Tetratricopeptide repeat protein 30

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative intraflagellar transport protein B2

Species:

Leishmania major

UniProt:

E9ADL7_LEIMA

TriTrypDb:

LmjF.29.0150 , LMJLV39_290006500 , LMJSD75_290006500

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0005874	microtubule	6	2
GO:0005879	axonemal microtubule	8	2
GO:0005881	cytoplasmic microtubule	7	2
GO:0005929	cilium	4	11
GO:0030990	intraciliary transport particle	2	2
GO:0030992	intraciliary transport particle B	2	2
GO:0031514	motile cilium	5	2
GO:0032991	protein-containing complex	1	2

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Expansion

Sequence features

E9ADL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADL7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	2
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0035720	intraciliary anterograde transport	4	2

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0044877	protein-containing complex binding	2	2
GO:0120170	intraciliary transport particle B binding	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.388
CLV_C14_Caspase3-7	635	639	PF00656	0.489
CLV_NRD_NRD_1	408	410	PF00675	0.398
CLV_NRD_NRD_1	427	429	PF00675	0.381
CLV_NRD_NRD_1	554	556	PF00675	0.405
CLV_NRD_NRD_1	607	609	PF00675	0.418
CLV_PCSK_KEX2_1	427	429	PF00082	0.531
CLV_PCSK_KEX2_1	554	556	PF00082	0.420
CLV_PCSK_KEX2_1	619	621	PF00082	0.379
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.379

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B4	Leptomonas seymouri	87%	100%
A0A0S4J480	Bodo saltans	74%	100%
A0A1X0NZF0	Trypanosomatidae	74%	100%
A0A3Q8IE38	Leishmania donovani	99%	100%
A0A3R7MWT3	Trypanosoma rangeli	75%	100%
A2AKQ8	Mus musculus	55%	100%
A2VE45	Bos taurus	54%	100%
A4HH23	Leishmania braziliensis	94%	100%
A4I452	Leishmania infantum	99%	100%
A4IHR1	Xenopus tropicalis	56%	100%

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