Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 27

Species:

Leishmania major

UniProt:

E9ADL1_LEIMA

TriTrypDb:

LmjF.29.0090 , LMJLV39_290005900 , LMJSD75_290005900

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005768	endosome	7	2
GO:0005794	Golgi apparatus	5	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	3
GO:0030990	intraciliary transport particle	2	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

E9ADL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADL1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3
GO:0010970	transport along microtubule	4	3
GO:0030705	cytoskeleton-dependent intracellular transport	4	3
GO:0031344	regulation of cell projection organization	5	2
GO:0031503	protein-containing complex localization	2	3
GO:0033043	regulation of organelle organization	5	2
GO:0035735	intraciliary transport involved in cilium assembly	4	2
GO:0042073	intraciliary transport	3	3
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0046907	intracellular transport	3	3
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0060491	regulation of cell projection assembly	5	2
GO:0065007	biological regulation	1	2
GO:0099111	microtubule-based transport	4	3
GO:0120032	regulation of plasma membrane bounded cell projection assembly	6	2
GO:0120035	regulation of plasma membrane bounded cell projection organization	6	2
GO:1902017	regulation of cilium assembly	6	2
GO:1902115	regulation of organelle assembly	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.416
CLV_NRD_NRD_1	99	101	PF00675	0.413
CLV_PCSK_KEX2_1	174	176	PF00082	0.464
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.464
CLV_PCSK_SKI1_1	101	105	PF00082	0.400
CLV_PCSK_SKI1_1	107	111	PF00082	0.390
CLV_PCSK_SKI1_1	166	170	PF00082	0.527
CLV_PCSK_SKI1_1	18	22	PF00082	0.366
DOC_CYCLIN_yClb1_LxF_4	141	147	PF00134	0.459
DOC_MAPK_gen_1	107	116	PF00069	0.421
DOC_USP7_MATH_2	160	166	PF00917	0.414
DOC_USP7_UBL2_3	101	105	PF12436	0.432
LIG_14-3-3_CanoR_1	72	81	PF00244	0.459
LIG_BRCT_BRCA1_1	164	168	PF00533	0.414
LIG_FHA_1	153	159	PF00498	0.465
LIG_FHA_1	17	23	PF00498	0.385
LIG_FHA_1	54	60	PF00498	0.390
LIG_LIR_Gen_1	19	25	PF02991	0.347
LIG_LIR_Gen_1	82	90	PF02991	0.389
LIG_LIR_Nem_3	82	87	PF02991	0.420
LIG_REV1ctd_RIR_1	144	152	PF16727	0.459
LIG_SH2_SRC	77	80	PF00017	0.411
LIG_SH2_STAT5	36	39	PF00017	0.366
LIG_SH2_STAT5	77	80	PF00017	0.347
LIG_SH3_3	8	14	PF00018	0.420
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.423
LIG_SUMO_SIM_par_1	52	60	PF11976	0.459
LIG_UBA3_1	113	121	PF00899	0.420
MOD_CK1_1	16	22	PF00069	0.454
MOD_CK1_1	180	186	PF00069	0.642
MOD_CK1_1	27	33	PF00069	0.280
MOD_GlcNHglycan	149	152	PF01048	0.390
MOD_GlcNHglycan	15	18	PF01048	0.387
MOD_GlcNHglycan	182	185	PF01048	0.631
MOD_GlcNHglycan	81	84	PF01048	0.492
MOD_GSK3_1	101	108	PF00069	0.347
MOD_GSK3_1	12	19	PF00069	0.347
MOD_GSK3_1	53	60	PF00069	0.459
MOD_GSK3_1	88	95	PF00069	0.337
MOD_N-GLC_1	27	32	PF02516	0.445
MOD_NEK2_1	147	152	PF00069	0.404
MOD_NEK2_1	24	29	PF00069	0.347
MOD_PIKK_1	177	183	PF00454	0.513
MOD_PKA_2	152	158	PF00069	0.459
MOD_PKA_2	162	168	PF00069	0.459
MOD_PKA_2	71	77	PF00069	0.459
MOD_Plk_1	53	59	PF00069	0.366
MOD_Plk_2-3	53	59	PF00069	0.371
MOD_Plk_4	142	148	PF00069	0.459
MOD_Plk_4	27	33	PF00069	0.499
MOD_Plk_4	57	63	PF00069	0.454
TRG_ENDOCYTIC_2	70	73	PF00928	0.331
