3,2-trans-enoyl-CoA isomerase, mitochondrial-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor-like protein

Species:

Leishmania major

UniProt:

E9ADK3_LEIMA

TriTrypDb:

LmjF.29.0010 , LMJLV39_290005000 , LMJSD75_290005000

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADK3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004300	enoyl-CoA hydratase activity	5	2
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2
GO:0016853	isomerase activity	2	14
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	4
GO:0016860	intramolecular oxidoreductase activity	3	4
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.419
CLV_NRD_NRD_1	191	193	PF00675	0.331
CLV_NRD_NRD_1	253	255	PF00675	0.284
CLV_PCSK_KEX2_1	155	157	PF00082	0.419
CLV_PCSK_KEX2_1	253	255	PF00082	0.311
CLV_PCSK_PC7_1	151	157	PF00082	0.416
CLV_PCSK_SKI1_1	117	121	PF00082	0.381
CLV_PCSK_SKI1_1	254	258	PF00082	0.318
CLV_PCSK_SKI1_1	283	287	PF00082	0.413
CLV_PCSK_SKI1_1	292	296	PF00082	0.595
DEG_APCC_DBOX_1	253	261	PF00400	0.338
DEG_Nend_UBRbox_1	1	4	PF02207	0.561
DOC_CKS1_1	260	265	PF01111	0.356
DOC_CKS1_1	53	58	PF01111	0.394
DOC_CYCLIN_RxL_1	232	241	PF00134	0.381
DOC_CYCLIN_yClb5_NLxxxL_5	271	280	PF00134	0.195
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.352
DOC_MAPK_gen_1	74	82	PF00069	0.322
DOC_MAPK_JIP1_4	160	166	PF00069	0.386
DOC_MAPK_MEF2A_6	160	168	PF00069	0.416
DOC_PP2B_LxvP_1	125	128	PF13499	0.351
DOC_PP2B_LxvP_1	237	240	PF13499	0.349
DOC_PP4_FxxP_1	175	178	PF00568	0.416
DOC_USP7_MATH_1	22	26	PF00917	0.643
DOC_USP7_MATH_1	72	76	PF00917	0.425
DOC_USP7_UBL2_3	292	296	PF12436	0.621
DOC_WW_Pin1_4	238	243	PF00397	0.407
DOC_WW_Pin1_4	259	264	PF00397	0.351
DOC_WW_Pin1_4	33	38	PF00397	0.413
DOC_WW_Pin1_4	52	57	PF00397	0.309
DOC_WW_Pin1_4	9	14	PF00397	0.418
LIG_14-3-3_CanoR_1	16	22	PF00244	0.597
LIG_14-3-3_CanoR_1	5	13	PF00244	0.523
LIG_Actin_WH2_2	195	213	PF00022	0.326
LIG_FHA_1	163	169	PF00498	0.364
LIG_FHA_1	25	31	PF00498	0.497
LIG_FHA_1	260	266	PF00498	0.301
LIG_Integrin_isoDGR_2	48	50	PF01839	0.383
LIG_LIR_Gen_1	113	122	PF02991	0.311
LIG_LIR_Gen_1	272	282	PF02991	0.371
LIG_LIR_Nem_3	106	111	PF02991	0.308
LIG_LIR_Nem_3	113	118	PF02991	0.276
LIG_LIR_Nem_3	272	277	PF02991	0.375
LIG_PCNA_yPIPBox_3	279	292	PF02747	0.261
LIG_Pex14_2	108	112	PF04695	0.273
LIG_Pex14_2	115	119	PF04695	0.261
LIG_Pex14_2	273	277	PF04695	0.386
LIG_Pex14_2	58	62	PF04695	0.380
LIG_SH2_STAT3	111	114	PF00017	0.320
LIG_SH2_STAT5	180	183	PF00017	0.336
LIG_SH3_1	155	161	PF00018	0.449
LIG_SH3_3	155	161	PF00018	0.385
LIG_SH3_3	50	56	PF00018	0.398
LIG_SUMO_SIM_anti_2	29	36	PF11976	0.489
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.409
LIG_SUMO_SIM_par_1	234	241	PF11976	0.416
LIG_SUMO_SIM_par_1	29	36	PF11976	0.392
LIG_SUMO_SIM_par_1	39	45	PF11976	0.286
LIG_UBA3_1	276	284	PF00899	0.195
LIG_WRC_WIRS_1	270	275	PF05994	0.195
MOD_CDK_SPxxK_3	259	266	PF00069	0.356
MOD_CDK_SPxxK_3	9	16	PF00069	0.423
MOD_CK1_1	75	81	PF00069	0.375
MOD_CK2_1	202	208	PF00069	0.221
MOD_GlcNHglycan	204	207	PF01048	0.395
MOD_GlcNHglycan	59	62	PF01048	0.364
MOD_GlcNHglycan	77	80	PF01048	0.159
MOD_GlcNHglycan	90	93	PF01048	0.206
MOD_GSK3_1	16	23	PF00069	0.602
MOD_N-GLC_1	101	106	PF02516	0.386
MOD_NEK2_1	118	123	PF00069	0.301
MOD_NEK2_1	202	207	PF00069	0.429
MOD_NEK2_1	4	9	PF00069	0.554
MOD_OFUCOSY	3	8	PF10250	0.561
MOD_PIKK_1	101	107	PF00454	0.381
MOD_PIKK_1	110	116	PF00454	0.329
