LeishMANIAdb
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CAP-Gly domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CAP-Gly domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9ADL8_LEIMA
TriTrypDb:
LmjF.29.0160 , LMJLV39_290006600 * , LMJSD75_290006600
Length:
569

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 2
GO:0005739 mitochondrion 5 2
GO:0016020 membrane 2 9
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 9
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Expansion

Sequence features

E9ADL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADL8

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 81 85 PF00656 0.285
CLV_NRD_NRD_1 200 202 PF00675 0.709
CLV_NRD_NRD_1 273 275 PF00675 0.430
CLV_NRD_NRD_1 438 440 PF00675 0.382
CLV_NRD_NRD_1 44 46 PF00675 0.735
CLV_NRD_NRD_1 557 559 PF00675 0.365
CLV_NRD_NRD_1 6 8 PF00675 0.462
CLV_PCSK_KEX2_1 200 202 PF00082 0.718
CLV_PCSK_KEX2_1 273 275 PF00082 0.409
CLV_PCSK_KEX2_1 342 344 PF00082 0.323
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HVM9 Leptomonas seymouri 41% 100%
A0A1X0NZT8 Trypanosomatidae 23% 100%
A0A3Q8IH23 Leishmania donovani 90% 100%
A0A3R7KT94 Trypanosoma rangeli 27% 100%
A4HH24 Leishmania braziliensis 72% 100%
A4I453 Leishmania infantum 90% 100%
C9ZKQ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9AM63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5B4T3 Trypanosoma cruzi 24% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS