Tetratricopeptide repeat protein 30

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative intraflagellar transport protein B2

Species:

Leishmania major

UniProt:

E9ADL7_LEIMA

TriTrypDb:

LmjF.29.0150 , LMJLV39_290006500 , LMJSD75_290006500

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0005874	microtubule	6	2
GO:0005879	axonemal microtubule	8	2
GO:0005881	cytoplasmic microtubule	7	2
GO:0005929	cilium	4	11
GO:0030990	intraciliary transport particle	2	2
GO:0030992	intraciliary transport particle B	2	2
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0031514	motile cilium	5	2

Expansion

Sequence features

E9ADL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADL7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0035720	intraciliary anterograde transport	4	2
GO:0035735	intraciliary transport involved in cilium assembly	4	2
GO:0042073	intraciliary transport	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0099111	microtubule-based transport	4	2
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0071840	cellular component organization or biogenesis	2	9

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0044877	protein-containing complex binding	2	2
GO:0120170	intraciliary transport particle B binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.388
CLV_C14_Caspase3-7	635	639	PF00656	0.489
CLV_NRD_NRD_1	408	410	PF00675	0.398
CLV_NRD_NRD_1	427	429	PF00675	0.381
CLV_NRD_NRD_1	554	556	PF00675	0.405
CLV_NRD_NRD_1	607	609	PF00675	0.418
CLV_PCSK_KEX2_1	427	429	PF00082	0.531
CLV_PCSK_KEX2_1	554	556	PF00082	0.420
CLV_PCSK_KEX2_1	619	621	PF00082	0.379
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.379
CLV_PCSK_PC7_1	423	429	PF00082	0.561
CLV_PCSK_SKI1_1	172	176	PF00082	0.467
CLV_PCSK_SKI1_1	300	304	PF00082	0.437
CLV_PCSK_SKI1_1	423	427	PF00082	0.439
CLV_PCSK_SKI1_1	598	602	PF00082	0.386
CLV_PCSK_SKI1_1	609	613	PF00082	0.380
CLV_PCSK_SKI1_1	620	624	PF00082	0.383
CLV_PCSK_SKI1_1	682	686	PF00082	0.397
CLV_Separin_Metazoa	551	555	PF03568	0.434
DOC_CYCLIN_RxL_1	682	693	PF00134	0.422
DOC_CYCLIN_yClb1_LxF_4	353	359	PF00134	0.377
DOC_MAPK_DCC_7	309	319	PF00069	0.438
DOC_MAPK_gen_1	619	625	PF00069	0.374
DOC_MAPK_gen_1	682	691	PF00069	0.410
DOC_MAPK_MEF2A_6	570	577	PF00069	0.400
DOC_MAPK_MEF2A_6	619	627	PF00069	0.376
DOC_MAPK_MEF2A_6	682	691	PF00069	0.394
DOC_MAPK_NFAT4_5	620	628	PF00069	0.393
DOC_PP4_FxxP_1	661	664	PF00568	0.516
DOC_PP4_MxPP_1	10	13	PF00568	0.695
DOC_USP7_MATH_1	21	25	PF00917	0.754
