WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADL2_LEIMA

TriTrypDb:

LmjF.29.0100 , LMJLV39_290006000 , LMJSD75_290006000

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0030286	dynein complex	3	2
GO:0030990	intraciliary transport particle	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

E9ADL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADL2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0010970	transport along microtubule	4	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0042073	intraciliary transport	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0099111	microtubule-based transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045503	dynein light chain binding	3	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.592
CLV_NRD_NRD_1	300	302	PF00675	0.483
CLV_NRD_NRD_1	438	440	PF00675	0.452
CLV_NRD_NRD_1	65	67	PF00675	0.603
CLV_PCSK_FUR_1	298	302	PF00082	0.551
CLV_PCSK_KEX2_1	300	302	PF00082	0.509
CLV_PCSK_KEX2_1	438	440	PF00082	0.452
CLV_PCSK_KEX2_1	65	67	PF00082	0.603
CLV_PCSK_SKI1_1	106	110	PF00082	0.467
CLV_PCSK_SKI1_1	287	291	PF00082	0.523
CLV_PCSK_SKI1_1	384	388	PF00082	0.434
CLV_PCSK_SKI1_1	439	443	PF00082	0.500
CLV_PCSK_SKI1_1	506	510	PF00082	0.554
DEG_APCC_DBOX_1	403	411	PF00400	0.433
DEG_APCC_DBOX_1	437	445	PF00400	0.449
DOC_CYCLIN_RxL_1	381	392	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.437
DOC_MAPK_gen_1	122	129	PF00069	0.544
DOC_MAPK_gen_1	172	178	PF00069	0.497
DOC_MAPK_gen_1	298	307	PF00069	0.415
DOC_MAPK_gen_1	341	349	PF00069	0.512
DOC_MAPK_gen_1	438	444	PF00069	0.427
DOC_MAPK_MEF2A_6	298	307	PF00069	0.435
DOC_MAPK_MEF2A_6	404	412	PF00069	0.309
DOC_USP7_MATH_1	108	112	PF00917	0.507
DOC_USP7_MATH_1	16	20	PF00917	0.645
DOC_USP7_MATH_1	215	219	PF00917	0.254
DOC_USP7_MATH_1	259	263	PF00917	0.547
DOC_USP7_MATH_1	273	277	PF00917	0.496
DOC_USP7_MATH_1	373	377	PF00917	0.401
DOC_USP7_MATH_1	434	438	PF00917	0.344
DOC_USP7_MATH_1	458	462	PF00917	0.455
DOC_USP7_MATH_1	471	475	PF00917	0.405
DOC_USP7_MATH_1	508	512	PF00917	0.479
DOC_USP7_MATH_1	522	526	PF00917	0.517
DOC_USP7_MATH_2	348	354	PF00917	0.601
DOC_USP7_UBL2_3	36	40	PF12436	0.698
DOC_WW_Pin1_4	114	119	PF00397	0.639
DOC_WW_Pin1_4	132	137	PF00397	0.287
DOC_WW_Pin1_4	280	285	PF00397	0.425
DOC_WW_Pin1_4	357	362	PF00397	0.342
DOC_WW_Pin1_4	377	382	PF00397	0.315
DOC_WW_Pin1_4	402	407	PF00397	0.459
DOC_WW_Pin1_4	423	428	PF00397	0.371
LIG_14-3-3_CanoR_1	106	116	PF00244	0.535
LIG_14-3-3_CanoR_1	122	131	PF00244	0.454
LIG_14-3-3_CanoR_1	132	136	PF00244	0.424
LIG_14-3-3_CanoR_1	190	196	PF00244	0.549
LIG_14-3-3_CanoR_1	300	306	PF00244	0.489
LIG_14-3-3_CanoR_1	341	346	PF00244	0.549
LIG_14-3-3_CanoR_1	397	406	PF00244	0.463
LIG_14-3-3_CanoR_1	438	442	PF00244	0.402
LIG_14-3-3_CanoR_1	510	514	PF00244	0.636
LIG_14-3-3_CanoR_1	65	69	PF00244	0.645
LIG_Actin_WH2_2	174	189	PF00022	0.454
LIG_Actin_WH2_2	494	512	PF00022	0.560
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BIR_III_4	484	488	PF00653	0.446
LIG_BRCT_BRCA1_1	109	113	PF00533	0.455
LIG_BRCT_BRCA1_1	379	383	PF00533	0.327
LIG_Clathr_ClatBox_1	331	335	PF01394	0.437
LIG_Clathr_ClatBox_1	407	411	PF01394	0.514
LIG_FHA_1	10	16	PF00498	0.579
LIG_FHA_1	107	113	PF00498	0.597
LIG_FHA_1	245	251	PF00498	0.511
