Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADK6_LEIMA

TriTrypDb:

LmjF.29.0040 , LMJLV39_290005400 , LMJSD75_290005400

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.612
CLV_NRD_NRD_1	135	137	PF00675	0.570
CLV_NRD_NRD_1	148	150	PF00675	0.527
CLV_NRD_NRD_1	154	156	PF00675	0.448
CLV_NRD_NRD_1	204	206	PF00675	0.502
CLV_NRD_NRD_1	22	24	PF00675	0.682
CLV_NRD_NRD_1	270	272	PF00675	0.376
CLV_NRD_NRD_1	282	284	PF00675	0.481
CLV_NRD_NRD_1	31	33	PF00675	0.571
CLV_PCSK_FUR_1	202	206	PF00082	0.498
CLV_PCSK_KEX2_1	120	122	PF00082	0.567
CLV_PCSK_KEX2_1	135	137	PF00082	0.627
CLV_PCSK_KEX2_1	147	149	PF00082	0.605
CLV_PCSK_KEX2_1	204	206	PF00082	0.564
CLV_PCSK_KEX2_1	22	24	PF00082	0.682
CLV_PCSK_KEX2_1	270	272	PF00082	0.460
CLV_PCSK_KEX2_1	31	33	PF00082	0.571
CLV_PCSK_PC7_1	144	150	PF00082	0.580
CLV_PCSK_SKI1_1	115	119	PF00082	0.496
CLV_PCSK_SKI1_1	135	139	PF00082	0.448
CLV_PCSK_SKI1_1	171	175	PF00082	0.343
CLV_PCSK_SKI1_1	183	187	PF00082	0.363
CLV_PCSK_SKI1_1	218	222	PF00082	0.487
CLV_PCSK_SKI1_1	252	256	PF00082	0.398
DEG_APCC_DBOX_1	21	29	PF00400	0.446
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DOC_CYCLIN_RxL_1	112	119	PF00134	0.562
DOC_CYCLIN_RxL_1	246	259	PF00134	0.367
DOC_MAPK_gen_1	22	30	PF00069	0.680
DOC_MAPK_gen_1	267	275	PF00069	0.419
DOC_PP4_FxxP_1	126	129	PF00568	0.601
DOC_USP7_UBL2_3	186	190	PF12436	0.591
LIG_14-3-3_CanoR_1	209	213	PF00244	0.479
LIG_14-3-3_CanoR_1	252	258	PF00244	0.365
LIG_14-3-3_CanoR_1	37	45	PF00244	0.559
LIG_14-3-3_CanoR_1	58	66	PF00244	0.599
LIG_Actin_WH2_2	268	285	PF00022	0.464
LIG_Actin_WH2_2	91	109	PF00022	0.365
LIG_AP_GAE_1	82	88	PF02883	0.569
LIG_FHA_1	175	181	PF00498	0.323
LIG_FHA_1	195	201	PF00498	0.356
LIG_FHA_1	66	72	PF00498	0.462
LIG_FHA_2	152	158	PF00498	0.440
LIG_FHA_2	254	260	PF00498	0.390
LIG_FHA_2	71	77	PF00498	0.663
LIG_LIR_Gen_1	82	91	PF02991	0.448
LIG_LIR_Gen_1	97	106	PF02991	0.392
LIG_LIR_Nem_3	132	137	PF02991	0.594
LIG_LIR_Nem_3	211	215	PF02991	0.446
LIG_LIR_Nem_3	276	282	PF02991	0.426
LIG_LIR_Nem_3	82	88	PF02991	0.465
LIG_LIR_Nem_3	97	103	PF02991	0.390
LIG_NRBOX	171	177	PF00104	0.331
LIG_PCNA_yPIPBox_3	171	185	PF02747	0.471
LIG_Pex14_2	215	219	PF04695	0.484
LIG_PTB_Apo_2	238	245	PF02174	0.506
LIG_SH2_CRK	100	104	PF00017	0.435
LIG_SH2_CRK	134	138	PF00017	0.598
LIG_SH2_CRK	203	207	PF00017	0.476
LIG_SH2_CRK	279	283	PF00017	0.451
LIG_SH2_NCK_1	100	104	PF00017	0.435
LIG_SH2_STAP1	100	104	PF00017	0.486
LIG_SH2_STAT5	165	168	PF00017	0.468
LIG_SH2_STAT5	253	256	PF00017	0.500
LIG_SUMO_SIM_anti_2	170	177	PF11976	0.354
LIG_SUMO_SIM_par_1	170	177	PF11976	0.336
LIG_TRAF2_1	73	76	PF00917	0.652
LIG_TRAF2_1	91	94	PF00917	0.222
LIG_TYR_ITIM	98	103	PF00017	0.417
MOD_CK1_1	40	46	PF00069	0.592
MOD_CK2_1	253	259	PF00069	0.354
MOD_CK2_1	43	49	PF00069	0.558
MOD_CK2_1	70	76	PF00069	0.579
MOD_GlcNHglycan	186	189	PF01048	0.421
MOD_GlcNHglycan	236	239	PF01048	0.549
MOD_GlcNHglycan	40	43	PF01048	0.743
MOD_NEK2_1	174	179	PF00069	0.342
MOD_NEK2_1	184	189	PF00069	0.434
MOD_NEK2_1	273	278	PF00069	0.446
MOD_NEK2_2	142	147	PF00069	0.607
MOD_PIKK_1	174	180	PF00454	0.415
MOD_PIKK_1	273	279	PF00454	0.472
MOD_PIKK_1	89	95	PF00454	0.341
MOD_PKA_2	208	214	PF00069	0.465
MOD_PKA_2	57	63	PF00069	0.603
MOD_Plk_1	142	148	PF00069	0.680
MOD_Plk_2-3	76	82	PF00069	0.590
MOD_SUMO_for_1	129	132	PF00179	0.635
MOD_SUMO_rev_2	69	79	PF00179	0.473
TRG_DiLeu_BaEn_4	75	81	PF01217	0.709
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.547
TRG_ENDOCYTIC_2	100	103	PF00928	0.472
TRG_ENDOCYTIC_2	134	137	PF00928	0.598
TRG_ENDOCYTIC_2	279	282	PF00928	0.468
TRG_ER_diArg_1	120	122	PF00400	0.594
TRG_ER_diArg_1	134	136	PF00400	0.559
TRG_ER_diArg_1	146	149	PF00400	0.528
TRG_ER_diArg_1	152	155	PF00400	0.428
TRG_ER_diArg_1	203	205	PF00400	0.577
TRG_ER_diArg_1	21	23	PF00400	0.702
TRG_ER_diArg_1	270	272	PF00400	0.380
TRG_ER_diArg_1	30	32	PF00400	0.645
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIG8	Leptomonas seymouri	65%	100%
A0A0S4ITL7	Bodo saltans	33%	100%
A0A1X0NZE1	Trypanosomatidae	67%	96%
A0A3Q8IB97	Leishmania donovani	91%	100%
A0A3R7KKG3	Trypanosoma rangeli	55%	100%
A4HH12	Leishmania braziliensis	76%	100%
A4I441	Leishmania infantum	91%	100%
C9ZKS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AM75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BUH7	Trypanosoma cruzi	60%	81%