DOC_USP7_MATH_1	432	436	PF00917	0.523
DOC_USP7_MATH_1	664	668	PF00917	0.542
DOC_USP7_MATH_1	86	90	PF00917	0.553
DOC_WW_Pin1_4	144	149	PF00397	0.614
DOC_WW_Pin1_4	400	405	PF00397	0.434
DOC_WW_Pin1_4	512	517	PF00397	0.433
DOC_WW_Pin1_4	669	674	PF00397	0.634
LIG_14-3-3_CanoR_1	140	145	PF00244	0.551
LIG_14-3-3_CanoR_1	31	37	PF00244	0.758
LIG_14-3-3_CanoR_1	562	566	PF00244	0.610
LIG_14-3-3_CanoR_1	598	604	PF00244	0.382
LIG_14-3-3_CanoR_1	608	617	PF00244	0.394
LIG_14-3-3_CanoR_1	85	91	PF00244	0.478
LIG_Actin_WH2_2	622	639	PF00022	0.402
LIG_BRCT_BRCA1_1	481	485	PF00533	0.407
LIG_Clathr_ClatBox_1	324	328	PF01394	0.564
LIG_Clathr_ClatBox_1	645	649	PF01394	0.489
LIG_DCNL_PONY_1	1	4	PF03556	0.568
LIG_deltaCOP1_diTrp_1	613	622	PF00928	0.379
LIG_EH1_1	593	601	PF00400	0.436
LIG_EVH1_2	348	352	PF00568	0.379
LIG_FHA_1	181	187	PF00498	0.529
LIG_FHA_1	269	275	PF00498	0.441
LIG_FHA_1	320	326	PF00498	0.404
LIG_FHA_1	424	430	PF00498	0.437
LIG_FHA_1	445	451	PF00498	0.540
LIG_FHA_1	53	59	PF00498	0.449
LIG_FHA_2	179	185	PF00498	0.587
LIG_FHA_2	256	262	PF00498	0.666
LIG_FHA_2	308	314	PF00498	0.601
LIG_FHA_2	449	455	PF00498	0.518
LIG_FHA_2	562	568	PF00498	0.495
LIG_FHA_2	74	80	PF00498	0.553
LIG_GBD_Chelix_1	625	633	PF00786	0.415
LIG_HCF-1_HBM_1	64	67	PF13415	0.335
LIG_LIR_Gen_1	106	116	PF02991	0.553
LIG_LIR_Gen_1	350	359	PF02991	0.421
LIG_LIR_Gen_1	389	398	PF02991	0.423
LIG_LIR_Gen_1	638	648	PF02991	0.379
LIG_LIR_Gen_1	656	666	PF02991	0.455
LIG_LIR_Nem_3	106	111	PF02991	0.513
LIG_LIR_Nem_3	119	124	PF02991	0.411
LIG_LIR_Nem_3	332	338	PF02991	0.406
LIG_LIR_Nem_3	350	355	PF02991	0.305
LIG_LIR_Nem_3	389	394	PF02991	0.432
LIG_LIR_Nem_3	406	411	PF02991	0.306
LIG_LIR_Nem_3	453	458	PF02991	0.376
LIG_LIR_Nem_3	470	475	PF02991	0.393
LIG_LIR_Nem_3	56	62	PF02991	0.441
LIG_LIR_Nem_3	638	644	PF02991	0.405
LIG_LIR_Nem_3	656	662	PF02991	0.448
LIG_LYPXL_yS_3	472	475	PF13949	0.381
LIG_PCNA_yPIPBox_3	579	589	PF02747	0.378
LIG_PTB_Apo_2	341	348	PF02174	0.425
LIG_SH2_CRK	514	518	PF00017	0.488
LIG_SH2_CRK	59	63	PF00017	0.462
LIG_SH2_NCK_1	365	369	PF00017	0.448
LIG_SH2_PTP2	455	458	PF00017	0.359
LIG_SH2_SRC	135	138	PF00017	0.467
LIG_SH2_SRC	199	202	PF00017	0.435
LIG_SH2_SRC	455	458	PF00017	0.388
LIG_SH2_SRC	565	568	PF00017	0.504
LIG_SH2_SRC	67	70	PF00017	0.478
LIG_SH2_STAP1	125	129	PF00017	0.528
LIG_SH2_STAP1	199	203	PF00017	0.428
LIG_SH2_STAP1	365	369	PF00017	0.425
LIG_SH2_STAP1	448	452	PF00017	0.386
LIG_SH2_STAP1	606	610	PF00017	0.518
LIG_SH2_STAP1	67	71	PF00017	0.477
LIG_SH2_STAT3	124	127	PF00017	0.467
LIG_SH2_STAT3	382	385	PF00017	0.436
LIG_SH2_STAT5	359	362	PF00017	0.376
LIG_SH2_STAT5	382	385	PF00017	0.470
LIG_SH2_STAT5	455	458	PF00017	0.359
LIG_SH2_STAT5	540	543	PF00017	0.373
LIG_SH2_STAT5	586	589	PF00017	0.400
LIG_SH2_STAT5	61	64	PF00017	0.490
LIG_SH2_STAT5	688	691	PF00017	0.390
LIG_SH2_STAT5	93	96	PF00017	0.478
LIG_SH3_3	26	32	PF00018	0.554
LIG_SH3_3	342	348	PF00018	0.498
LIG_SUMO_SIM_anti_2	68	76	PF11976	0.478
LIG_SUMO_SIM_par_1	632	640	PF11976	0.420
LIG_TRAF2_1	198	201	PF00917	0.488
LIG_TRAF2_1	451	454	PF00917	0.402
LIG_TRAF2_1	640	643	PF00917	0.417
LIG_TYR_ITSM	55	62	PF00017	0.460
LIG_WW_3	306	310	PF00397	0.429
MOD_CDK_SPK_2	669	674	PF00069	0.634
MOD_CK1_1	24	30	PF00069	0.729
MOD_CK2_1	103	109	PF00069	0.562
MOD_CK2_1	195	201	PF00069	0.485
MOD_CK2_1	255	261	PF00069	0.526
MOD_CK2_1	307	313	PF00069	0.572
MOD_CK2_1	400	406	PF00069	0.435
MOD_CK2_1	448	454	PF00069	0.513
MOD_CK2_1	636	642	PF00069	0.415
MOD_CK2_1	687	693	PF00069	0.534
MOD_CK2_1	73	79	PF00069	0.572
MOD_GlcNHglycan	19	22	PF01048	0.703
MOD_GlcNHglycan	215	218	PF01048	0.491
MOD_GlcNHglycan	481	484	PF01048	0.411
MOD_GlcNHglycan	528	531	PF01048	0.384
MOD_GSK3_1	140	147	PF00069	0.464
MOD_GSK3_1	17	24	PF00069	0.714
MOD_GSK3_1	191	198	PF00069	0.519
MOD_GSK3_1	213	220	PF00069	0.512
MOD_GSK3_1	264	271	PF00069	0.492
MOD_GSK3_1	315	322	PF00069	0.408
MOD_GSK3_1	396	403	PF00069	0.416
MOD_GSK3_1	440	447	PF00069	0.546
MOD_GSK3_1	50	57	PF00069	0.567
MOD_GSK3_1	536	543	PF00069	0.441
MOD_GSK3_1	561	568	PF00069	0.374
MOD_GSK3_1	581	588	PF00069	0.363
MOD_GSK3_1	632	639	PF00069	0.496
MOD_GSK3_1	664	671	PF00069	0.504
MOD_N-GLC_1	149	154	PF02516	0.509
MOD_N-GLC_1	386	391	PF02516	0.444
MOD_N-GLC_1	423	428	PF02516	0.552
MOD_N-GLC_1	526	531	PF02516	0.367
MOD_N-GLC_2	535	537	PF02516	0.340
MOD_NEK2_1	17	22	PF00069	0.669
MOD_NEK2_1	274	279	PF00069	0.394
MOD_NEK2_1	319	324	PF00069	0.399
MOD_NEK2_1	502	507	PF00069	0.434
MOD_NEK2_1	526	531	PF00069	0.391
MOD_NEK2_1	536	541	PF00069	0.346
MOD_NEK2_1	54	59	PF00069	0.469
MOD_NEK2_1	585	590	PF00069	0.406
MOD_NEK2_1	594	599	PF00069	0.362
MOD_NEK2_1	611	616	PF00069	0.388
MOD_NEK2_1	636	641	PF00069	0.443
MOD_NEK2_1	687	692	PF00069	0.518
MOD_NEK2_1	73	78	PF00069	0.492
MOD_NEK2_2	125	130	PF00069	0.528
MOD_PIKK_1	268	274	PF00454	0.443
MOD_PIKK_1	381	387	PF00454	0.445
MOD_PIKK_1	432	438	PF00454	0.586
MOD_PIKK_1	73	79	PF00454	0.553
MOD_PKA_2	274	280	PF00069	0.510
MOD_PKA_2	30	36	PF00069	0.674
MOD_PKA_2	4	10	PF00069	0.622
MOD_PKA_2	479	485	PF00069	0.405
MOD_PKA_2	561	567	PF00069	0.606
MOD_PKA_2	673	679	PF00069	0.501
MOD_Plk_1	149	155	PF00069	0.508
MOD_Plk_1	386	392	PF00069	0.443
MOD_Plk_1	448	454	PF00069	0.503
MOD_Plk_1	526	532	PF00069	0.360
MOD_Plk_1	637	643	PF00069	0.435
MOD_Plk_2-3	103	109	PF00069	0.572
MOD_Plk_2-3	484	490	PF00069	0.412
MOD_Plk_2-3	561	567	PF00069	0.494
MOD_Plk_4	103	109	PF00069	0.528
MOD_Plk_4	125	131	PF00069	0.492
MOD_Plk_4	140	146	PF00069	0.441
MOD_Plk_4	170	176	PF00069	0.467
MOD_Plk_4	386	392	PF00069	0.443
MOD_Plk_4	536	542	PF00069	0.426
MOD_Plk_4	54	60	PF00069	0.447
MOD_Plk_4	581	587	PF00069	0.369
MOD_Plk_4	611	617	PF00069	0.394
MOD_Plk_4	86	92	PF00069	0.528
MOD_ProDKin_1	144	150	PF00069	0.608
MOD_ProDKin_1	400	406	PF00069	0.435
MOD_ProDKin_1	512	518	PF00069	0.428
MOD_ProDKin_1	669	675	PF00069	0.626
MOD_SUMO_rev_2	602	611	PF00179	0.517
TRG_DiLeu_BaEn_1	69	74	PF01217	0.528
TRG_DiLeu_BaEn_4	249	255	PF01217	0.525
TRG_ENDOCYTIC_2	108	111	PF00928	0.463
TRG_ENDOCYTIC_2	227	230	PF00928	0.407
TRG_ENDOCYTIC_2	364	367	PF00928	0.394
TRG_ENDOCYTIC_2	391	394	PF00928	0.377
TRG_ENDOCYTIC_2	408	411	PF00928	0.380
TRG_ENDOCYTIC_2	455	458	PF00928	0.359
TRG_ENDOCYTIC_2	466	469	PF00928	0.402
TRG_ENDOCYTIC_2	472	475	PF00928	0.381
TRG_ENDOCYTIC_2	514	517	PF00928	0.394
TRG_ENDOCYTIC_2	59	62	PF00928	0.434
TRG_ENDOCYTIC_2	688	691	PF00928	0.390
TRG_ENDOCYTIC_2	95	98	PF00928	0.469
TRG_ER_diArg_1	427	429	PF00400	0.569
TRG_ER_diArg_1	553	555	PF00400	0.427
TRG_ER_diArg_1	82	85	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B4	Leptomonas seymouri	87%	100%
A0A0S4J480	Bodo saltans	74%	100%
A0A1X0NZF0	Trypanosomatidae	74%	100%
A0A3Q8IE38	Leishmania donovani	99%	100%
A0A3R7MWT3	Trypanosoma rangeli	75%	100%
A2AKQ8	Mus musculus	55%	100%
A2VE45	Bos taurus	54%	100%
A4HH23	Leishmania braziliensis	94%	100%
A4I452	Leishmania infantum	99%	100%
A4IHR1	Xenopus tropicalis	56%	100%
A6H739	Bos taurus	53%	100%
A7YE96	Danio rerio	56%	100%
A8XBR9	Caenorhabditis briggsae	42%	100%
B2RYD6	Rattus norvegicus	55%	100%
C9ZKR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AM64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q16JL4	Aedes aegypti	44%	100%
Q29L58	Drosophila pseudoobscura pseudoobscura	43%	100%
Q4QQS2	Rattus norvegicus	55%	100%
Q6INU8	Xenopus laevis	56%	100%
Q7PRA4	Anopheles gambiae	45%	100%
Q86WT1	Homo sapiens	55%	100%
Q8I7G4	Caenorhabditis elegans	43%	100%
Q8N4P2	Homo sapiens	55%	100%
Q99J38	Mus musculus	56%	100%
Q9CY00	Mus musculus	55%	100%
Q9VK41	Drosophila melanogaster	42%	100%
V5BKA3	Trypanosoma cruzi	76%	100%