C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ADK0_LEIMA

TriTrypDb:

LmjF.28.1405 , LMJLV39_280021700 , LMJSD75_280021200

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADK0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.638
CLV_NRD_NRD_1	333	335	PF00675	0.639
CLV_NRD_NRD_1	362	364	PF00675	0.634
CLV_PCSK_KEX2_1	333	335	PF00082	0.639
CLV_PCSK_KEX2_1	362	364	PF00082	0.634
CLV_PCSK_SKI1_1	149	153	PF00082	0.555
CLV_PCSK_SKI1_1	334	338	PF00082	0.642
CLV_PCSK_SKI1_1	356	360	PF00082	0.647
CLV_PCSK_SKI1_1	36	40	PF00082	0.733
DEG_Nend_UBRbox_3	1	3	PF02207	0.541
DEG_SPOP_SBC_1	4	8	PF00917	0.712
DOC_CKS1_1	137	142	PF01111	0.588
DOC_CKS1_1	143	148	PF01111	0.589
DOC_CKS1_1	150	155	PF01111	0.580
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.626
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.494
DOC_PP2B_LxvP_1	270	273	PF13499	0.668
DOC_PP4_FxxP_1	128	131	PF00568	0.424
DOC_PP4_FxxP_1	183	186	PF00568	0.756
DOC_PP4_FxxP_1	206	209	PF00568	0.602
DOC_USP7_MATH_1	186	190	PF00917	0.601
DOC_USP7_MATH_1	213	217	PF00917	0.755
DOC_USP7_MATH_1	219	223	PF00917	0.654
DOC_USP7_MATH_1	266	270	PF00917	0.544
DOC_USP7_MATH_1	287	291	PF00917	0.583
DOC_USP7_MATH_1	3	7	PF00917	0.711
DOC_USP7_MATH_1	346	350	PF00917	0.571
DOC_USP7_MATH_1	351	355	PF00917	0.593
DOC_USP7_MATH_1	76	80	PF00917	0.686
DOC_WW_Pin1_4	136	141	PF00397	0.583
DOC_WW_Pin1_4	142	147	PF00397	0.590
DOC_WW_Pin1_4	149	154	PF00397	0.583
DOC_WW_Pin1_4	165	170	PF00397	0.594
DOC_WW_Pin1_4	182	187	PF00397	0.720
DOC_WW_Pin1_4	205	210	PF00397	0.604
DOC_WW_Pin1_4	225	230	PF00397	0.461
DOC_WW_Pin1_4	238	243	PF00397	0.533
DOC_WW_Pin1_4	301	306	PF00397	0.608
DOC_WW_Pin1_4	336	341	PF00397	0.692
DOC_WW_Pin1_4	357	362	PF00397	0.695
DOC_WW_Pin1_4	372	377	PF00397	0.530
DOC_WW_Pin1_4	38	43	PF00397	0.631
DOC_WW_Pin1_4	385	390	PF00397	0.538
DOC_WW_Pin1_4	6	11	PF00397	0.633
DOC_WW_Pin1_4	72	77	PF00397	0.651
DOC_WW_Pin1_4	97	102	PF00397	0.616
LIG_14-3-3_CanoR_1	122	131	PF00244	0.429
LIG_14-3-3_CanoR_1	176	181	PF00244	0.621
LIG_14-3-3_CanoR_1	18	24	PF00244	0.572
LIG_14-3-3_CanoR_1	187	191	PF00244	0.610
LIG_14-3-3_CanoR_1	221	229	PF00244	0.601
LIG_14-3-3_CanoR_1	36	44	PF00244	0.654
LIG_BRCT_BRCA1_1	124	128	PF00533	0.441
LIG_BRCT_BRCA1_1	221	225	PF00533	0.798
LIG_BRCT_BRCA1_1	240	244	PF00533	0.613
LIG_FHA_1	176	182	PF00498	0.649
LIG_FHA_1	221	227	PF00498	0.581
LIG_FHA_1	44	50	PF00498	0.573
LIG_FHA_2	290	296	PF00498	0.706
LIG_IBAR_NPY_1	370	372	PF08397	0.678
LIG_LIR_Apic_2	125	131	PF02991	0.429
LIG_LIR_Apic_2	204	209	PF02991	0.608
LIG_LIR_Gen_1	59	66	PF02991	0.565
LIG_LIR_Nem_3	59	63	PF02991	0.607
LIG_Pex14_2	244	248	PF04695	0.692
LIG_SH2_GRB2like	104	107	PF00017	0.555
LIG_SH2_SRC	372	375	PF00017	0.684
LIG_SH2_STAT5	275	278	PF00017	0.671
LIG_SH2_STAT5	316	319	PF00017	0.612
LIG_SH2_STAT5	43	46	PF00017	0.565
LIG_SH3_2	386	391	PF14604	0.675
LIG_SH3_3	134	140	PF00018	0.563
LIG_SH3_3	147	153	PF00018	0.582
LIG_SH3_3	223	229	PF00018	0.531
LIG_SH3_3	299	305	PF00018	0.627
LIG_SH3_3	355	361	PF00018	0.642
LIG_SH3_3	383	389	PF00018	0.667
MOD_CDC14_SPxK_1	360	363	PF00782	0.630
MOD_CDC14_SPxK_1	375	378	PF00782	0.557
MOD_CDC14_SPxK_1	388	391	PF00782	0.570
