Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania major

UniProt:

E9ADJ1_LEIMA

TriTrypDb:

LmjF.27.2110 , LMJLV39_270028600 , LMJSD75_270028500

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADJ1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	6
GO:0008152	metabolic process	1	6
GO:0009056	catabolic process	2	2
GO:0016042	lipid catabolic process	4	2
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016298	lipase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.478
CLV_C14_Caspase3-7	411	415	PF00656	0.260
CLV_C14_Caspase3-7	443	447	PF00656	0.405
CLV_C14_Caspase3-7	671	675	PF00656	0.690
CLV_NRD_NRD_1	200	202	PF00675	0.609
CLV_NRD_NRD_1	253	255	PF00675	0.486
CLV_NRD_NRD_1	376	378	PF00675	0.402
CLV_NRD_NRD_1	530	532	PF00675	0.411
CLV_NRD_NRD_1	693	695	PF00675	0.739
CLV_PCSK_KEX2_1	109	111	PF00082	0.555
CLV_PCSK_KEX2_1	253	255	PF00082	0.486
CLV_PCSK_KEX2_1	270	272	PF00082	0.453
CLV_PCSK_KEX2_1	399	401	PF00082	0.372
CLV_PCSK_KEX2_1	495	497	PF00082	0.405
CLV_PCSK_KEX2_1	530	532	PF00082	0.411
CLV_PCSK_KEX2_1	693	695	PF00082	0.724
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.555
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.579
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.356
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.380
CLV_PCSK_SKI1_1	176	180	PF00082	0.621
CLV_PCSK_SKI1_1	192	196	PF00082	0.510
CLV_PCSK_SKI1_1	242	246	PF00082	0.427
CLV_PCSK_SKI1_1	378	382	PF00082	0.260
CLV_PCSK_SKI1_1	60	64	PF00082	0.564
CLV_PCSK_SKI1_1	709	713	PF00082	0.490
CLV_PCSK_SKI1_1	741	745	PF00082	0.526
CLV_PCSK_SKI1_1	82	86	PF00082	0.542
DEG_Nend_UBRbox_1	1	4	PF02207	0.557
DEG_SPOP_SBC_1	221	225	PF00917	0.607
DEG_SPOP_SBC_1	25	29	PF00917	0.605
DEG_SPOP_SBC_1	33	37	PF00917	0.607
DOC_CDC14_PxL_1	553	561	PF14671	0.405
DOC_CDC14_PxL_1	96	104	PF14671	0.464
DOC_CKS1_1	442	447	PF01111	0.405
DOC_CYCLIN_RxL_1	705	715	PF00134	0.494
DOC_MAPK_DCC_7	98	107	PF00069	0.471
DOC_MAPK_gen_1	495	502	PF00069	0.405
DOC_MAPK_MEF2A_6	427	434	PF00069	0.356
DOC_PP1_RVXF_1	137	144	PF00149	0.540
DOC_PP1_RVXF_1	145	151	PF00149	0.559
DOC_PP2B_LxvP_1	289	292	PF13499	0.489
DOC_PP2B_LxvP_1	508	511	PF13499	0.405
DOC_PP4_FxxP_1	195	198	PF00568	0.673
DOC_USP7_MATH_1	16	20	PF00917	0.601
DOC_USP7_MATH_1	25	29	PF00917	0.650
DOC_USP7_MATH_1	274	278	PF00917	0.477
DOC_USP7_MATH_1	284	288	PF00917	0.394
DOC_USP7_MATH_1	339	343	PF00917	0.356
DOC_USP7_MATH_1	34	38	PF00917	0.614
DOC_USP7_MATH_1	392	396	PF00917	0.263
DOC_USP7_MATH_1	412	416	PF00917	0.296
DOC_USP7_MATH_1	45	49	PF00917	0.499
DOC_USP7_MATH_1	511	515	PF00917	0.405
DOC_USP7_MATH_1	534	538	PF00917	0.405
DOC_USP7_MATH_1	580	584	PF00917	0.638
DOC_USP7_MATH_1	658	662	PF00917	0.734
DOC_USP7_MATH_1	687	691	PF00917	0.730
DOC_USP7_MATH_1	69	73	PF00917	0.567
DOC_USP7_UBL2_3	183	187	PF12436	0.501
DOC_WW_Pin1_4	100	105	PF00397	0.526
DOC_WW_Pin1_4	160	165	PF00397	0.646
DOC_WW_Pin1_4	194	199	PF00397	0.675
DOC_WW_Pin1_4	203	208	PF00397	0.594
DOC_WW_Pin1_4	390	395	PF00397	0.356
