PI3K/PI4K catalytic domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol 3- and 4-kinase, putative

Species:

Leishmania major

UniProt:

E9ADJ4_LEIMA

TriTrypDb:

LmjF.27.2140 , LMJLV39_270028900 , LMJSD75_270028800

Length:

1010

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ADJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADJ4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.615
CLV_C14_Caspase3-7	410	414	PF00656	0.625
CLV_C14_Caspase3-7	514	518	PF00656	0.249
CLV_C14_Caspase3-7	843	847	PF00656	0.658
CLV_C14_Caspase3-7	873	877	PF00656	0.603
CLV_NRD_NRD_1	242	244	PF00675	0.712
CLV_NRD_NRD_1	260	262	PF00675	0.586
CLV_NRD_NRD_1	326	328	PF00675	0.760
CLV_NRD_NRD_1	38	40	PF00675	0.690
CLV_NRD_NRD_1	456	458	PF00675	0.399
CLV_NRD_NRD_1	49	51	PF00675	0.774
CLV_NRD_NRD_1	609	611	PF00675	0.421
CLV_NRD_NRD_1	615	617	PF00675	0.368
CLV_NRD_NRD_1	621	623	PF00675	0.267
CLV_NRD_NRD_1	964	966	PF00675	0.499
CLV_PCSK_FUR_1	204	208	PF00082	0.587
CLV_PCSK_FUR_1	324	328	PF00082	0.649
CLV_PCSK_FUR_1	47	51	PF00082	0.682
CLV_PCSK_KEX2_1	206	208	PF00082	0.596
CLV_PCSK_KEX2_1	242	244	PF00082	0.712
CLV_PCSK_KEX2_1	326	328	PF00082	0.760
CLV_PCSK_KEX2_1	456	458	PF00082	0.399
CLV_PCSK_KEX2_1	49	51	PF00082	0.796
CLV_PCSK_KEX2_1	609	611	PF00082	0.396
CLV_PCSK_KEX2_1	615	617	PF00082	0.343
CLV_PCSK_KEX2_1	621	623	PF00082	0.317
CLV_PCSK_KEX2_1	964	966	PF00082	0.499
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.596
CLV_PCSK_PC7_1	322	328	PF00082	0.651
CLV_PCSK_SKI1_1	367	371	PF00082	0.526
CLV_PCSK_SKI1_1	457	461	PF00082	0.399
CLV_PCSK_SKI1_1	719	723	PF00082	0.388
CLV_PCSK_SKI1_1	731	735	PF00082	0.433
CLV_PCSK_SKI1_1	791	795	PF00082	0.603
CLV_Separin_Metazoa	247	251	PF03568	0.665
CLV_Separin_Metazoa	716	720	PF03568	0.399
CLV_Separin_Metazoa	936	940	PF03568	0.345
DEG_APCC_DBOX_1	456	464	PF00400	0.349
DEG_APCC_DBOX_1	998	1006	PF00400	0.441
DEG_Nend_UBRbox_1	1	4	PF02207	0.569
DEG_SCF_FBW7_1	221	226	PF00400	0.620
DEG_SCF_FBW7_2	134	141	PF00400	0.670
DEG_SCF_TRCP1_1	273	278	PF00400	0.621
DEG_SPOP_SBC_1	189	193	PF00917	0.587
DEG_SPOP_SBC_1	282	286	PF00917	0.650
DEG_SPOP_SBC_1	502	506	PF00917	0.262
DEG_SPOP_SBC_1	822	826	PF00917	0.640
DEG_SPOP_SBC_1	901	905	PF00917	0.668
DOC_CKS1_1	162	167	PF01111	0.578
DOC_CKS1_1	71	76	PF01111	0.631
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.665
DOC_MAPK_MEF2A_6	556	564	PF00069	0.349
DOC_PP2B_LxvP_1	562	565	PF13499	0.399
DOC_PP2B_LxvP_1	72	75	PF13499	0.687