MOD_CDK_SPK_2	182	187	PF00069	0.615
MOD_CDK_SPK_2	357	362	PF00069	0.695
MOD_CDK_SPxK_1	136	142	PF00069	0.662
MOD_CDK_SPxK_1	357	363	PF00069	0.631
MOD_CDK_SPxK_1	372	378	PF00069	0.556
MOD_CDK_SPxK_1	385	391	PF00069	0.571
MOD_CDK_SPxxK_3	142	149	PF00069	0.590
MOD_CDK_SPxxK_3	169	176	PF00069	0.614
MOD_CDK_SPxxK_3	6	13	PF00069	0.621
MOD_CK1_1	198	204	PF00069	0.612
MOD_CK1_1	205	211	PF00069	0.627
MOD_CK1_1	21	27	PF00069	0.480
MOD_CK1_1	212	218	PF00069	0.649
MOD_CK1_1	240	246	PF00069	0.651
MOD_CK1_1	289	295	PF00069	0.611
MOD_CK1_1	304	310	PF00069	0.589
MOD_CK1_1	325	331	PF00069	0.682
MOD_CK1_1	354	360	PF00069	0.673
MOD_CK1_1	6	12	PF00069	0.633
MOD_CK1_1	75	81	PF00069	0.630
MOD_CK1_1	91	97	PF00069	0.677
MOD_CK2_1	198	204	PF00069	0.674
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.615
MOD_DYRK1A_RPxSP_1	149	153	PF00069	0.529
MOD_DYRK1A_RPxSP_1	301	305	PF00069	0.686
MOD_GlcNHglycan	161	164	PF01048	0.684
MOD_GlcNHglycan	193	196	PF01048	0.732
MOD_GlcNHglycan	197	200	PF01048	0.796
MOD_GlcNHglycan	217	220	PF01048	0.471
MOD_GlcNHglycan	289	292	PF01048	0.616
MOD_GlcNHglycan	327	330	PF01048	0.803
MOD_GlcNHglycan	78	81	PF01048	0.669
MOD_GlcNHglycan	93	96	PF01048	0.635
MOD_GSK3_1	138	145	PF00069	0.594
MOD_GSK3_1	161	168	PF00069	0.632
MOD_GSK3_1	182	189	PF00069	0.725
MOD_GSK3_1	191	198	PF00069	0.534
MOD_GSK3_1	205	212	PF00069	0.639
MOD_GSK3_1	21	28	PF00069	0.596
MOD_GSK3_1	215	222	PF00069	0.598
MOD_GSK3_1	246	253	PF00069	0.587
MOD_GSK3_1	297	304	PF00069	0.618
MOD_GSK3_1	352	359	PF00069	0.647
MOD_GSK3_1	38	45	PF00069	0.587
MOD_GSK3_1	381	388	PF00069	0.655
MOD_GSK3_1	68	75	PF00069	0.701
MOD_GSK3_1	84	91	PF00069	0.541
MOD_LATS_1	174	180	PF00433	0.585
MOD_N-GLC_1	19	24	PF02516	0.620
MOD_N-GLC_1	88	93	PF02516	0.645
MOD_N-GLC_2	110	112	PF02516	0.410
MOD_NEK2_1	181	186	PF00069	0.684
MOD_NEK2_1	250	255	PF00069	0.637
MOD_NEK2_1	322	327	PF00069	0.670
MOD_NEK2_1	88	93	PF00069	0.641
MOD_NEK2_2	186	191	PF00069	0.605
MOD_OFUCOSY	120	126	PF10250	0.420
MOD_PIKK_1	144	150	PF00454	0.565
MOD_PIKK_1	381	387	PF00454	0.632
MOD_PK_1	176	182	PF00069	0.576
MOD_PKA_2	121	127	PF00069	0.435
MOD_PKA_2	175	181	PF00069	0.620
MOD_PKA_2	186	192	PF00069	0.607
MOD_PKA_2	220	226	PF00069	0.607
MOD_PKB_1	142	150	PF00069	0.616
MOD_Plk_1	19	25	PF00069	0.501
MOD_Plk_4	176	182	PF00069	0.622
MOD_Plk_4	21	27	PF00069	0.604
MOD_ProDKin_1	136	142	PF00069	0.586
MOD_ProDKin_1	149	155	PF00069	0.579
MOD_ProDKin_1	165	171	PF00069	0.596
MOD_ProDKin_1	182	188	PF00069	0.721
MOD_ProDKin_1	205	211	PF00069	0.605
MOD_ProDKin_1	225	231	PF00069	0.461
MOD_ProDKin_1	238	244	PF00069	0.532
MOD_ProDKin_1	301	307	PF00069	0.606
MOD_ProDKin_1	336	342	PF00069	0.690
MOD_ProDKin_1	357	363	PF00069	0.698
MOD_ProDKin_1	372	378	PF00069	0.533
MOD_ProDKin_1	38	44	PF00069	0.630
MOD_ProDKin_1	385	391	PF00069	0.539
MOD_ProDKin_1	6	12	PF00069	0.634
MOD_ProDKin_1	72	78	PF00069	0.651
MOD_ProDKin_1	97	103	PF00069	0.609
TRG_ER_diArg_1	361	363	PF00400	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W6	Leptomonas seymouri	41%	100%
A0A3S7X1G7	Leishmania donovani	95%	100%
A4HGJ2	Leishmania braziliensis	68%	100%
E9AHG4	Leishmania infantum	95%	100%
E9AZW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%