LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9ADK7_LEIMA
TriTrypDb:
LmjF.29.0050 , LMJLV39_290005500 * , LMJSD75_290005500 *
Length:
671

Annotations

LeishMANIAdb annotations

Despite the helix-rich unique Kinetoplastid fold, no TM domain can be discerned.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADK7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADK7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 454 458 PF00656 0.587
CLV_C14_Caspase3-7 476 480 PF00656 0.589
CLV_C14_Caspase3-7 513 517 PF00656 0.583
CLV_C14_Caspase3-7 602 606 PF00656 0.734
CLV_NRD_NRD_1 169 171 PF00675 0.595
CLV_NRD_NRD_1 183 185 PF00675 0.454
CLV_NRD_NRD_1 2 4 PF00675 0.620
CLV_NRD_NRD_1 241 243 PF00675 0.553
CLV_NRD_NRD_1 508 510 PF00675 0.675
CLV_NRD_NRD_1 669 671 PF00675 0.514
CLV_PCSK_KEX2_1 169 171 PF00082 0.595
CLV_PCSK_KEX2_1 2 4 PF00082 0.548
CLV_PCSK_KEX2_1 241 243 PF00082 0.553
CLV_PCSK_KEX2_1 496 498 PF00082 0.716
CLV_PCSK_KEX2_1 508 510 PF00082 0.619
CLV_PCSK_KEX2_1 669 671 PF00082 0.514
CLV_PCSK_PC1ET2_1 496 498 PF00082 0.746
CLV_PCSK_PC7_1 237 243 PF00082 0.479
CLV_PCSK_SKI1_1 110 114 PF00082 0.444
CLV_PCSK_SKI1_1 401 405 PF00082 0.681
CLV_PCSK_SKI1_1 470 474 PF00082 0.702
CLV_PCSK_SKI1_1 503 507 PF00082 0.738
CLV_PCSK_SKI1_1 509 513 PF00082 0.693
DEG_APCC_DBOX_1 225 233 PF00400 0.632
DEG_APCC_DBOX_1 538 546 PF00400 0.497
DEG_Nend_UBRbox_1 1 4 PF02207 0.713
DEG_SPOP_SBC_1 90 94 PF00917 0.799
DOC_CKS1_1 18 23 PF01111 0.764
DOC_CYCLIN_RxL_1 107 114 PF00134 0.708
DOC_CYCLIN_RxL_1 151 162 PF00134 0.715
DOC_CYCLIN_RxL_1 467 476 PF00134 0.497
DOC_CYCLIN_RxL_1 503 516 PF00134 0.556
DOC_CYCLIN_yCln2_LP_2 446 452 PF00134 0.572
DOC_MAPK_FxFP_2 569 572 PF00069 0.411
DOC_MAPK_gen_1 496 504 PF00069 0.540
DOC_MAPK_gen_1 559 569 PF00069 0.252
DOC_MAPK_JIP1_4 226 232 PF00069 0.698
DOC_MAPK_MEF2A_6 497 506 PF00069 0.534
DOC_MAPK_MEF2A_6 562 569 PF00069 0.363
DOC_MAPK_NFAT4_5 562 570 PF00069 0.363
DOC_PP2B_LxvP_1 116 119 PF13499 0.716
DOC_PP2B_LxvP_1 446 449 PF13499 0.574
DOC_PP4_FxxP_1 569 572 PF00568 0.411
DOC_USP7_MATH_1 104 108 PF00917 0.598
DOC_USP7_MATH_1 119 123 PF00917 0.746
DOC_USP7_MATH_1 199 203 PF00917 0.772
DOC_USP7_MATH_1 205 209 PF00917 0.714
DOC_USP7_MATH_1 221 225 PF00917 0.584
DOC_USP7_MATH_1 286 290 PF00917 0.470
DOC_USP7_MATH_1 374 378 PF00917 0.586
DOC_USP7_MATH_1 403 407 PF00917 0.529
DOC_USP7_MATH_1 440 444 PF00917 0.484
DOC_USP7_MATH_1 587 591 PF00917 0.593
DOC_USP7_MATH_1 90 94 PF00917 0.766
DOC_USP7_MATH_2 190 196 PF00917 0.637
DOC_WW_Pin1_4 17 22 PF00397 0.685
DOC_WW_Pin1_4 186 191 PF00397 0.746
DOC_WW_Pin1_4 612 617 PF00397 0.682
LIG_14-3-3_CanoR_1 481 489 PF00244 0.542