TRG_ER_diArg_1	4	7	PF00400	0.517
TRG_NES_CRM1_1	112	126	PF08389	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z9	Leptomonas seymouri	30%	79%
A0A0N0P3A0	Leptomonas seymouri	28%	69%
A0A0N0P3G2	Leptomonas seymouri	84%	100%
A0A0N0P6K4	Leptomonas seymouri	24%	86%
A0A0N0P6P8	Leptomonas seymouri	29%	89%
A0A0N0P8G7	Leptomonas seymouri	27%	86%
A0A0N0P8I1	Leptomonas seymouri	29%	84%
A0A0N1HYV5	Leptomonas seymouri	22%	86%
A0A0N1I011	Leptomonas seymouri	28%	92%
A0A0N1IJ36	Leptomonas seymouri	31%	84%
A0A0N1IL60	Leptomonas seymouri	28%	90%
A0A0N1ILN4	Leptomonas seymouri	25%	93%
A0A0N1PC08	Leptomonas seymouri	27%	90%
A0A0S4IJB7	Bodo saltans	22%	85%
A0A0S4IM06	Bodo saltans	29%	85%
A0A0S4IWV0	Bodo saltans	31%	89%
A0A0S4IX77	Bodo saltans	29%	93%
A0A0S4IY79	Bodo saltans	26%	85%
A0A0S4J1G8	Bodo saltans	31%	85%
A0A0S4JBJ9	Bodo saltans	28%	90%
A0A0S4JDW3	Bodo saltans	32%	77%
A0A0S4JF89	Bodo saltans	30%	84%
A0A0S4JJX5	Bodo saltans	28%	91%
A0A0S4JKI9	Bodo saltans	29%	82%
A0A0S4JR87	Bodo saltans	28%	74%
A0A0S4JRU1	Bodo saltans	29%	89%
A0A0S4JSC1	Bodo saltans	29%	89%
A0A0S4JVK4	Bodo saltans	29%	70%
A0A0S4JYJ1	Bodo saltans	30%	81%
A0A0S4KGN8	Bodo saltans	25%	83%
A0A0S4KHE5	Bodo saltans	26%	86%
A0A0S4KLB5	Bodo saltans	59%	100%
A0A0S4KLN8	Bodo saltans	28%	78%
A0A1X0NLK7	Trypanosomatidae	30%	80%
A0A1X0NLM1	Trypanosomatidae	31%	81%
A0A1X0NLX4	Trypanosomatidae	24%	86%
A0A1X0NN96	Trypanosomatidae	30%	92%
A0A1X0NQB8	Trypanosomatidae	29%	86%
A0A1X0NR18	Trypanosomatidae	24%	85%
A0A1X0NR74	Trypanosomatidae	23%	89%
A0A1X0NRC4	Trypanosomatidae	24%	84%
A0A1X0NRE0	Trypanosomatidae	27%	87%
A0A1X0NTV9	Trypanosomatidae	30%	67%
A0A1X0NVM5	Trypanosomatidae	28%	86%
A0A1X0NWF8	Trypanosomatidae	29%	93%
A0A1X0NYR7	Trypanosomatidae	30%	86%
A0A1X0P0N4	Trypanosomatidae	55%	100%
A0A1X0P1V3	Trypanosomatidae	28%	80%
A0A1X0P6K3	Trypanosomatidae	29%	82%
A0A1X0P706	Trypanosomatidae	26%	84%
A0A3Q8I8T8	Leishmania donovani	22%	86%
A0A3Q8ICX9	Leishmania donovani	27%	92%
A0A3Q8ID64	Leishmania donovani	29%	88%
A0A3Q8IE68	Leishmania donovani	26%	93%
A0A3Q8IK84	Leishmania donovani	28%	86%
A0A3R7K3A9	Trypanosoma rangeli	25%	89%
A0A3R7K3N3	Trypanosoma rangeli	25%	80%
A0A3R7KA22	Trypanosoma rangeli	29%	81%
A0A3R7KBN3	Trypanosoma rangeli	29%	86%
A0A3R7KD28	Trypanosoma rangeli	30%	93%
A0A3R7L455	Trypanosoma rangeli	31%	93%
A0A3R7L7N2	Trypanosoma rangeli	59%	100%
A0A3R7LXW6	Trypanosoma rangeli	25%	83%
A0A3R7ME44	Trypanosoma rangeli	32%	77%
A0A3R7N2H4	Trypanosoma rangeli	24%	86%
A0A3R7N6U0	Trypanosoma rangeli	31%	68%
A0A3R7N9H9	Trypanosoma rangeli	29%	90%
A0A3R7N9V4	Trypanosoma rangeli	24%	85%
A0A3R7RHV7	Trypanosoma rangeli	24%	84%
A0A3R7RKC1	Trypanosoma rangeli	30%	85%
A0A3S5H4Z2	Leishmania donovani	30%	68%
A0A3S5H5Y5	Leishmania donovani	28%	83%
A0A3S5H7K4	Leishmania donovani	98%	100%
A0A3S7WRA9	Leishmania donovani	27%	89%
A0A3S7WUY8	Leishmania donovani	26%	83%
A0A3S7WV84	Leishmania donovani	22%	79%
A0A3S7X3D1	Leishmania donovani	28%	79%
A0A422MUR1	Trypanosoma rangeli	33%	84%
A0A422NH56	Trypanosoma rangeli	28%	86%
A0A422P0L6	Trypanosoma rangeli	24%	82%
A0A422P3H9	Trypanosoma rangeli	30%	81%
A1KXP5	Leishmania donovani	26%	88%
A4D1S5	Homo sapiens	31%	86%
A4FV54	Bos taurus	27%	90%
A4H506	Leishmania braziliensis	29%	83%
A4H679	Leishmania braziliensis	28%	89%
