219	PF00069	0.501
DOC_MAPK_MEF2A_6	505	514	PF00069	0.669
DOC_PP1_RVXF_1	250	256	PF00149	0.548
DOC_PP2B_LxvP_1	131	134	PF13499	0.693
DOC_PP2B_LxvP_1	169	172	PF13499	0.565
DOC_PP2B_LxvP_1	520	523	PF13499	0.590
DOC_PP4_FxxP_1	296	299	PF00568	0.527
DOC_PP4_FxxP_1	491	494	PF00568	0.568
DOC_USP7_MATH_1	102	106	PF00917	0.719
DOC_USP7_MATH_1	199	203	PF00917	0.601
DOC_USP7_MATH_1	37	41	PF00917	0.705
DOC_USP7_MATH_1	384	388	PF00917	0.727
DOC_USP7_MATH_1	476	480	PF00917	0.711
DOC_USP7_UBL2_3	396	400	PF12436	0.731
DOC_USP7_UBL2_3	416	420	PF12436	0.586
DOC_WW_Pin1_4	133	138	PF00397	0.647
DOC_WW_Pin1_4	33	38	PF00397	0.725
DOC_WW_Pin1_4	361	366	PF00397	0.715
DOC_WW_Pin1_4	380	385	PF00397	0.760
DOC_WW_Pin1_4	388	393	PF00397	0.728
DOC_WW_Pin1_4	474	479	PF00397	0.678
DOC_WW_Pin1_4	64	69	PF00397	0.718
LIG_14-3-3_CanoR_1	250	256	PF00244	0.553
LIG_14-3-3_CanoR_1	39	44	PF00244	0.734
LIG_14-3-3_CanoR_1	415	422	PF00244	0.680
LIG_14-3-3_CanoR_1	511	517	PF00244	0.640
LIG_BIR_II_1	1	5	PF00653	0.758
LIG_BRCT_BRCA1_1	13	17	PF00533	0.703
LIG_BRCT_BRCA1_1	470	474	PF00533	0.715
LIG_DLG_GKlike_1	39	47	PF00625	0.783
LIG_FHA_1	224	230	PF00498	0.414
LIG_FHA_1	373	379	PF00498	0.654
LIG_FHA_2	134	140	PF00498	0.622
LIG_FHA_2	206	212	PF00498	0.551
LIG_FHA_2	389	395	PF00498	0.539
LIG_LIR_Apic_2	301	305	PF02991	0.540
LIG_LIR_Apic_2	489	494	PF02991	0.713
LIG_LIR_Gen_1	22	31	PF02991	0.726
LIG_LIR_Gen_1	322	331	PF02991	0.496
LIG_LIR_Nem_3	22	27	PF02991	0.718
LIG_LIR_Nem_3	322	328	PF02991	0.457
LIG_MYND_1	108	112	PF01753	0.756
LIG_NRP_CendR_1	534	537	PF00754	0.692
LIG_SH2_CRK	497	501	PF00017	0.650
LIG_SH2_SRC	164	167	PF00017	0.532
LIG_SH2_STAP1	164	168	PF00017	0.529
LIG_SH2_STAP1	174	178	PF00017	0.467
LIG_SH2_STAP1	336	340	PF00017	0.556
LIG_SH2_STAP1	43	47	PF00017	0.725
LIG_SH2_STAT5	205	208	PF00017	0.473
LIG_SH2_STAT5	216	219	PF00017	0.374
LIG_SH2_STAT5	497	500	PF00017	0.531
LIG_SH3_1	303	309	PF00018	0.551
LIG_SH3_3	10	16	PF00018	0.765
LIG_SH3_3	105	111	PF00018	0.729
LIG_SH3_3	131	137	PF00018	0.607
LIG_SH3_3	303	309	PF00018	0.517
LIG_SH3_3	371	377	PF00018	0.678
LIG_SH3_3	419	425	PF00018	0.753
LIG_SH3_3	472	478	PF00018	0.704
LIG_SH3_3	507	513	PF00018	0.678
LIG_TRAF2_1	221	224	PF00917	0.559
LIG_TRFH_1	255	259	PF08558	0.606
LIG_TYR_ITIM	495	500	PF00017	0.646
LIG_WW_1	96	99	PF00397	0.748
MOD_CDC14_SPxK_1	36	39	PF00782	0.753
MOD_CDC14_SPxK_1	364	367	PF00782	0.721
MOD_CDK_SPxK_1	33	39	PF00069	0.750
MOD_CDK_SPxK_1	361	367	PF00069	0.722
MOD_CK1_1	103	109	PF00069	0.565
MOD_CK1_1	184	190	PF00069	0.471
MOD_CK1_1	20	26	PF00069	0.648
MOD_CK1_1	248	254	PF00069	0.478
MOD_CK1_1	30	36	PF00069	0.594
MOD_CK1_1	307	313	PF00069	0.501
MOD_CK1_1	319	325	PF00069	0.568
MOD_CK1_1	350	356	PF00069	0.625
MOD_CK1_1	379	385	PF00069	0.740
MOD_CK1_1	388	394	PF00069	0.726
MOD_CK1_1	42	48	PF00069	0.744
MOD_CK1_1	454	460	PF00069	0.711
MOD_CK1_1	49	55	PF00069	0.700
MOD_CK1_1	69	75	PF00069	0.471
MOD_CK1_1	91	97	PF00069	0.744
MOD_CK2_1	133	139	PF00069	0.630
MOD_CK2_1	205	211	PF00069	0.561