MOD_PIKK_1	264	270	PF00454	0.322
MOD_PKA_2	4	10	PF00069	0.575
MOD_Plk_1	222	228	PF00069	0.267
MOD_Plk_4	176	182	PF00069	0.390
MOD_Plk_4	222	228	PF00069	0.327
MOD_Plk_4	269	275	PF00069	0.354
MOD_ProDKin_1	238	244	PF00069	0.407
MOD_ProDKin_1	259	265	PF00069	0.351
MOD_ProDKin_1	33	39	PF00069	0.409
MOD_ProDKin_1	52	58	PF00069	0.309
MOD_ProDKin_1	9	15	PF00069	0.419
TRG_ENDOCYTIC_2	150	153	PF00928	0.310
TRG_ENDOCYTIC_2	245	248	PF00928	0.328
TRG_ENDOCYTIC_2	274	277	PF00928	0.328
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z0	Leptomonas seymouri	26%	100%
A0A0N1I4C8	Leptomonas seymouri	33%	84%
A0A0N1PBS2	Leptomonas seymouri	68%	99%
A0A0N1PCQ9	Leptomonas seymouri	30%	100%
A0A0S4IKH3	Bodo saltans	36%	86%
A0A0S4JA19	Bodo saltans	47%	88%
A0A1X0NRI1	Trypanosomatidae	33%	80%
A0A1X0P9A2	Trypanosomatidae	26%	100%
A0A3Q8IE71	Leishmania donovani	93%	100%
A0A3Q8IIZ5	Leishmania donovani	26%	100%
A0A3Q8IV04	Leishmania donovani	24%	100%
A0A3R7N7B2	Trypanosoma rangeli	25%	100%
A0A3S7X4R5	Leishmania donovani	34%	87%
A0A3S7X4T7	Leishmania donovani	33%	87%
A0A422N418	Trypanosoma rangeli	37%	86%
A0A422NUW6	Trypanosoma rangeli	47%	100%
A4HH09	Leishmania braziliensis	78%	100%
A4HHN0	Leishmania braziliensis	26%	100%
A4HJK3	Leishmania braziliensis	33%	86%
A4HJK8	Leishmania braziliensis	32%	86%
A4HJL5	Leishmania braziliensis	33%	86%
A4I438	Leishmania infantum	93%	100%
A4I4U5	Leishmania infantum	26%	100%
A4I708	Leishmania infantum	34%	87%
A4I738	Leishmania infantum	33%	85%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	95%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	83%
E9AE93	Leishmania major	26%	100%
E9AEL3	Leishmania major	23%	100%
E9AHU0	Leishmania infantum	24%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	87%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	87%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F1LU71	Rattus norvegicus	29%	94%
F4JML5	Arabidopsis thaliana	26%	98%
F9XMX6	Zymoseptoria tritici (strain CBS 115943 / IPO323)	25%	97%
O04469	Arabidopsis thaliana	25%	100%
P14604	Rattus norvegicus	23%	100%
P23965	Rattus norvegicus	34%	100%
P23966	Bacillus subtilis (strain 168)	24%	100%
P30084	Homo sapiens	25%	100%
P34559	Caenorhabditis elegans	25%	100%
P42125	Mus musculus	35%	100%
P42126	Homo sapiens	33%	98%
P76082	Escherichia coli (strain K12)	28%	100%
P9WNN6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WNN7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q13825	Homo sapiens	31%	87%
Q2HJD5	Bos taurus	27%	97%
Q2TBT3	Bos taurus	27%	100%
Q3TLP5	Mus musculus	26%	100%
Q49WG8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	26%	100%
Q4Q628	Leishmania major	33%	85%
Q4Q636	Leishmania major	35%	78%
Q52995	Rhizobium meliloti (strain 1021)	25%	100%
Q58DM8	Bos taurus	24%	100%
Q5HQC3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	26%	100%
Q5R646	Pongo abelii	27%	100%
Q6AYG5	Rattus norvegicus	28%	99%
Q7U004	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	100%
Q869N6	Dictyostelium discoideum	29%	99%
Q86YB7	Homo sapiens	27%	100%
Q8BH95	Mus musculus	24%	100%
Q8CPQ4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	26%	100%
Q8GYN9	Arabidopsis thaliana	28%	88%
Q96DC8	Homo sapiens	28%	98%
Q9D9V3	Mus musculus	29%	92%
Q9JLZ3	Mus musculus	30%	94%
Q9TM10	Cyanidium caldarium	23%	100%
V5B2L9	Trypanosoma cruzi	35%	76%
V5BK92	Trypanosoma cruzi	47%	100%
V5DTT7	Trypanosoma cruzi	28%	100%