LIG_FHA_1	32	38	PF00498	0.569
LIG_FHA_1	342	348	PF00498	0.518
LIG_FHA_1	407	413	PF00498	0.468
LIG_FHA_1	455	461	PF00498	0.519
LIG_FHA_1	524	530	PF00498	0.564
LIG_FHA_2	23	29	PF00498	0.645
LIG_FHA_2	358	364	PF00498	0.339
LIG_FHA_2	388	394	PF00498	0.479
LIG_FHA_2	473	479	PF00498	0.488
LIG_FHA_2	500	506	PF00498	0.424
LIG_FHA_2	89	95	PF00498	0.559
LIG_LIR_Apic_2	344	348	PF02991	0.595
LIG_LIR_Nem_3	110	116	PF02991	0.459
LIG_LIR_Nem_3	311	315	PF02991	0.489
LIG_LIR_Nem_3	380	386	PF02991	0.333
LIG_LIR_Nem_3	422	428	PF02991	0.459
LIG_MLH1_MIPbox_1	379	383	PF16413	0.327
LIG_PCNA_PIPBox_1	86	95	PF02747	0.358
LIG_PDZ_Class_1	531	536	PF00595	0.631
LIG_Pex14_2	383	387	PF04695	0.462
LIG_REV1ctd_RIR_1	380	388	PF16727	0.417
LIG_RPA_C_Fungi	296	308	PF08784	0.298
LIG_SH2_CRK	312	316	PF00017	0.507
LIG_SH2_CRK	79	83	PF00017	0.565
LIG_SH2_PTP2	175	178	PF00017	0.447
LIG_SH2_SRC	322	325	PF00017	0.432
LIG_SH2_STAP1	237	241	PF00017	0.570
LIG_SH2_STAP1	456	460	PF00017	0.496
LIG_SH2_STAT5	175	178	PF00017	0.447
LIG_SH2_STAT5	268	271	PF00017	0.406
LIG_SH2_STAT5	322	325	PF00017	0.432
LIG_SH2_STAT5	419	422	PF00017	0.516
LIG_SH2_STAT5	456	459	PF00017	0.550
LIG_SH2_STAT5	77	80	PF00017	0.488
LIG_SH3_1	424	430	PF00018	0.468
LIG_SH3_3	12	18	PF00018	0.541
LIG_SH3_3	205	211	PF00018	0.529
LIG_SH3_3	253	259	PF00018	0.502
LIG_SH3_3	424	430	PF00018	0.375
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.530
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.516
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.390
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.389
LIG_SUMO_SIM_par_1	212	218	PF11976	0.423
LIG_SUMO_SIM_par_1	360	365	PF11976	0.480
LIG_SUMO_SIM_par_1	405	411	PF11976	0.513
LIG_SUMO_SIM_par_1	431	437	PF11976	0.389
LIG_TRAF2_1	137	140	PF00917	0.432
LIG_TYR_ITIM	310	315	PF00017	0.486
LIG_WRC_WIRS_1	89	94	PF05994	0.524
MOD_CDC14_SPxK_1	426	429	PF00782	0.359
MOD_CDK_SPxK_1	423	429	PF00069	0.359
MOD_CDK_SPxxK_3	280	287	PF00069	0.463
MOD_CDK_SPxxK_3	377	384	PF00069	0.437
MOD_CK1_1	239	245	PF00069	0.462
MOD_CK1_1	296	302	PF00069	0.462
MOD_CK1_1	392	398	PF00069	0.393
MOD_CK1_1	41	47	PF00069	0.666
MOD_CK1_1	413	419	PF00069	0.428
MOD_CK1_1	437	443	PF00069	0.374
MOD_CK1_1	499	505	PF00069	0.495
MOD_CK1_1	512	518	PF00069	0.545
MOD_CK2_1	22	28	PF00069	0.656
MOD_CK2_1	237	243	PF00069	0.447
MOD_CK2_1	357	363	PF00069	0.347
MOD_CK2_1	472	478	PF00069	0.497
MOD_CK2_1	499	505	PF00069	0.415
MOD_CK2_1	515	521	PF00069	0.591
MOD_CK2_1	88	94	PF00069	0.504
MOD_GlcNHglycan	165	169	PF01048	0.535
MOD_GlcNHglycan	219	222	PF01048	0.355
MOD_GlcNHglycan	239	242	PF01048	0.546
MOD_GlcNHglycan	271	274	PF01048	0.334
MOD_GlcNHglycan	275	278	PF01048	0.361
MOD_GlcNHglycan	377	380	PF01048	0.476
MOD_GlcNHglycan	393	397	PF01048	0.272
MOD_GlcNHglycan	460	463	PF01048	0.506
MOD_GSK3_1	114	121	PF00069	0.516
MOD_GSK3_1	16	23	PF00069	0.599
MOD_GSK3_1	235	242	PF00069	0.439
MOD_GSK3_1	244	251	PF00069	0.370
MOD_GSK3_1	269	276	PF00069	0.458
MOD_GSK3_1	314	321	PF00069	0.540
MOD_GSK3_1	373	380	PF00069	0.390
MOD_GSK3_1	388	395	PF00069	0.261
MOD_GSK3_1	402	409	PF00069	0.398
MOD_GSK3_1	454	461	PF00069	0.458
MOD_GSK3_1	508	515	PF00069	0.569
MOD_GSK3_1	60	67	PF00069	0.632
MOD_N-GLC_1	106	111	PF02516	0.520
