CAP-Gly domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADL8_LEIMA

TriTrypDb:

LmjF.29.0160 , LMJLV39_290006600 , LMJSD75_290006600

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	9
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ADL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.285
CLV_NRD_NRD_1	200	202	PF00675	0.709
CLV_NRD_NRD_1	273	275	PF00675	0.430
CLV_NRD_NRD_1	438	440	PF00675	0.382
CLV_NRD_NRD_1	44	46	PF00675	0.735
CLV_NRD_NRD_1	557	559	PF00675	0.365
CLV_NRD_NRD_1	6	8	PF00675	0.462
CLV_PCSK_KEX2_1	200	202	PF00082	0.718
CLV_PCSK_KEX2_1	273	275	PF00082	0.409
CLV_PCSK_KEX2_1	342	344	PF00082	0.323
CLV_PCSK_KEX2_1	438	440	PF00082	0.382
CLV_PCSK_KEX2_1	559	561	PF00082	0.370
CLV_PCSK_KEX2_1	6	8	PF00082	0.455
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.718
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.323
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.368
CLV_PCSK_SKI1_1	201	205	PF00082	0.621
CLV_PCSK_SKI1_1	23	27	PF00082	0.246
CLV_PCSK_SKI1_1	274	278	PF00082	0.364
CLV_PCSK_SKI1_1	343	347	PF00082	0.349
CLV_PCSK_SKI1_1	402	406	PF00082	0.321
CLV_PCSK_SKI1_1	409	413	PF00082	0.331
CLV_PCSK_SKI1_1	453	457	PF00082	0.351
CLV_PCSK_SKI1_1	548	552	PF00082	0.400
DEG_APCC_DBOX_1	342	350	PF00400	0.549
DEG_APCC_DBOX_1	401	409	PF00400	0.481
DEG_APCC_DBOX_1	5	13	PF00400	0.562
DEG_MDM2_SWIB_1	118	125	PF02201	0.447
DEG_SCF_FBW7_1	443	450	PF00400	0.469
DOC_CDC14_PxL_1	303	311	PF14671	0.466
DOC_CKS1_1	444	449	PF01111	0.470
DOC_CYCLIN_RxL_1	399	407	PF00134	0.486
DOC_CYCLIN_RxL_1	4	14	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	125	131	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.459
DOC_MAPK_gen_1	165	174	PF00069	0.654
DOC_MAPK_gen_1	273	282	PF00069	0.615
DOC_MAPK_gen_1	341	350	PF00069	0.513
DOC_MAPK_gen_1	558	568	PF00069	0.643
DOC_MAPK_gen_1	59	67	PF00069	0.479
DOC_MAPK_gen_1	6	12	PF00069	0.562
DOC_MAPK_MEF2A_6	341	349	PF00069	0.515
DOC_MAPK_MEF2A_6	367	374	PF00069	0.484
DOC_MAPK_MEF2A_6	453	462	PF00069	0.548
DOC_MAPK_MEF2A_6	548	555	PF00069	0.612
DOC_MAPK_MEF2A_6	61	69	PF00069	0.359
DOC_MAPK_NFAT4_5	341	349	PF00069	0.586
DOC_PP1_RVXF_1	21	27	PF00149	0.246
DOC_PP1_RVXF_1	546	553	PF00149	0.638
DOC_PP2B_LxvP_1	125	128	PF13499	0.389
DOC_PP2B_LxvP_1	471	474	PF13499	0.522
DOC_PP4_FxxP_1	327	330	PF00568	0.400
DOC_USP7_MATH_1	323	327	PF00917	0.405
DOC_USP7_MATH_1	384	388	PF00917	0.310
DOC_USP7_MATH_1	432	436	PF00917	0.620
DOC_USP7_MATH_1	447	451	PF00917	0.503
DOC_USP7_MATH_1	465	469	PF00917	0.300
DOC_USP7_MATH_1	90	94	PF00917	0.441
DOC_USP7_MATH_2	447	453	PF00917	0.584
DOC_WW_Pin1_4	428	433	PF00397	0.616
DOC_WW_Pin1_4	443	448	PF00397	0.570
DOC_WW_Pin1_4	99	104	PF00397	0.675
LIG_14-3-3_CanoR_1	149	157	PF00244	0.614