A4H6A4	Leishmania braziliensis	22%	86%
A4H9M3	Leishmania braziliensis	22%	79%
A4HEE8	Leishmania braziliensis	24%	86%
A4HFK0	Leishmania braziliensis	26%	93%
A4HH17	Leishmania braziliensis	89%	100%
A4HHR8	Leishmania braziliensis	23%	88%
A4HIB4	Leishmania braziliensis	30%	79%
A4HK33	Leishmania braziliensis	28%	92%
A4HKJ3	Leishmania braziliensis	29%	88%
A4HLP5	Leishmania braziliensis	28%	85%
A4HRM3	Leishmania infantum	30%	68%
A4HT72	Leishmania infantum	28%	83%
A4HUK3	Leishmania infantum	27%	89%
A4HUM8	Leishmania infantum	22%	86%
A4HVF7	Leishmania infantum	26%	88%
A4HXY7	Leishmania infantum	22%	79%
A4I1I6	Leishmania infantum	24%	86%
A4I446	Leishmania infantum	98%	100%
A4I5J8	Leishmania infantum	28%	79%
A4I7N3	Leishmania infantum	27%	92%
A4I825	Leishmania infantum	29%	88%
A4I946	Leishmania infantum	28%	86%
A5D7F5	Bos taurus	23%	68%
A6QR46	Bos taurus	33%	89%
A8HN58	Chlamydomonas reinhardtii	37%	91%
B1A5Z4	Leishmania donovani	24%	86%
B6DT76	Bodo saltans	27%	91%
C4YDI6	Candida albicans (strain WO-1)	27%	97%
C4YL11	Candida albicans (strain WO-1)	26%	89%
C8VQY7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	91%
C9ZIZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	81%
C9ZJY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	86%
C9ZKR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
C9ZQX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	78%
C9ZUL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	89%
C9ZVM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	86%
C9ZVR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	85%
C9ZVS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	87%
C9ZYS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	85%
D0A3U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	82%
D0A5C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	81%
D0A6V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
D0A9R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	94%
D0AA67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	79%
D0AA91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	88%
D3Z8L7	Rattus norvegicus	28%	85%
E2RQ15	Canis lupus familiaris	28%	87%
E9ACA1	Leishmania major	30%	68%
E9AD53	Leishmania major	26%	93%
E9AGQ4	Leishmania infantum	26%	83%
E9AHE8	Leishmania infantum	26%	93%
E9AJI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	68%
E9AL68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	83%
E9AM70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9ANA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	89%
E9ANC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	86%
E9AP56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	88%
E9ARM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	83%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	79%
E9AXM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	86%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	93%
E9B0U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	79%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	92%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	88%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	86%
F1PTE3	Canis lupus familiaris	28%	92%
G4MYS1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	91%
H9BW96	Epinephelus coioides	27%	90%
I1RMF2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	28%	91%
M0RC99	Rattus norvegicus	32%	87%
O00194	Homo sapiens	25%	85%
O01803	Caenorhabditis elegans	30%	88%
O04157	Arabidopsis thaliana	31%	92%
O04486	Arabidopsis thaliana	30%	86%
O13876	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	79%
O14966	Homo sapiens	29%	92%
O18334	Drosophila melanogaster	33%	89%
O23561	Arabidopsis thaliana	30%	91%
O23657	Arabidopsis thaliana	30%	88%
O24461	Prunus armeniaca	28%	90%
O24466	Arabidopsis thaliana	26%	86%
O35509	Rattus norvegicus	30%	85%
O35963	Mus musculus	33%	81%
O42819	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	87%
O49513	Arabidopsis thaliana	28%	86%
O49841	Arabidopsis thaliana	25%	89%
O76173	Dictyostelium discoideum	27%	93%
O80501	Arabidopsis thaliana	34%	89%
O88931	Cavia porcellus	27%	97%
O94655	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	91%
O95716	Homo sapiens	28%	85%
O97572	Oryctolagus cuniculus	27%	90%
P01113	Moloney murine sarcoma virus	30%	98%
P01123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	90%
P05712	Rattus norvegicus	25%	88%
P05714	Rattus norvegicus	30%	85%
P07560	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	87%
P09527	Rattus norvegicus	27%	90%
P0C0E4	Homo sapiens	27%	67%
P0CY30	Candida albicans	26%	89%
P0CY31	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	89%
P0CY33	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	97%
P10301	Homo sapiens	27%	85%
P10536	Rattus norvegicus	27%	93%
P10833	Mus musculus	28%	85%
P10948	Bos taurus	29%	85%
P10949	Bos taurus	26%	82%
P11023	Bos taurus	28%	85%
P11620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	92%
P15153	Homo sapiens	27%	97%
P16976	Zea mays	28%	89%
P17608	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	93%
P17609	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	93%
P17610	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	87%
P18066	Canis lupus familiaris	32%	87%
P18067	Canis lupus familiaris	27%	90%
P19073	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	97%
P19892	Arabidopsis thaliana	27%	85%
P20336	Homo sapiens	28%	85%
P20337	Homo sapiens	29%	85%
P20338	Homo sapiens	30%	85%
P20339	Homo sapiens	32%	87%
P20340	Homo sapiens	33%	89%
P20790	Dictyostelium discoideum	24%	89%
P20791	Dictyostelium discoideum	27%	92%
P22125	Diplobatis ommata	27%	92%
P22127	Diplobatis ommata	30%	93%
P22128	Diplobatis ommata	24%	89%
P22129	Diplobatis ommata	30%	85%
P23175	Murine sarcoma virus NS.C58	29%	98%
P23640	Rattus norvegicus	26%	84%
P24409	Canis lupus familiaris	30%	93%
P25228	Drosophila melanogaster	29%	85%
P25766	Oryza sativa subsp. japonica	30%	82%
P28185	Arabidopsis thaliana	30%	86%
P28186	Arabidopsis thaliana	26%	86%
P28187	Arabidopsis thaliana	26%	87%
P28188	Arabidopsis thaliana	26%	92%
P29687	Nicotiana tabacum	29%	93%
P31022	Pisum sativum	25%	90%
P31582	Arabidopsis thaliana	31%	93%
P31583	Nicotiana plumbaginifolia	30%	93%
P31584	Volvox carteri	27%	92%
P32939	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	89%
P33723	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	92%
P34139	Dictyostelium discoideum	30%	92%
P34140	Dictyostelium discoideum	27%	90%
P34141	Dictyostelium discoideum	28%	93%
P34143	Dictyostelium discoideum	31%	95%
P34149	Dictyostelium discoideum	27%	97%
P34213	Caenorhabditis elegans	34%	91%
P34726	Physarum polycephalum	31%	96%
P35276	Mus musculus	27%	85%
P35278	Mus musculus	32%	86%
P35279	Mus musculus	33%	89%
P35280	Rattus norvegicus	27%	90%
P35281	Rattus norvegicus	28%	93%
P35282	Mus musculus	27%	84%
P35283	Mus musculus	31%	77%
P35284	Rattus norvegicus	31%	77%
P35285	Mus musculus	28%	96%
P35286	Rattus norvegicus	29%	92%
P35288	Mus musculus	27%	78%
P35289	Rattus norvegicus	28%	88%
P35290	Mus musculus	28%	92%
P35293	Mus musculus	29%	90%
P35294	Mus musculus	32%	86%
P36017	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	89%
P36018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	79%
P36019	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	85%
P36409	Dictyostelium discoideum	25%	90%
P36410	Dictyostelium discoideum	27%	90%
P36411	Dictyostelium discoideum	27%	92%
P36412	Dictyostelium discoideum	30%	87%
P36586	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	88%
P36861	Volvox carteri	29%	86%
P36862	Volvox carteri	29%	92%
P36863	Volvox carteri	27%	87%
P36864	Volvox carteri	30%	91%
P38555	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	83%
P40392	Oryza sativa subsp. japonica	25%	92%
P40393	Oryza sativa subsp. japonica	29%	86%
P40792	Drosophila melanogaster	26%	97%
P41924	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	92%
P42558	Gallus gallus	23%	86%
P46629	Oryctolagus cuniculus	29%	87%
P46638	Mus musculus	30%	85%
P48554	Drosophila melanogaster	25%	97%
P49103	Zea mays	27%	89%
P49104	Zea mays	27%	89%
P51146	Rattus norvegicus	32%	87%
P51147	Canis lupus familiaris	32%	86%
P51148	Homo sapiens	32%	86%
P51149	Homo sapiens	27%	90%
P51150	Mus musculus	27%	90%
P51152	Canis lupus familiaris	32%	89%
P51153	Homo sapiens	28%	92%
P51154	Canis lupus familiaris	28%	96%
P51156	Rattus norvegicus	31%	72%
P51157	Homo sapiens	27%	84%
P51158	Rattus norvegicus	28%	84%
P51159	Homo sapiens	25%	84%
P51996	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	84%
P52301	Xenopus laevis	23%	86%
P53994	Mus musculus	24%	88%
P55258	Mus musculus	27%	90%
P55745	Canis lupus familiaris	26%	83%
P56371	Mus musculus	30%	85%
P57735	Homo sapiens	29%	87%
P59190	Homo sapiens	28%	88%
P59279	Mus musculus	27%	86%
P60763	Homo sapiens	28%	97%
P60764	Mus musculus	28%	97%
P61006	Homo sapiens	27%	90%
P61007	Canis lupus familiaris	27%	90%
P61017	Canis lupus familiaris	32%	87%
P61018	Homo sapiens	32%	87%
P61019	Homo sapiens	24%	88%
P61020	Homo sapiens	32%	87%
P61021	Mus musculus	32%	87%
P61026	Homo sapiens	30%	93%
P61027	Mus musculus	30%	93%
P61028	Mus musculus	25%	90%
P61105	Canis lupus familiaris	24%	88%
P61106	Homo sapiens	28%	87%
P61107	Rattus norvegicus	28%	87%
P61271	Macaca fascicularis	32%	87%
P61294	Mus musculus	33%	89%
P62490	Canis lupus familiaris	30%	86%
P62491	Homo sapiens	30%	86%
P62492	Mus musculus	30%	86%
P62493	Oryctolagus cuniculus	30%	86%
P62494	Rattus norvegicus	30%	86%
P62820	Homo sapiens	27%	91%
P62821	Mus musculus	27%	91%
P62822	Canis lupus familiaris	27%	91%
P62823	Mus musculus	26%	82%
P62824	Rattus norvegicus	26%	82%
P62825	Canis lupus familiaris	23%	86%
P62826	Homo sapiens	23%	86%
P62827	Mus musculus	23%	86%
P62828	Rattus norvegicus	23%	86%
P62998	Bos taurus	27%	97%
P62999	Canis lupus familiaris	27%	97%
P63000	Homo sapiens	27%	97%
P63001	Mus musculus	27%	97%
P63011	Mus musculus	28%	85%
P63012	Rattus norvegicus	28%	85%