MOD_N-GLC_1	227	232	PF02516	0.431
MOD_N-GLC_1	472	477	PF02516	0.445
MOD_NEK2_1	146	151	PF00069	0.394
MOD_NEK2_1	163	168	PF00069	0.539
MOD_NEK2_1	186	191	PF00069	0.567
MOD_NEK2_1	386	391	PF00069	0.326
MOD_NEK2_1	472	477	PF00069	0.419
MOD_NEK2_1	509	514	PF00069	0.627
MOD_NEK2_1	531	536	PF00069	0.631
MOD_NEK2_1	93	98	PF00069	0.439
MOD_NEK2_2	108	113	PF00069	0.563
MOD_NEK2_2	293	298	PF00069	0.507
MOD_PIKK_1	16	22	PF00454	0.691
MOD_PIKK_1	271	277	PF00454	0.415
MOD_PIKK_1	29	35	PF00454	0.572
MOD_PIKK_1	314	320	PF00454	0.575
MOD_PIKK_1	350	356	PF00454	0.671
MOD_PIKK_1	41	47	PF00454	0.524
MOD_PIKK_1	496	502	PF00454	0.475
MOD_PIKK_1	509	515	PF00454	0.577
MOD_PK_1	301	307	PF00069	0.502
MOD_PKA_1	122	128	PF00069	0.511
MOD_PKA_2	131	137	PF00069	0.405
MOD_PKA_2	186	192	PF00069	0.561
MOD_PKA_2	318	324	PF00069	0.551
MOD_PKA_2	428	434	PF00069	0.367
MOD_PKA_2	437	443	PF00069	0.360
MOD_PKA_2	509	515	PF00069	0.526
MOD_PKA_2	64	70	PF00069	0.632
MOD_Plk_1	125	131	PF00069	0.393
MOD_Plk_1	46	52	PF00069	0.636
MOD_Plk_1	496	502	PF00069	0.499
MOD_Plk_1	93	99	PF00069	0.537
MOD_Plk_4	108	114	PF00069	0.264
MOD_Plk_4	125	131	PF00069	0.456
MOD_Plk_4	248	254	PF00069	0.473
MOD_Plk_4	318	324	PF00069	0.532
MOD_Plk_4	428	434	PF00069	0.371
MOD_Plk_4	88	94	PF00069	0.490
MOD_Plk_4	99	105	PF00069	0.394
MOD_ProDKin_1	114	120	PF00069	0.640
MOD_ProDKin_1	132	138	PF00069	0.283
MOD_ProDKin_1	280	286	PF00069	0.429
MOD_ProDKin_1	357	363	PF00069	0.347
MOD_ProDKin_1	377	383	PF00069	0.315
MOD_ProDKin_1	402	408	PF00069	0.455
MOD_ProDKin_1	423	429	PF00069	0.369
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.309
TRG_ENDOCYTIC_2	161	164	PF00928	0.379
TRG_ENDOCYTIC_2	175	178	PF00928	0.298
TRG_ENDOCYTIC_2	312	315	PF00928	0.495
TRG_ENDOCYTIC_2	399	402	PF00928	0.368
TRG_ENDOCYTIC_2	79	82	PF00928	0.503
TRG_ER_diArg_1	297	300	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P997	Leptomonas seymouri	24%	89%
A0A0N1HUS1	Leptomonas seymouri	65%	100%
A0A0S4INJ7	Bodo saltans	23%	83%
A0A0S4KLW0	Bodo saltans	41%	96%
A0A1X0NUK4	Trypanosomatidae	24%	89%
A0A1X0P0W1	Trypanosomatidae	46%	100%
A0A3S5IRX8	Trypanosoma rangeli	48%	100%
A0A3S7X1Z8	Leishmania donovani	95%	100%
A0A3S7X5B2	Leishmania donovani	25%	89%
A0A422P1D5	Trypanosoma rangeli	24%	89%
A2AC93	Mus musculus	24%	86%
A4HH18	Leishmania braziliensis	79%	100%
A4HK88	Leishmania braziliensis	24%	89%
A4I447	Leishmania infantum	95%	100%
A4I7S3	Leishmania infantum	25%	89%
C9ZKR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A9Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
E9AM69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B2N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	89%
E9PYY5	Mus musculus	23%	66%
Q16959	Heliocidaris crassispina	23%	76%
Q16960	Heliocidaris crassispina	26%	90%
Q24246	Drosophila melanogaster	25%	81%
Q32KS2	Bos taurus	22%	76%
Q39578	Chlamydomonas reinhardtii	23%	78%
Q4Q5H6	Leishmania major	24%	89%
Q4QR00	Xenopus laevis	23%	91%
Q4V8G4	Rattus norvegicus	22%	67%
Q5U4F6	Mus musculus	29%	100%
Q5XIL8	Rattus norvegicus	21%	76%
Q66HC9	Rattus norvegicus	24%	87%
Q8C0M8	Mus musculus	21%	76%
Q96EX3	Homo sapiens	29%	100%
Q9GZS0	Homo sapiens	22%	89%
V5B145	Trypanosoma cruzi	24%	89%
V5BUI1	Trypanosoma cruzi	48%	100%