LIG_14-3-3_CanoR_1	229	238	PF00244	0.678
LIG_14-3-3_CanoR_1	23	33	PF00244	0.246
LIG_14-3-3_CanoR_1	268	272	PF00244	0.561
LIG_14-3-3_CanoR_1	273	277	PF00244	0.514
LIG_14-3-3_CanoR_1	308	316	PF00244	0.376
LIG_14-3-3_CanoR_1	453	458	PF00244	0.568
LIG_Actin_WH2_2	48	63	PF00022	0.472
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	503	507	PF00533	0.477
LIG_CaM_IQ_9	260	276	PF13499	0.588
LIG_CaM_IQ_9	550	566	PF13499	0.652
LIG_Clathr_ClatBox_1	39	43	PF01394	0.482
LIG_eIF4E_1	34	40	PF01652	0.473
LIG_FHA_1	138	144	PF00498	0.433
LIG_FHA_1	317	323	PF00498	0.327
LIG_FHA_1	435	441	PF00498	0.526
LIG_FHA_1	454	460	PF00498	0.458
LIG_FHA_1	51	57	PF00498	0.480
LIG_FHA_1	515	521	PF00498	0.322
LIG_FHA_1	526	532	PF00498	0.295
LIG_FHA_2	257	263	PF00498	0.678
LIG_FHA_2	444	450	PF00498	0.468
LIG_IRF3_LxIS_1	56	63	PF10401	0.356
LIG_LIR_Apic_2	326	330	PF02991	0.480
LIG_LIR_Gen_1	463	474	PF02991	0.377
LIG_LIR_Nem_3	121	125	PF02991	0.346
LIG_LIR_Nem_3	262	266	PF02991	0.577
LIG_LIR_Nem_3	27	33	PF02991	0.317
LIG_LIR_Nem_3	463	469	PF02991	0.424
LIG_LIR_Nem_3	504	510	PF02991	0.439
LIG_NRBOX	345	351	PF00104	0.402
LIG_NRBOX	396	402	PF00104	0.420
LIG_Pex14_1	539	543	PF04695	0.527
LIG_Pex14_2	114	118	PF04695	0.343
LIG_Pex14_2	203	207	PF04695	0.418
LIG_Pex14_2	26	30	PF04695	0.447
LIG_Pex14_2	462	466	PF04695	0.470
LIG_REV1ctd_RIR_1	362	371	PF16727	0.513
LIG_SH2_GRB2like	542	545	PF00017	0.609
LIG_SH2_NCK_1	77	81	PF00017	0.368
LIG_SH2_SRC	288	291	PF00017	0.480
LIG_SH2_SRC	34	37	PF00017	0.434
LIG_SH2_STAT5	288	291	PF00017	0.349
LIG_SH2_STAT5	34	37	PF00017	0.397
LIG_SH2_STAT5	77	80	PF00017	0.368
LIG_SH3_3	125	131	PF00018	0.447
LIG_SH3_3	319	325	PF00018	0.436
LIG_SH3_3	441	447	PF00018	0.612
LIG_SH3_3	467	473	PF00018	0.661
LIG_Sin3_3	507	514	PF02671	0.339
LIG_SUMO_SIM_anti_2	456	461	PF11976	0.397
LIG_SUMO_SIM_anti_2	517	525	PF11976	0.353
LIG_SUMO_SIM_anti_2	528	535	PF11976	0.389
LIG_SUMO_SIM_par_1	210	215	PF11976	0.398
LIG_SUMO_SIM_par_1	38	44	PF11976	0.460
LIG_SUMO_SIM_par_1	517	525	PF11976	0.352
LIG_SUMO_SIM_par_1	8	14	PF11976	0.586
LIG_TRAF2_1	166	169	PF00917	0.729
LIG_UBA3_1	551	559	PF00899	0.552
LIG_WRC_WIRS_1	317	322	PF05994	0.246
MOD_CDK_SPK_2	99	104	PF00069	0.605
MOD_CDK_SPxxK_3	99	106	PF00069	0.610
MOD_CK1_1	132	138	PF00069	0.415
MOD_CK1_1	246	252	PF00069	0.699
MOD_CK1_1	480	486	PF00069	0.654
MOD_CK1_1	502	508	PF00069	0.632
MOD_CK1_1	525	531	PF00069	0.420
MOD_CK2_1	229	235	PF00069	0.648
MOD_CK2_1	256	262	PF00069	0.430
MOD_CK2_1	443	449	PF00069	0.319
MOD_Cter_Amidation	339	342	PF01082	0.398
MOD_Cter_Amidation	46	49	PF01082	0.664
MOD_GlcNHglycan	131	134	PF01048	0.408
MOD_GlcNHglycan	179	182	PF01048	0.376
MOD_GlcNHglycan	214	217	PF01048	0.447
MOD_GlcNHglycan	222	225	PF01048	0.456
MOD_GlcNHglycan	238	241	PF01048	0.526
MOD_GlcNHglycan	252	255	PF01048	0.567
MOD_GlcNHglycan	309	312	PF01048	0.529
MOD_GlcNHglycan	334	337	PF01048	0.564
MOD_GlcNHglycan	386	389	PF01048	0.426
MOD_GlcNHglycan	486	489	PF01048	0.677
MOD_GlcNHglycan	504	507	PF01048	0.550
MOD_GlcNHglycan	528	531	PF01048	0.432
MOD_GlcNHglycan	84	88	PF01048	0.475
MOD_GSK3_1	144	151	PF00069	0.512
MOD_GSK3_1	173	180	PF00069	0.613
MOD_GSK3_1	246	253	PF00069	0.640
MOD_GSK3_1	380	387	PF00069	0.594
MOD_GSK3_1	428	435	PF00069	0.462
MOD_GSK3_1	443	450	PF00069	0.366
MOD_GSK3_1	480	487	PF00069	0.665
MOD_GSK3_1	510	517	PF00069	0.503
MOD_GSK3_1	522	529	PF00069	0.253
MOD_N-GLC_1	478	483	PF02516	0.691
MOD_N-GLC_1	514	519	PF02516	0.462
MOD_NEK2_1	11	16	PF00069	0.441
MOD_NEK2_1	118	123	PF00069	0.402
MOD_NEK2_1	212	217	PF00069	0.331
MOD_NEK2_1	299	304	PF00069	0.463
MOD_NEK2_1	404	409	PF00069	0.426
MOD_NEK2_1	460	465	PF00069	0.353
MOD_NEK2_1	526	531	PF00069	0.264
MOD_NEK2_1	60	65	PF00069	0.584
MOD_NEK2_1	75	80	PF00069	0.319
MOD_NEK2_1	83	88	PF00069	0.393
MOD_NEK2_2	522	527	PF00069	0.480
MOD_PIKK_1	160	166	PF00454	0.667
MOD_PIKK_1	480	486	PF00454	0.618
MOD_PKA_1	48	54	PF00069	0.453
MOD_PKA_2	148	154	PF00069	0.524
MOD_PKA_2	228	234	PF00069	0.601
MOD_PKA_2	267	273	PF00069	0.434
MOD_PKA_2	307	313	PF00069	0.562
MOD_PKA_2	60	66	PF00069	0.581
MOD_PKB_1	104	112	PF00069	0.576
MOD_PKB_1	227	235	PF00069	0.613
MOD_Plk_1	243	249	PF00069	0.706
MOD_Plk_1	477	483	PF00069	0.690
MOD_Plk_4	118	124	PF00069	0.362
MOD_Plk_4	13	19	PF00069	0.389
MOD_Plk_4	256	262	PF00069	0.551
MOD_Plk_4	316	322	PF00069	0.401
MOD_Plk_4	323	329	PF00069	0.330
MOD_Plk_4	356	362	PF00069	0.436
MOD_Plk_4	396	402	PF00069	0.382
MOD_Plk_4	453	459	PF00069	0.331
MOD_Plk_4	465	471	PF00069	0.363
MOD_Plk_4	516	522	PF00069	0.360
MOD_Plk_4	78	84	PF00069	0.426
MOD_Plk_4	90	96	PF00069	0.518
MOD_ProDKin_1	428	434	PF00069	0.518
MOD_ProDKin_1	443	449	PF00069	0.461
MOD_ProDKin_1	99	105	PF00069	0.606
MOD_SUMO_for_1	166	169	PF00179	0.694
TRG_DiLeu_BaEn_1	546	551	PF01217	0.557
TRG_DiLeu_BaEn_2	261	267	PF01217	0.533
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.524
TRG_ENDOCYTIC_2	542	545	PF00928	0.443
TRG_ER_diArg_1	103	106	PF00400	0.634
TRG_ER_diArg_1	438	440	PF00400	0.475
TRG_ER_diArg_1	58	61	PF00400	0.646
TRG_NES_CRM1_1	20	32	PF08389	0.397
TRG_NLS_MonoExtC_3	44	49	PF00514	0.449
TRG_NLS_MonoExtN_4	199	204	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM9	Leptomonas seymouri	41%	100%
A0A1X0NZT8	Trypanosomatidae	23%	100%
A0A3Q8IH23	Leishmania donovani	90%	100%
A0A3R7KT94	Trypanosoma rangeli	27%	100%
A4HH24	Leishmania braziliensis	72%	100%
A4I453	Leishmania infantum	90%	100%
C9ZKQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AM63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B4T3	Trypanosoma cruzi	24%	100%