DOC_PP4_MxPP_1	221	224	PF00568	0.695
DOC_USP7_MATH_1	10	14	PF00917	0.629
DOC_USP7_MATH_1	127	131	PF00917	0.680
DOC_USP7_MATH_1	189	193	PF00917	0.588
DOC_USP7_MATH_1	34	38	PF00917	0.698
DOC_USP7_MATH_1	357	361	PF00917	0.605
DOC_USP7_MATH_1	400	404	PF00917	0.681
DOC_USP7_MATH_1	411	415	PF00917	0.349
DOC_USP7_MATH_1	500	504	PF00917	0.347
DOC_USP7_MATH_1	520	524	PF00917	0.202
DOC_USP7_MATH_1	631	635	PF00917	0.381
DOC_USP7_MATH_1	652	656	PF00917	0.341
DOC_USP7_MATH_1	724	728	PF00917	0.476
DOC_USP7_MATH_1	755	759	PF00917	0.575
DOC_USP7_MATH_1	783	787	PF00917	0.629
DOC_USP7_MATH_1	799	803	PF00917	0.619
DOC_USP7_MATH_1	823	827	PF00917	0.584
DOC_USP7_MATH_1	829	833	PF00917	0.577
DOC_USP7_MATH_1	839	843	PF00917	0.518
DOC_USP7_MATH_1	856	860	PF00917	0.606
DOC_USP7_MATH_1	901	905	PF00917	0.664
DOC_WW_Pin1_4	122	127	PF00397	0.737
DOC_WW_Pin1_4	134	139	PF00397	0.671
DOC_WW_Pin1_4	161	166	PF00397	0.673
DOC_WW_Pin1_4	205	210	PF00397	0.679
DOC_WW_Pin1_4	213	218	PF00397	0.670
DOC_WW_Pin1_4	219	224	PF00397	0.586
DOC_WW_Pin1_4	22	27	PF00397	0.778
DOC_WW_Pin1_4	242	247	PF00397	0.665
DOC_WW_Pin1_4	283	288	PF00397	0.715
DOC_WW_Pin1_4	398	403	PF00397	0.649
DOC_WW_Pin1_4	637	642	PF00397	0.434
DOC_WW_Pin1_4	648	653	PF00397	0.402
DOC_WW_Pin1_4	67	72	PF00397	0.825
DOC_WW_Pin1_4	807	812	PF00397	0.683
DOC_WW_Pin1_4	88	93	PF00397	0.661
DOC_WW_Pin1_4	903	908	PF00397	0.690
LIG_14-3-3_CanoR_1	242	246	PF00244	0.705
LIG_14-3-3_CanoR_1	283	287	PF00244	0.719
LIG_14-3-3_CanoR_1	548	557	PF00244	0.390
LIG_14-3-3_CanoR_1	624	629	PF00244	0.380
LIG_14-3-3_CanoR_1	63	68	PF00244	0.696
LIG_14-3-3_CanoR_1	939	947	PF00244	0.443
LIG_14-3-3_CanoR_1	965	974	PF00244	0.464
LIG_Actin_WH2_2	542	558	PF00022	0.349
LIG_APCC_ABBA_1	136	141	PF00400	0.670
LIG_BRCT_BRCA1_1	227	231	PF00533	0.554
LIG_BRCT_BRCA1_1	904	908	PF00533	0.533
LIG_Clathr_ClatBox_1	379	383	PF01394	0.505
LIG_Clathr_ClatBox_1	668	672	PF01394	0.399
LIG_deltaCOP1_diTrp_1	685	691	PF00928	0.399
LIG_deltaCOP1_diTrp_1	983	994	PF00928	0.523
LIG_FHA_1	106	112	PF00498	0.664
LIG_FHA_1	157	163	PF00498	0.622
LIG_FHA_1	174	180	PF00498	0.617
LIG_FHA_1	276	282	PF00498	0.712
LIG_FHA_1	390	396	PF00498	0.536
LIG_FHA_1	473	479	PF00498	0.418
LIG_FHA_1	504	510	PF00498	0.309
LIG_FHA_1	67	73	PF00498	0.664
LIG_FHA_1	728	734	PF00498	0.517
LIG_FHA_1	823	829	PF00498	0.577
LIG_FHA_1	861	867	PF00498	0.566
LIG_FHA_1	904	910	PF00498	0.623
LIG_FHA_1	939	945	PF00498	0.566
LIG_FHA_2	141	147	PF00498	0.580
