Putative QA-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania major

UniProt:

E9ADK9_LEIMA

TriTrypDb:

LmjF.29.0070 , LMJLV39_290005700 , LMJSD75_290005700

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	12
GO:0031201	SNARE complex	3	2
GO:0031982	vesicle	4	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2

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Expansion

Sequence features

E9ADK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADK9

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	3
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0016192	vesicle-mediated transport	4	10

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	3
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	3
GO:0060090	molecular adaptor activity	1	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.380
CLV_NRD_NRD_1	108	110	PF00675	0.398
CLV_NRD_NRD_1	221	223	PF00675	0.490
CLV_NRD_NRD_1	31	33	PF00675	0.347
CLV_NRD_NRD_1	36	38	PF00675	0.390
CLV_NRD_NRD_1	65	67	PF00675	0.398
CLV_NRD_NRD_1	86	88	PF00675	0.387
CLV_PCSK_KEX2_1	10	12	PF00082	0.364
CLV_PCSK_KEX2_1	221	223	PF00082	0.477
CLV_PCSK_KEX2_1	31	33	PF00082	0.336

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V3	Leptomonas seymouri	69%	100%
A0A0S4IMX4	Bodo saltans	36%	100%
A0A1X0NZD7	Trypanosomatidae	42%	98%
A0A3Q8IF56	Leishmania donovani	95%	100%
A0A3R7NXH1	Trypanosoma rangeli	41%	98%
A4HH15	Leishmania braziliensis	88%	100%
A4I444	Leishmania infantum	95%	100%
C9ZKR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AM72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O94651	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	97%

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