Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADJ9_LEIMA

TriTrypDb:

LmjF.28.0822 , LMJLV39_280014100 , LMJSD75_280014100

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.613
CLV_NRD_NRD_1	6	8	PF00675	0.599
CLV_PCSK_KEX2_1	149	151	PF00082	0.718
CLV_PCSK_KEX2_1	207	209	PF00082	0.746
CLV_PCSK_KEX2_1	6	8	PF00082	0.599
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.746
DEG_Nend_Nbox_1	1	3	PF02207	0.749
DEG_SPOP_SBC_1	45	49	PF00917	0.532
DOC_CYCLIN_yClb5_NLxxxL_5	220	229	PF00134	0.705
DOC_MAPK_gen_1	17	25	PF00069	0.573
DOC_MIT_MIM_1	202	212	PF04212	0.620
DOC_USP7_MATH_1	156	160	PF00917	0.760
DOC_USP7_MATH_1	176	180	PF00917	0.445
DOC_USP7_MATH_1	45	49	PF00917	0.688
DOC_USP7_MATH_1	75	79	PF00917	0.684
DOC_USP7_MATH_1	81	85	PF00917	0.685
DOC_WW_Pin1_4	119	124	PF00397	0.626
LIG_14-3-3_CanoR_1	11	16	PF00244	0.714
LIG_14-3-3_CanoR_1	245	253	PF00244	0.690
LIG_BRCT_BRCA1_1	239	243	PF00533	0.661
LIG_FHA_1	236	242	PF00498	0.653
LIG_FHA_1	29	35	PF00498	0.607
LIG_FHA_2	245	251	PF00498	0.688
LIG_FHA_2	91	97	PF00498	0.727
LIG_LIR_Gen_1	170	180	PF02991	0.728
LIG_LIR_Nem_3	170	175	PF02991	0.733
LIG_SH2_CRK	172	176	PF00017	0.736
LIG_SH2_STAT5	110	113	PF00017	0.690
LIG_SH2_STAT5	152	155	PF00017	0.687
LIG_SH3_3	150	156	PF00018	0.675
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.672
LIG_UBA3_1	222	227	PF00899	0.712
MOD_CK1_1	129	135	PF00069	0.794
MOD_CK1_1	138	144	PF00069	0.625
MOD_CK1_1	89	95	PF00069	0.685
MOD_CK2_1	129	135	PF00069	0.759
MOD_CK2_1	244	250	PF00069	0.691
MOD_CK2_1	90	96	PF00069	0.652
MOD_GlcNHglycan	140	143	PF01048	0.546
MOD_GlcNHglycan	235	238	PF01048	0.742
MOD_GlcNHglycan	25	28	PF01048	0.632
MOD_GlcNHglycan	48	51	PF01048	0.707
MOD_GlcNHglycan	83	86	PF01048	0.696
MOD_GlcNHglycan	88	91	PF01048	0.668
MOD_GSK3_1	137	144	PF00069	0.632
MOD_GSK3_1	156	163	PF00069	0.624
MOD_GSK3_1	233	240	PF00069	0.744
MOD_GSK3_1	40	47	PF00069	0.657
MOD_GSK3_1	86	93	PF00069	0.691
MOD_LATS_1	9	15	PF00433	0.724
MOD_N-GLC_1	129	134	PF02516	0.759
MOD_N-GLC_1	223	228	PF02516	0.678
MOD_N-GLC_2	246	248	PF02516	0.691
MOD_NEK2_1	210	215	PF00069	0.672
MOD_NEK2_1	223	228	PF00069	0.623
MOD_NEK2_1	40	45	PF00069	0.640
MOD_NEK2_1	99	104	PF00069	0.728
MOD_PIKK_1	75	81	PF00454	0.522
MOD_PIKK_1	90	96	PF00454	0.650
MOD_PKA_2	244	250	PF00069	0.693
MOD_Plk_1	176	182	PF00069	0.720
MOD_Plk_4	11	17	PF00069	0.708
MOD_Plk_4	167	173	PF00069	0.752
MOD_ProDKin_1	119	125	PF00069	0.638
MOD_SUMO_rev_2	129	139	PF00179	0.720
TRG_DiLeu_BaEn_1	218	223	PF01217	0.690
TRG_ENDOCYTIC_2	172	175	PF00928	0.736
TRG_ER_diArg_1	148	150	PF00400	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGN7	Leishmania donovani	89%	100%
A4HGC5	Leishmania braziliensis	71%	100%
E9AHH8	Leishmania infantum	90%	100%
E9AZP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%