LIG_FHA_2	173	179	PF00498	0.657
LIG_FHA_2	357	363	PF00498	0.481
LIG_FHA_2	408	414	PF00498	0.634
LIG_FHA_2	758	764	PF00498	0.600
LIG_FHA_2	931	937	PF00498	0.422
LIG_FHA_2	953	959	PF00498	0.453
LIG_HCF-1_HBM_1	672	675	PF13415	0.399
LIG_Integrin_RGD_1	874	876	PF01839	0.635
LIG_IRF3_LxIS_1	165	171	PF10401	0.643
LIG_LIR_Apic_2	672	678	PF02991	0.399
LIG_LIR_Apic_2	679	684	PF02991	0.329
LIG_LIR_Gen_1	191	200	PF02991	0.648
LIG_LIR_Gen_1	228	239	PF02991	0.549
LIG_LIR_Gen_1	683	692	PF02991	0.399
LIG_LIR_Gen_1	988	998	PF02991	0.425
LIG_LIR_Nem_3	191	197	PF02991	0.648
LIG_LIR_Nem_3	228	234	PF02991	0.552
LIG_LIR_Nem_3	45	51	PF02991	0.664
LIG_LIR_Nem_3	683	689	PF02991	0.399
LIG_LIR_Nem_3	744	748	PF02991	0.579
LIG_LIR_Nem_3	984	990	PF02991	0.538
LIG_LIR_Nem_3	992	997	PF02991	0.404
LIG_MYND_1	666	670	PF01753	0.399
LIG_NRBOX	459	465	PF00104	0.349
LIG_SH2_NCK_1	681	685	PF00017	0.399
LIG_SH2_PTP2	675	678	PF00017	0.399
LIG_SH2_SRC	681	684	PF00017	0.399
LIG_SH2_SRC	957	960	PF00017	0.454
LIG_SH2_STAP1	300	304	PF00017	0.484
LIG_SH2_STAP1	926	930	PF00017	0.540
LIG_SH2_STAT5	462	465	PF00017	0.349
LIG_SH2_STAT5	675	678	PF00017	0.399
LIG_SH2_STAT5	705	708	PF00017	0.399
LIG_SH2_STAT5	90	93	PF00017	0.662
LIG_SH3_3	23	29	PF00018	0.659
LIG_SH3_3	420	426	PF00018	0.403
LIG_SH3_3	638	644	PF00018	0.406
LIG_SH3_3	68	74	PF00018	0.712
LIG_SH3_3	810	816	PF00018	0.599
LIG_SH3_3	825	831	PF00018	0.566
LIG_SH3_3	917	923	PF00018	0.528
LIG_SUMO_SIM_par_1	130	137	PF11976	0.670
LIG_SUMO_SIM_par_1	474	481	PF11976	0.399
LIG_TRAF2_1	200	203	PF00917	0.677
MOD_CDK_SPK_2	88	93	PF00069	0.649
MOD_CDK_SPxxK_3	807	814	PF00069	0.553
MOD_CK1_1	102	108	PF00069	0.676
MOD_CK1_1	109	115	PF00069	0.599
MOD_CK1_1	128	134	PF00069	0.714
MOD_CK1_1	187	193	PF00069	0.719
MOD_CK1_1	225	231	PF00069	0.756
MOD_CK1_1	27	33	PF00069	0.710
MOD_CK1_1	333	339	PF00069	0.634
MOD_CK1_1	356	362	PF00069	0.487
MOD_CK1_1	401	407	PF00069	0.666
MOD_CK1_1	443	449	PF00069	0.375
MOD_CK1_1	503	509	PF00069	0.347
MOD_CK1_1	523	529	PF00069	0.246
MOD_CK1_1	639	645	PF00069	0.366
MOD_CK1_1	655	661	PF00069	0.264
MOD_CK1_1	66	72	PF00069	0.711
MOD_CK1_1	726	732	PF00069	0.441
MOD_CK1_1	877	883	PF00069	0.614
MOD_CK1_1	900	906	PF00069	0.763
MOD_CK2_1	10	16	PF00069	0.675
MOD_CK2_1	241	247	PF00069	0.705
MOD_CK2_1	356	362	PF00069	0.487
MOD_CK2_1	452	458	PF00069	0.524
MOD_CK2_1	930	936	PF00069	0.428
MOD_CK2_1	952	958	PF00069	0.457
MOD_CK2_1	969	975	PF00069	0.494
MOD_CMANNOS	688	691	PF00535	0.399
MOD_Cter_Amidation	37	40	PF01082	0.613