P70550	Rattus norvegicus	25%	90%
P79735	Danio rerio	23%	87%
P84095	Homo sapiens	27%	97%
P84096	Mus musculus	27%	97%
P84097	Cricetus cricetus	27%	97%
P87027	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	94%
P90726	Caenorhabditis briggsae	27%	92%
P91580	Ciona intestinalis	33%	85%
P92963	Arabidopsis thaliana	27%	88%
P93267	Mesembryanthemum crystallinum	28%	90%
P97950	Mus musculus	31%	78%
Q01111	Nicotiana plumbaginifolia	28%	85%
Q01112	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	97%
Q01890	Phytophthora infestans	27%	93%
Q01971	Oryctolagus cuniculus	24%	88%
Q05144	Mus musculus	27%	97%
Q05737	Zea mays	26%	92%
Q05974	Lymnaea stagnalis	26%	91%
Q05975	Lymnaea stagnalis	27%	88%
Q05976	Lymnaea stagnalis	33%	92%
Q06AU3	Sus scrofa	28%	85%
Q06AU4	Sus scrofa	26%	72%
Q06AU5	Sus scrofa	29%	82%
Q06AU6	Sus scrofa	32%	87%
Q06AU7	Sus scrofa	27%	93%
Q08DE8	Bos taurus	26%	93%
Q0IIG7	Bos taurus	32%	87%
Q0IIG8	Bos taurus	29%	90%
Q0ILQ6	Oryza sativa subsp. japonica	27%	92%
Q0PD08	Mus musculus	28%	87%
Q0VCN3	Bos taurus	37%	100%
Q12829	Homo sapiens	27%	67%
Q13636	Homo sapiens	25%	96%
Q13637	Homo sapiens	30%	83%
Q14088	Homo sapiens	31%	78%
Q14964	Homo sapiens	28%	86%
Q15286	Homo sapiens	24%	93%
Q15771	Homo sapiens	30%	92%
Q15907	Homo sapiens	30%	85%
Q17QB7	Bos taurus	30%	92%
Q17QU4	Bos taurus	26%	87%
Q17R06	Bos taurus	26%	84%
Q1HE58	Canis lupus familiaris	25%	84%
Q1KME6	Gallus gallus	33%	89%
Q1PEX3	Arabidopsis thaliana	28%	85%
Q1RMR4	Bos taurus	28%	88%
Q22782	Caenorhabditis elegans	33%	91%
Q24192	Drosophila melanogaster	26%	98%
Q28IZ3	Xenopus tropicalis	30%	87%
Q29RR0	Bos taurus	33%	73%
Q2HJH2	Bos taurus	27%	93%
Q2HJI8	Bos taurus	24%	90%
Q2TA29	Bos taurus	30%	86%
Q2TBH7	Bos taurus	30%	85%
Q32NQ0	Xenopus laevis	29%	87%
Q38919	Arabidopsis thaliana	27%	95%
Q38922	Arabidopsis thaliana	28%	88%
Q38937	Arabidopsis thaliana	27%	95%
Q39222	Arabidopsis thaliana	28%	86%
Q39433	Beta vulgaris	26%	87%
Q39434	Beta vulgaris	27%	87%
Q39570	Chlamydomonas reinhardtii	27%	87%
Q39571	Chlamydomonas reinhardtii	27%	92%
Q39572	Chlamydomonas reinhardtii	29%	86%
Q39573	Chlamydomonas reinhardtii	30%	90%
Q3MHP2	Bos taurus	30%	85%
Q3SWY9	Bos taurus	28%	84%
Q3T054	Bos taurus	23%	86%
Q3T0F5	Bos taurus	27%	90%
Q3ZC27	Bos taurus	30%	86%
Q40191	Lotus japonicus	30%	82%
Q40193	Lotus japonicus	26%	86%
Q40194	Lotus japonicus	30%	85%
Q40195	Lotus japonicus	28%	85%
Q40520	Nicotiana tabacum	29%	84%
Q40521	Nicotiana tabacum	28%	86%
Q40522	Nicotiana tabacum	29%	84%
Q40523	Nicotiana tabacum	26%	86%
Q40723	Oryza sativa subsp. japonica	24%	86%
Q40787	Cenchrus ciliaris	29%	90%
Q41253	Gossypium hirsutum	25%	95%
Q41254	Gossypium hirsutum	25%	95%
Q41640	Vigna aconitifolia	30%	90%
Q43463	Glycine max	30%	90%
Q4LE85	Sus scrofa	25%	84%
Q4Q404	Leishmania major	29%	86%
Q4Q573	Leishmania major	29%	88%
Q4Q5N4	Leishmania major	29%	92%
Q4Q7C3	Leishmania major	28%	79%
Q4Q9V1	Leishmania major	24%	86%
Q4QDS9	Leishmania major	23%	79%
Q4QGD2	Leishmania major	26%	88%
Q4QH98	Leishmania major	22%	86%
Q4QHC3	Leishmania major	27%	89%
Q4QIN6	Leishmania major	28%	83%
Q4R4M9	Macaca fascicularis	23%	86%
Q4R4R9	Macaca fascicularis	28%	85%
Q4R4X6	Macaca fascicularis	24%	88%
Q4R5P1	Macaca fascicularis	27%	90%
Q4R8X3	Macaca fascicularis	27%	93%
Q4UB16	Theileria annulata	29%	85%
Q504M8	Mus musculus	31%	72%
Q52NJ1	Sus scrofa	30%	86%
Q52NJ2	Sus scrofa	27%	91%
Q52NJ6	Sus scrofa	28%	87%
Q53B90	Rattus norvegicus	33%	89%
Q53S08	Homo sapiens	32%	73%
Q54DA7	Dictyostelium discoideum	28%	91%
Q54G48	Dictyostelium discoideum	28%	85%
Q54GY8	Dictyostelium discoideum	27%	92%
Q54KM9	Dictyostelium discoideum	29%	85%
Q54NU2	Dictyostelium discoideum	27%	91%
Q54P07	Dictyostelium discoideum	27%	82%
Q54QR3	Dictyostelium discoideum	29%	85%
Q54RX9	Dictyostelium discoideum	29%	87%
Q550H6	Dictyostelium discoideum	29%	83%
Q558I0	Dictyostelium discoideum	24%	98%
Q559X6	Dictyostelium discoideum	28%	92%
Q55CA9	Dictyostelium discoideum	27%	87%
Q55CB0	Dictyostelium discoideum	29%	87%
Q55E31	Dictyostelium discoideum	29%	72%
Q55EF0	Dictyostelium discoideum	22%	85%
Q55EG6	Dictyostelium discoideum	22%	84%
Q55ET3	Dictyostelium discoideum	25%	91%
Q55FK2	Dictyostelium discoideum	33%	89%
Q580S0	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	59%	100%
Q58DS5	Bos taurus	28%	92%
Q58DS9	Bos taurus	32%	86%
Q58DW6	Bos taurus	28%	87%
Q5EB77	Rattus norvegicus	29%	90%
Q5F470	Gallus gallus	29%	90%
Q5JT25	Homo sapiens	31%	84%
Q5KTJ6	Mesocricetus auratus	28%	92%
Q5KTJ7	Mesocricetus auratus	29%	85%
Q5M7D1	Xenopus laevis	24%	67%
Q5M7U5	Rattus norvegicus	32%	86%
Q5R4A3	Pongo abelii	27%	90%
Q5R556	Pongo abelii	23%	86%
Q5R5H5	Pongo abelii	29%	90%
Q5R5U1	Pongo abelii	30%	93%
Q5R615	Pongo abelii	31%	81%
Q5R6B6	Pongo abelii	24%	88%
Q5R7A4	Pongo abelii	29%	92%
Q5R7L7	Pongo abelii	32%	86%
Q5R8Z8	Pongo abelii	28%	87%
Q5R9M7	Pongo abelii	30%	86%
Q5R9Y4	Pongo abelii	27%	90%
Q5RAV6	Pongo abelii	33%	89%
Q5RBG1	Pongo abelii	32%	87%
Q5RDE5	Pongo abelii	24%	68%
Q5RE13	Pongo abelii	27%	93%
Q5REC9	Pongo abelii	25%	90%
Q5RFI2	Pongo abelii	27%	84%
Q5U1Y1	Rattus norvegicus	26%	72%
Q5U316	Rattus norvegicus	24%	93%
Q5ZHV1	Gallus gallus	31%	82%
Q5ZHW4	Gallus gallus	32%	87%
Q5ZIT5	Gallus gallus	30%	93%
Q5ZJN2	Gallus gallus	30%	86%
Q5ZKU5	Gallus gallus	28%	87%
Q5ZLG1	Gallus gallus	29%	90%
Q63481	Rattus norvegicus	29%	91%
Q63941	Rattus norvegicus	29%	85%
Q63942	Rattus norvegicus	27%	85%
Q64008	Mus musculus	27%	72%
Q68EK7	Danio rerio	31%	87%
Q6AXT5	Rattus norvegicus	27%	83%
Q6DGL2	Danio rerio	26%	97%
Q6DHC1	Danio rerio	30%	91%
Q6DUB4	Paramecium octaurelia	25%	90%
Q6GL85	Xenopus tropicalis	23%	86%
Q6GQP4	Rattus norvegicus	25%	96%
Q6IMK3	Danio rerio	25%	68%
Q6IML7	Rattus norvegicus	23%	68%
Q6IMM1	Gallus gallus	26%	68%
Q6IQ22	Homo sapiens	32%	76%
Q6NYB7	Rattus norvegicus	27%	91%
Q6PHI9	Danio rerio	30%	87%
Q6PHN9	Mus musculus	24%	93%
Q6RUV5	Rattus norvegicus	27%	97%
Q6ZHA3	Oryza sativa subsp. japonica	28%	94%
Q76NM7	Plasmodium falciparum (isolate 3D7)	22%	90%
Q7T3A4	Danio rerio	28%	93%
Q7ZYF1	Xenopus laevis	27%	68%
Q7ZZX9	Carassius auratus	23%	87%
Q86JC8	Dictyostelium discoideum	25%	94%
Q86JP3	Dictyostelium discoideum	30%	93%
Q86YS6	Homo sapiens	30%	88%
Q8BHC1	Mus musculus	26%	87%
Q8BHD0	Mus musculus	27%	86%
Q8CFP6	Mus musculus	25%	68%
Q8CG50	Mus musculus	33%	89%
Q8HZJ5	Bos taurus	26%	85%
Q8K386	Mus musculus	28%	88%
Q8MXQ2	Dictyostelium discoideum	29%	83%
Q8MXS1	Caenorhabditis elegans	29%	92%
Q8MYF2	Dictyostelium discoideum	27%	73%
Q8R367	Mus musculus	27%	93%
Q8T6H9	Leishmania braziliensis	27%	83%
Q8VEA8	Mus musculus	28%	93%
Q8VHP8	Mus musculus	26%	67%
Q8VHQ4	Mus musculus	27%	66%
Q8WQ53	Geodia cydonium	25%	81%