LIG_14-3-3_CanoR_1 490 496 PF00244 0.414
LIG_14-3-3_CanoR_1 539 543 PF00244 0.499
LIG_14-3-3_CanoR_1 586 592 PF00244 0.541
LIG_14-3-3_CanoR_1 9 18 PF00244 0.795
LIG_14-3-3_CterR_2 669 671 PF00244 0.714
LIG_Actin_WH2_2 11 27 PF00022 0.779
LIG_Actin_WH2_2 653 671 PF00022 0.640
LIG_BIR_III_4 457 461 PF00653 0.573
LIG_CSL_BTD_1 449 452 PF09270 0.551
LIG_FHA_1 153 159 PF00498 0.771
LIG_FHA_1 18 24 PF00498 0.721
LIG_FHA_1 322 328 PF00498 0.558
LIG_FHA_1 392 398 PF00498 0.452
LIG_FHA_1 545 551 PF00498 0.519
LIG_FHA_1 599 605 PF00498 0.720
LIG_FHA_1 616 622 PF00498 0.572
LIG_FHA_1 636 642 PF00498 0.460
LIG_FHA_2 262 268 PF00498 0.606
LIG_FHA_2 452 458 PF00498 0.520
LIG_FHA_2 77 83 PF00498 0.718
LIG_FHA_2 97 103 PF00498 0.734
LIG_Integrin_RGD_1 410 412 PF01839 0.810
LIG_LIR_Gen_1 5 14 PF02991 0.801
LIG_LIR_Gen_1 520 530 PF02991 0.473
LIG_LIR_Nem_3 107 112 PF02991 0.666
LIG_LIR_Nem_3 261 265 PF02991 0.380
LIG_LIR_Nem_3 381 387 PF02991 0.460
LIG_LIR_Nem_3 5 10 PF02991 0.803
LIG_LIR_Nem_3 520 526 PF02991 0.473
LIG_NRBOX 563 569 PF00104 0.389
LIG_PCNA_PIPBox_1 522 531 PF02747 0.472
LIG_PCNA_yPIPBox_3 559 568 PF02747 0.252
LIG_Pex14_1 109 113 PF04695 0.681
LIG_SH2_CRK 384 388 PF00017 0.425
LIG_SH2_CRK 523 527 PF00017 0.470
LIG_SH2_STAT5 144 147 PF00017 0.688
LIG_SH2_STAT5 71 74 PF00017 0.651
LIG_SH3_3 38 44 PF00018 0.766
LIG_SH3_3 423 429 PF00018 0.436
LIG_SH3_3 446 452 PF00018 0.572
LIG_SH3_3 551 557 PF00018 0.552
LIG_SH3_3 616 622 PF00018 0.709
LIG_SH3_3 95 101 PF00018 0.764
LIG_SUMO_SIM_anti_2 114 120 PF11976 0.692
LIG_SUMO_SIM_anti_2 250 256 PF11976 0.513
LIG_SUMO_SIM_anti_2 328 334 PF11976 0.539
LIG_SUMO_SIM_par_1 114 120 PF11976 0.629
LIG_SUMO_SIM_par_1 256 261 PF11976 0.436
LIG_SUMO_SIM_par_1 327 334 PF11976 0.561
LIG_TRAF2_1 190 193 PF00917 0.741
LIG_WRC_WIRS_1 259 264 PF05994 0.397
MOD_CK1_1 386 392 PF00069 0.758
MOD_CK1_1 521 527 PF00069 0.581
MOD_CK1_1 55 61 PF00069 0.616
MOD_CK1_1 575 581 PF00069 0.499
MOD_CK1_1 590 596 PF00069 0.466
MOD_CK1_1 607 613 PF00069 0.681
MOD_CK1_1 615 621 PF00069 0.577
MOD_CK1_1 92 98 PF00069 0.779
MOD_CK2_1 186 192 PF00069 0.742
MOD_CK2_1 55 61 PF00069 0.589
MOD_CK2_1 76 82 PF00069 0.675
MOD_CK2_1 96 102 PF00069 0.682
MOD_GlcNHglycan 223 226 PF01048 0.667
MOD_GlcNHglycan 279 282 PF01048 0.658
MOD_GlcNHglycan 290 293 PF01048 0.526
MOD_GlcNHglycan 372 375 PF01048 0.647
MOD_GlcNHglycan 376 379 PF01048 0.632
MOD_GlcNHglycan 380 383 PF01048 0.735
MOD_GlcNHglycan 405 408 PF01048 0.741
MOD_GlcNHglycan 44 47 PF01048 0.762
MOD_GlcNHglycan 531 534 PF01048 0.727
MOD_GlcNHglycan 536 539 PF01048 0.591
MOD_GlcNHglycan 56 60 PF01048 0.517
MOD_GlcNHglycan 609 612 PF01048 0.727
MOD_GSK3_1 180 187 PF00069 0.636