MOD_CK2_1	217	223	PF00069	0.419
MOD_CK2_1	229	235	PF00069	0.425
MOD_CK2_1	388	394	PF00069	0.598
MOD_CK2_1	48	54	PF00069	0.788
MOD_CK2_1	512	518	PF00069	0.617
MOD_CK2_1	64	70	PF00069	0.532
MOD_DYRK1A_RPxSP_1	64	68	PF00069	0.753
MOD_GlcNHglycan	105	108	PF01048	0.508
MOD_GlcNHglycan	18	22	PF01048	0.707
MOD_GlcNHglycan	186	189	PF01048	0.434
MOD_GlcNHglycan	309	312	PF01048	0.637
MOD_GlcNHglycan	321	324	PF01048	0.585
MOD_GlcNHglycan	378	381	PF01048	0.734
MOD_GlcNHglycan	416	419	PF01048	0.733
MOD_GlcNHglycan	453	456	PF01048	0.706
MOD_GlcNHglycan	470	473	PF01048	0.519
MOD_GlcNHglycan	70	74	PF01048	0.583
MOD_GlcNHglycan	90	93	PF01048	0.733
MOD_GSK3_1	144	151	PF00069	0.405
MOD_GSK3_1	19	26	PF00069	0.613
MOD_GSK3_1	27	34	PF00069	0.603
MOD_GSK3_1	344	351	PF00069	0.622
MOD_GSK3_1	35	42	PF00069	0.691
MOD_GSK3_1	372	379	PF00069	0.729
MOD_GSK3_1	380	387	PF00069	0.676
MOD_GSK3_1	395	402	PF00069	0.558
MOD_GSK3_1	43	50	PF00069	0.688
MOD_GSK3_1	450	457	PF00069	0.676
MOD_GSK3_1	62	69	PF00069	0.525
MOD_GSK3_1	87	94	PF00069	0.664
MOD_LATS_1	263	269	PF00433	0.739
MOD_LATS_1	448	454	PF00433	0.800
MOD_LATS_1	60	66	PF00433	0.755
MOD_LATS_1	9	15	PF00433	0.713
MOD_N-GLC_1	199	204	PF02516	0.606
MOD_NEK2_1	17	22	PF00069	0.705
MOD_NEK2_1	229	234	PF00069	0.488
MOD_NEK2_1	253	258	PF00069	0.489
MOD_NEK2_1	317	322	PF00069	0.537
MOD_NEK2_1	344	349	PF00069	0.677
MOD_NEK2_1	463	468	PF00069	0.588
MOD_NEK2_1	495	500	PF00069	0.556
MOD_NEK2_1	87	92	PF00069	0.687
MOD_NEK2_2	199	204	PF00069	0.589
MOD_PIKK_1	436	442	PF00454	0.760
MOD_PIKK_1	476	482	PF00454	0.731
MOD_PK_1	78	84	PF00069	0.711
MOD_PKA_1	265	271	PF00069	0.692
MOD_PKA_2	153	159	PF00069	0.566
MOD_PKA_2	251	257	PF00069	0.589
MOD_PKA_2	273	279	PF00069	0.638
MOD_PKA_2	414	420	PF00069	0.644
MOD_PKB_1	64	72	PF00069	0.707
MOD_Plk_1	174	180	PF00069	0.564
MOD_Plk_1	199	205	PF00069	0.588
MOD_Plk_2-3	326	332	PF00069	0.563
MOD_Plk_4	126	132	PF00069	0.706
MOD_Plk_4	164	170	PF00069	0.505
MOD_Plk_4	78	84	PF00069	0.699
MOD_ProDKin_1	133	139	PF00069	0.646
MOD_ProDKin_1	33	39	PF00069	0.728
MOD_ProDKin_1	361	367	PF00069	0.718
MOD_ProDKin_1	380	386	PF00069	0.763
MOD_ProDKin_1	388	394	PF00069	0.730
MOD_ProDKin_1	474	480	PF00069	0.679
MOD_ProDKin_1	64	70	PF00069	0.720
MOD_SUMO_rev_2	337	343	PF00179	0.574
MOD_SUMO_rev_2	388	398	PF00179	0.534
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.583
TRG_ENDOCYTIC_2	216	219	PF00928	0.427
TRG_ENDOCYTIC_2	497	500	PF00928	0.644
TRG_ER_diArg_1	194	196	PF00400	0.525
TRG_ER_diArg_1	249	252	PF00400	0.541
TRG_ER_diArg_1	61	64	PF00400	0.671
TRG_NLS_MonoExtC_3	408	414	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y5	Leptomonas seymouri	46%	100%
A0A3Q8IE82	Leishmania donovani	93%	100%
A0A422NUU8	Trypanosoma rangeli	31%	100%
A4HH26	Leishmania braziliensis	80%	100%
A4I471	Leishmania infantum	93%	100%
C9ZKQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AM61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DLD2	Trypanosoma cruzi	27%	100%