Q8WUD1	Homo sapiens	27%	86%
Q8WXH6	Homo sapiens	27%	67%
Q90965	Gallus gallus	24%	88%
Q91V41	Mus musculus	28%	87%
Q91YQ1	Mus musculus	29%	91%
Q91ZR1	Mus musculus	32%	87%
Q921E2	Mus musculus	25%	96%
Q923S9	Mus musculus	30%	92%
Q92928	Homo sapiens	27%	93%
Q92930	Homo sapiens	24%	90%
Q94148	Caenorhabditis elegans	27%	93%
Q948K8	Arabidopsis thaliana	30%	90%
Q94986	Caenorhabditis elegans	27%	85%
Q95UJ0	Paramecium octaurelia	26%	90%
Q96283	Arabidopsis thaliana	26%	86%
Q969Q5	Homo sapiens	28%	92%
Q96A58	Homo sapiens	27%	93%
Q96AH8	Homo sapiens	30%	93%
Q96AX2	Homo sapiens	30%	83%
Q96DA2	Homo sapiens	26%	87%
Q96E17	Homo sapiens	26%	82%
Q96S21	Homo sapiens	27%	66%
Q98932	Gallus gallus	32%	86%
Q99260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	87%
Q99KL7	Mus musculus	28%	84%
Q99P58	Mus musculus	26%	85%
Q99P74	Rattus norvegicus	26%	85%
Q9BW83	Homo sapiens	35%	100%
Q9BZG1	Homo sapiens	27%	72%
Q9C2L8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	91%
Q9C820	Arabidopsis thaliana	27%	90%
Q9C9U7	Arabidopsis thaliana	25%	80%
Q9CB01	Arabidopsis thaliana	27%	92%
Q9CQD1	Mus musculus	32%	87%
Q9CZE3	Mus musculus	32%	83%
Q9CZT8	Mus musculus	29%	85%
Q9D0P8	Mus musculus	39%	100%
Q9D1G1	Mus musculus	27%	93%
Q9DD03	Mus musculus	29%	92%
Q9ERI2	Mus musculus	25%	84%
Q9FE79	Arabidopsis thaliana	29%	83%
Q9FGK5	Arabidopsis thaliana	27%	84%
Q9FIF9	Arabidopsis thaliana	28%	86%
Q9FJH0	Arabidopsis thaliana	29%	86%
Q9FJN8	Arabidopsis thaliana	28%	82%
Q9FK68	Arabidopsis thaliana	30%	86%
Q9FPJ4	Arabidopsis thaliana	26%	92%
Q9GP33	Echinococcus multilocularis	30%	83%
Q9H082	Homo sapiens	31%	81%
Q9H0N0	Homo sapiens	31%	73%
Q9H0U4	Homo sapiens	27%	93%
Q9HDY0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	89%
Q9HF56	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	97%
Q9JKM7	Mus musculus	29%	83%
Q9LFT9	Arabidopsis thaliana	33%	90%
Q9LH50	Arabidopsis thaliana	32%	84%
Q9LK99	Arabidopsis thaliana	30%	86%
Q9LNK1	Arabidopsis thaliana	31%	78%
Q9LNW1	Arabidopsis thaliana	28%	87%
Q9LS94	Arabidopsis thaliana	28%	90%
Q9LV79	Arabidopsis thaliana	31%	90%
Q9N2P5	Leishmania major	27%	83%
Q9NP72	Homo sapiens	29%	90%
Q9NRW1	Homo sapiens	33%	89%
Q9NZQ0	Homo sapiens	24%	68%
Q9S810	Arabidopsis thaliana	29%	85%
Q9SEH3	Arabidopsis thaliana	26%	92%
Q9SF91	Arabidopsis thaliana	26%	85%
Q9SID8	Arabidopsis thaliana	31%	90%
Q9SIP0	Arabidopsis thaliana	27%	85%
Q9SJ11	Arabidopsis thaliana	34%	88%
Q9SMQ6	Arabidopsis thaliana	30%	83%
Q9SMR4	Arabidopsis thaliana	32%	87%
Q9SN35	Arabidopsis thaliana	29%	87%
Q9SN68	Arabidopsis thaliana	31%	93%
Q9SRS5	Arabidopsis thaliana	25%	86%
Q9TU25	Bos taurus	27%	97%
Q9TVU5	Theileria parva	29%	85%
Q9UL25	Homo sapiens	26%	83%
Q9UL26	Homo sapiens	28%	96%
Q9ULC3	Homo sapiens	27%	78%
Q9ULW5	Homo sapiens	33%	73%
Q9WTL2	Mus musculus	29%	87%
Q9WVB1	Rattus norvegicus	33%	89%
Q9XER8	Gossypium hirsutum	25%	90%
Q9XGU0	Arabidopsis thaliana	27%	89%
Q9XI98	Arabidopsis thaliana	27%	90%
Q9XWR6	Caenorhabditis elegans	30%	75%
Q9YGC0	Salmo salar	23%	87%
Q9ZRE2	Arabidopsis thaliana	24%	91%
V5BBM5	Trypanosoma cruzi	28%	90%
V5BCH4	Trypanosoma cruzi	24%	80%
V5BJM4	Trypanosoma cruzi	29%	71%
V5BU30	Trypanosoma cruzi	29%	81%
V5D027	Trypanosoma cruzi	31%	85%
V5D1K6	Trypanosoma cruzi	29%	81%
V5D6P4	Trypanosoma cruzi	30%	68%
V5D9W7	Trypanosoma cruzi	28%	93%