MOD_GSK3_1 221 228 PF00069 0.614
MOD_GSK3_1 321 328 PF00069 0.683
MOD_GSK3_1 370 377 PF00069 0.740
MOD_GSK3_1 383 390 PF00069 0.719
MOD_GSK3_1 42 49 PF00069 0.689
MOD_GSK3_1 473 480 PF00069 0.712
MOD_GSK3_1 517 524 PF00069 0.628
MOD_GSK3_1 534 541 PF00069 0.470
MOD_GSK3_1 606 613 PF00069 0.744
MOD_GSK3_1 88 95 PF00069 0.732
MOD_LATS_1 475 481 PF00433 0.671
MOD_N-GLC_1 517 522 PF02516 0.628
MOD_N-GLC_1 52 57 PF02516 0.636
MOD_NEK2_1 219 224 PF00069 0.719
MOD_NEK2_1 258 263 PF00069 0.416
MOD_NEK2_1 327 332 PF00069 0.704
MOD_NEK2_1 357 362 PF00069 0.517
MOD_NEK2_1 466 471 PF00069 0.678
MOD_NEK2_1 473 478 PF00069 0.613
MOD_NEK2_1 529 534 PF00069 0.549
MOD_NEK2_1 545 550 PF00069 0.616
MOD_NEK2_1 598 603 PF00069 0.627
MOD_NEK2_1 604 609 PF00069 0.647
MOD_NEK2_2 199 204 PF00069 0.676
MOD_NEK2_2 572 577 PF00069 0.496
MOD_OFUCOSY 596 603 PF10250 0.614
MOD_PIKK_1 321 327 PF00454 0.618
MOD_PIKK_1 518 524 PF00454 0.591
MOD_PIKK_1 604 610 PF00454 0.732
MOD_PIKK_1 76 82 PF00454 0.793
MOD_PKA_1 184 190 PF00069 0.700
MOD_PKA_2 14 20 PF00069 0.620
MOD_PKA_2 225 231 PF00069 0.538
MOD_PKA_2 387 393 PF00069 0.649
MOD_PKA_2 483 489 PF00069 0.683
MOD_PKA_2 538 544 PF00069 0.628
MOD_PKA_2 635 641 PF00069 0.591
MOD_Plk_1 192 198 PF00069 0.698
MOD_Plk_1 55 61 PF00069 0.642
MOD_Plk_1 76 82 PF00069 0.691
MOD_Plk_4 225 231 PF00069 0.574
MOD_Plk_4 261 267 PF00069 0.591
MOD_Plk_4 327 333 PF00069 0.707
MOD_Plk_4 357 363 PF00069 0.517
MOD_Plk_4 461 467 PF00069 0.613
MOD_Plk_4 521 527 PF00069 0.693
MOD_Plk_4 538 544 PF00069 0.526
MOD_Plk_4 663 669 PF00069 0.588
MOD_ProDKin_1 17 23 PF00069 0.607
MOD_ProDKin_1 186 192 PF00069 0.691
MOD_ProDKin_1 612 618 PF00069 0.594
MOD_SUMO_rev_2 419 426 PF00179 0.765
TRG_DiLeu_BaEn_1 214 219 PF01217 0.655
TRG_DiLeu_BaEn_1 364 369 PF01217 0.732
TRG_DiLeu_BaEn_2 161 167 PF01217 0.656
TRG_DiLeu_BaEn_4 364 370 PF01217 0.734
TRG_DiLeu_BaLyEn_6 6 11 PF01217 0.669
TRG_ENDOCYTIC_2 266 269 PF00928 0.689
TRG_ENDOCYTIC_2 384 387 PF00928 0.517
TRG_ENDOCYTIC_2 523 526 PF00928 0.585
TRG_ENDOCYTIC_2 54 57 PF00928 0.703
TRG_ER_diArg_1 1 3 PF00400 0.815
TRG_ER_diArg_1 168 170 PF00400 0.742
TRG_ER_diArg_1 174 177 PF00400 0.665
TRG_ER_diArg_1 507 509 PF00400 0.565
TRG_ER_diArg_1 668 670 PF00400 0.619
TRG_Pf-PMV_PEXEL_1 110 114 PF00026 0.692
TRG_Pf-PMV_PEXEL_1 233 238 PF00026 0.550
TRG_Pf-PMV_PEXEL_1 420 424 PF00026 0.767
TRG_Pf-PMV_PEXEL_1 509 513 PF00026 0.639

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2S1 Leptomonas seymouri 34% 99%
A0A3S7X214 Leishmania donovani 90% 100%
A4HH13 Leishmania braziliensis 74% 100%
A4I442 Leishmania infantum 90% 100%
E9AM74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS