Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADJ6_LEIMA

TriTrypDb:

LmjF.27.2160 , LMJLV39_270029000 , LMJSD75_270028900

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.674
CLV_NRD_NRD_1	23	25	PF00675	0.604
CLV_NRD_NRD_1	346	348	PF00675	0.490
CLV_PCSK_KEX2_1	2	4	PF00082	0.674
CLV_PCSK_KEX2_1	346	348	PF00082	0.490
CLV_PCSK_SKI1_1	27	31	PF00082	0.559
CLV_PCSK_SKI1_1	76	80	PF00082	0.367
DEG_COP1_1	238	246	PF00400	0.374
DEG_Nend_UBRbox_1	1	4	PF02207	0.657
DOC_CKS1_1	150	155	PF01111	0.438
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.537
DOC_MAPK_gen_1	235	243	PF00069	0.432
DOC_PP2B_LxvP_1	283	286	PF13499	0.474
DOC_USP7_MATH_1	236	240	PF00917	0.520
DOC_USP7_MATH_1	74	78	PF00917	0.279
DOC_WW_Pin1_4	149	154	PF00397	0.331
DOC_WW_Pin1_4	84	89	PF00397	0.394
LIG_14-3-3_CanoR_1	142	147	PF00244	0.346
LIG_14-3-3_CanoR_1	2	6	PF00244	0.642
LIG_14-3-3_CanoR_1	27	36	PF00244	0.623
LIG_Actin_RPEL_3	66	85	PF02755	0.353
LIG_Actin_WH2_2	59	75	PF00022	0.373
LIG_APCC_ABBA_1	16	21	PF00400	0.571
LIG_BIR_III_2	251	255	PF00653	0.342
LIG_BRCT_BRCA1_1	106	110	PF00533	0.442
LIG_BRCT_BRCA1_1	89	93	PF00533	0.443
LIG_DLG_GKlike_1	142	150	PF00625	0.387
LIG_FHA_1	150	156	PF00498	0.346
LIG_FHA_1	61	67	PF00498	0.490
LIG_FHA_1	84	90	PF00498	0.449
LIG_FHA_2	261	267	PF00498	0.470
LIG_LIR_Apic_2	101	106	PF02991	0.480
LIG_LIR_Gen_1	90	99	PF02991	0.316
LIG_LIR_Nem_3	148	154	PF02991	0.340
LIG_LIR_Nem_3	203	209	PF02991	0.320
LIG_LIR_Nem_3	266	270	PF02991	0.479
LIG_LIR_Nem_3	90	96	PF02991	0.314
LIG_MYND_1	244	248	PF01753	0.322
LIG_MYND_3	253	257	PF01753	0.389
LIG_Pex14_2	201	205	PF04695	0.462
LIG_Pex14_2	348	352	PF04695	0.454
LIG_REV1ctd_RIR_1	203	211	PF16727	0.448
LIG_REV1ctd_RIR_1	231	241	PF16727	0.403
LIG_REV1ctd_RIR_1	285	294	PF16727	0.532
LIG_REV1ctd_RIR_1	326	335	PF16727	0.372
LIG_SH2_CRK	103	107	PF00017	0.516
LIG_SH2_CRK	57	61	PF00017	0.482
LIG_SH2_NCK_1	103	107	PF00017	0.516
LIG_SH2_STAT5	151	154	PF00017	0.331
LIG_SH2_STAT5	157	160	PF00017	0.304
LIG_SH2_STAT5	186	189	PF00017	0.421
LIG_SH2_STAT5	242	245	PF00017	0.520
LIG_SH2_STAT5	344	347	PF00017	0.368
LIG_SH3_3	147	153	PF00018	0.466
LIG_SUMO_SIM_par_1	335	341	PF11976	0.392
LIG_TRAF2_1	145	148	PF00917	0.398
MOD_CK1_1	149	155	PF00069	0.326
MOD_CK1_1	260	266	PF00069	0.410
MOD_CK1_1	87	93	PF00069	0.396
MOD_CK2_1	142	148	PF00069	0.384
MOD_CK2_1	260	266	PF00069	0.445
MOD_GlcNHglycan	127	130	PF01048	0.441
MOD_GlcNHglycan	177	182	PF01048	0.502
MOD_GlcNHglycan	89	92	PF01048	0.445
MOD_GSK3_1	138	145	PF00069	0.382
MOD_GSK3_1	185	192	PF00069	0.432
MOD_GSK3_1	268	275	PF00069	0.434
MOD_GSK3_1	27	34	PF00069	0.612
MOD_GSK3_1	83	90	PF00069	0.332
MOD_N-GLC_1	257	262	PF02516	0.409
MOD_N-GLC_1	43	48	PF02516	0.387
MOD_NEK2_1	1	6	PF00069	0.634
MOD_NEK2_1	125	130	PF00069	0.403
MOD_NEK2_1	146	151	PF00069	0.384
MOD_NEK2_1	159	164	PF00069	0.320
MOD_NEK2_1	62	67	PF00069	0.548
MOD_NEK2_1	72	77	PF00069	0.430
MOD_PIKK_1	213	219	PF00454	0.457
MOD_PKA_1	38	44	PF00069	0.433
MOD_PKA_2	1	7	PF00069	0.647
MOD_PKA_2	19	25	PF00069	0.416
MOD_PKA_2	72	78	PF00069	0.448
MOD_Plk_1	146	152	PF00069	0.375
MOD_Plk_4	146	152	PF00069	0.468
MOD_Plk_4	242	248	PF00069	0.346
MOD_Plk_4	260	266	PF00069	0.350
MOD_Plk_4	31	37	PF00069	0.421
MOD_Plk_4	74	80	PF00069	0.283
MOD_ProDKin_1	149	155	PF00069	0.329
MOD_ProDKin_1	84	90	PF00069	0.398
TRG_DiLeu_BaEn_1	366	371	PF01217	0.486
TRG_DiLeu_BaEn_2	120	126	PF01217	0.393
TRG_DiLeu_BaEn_4	178	184	PF01217	0.580
TRG_DiLeu_LyEn_5	366	371	PF01217	0.572
TRG_ENDOCYTIC_2	267	270	PF00928	0.478
TRG_ENDOCYTIC_2	57	60	PF00928	0.472
TRG_ER_diArg_1	1	3	PF00400	0.682
TRG_ER_diArg_1	345	347	PF00400	0.471
TRG_NLS_MonoCore_2	23	28	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W1	Leptomonas seymouri	74%	100%
A0A0S4ISK5	Bodo saltans	46%	100%
A0A1X0NRI0	Trypanosomatidae	53%	100%
A0A3Q8ICV5	Leishmania donovani	97%	100%
A4HFZ3	Leishmania braziliensis	88%	100%
A4I312	Leishmania infantum	97%	100%
C9ZJH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AZC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BNB6	Trypanosoma cruzi	59%	100%