MOD_Cter_Amidation	613	616	PF01082	0.399
MOD_GlcNHglycan	1007	1010	PF01048	0.578
MOD_GlcNHglycan	273	276	PF01048	0.605
MOD_GlcNHglycan	32	35	PF01048	0.587
MOD_GlcNHglycan	346	349	PF01048	0.485
MOD_GlcNHglycan	355	358	PF01048	0.535
MOD_GlcNHglycan	36	39	PF01048	0.580
MOD_GlcNHglycan	387	390	PF01048	0.652
MOD_GlcNHglycan	403	406	PF01048	0.600
MOD_GlcNHglycan	452	455	PF01048	0.406
MOD_GlcNHglycan	653	657	PF01048	0.322
MOD_GlcNHglycan	678	681	PF01048	0.519
MOD_GlcNHglycan	698	701	PF01048	0.367
MOD_GlcNHglycan	719	722	PF01048	0.456
MOD_GlcNHglycan	738	741	PF01048	0.631
MOD_GlcNHglycan	780	783	PF01048	0.615
MOD_GlcNHglycan	825	828	PF01048	0.759
MOD_GlcNHglycan	831	834	PF01048	0.667
MOD_GlcNHglycan	842	845	PF01048	0.528
MOD_GlcNHglycan	852	855	PF01048	0.692
MOD_GlcNHglycan	886	890	PF01048	0.715
MOD_GlcNHglycan	899	902	PF01048	0.671
MOD_GSK3_1	105	112	PF00069	0.688
MOD_GSK3_1	156	163	PF00069	0.574
MOD_GSK3_1	168	175	PF00069	0.745
MOD_GSK3_1	177	184	PF00069	0.685
MOD_GSK3_1	188	195	PF00069	0.572
MOD_GSK3_1	215	222	PF00069	0.747
MOD_GSK3_1	223	230	PF00069	0.678
MOD_GSK3_1	24	31	PF00069	0.663
MOD_GSK3_1	271	278	PF00069	0.654
MOD_GSK3_1	281	288	PF00069	0.662
MOD_GSK3_1	290	297	PF00069	0.656
MOD_GSK3_1	329	336	PF00069	0.667
MOD_GSK3_1	353	360	PF00069	0.608
MOD_GSK3_1	385	392	PF00069	0.654
MOD_GSK3_1	401	408	PF00069	0.517
MOD_GSK3_1	409	416	PF00069	0.578
MOD_GSK3_1	486	493	PF00069	0.471
MOD_GSK3_1	498	505	PF00069	0.328
MOD_GSK3_1	520	527	PF00069	0.359
MOD_GSK3_1	62	69	PF00069	0.811
MOD_GSK3_1	639	646	PF00069	0.422
MOD_GSK3_1	648	655	PF00069	0.408
MOD_GSK3_1	687	694	PF00069	0.393
MOD_GSK3_1	723	730	PF00069	0.485
MOD_GSK3_1	732	739	PF00069	0.563
MOD_GSK3_1	831	838	PF00069	0.619
MOD_GSK3_1	856	863	PF00069	0.567
MOD_GSK3_1	893	900	PF00069	0.671
MOD_GSK3_1	95	102	PF00069	0.747
MOD_LATS_1	554	560	PF00433	0.349
MOD_N-GLC_1	109	114	PF02516	0.697
MOD_N-GLC_1	128	133	PF02516	0.603
MOD_N-GLC_1	252	257	PF02516	0.618
MOD_N-GLC_1	520	525	PF02516	0.312
MOD_N-GLC_1	88	93	PF02516	0.711
MOD_NEK2_1	1005	1010	PF00069	0.535
MOD_NEK2_1	160	165	PF00069	0.756
MOD_NEK2_1	168	173	PF00069	0.676
MOD_NEK2_1	295	300	PF00069	0.568
MOD_NEK2_1	32	37	PF00069	0.610
MOD_NEK2_1	353	358	PF00069	0.531
MOD_NEK2_1	375	380	PF00069	0.559
MOD_NEK2_1	524	529	PF00069	0.349
MOD_NEK2_1	717	722	PF00069	0.399
MOD_NEK2_1	723	728	PF00069	0.472
MOD_NEK2_1	736	741	PF00069	0.531
MOD_NEK2_1	938	943	PF00069	0.410
MOD_NEK2_1	952	957	PF00069	0.483
