Putative QA-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania major

UniProt:

E9ADK9_LEIMA

TriTrypDb:

LmjF.29.0070 , LMJLV39_290005700 , LMJSD75_290005700

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	12
GO:0031201	SNARE complex	3	2
GO:0031982	vesicle	4	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0097014	ciliary plasm	5	2
GO:0098796	membrane protein complex	2	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ADK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADK9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	3
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	3
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0016192	vesicle-mediated transport	4	10

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	3
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	3
GO:0060090	molecular adaptor activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.380
CLV_NRD_NRD_1	108	110	PF00675	0.398
CLV_NRD_NRD_1	221	223	PF00675	0.490
CLV_NRD_NRD_1	31	33	PF00675	0.347
CLV_NRD_NRD_1	36	38	PF00675	0.390
CLV_NRD_NRD_1	65	67	PF00675	0.398
CLV_NRD_NRD_1	86	88	PF00675	0.387
CLV_PCSK_KEX2_1	10	12	PF00082	0.364
CLV_PCSK_KEX2_1	221	223	PF00082	0.477
CLV_PCSK_KEX2_1	31	33	PF00082	0.336
CLV_PCSK_KEX2_1	36	38	PF00082	0.379
CLV_PCSK_PC7_1	32	38	PF00082	0.441
CLV_PCSK_SKI1_1	234	238	PF00082	0.360
CLV_PCSK_SKI1_1	31	35	PF00082	0.370
CLV_PCSK_SKI1_1	51	55	PF00082	0.299
CLV_PCSK_SKI1_1	67	71	PF00082	0.289
CLV_PCSK_SKI1_1	74	78	PF00082	0.418
CLV_PCSK_SKI1_1	88	92	PF00082	0.361
DEG_Nend_UBRbox_3	1	3	PF02207	0.595
DOC_MAPK_gen_1	87	97	PF00069	0.622
DOC_MAPK_MEF2A_6	232	240	PF00069	0.463
DOC_PP1_RVXF_1	150	156	PF00149	0.707
DOC_USP7_MATH_1	228	232	PF00917	0.661
DOC_USP7_MATH_1	245	249	PF00917	0.268
DOC_WW_Pin1_4	146	151	PF00397	0.740
LIG_14-3-3_CanoR_1	36	43	PF00244	0.606
LIG_APCC_ABBAyCdc20_2	109	115	PF00400	0.628
LIG_FHA_1	169	175	PF00498	0.594
LIG_FHA_2	101	107	PF00498	0.595
LIG_LIR_Gen_1	158	165	PF02991	0.695
LIG_LIR_Gen_1	183	192	PF02991	0.533
LIG_LIR_Gen_1	71	78	PF02991	0.534
LIG_LIR_Nem_3	158	163	PF02991	0.695
LIG_LIR_Nem_3	183	188	PF02991	0.524
LIG_LIR_Nem_3	71	75	PF02991	0.509
LIG_SH2_STAP1	160	164	PF00017	0.693
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.665
LIG_SUMO_SIM_par_1	242	248	PF11976	0.450
LIG_TRAF2_1	39	42	PF00917	0.703
LIG_WRC_WIRS_1	69	74	PF05994	0.614
MOD_CDC14_SPxK_1	149	152	PF00782	0.728
MOD_CDK_SPxK_1	146	152	PF00069	0.738
MOD_CK2_1	204	210	PF00069	0.677
MOD_CK2_1	35	41	PF00069	0.672
MOD_Cter_Amidation	85	88	PF01082	0.411
MOD_GlcNHglycan	115	118	PF01048	0.454
MOD_GlcNHglycan	207	210	PF01048	0.431
MOD_GSK3_1	113	120	PF00069	0.624
MOD_GSK3_1	210	217	PF00069	0.619
MOD_GSK3_1	31	38	PF00069	0.563
MOD_N-GLC_1	204	209	PF02516	0.448
MOD_N-GLC_1	214	219	PF02516	0.412
MOD_N-GLC_1	57	62	PF02516	0.406
MOD_PIKK_1	117	123	PF00454	0.636
MOD_PIKK_1	214	220	PF00454	0.657
MOD_PK_1	36	42	PF00069	0.695
MOD_PKA_1	31	37	PF00069	0.552
MOD_PKA_2	117	123	PF00069	0.650
MOD_PKA_2	168	174	PF00069	0.606
MOD_PKA_2	210	216	PF00069	0.629
MOD_PKA_2	31	37	PF00069	0.569
MOD_ProDKin_1	146	152	PF00069	0.738
MOD_SUMO_for_1	43	46	PF00179	0.662
MOD_SUMO_rev_2	46	53	PF00179	0.625
TRG_DiLeu_BaEn_1	140	145	PF01217	0.691
TRG_DiLeu_BaEn_1	73	78	PF01217	0.644
TRG_ENDOCYTIC_2	160	163	PF00928	0.693
TRG_ER_diArg_1	220	222	PF00400	0.711
TRG_ER_diArg_1	30	32	PF00400	0.547
TRG_ER_diArg_1	9	11	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V3	Leptomonas seymouri	69%	100%
A0A0S4IMX4	Bodo saltans	36%	100%
A0A1X0NZD7	Trypanosomatidae	42%	98%
A0A3Q8IF56	Leishmania donovani	95%	100%
A0A3R7NXH1	Trypanosoma rangeli	41%	98%
A4HH15	Leishmania braziliensis	88%	100%
A4I444	Leishmania infantum	95%	100%
C9ZKR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AM72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O94651	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	97%
V5BPW1	Trypanosoma cruzi	42%	98%