MOD_NEK2_2	317	322	PF00069	0.647
MOD_NEK2_2	520	525	PF00069	0.264
MOD_OFUCOSY	328	334	PF10250	0.630
MOD_PIKK_1	966	972	PF00454	0.469
MOD_PK_1	63	69	PF00069	0.696
MOD_PKA_1	840	846	PF00069	0.776
MOD_PKA_2	149	155	PF00069	0.780
MOD_PKA_2	173	179	PF00069	0.673
MOD_PKA_2	184	190	PF00069	0.578
MOD_PKA_2	241	247	PF00069	0.745
MOD_PKA_2	275	281	PF00069	0.706
MOD_PKA_2	282	288	PF00069	0.719
MOD_PKA_2	344	350	PF00069	0.476
MOD_PKA_2	440	446	PF00069	0.424
MOD_PKA_2	524	530	PF00069	0.399
MOD_PKA_2	534	540	PF00069	0.336
MOD_PKA_2	62	68	PF00069	0.664
MOD_PKA_2	938	944	PF00069	0.369
MOD_PKA_2	966	972	PF00069	0.474
MOD_PKB_1	327	335	PF00069	0.742
MOD_PKB_1	622	630	PF00069	0.262
MOD_Plk_1	128	134	PF00069	0.723
MOD_Plk_1	317	323	PF00069	0.699
MOD_Plk_1	652	658	PF00069	0.291
MOD_Plk_1	671	677	PF00069	0.291
MOD_Plk_1	885	891	PF00069	0.555
MOD_Plk_1	983	989	PF00069	0.538
MOD_Plk_2-3	773	779	PF00069	0.497
MOD_Plk_2-3	983	989	PF00069	0.538
MOD_Plk_4	375	381	PF00069	0.480
MOD_Plk_4	389	395	PF00069	0.414
MOD_Plk_4	478	484	PF00069	0.372
MOD_Plk_4	671	677	PF00069	0.375
MOD_Plk_4	969	975	PF00069	0.588
MOD_ProDKin_1	122	128	PF00069	0.735
MOD_ProDKin_1	134	140	PF00069	0.669
MOD_ProDKin_1	161	167	PF00069	0.672
MOD_ProDKin_1	205	211	PF00069	0.679
MOD_ProDKin_1	213	219	PF00069	0.670
MOD_ProDKin_1	22	28	PF00069	0.778
MOD_ProDKin_1	242	248	PF00069	0.667
MOD_ProDKin_1	283	289	PF00069	0.714
MOD_ProDKin_1	398	404	PF00069	0.652
MOD_ProDKin_1	637	643	PF00069	0.434
MOD_ProDKin_1	648	654	PF00069	0.402
MOD_ProDKin_1	67	73	PF00069	0.826
MOD_ProDKin_1	807	813	PF00069	0.680
MOD_ProDKin_1	88	94	PF00069	0.661
MOD_ProDKin_1	903	909	PF00069	0.690
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.664
TRG_DiLeu_BaLyEn_6	940	945	PF01217	0.434
TRG_ENDOCYTIC_2	194	197	PF00928	0.650
TRG_ENDOCYTIC_2	686	689	PF00928	0.399
TRG_ER_diArg_1	241	243	PF00400	0.728
TRG_ER_diArg_1	321	324	PF00400	0.800
TRG_ER_diArg_1	325	327	PF00400	0.720
TRG_ER_diArg_1	48	50	PF00400	0.677
TRG_ER_diArg_1	608	610	PF00400	0.316
TRG_ER_diArg_1	615	617	PF00400	0.266
TRG_ER_diArg_1	621	624	PF00400	0.317
TRG_ER_diArg_1	964	967	PF00400	0.508
TRG_ER_diArg_1	998	1001	PF00400	0.555
TRG_NLS_MonoExtC_3	611	616	PF00514	0.262
TRG_NLS_MonoExtN_4	609	616	PF00514	0.262
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEF4	Leishmania donovani	85%	100%
A4HFZ1	Leishmania braziliensis	64%	100%
A4I310	Leishmania infantum	85%	90%
E9AZC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%