DOC_WW_Pin1_4	441	446	PF00397	0.477
DOC_WW_Pin1_4	712	717	PF00397	0.520
LIG_14-3-3_CanoR_1	110	115	PF00244	0.536
LIG_14-3-3_CanoR_1	139	144	PF00244	0.513
LIG_14-3-3_CanoR_1	242	251	PF00244	0.435
LIG_14-3-3_CanoR_1	254	263	PF00244	0.407
LIG_14-3-3_CanoR_1	300	308	PF00244	0.472
LIG_14-3-3_CanoR_1	320	326	PF00244	0.233
LIG_14-3-3_CanoR_1	377	386	PF00244	0.260
LIG_14-3-3_CanoR_1	668	674	PF00244	0.638
LIG_Actin_WH2_2	281	299	PF00022	0.440
LIG_BIR_III_2	391	395	PF00653	0.356
LIG_BRCT_BRCA1_1	195	199	PF00533	0.620
LIG_BRCT_BRCA1_1	257	261	PF00533	0.476
LIG_BRCT_BRCA1_1	341	345	PF00533	0.356
LIG_BRCT_BRCA1_1	50	54	PF00533	0.602
LIG_EH1_1	230	238	PF00400	0.446
LIG_EH1_1	737	745	PF00400	0.526
LIG_eIF4E_1	231	237	PF01652	0.484
LIG_FHA_1	133	139	PF00498	0.507
LIG_FHA_1	21	27	PF00498	0.661
LIG_FHA_1	223	229	PF00498	0.654
LIG_FHA_1	258	264	PF00498	0.511
LIG_FHA_1	284	290	PF00498	0.590
LIG_FHA_1	329	335	PF00498	0.405
LIG_FHA_1	415	421	PF00498	0.405
LIG_FHA_1	505	511	PF00498	0.405
LIG_FHA_1	606	612	PF00498	0.603
LIG_FHA_1	617	623	PF00498	0.568
LIG_FHA_1	719	725	PF00498	0.481
LIG_FHA_2	111	117	PF00498	0.460
LIG_FHA_2	358	364	PF00498	0.405
LIG_FHA_2	382	388	PF00498	0.414
LIG_FHA_2	411	417	PF00498	0.359
LIG_FHA_2	646	652	PF00498	0.635
LIG_FHA_2	669	675	PF00498	0.691
LIG_LIR_Apic_2	65	69	PF02991	0.545
LIG_LIR_Gen_1	140	148	PF02991	0.590
LIG_LIR_Gen_1	163	174	PF02991	0.619
LIG_LIR_Gen_1	307	318	PF02991	0.467
LIG_LIR_Gen_1	331	340	PF02991	0.511
LIG_LIR_Gen_1	461	466	PF02991	0.441
LIG_LIR_Gen_1	514	524	PF02991	0.356
LIG_LIR_Nem_3	140	146	PF02991	0.586
LIG_LIR_Nem_3	163	169	PF02991	0.585
LIG_LIR_Nem_3	245	251	PF02991	0.439
LIG_LIR_Nem_3	307	313	PF02991	0.460
LIG_LIR_Nem_3	461	465	PF02991	0.441
LIG_LIR_Nem_3	514	519	PF02991	0.405
LIG_LYPXL_yS_3	99	102	PF13949	0.506
LIG_MYND_1	100	104	PF01753	0.471
LIG_Pex14_2	195	199	PF04695	0.674
LIG_PTAP_UEV_1	624	629	PF05743	0.638
LIG_PTB_Apo_2	356	363	PF02174	0.405
LIG_PTB_Apo_2	456	463	PF02174	0.260
LIG_PTB_Phospho_1	456	462	PF10480	0.260
LIG_Rb_pABgroove_1	356	364	PF01858	0.405
LIG_SH2_CRK	310	314	PF00017	0.390
LIG_SH2_CRK	462	466	PF00017	0.380
LIG_SH2_SRC	485	488	PF00017	0.332
LIG_SH2_SRC	66	69	PF00017	0.573
LIG_SH2_STAP1	125	129	PF00017	0.480
LIG_SH2_STAP1	243	247	PF00017	0.425
LIG_SH2_STAP1	310	314	PF00017	0.390
LIG_SH2_STAP1	462	466	PF00017	0.380
LIG_SH2_STAP1	485	489	PF00017	0.405
LIG_SH2_STAP1	752	756	PF00017	0.522
LIG_SH2_STAT3	231	234	PF00017	0.490
LIG_SH2_STAT3	349	352	PF00017	0.356
LIG_SH2_STAT3	437	440	PF00017	0.356
LIG_SH2_STAT5	66	69	PF00017	0.622
LIG_SH3_2	394	399	PF14604	0.380
LIG_SH3_2	625	630	PF14604	0.663
LIG_SH3_3	338	344	PF00018	0.459
LIG_SH3_3	391	397	PF00018	0.260
LIG_SH3_3	47	53	PF00018	0.580
LIG_SH3_3	485	491	PF00018	0.405
LIG_SH3_3	568	574	PF00018	0.497
LIG_SH3_3	6	12	PF00018	0.687
LIG_SH3_3	619	625	PF00018	0.667
LIG_SH3_3	722	728	PF00018	0.524
LIG_SUMO_SIM_anti_2	103	109	PF11976	0.403
LIG_SUMO_SIM_anti_2	262	268	PF11976	0.518
LIG_SUMO_SIM_par_1	709	715	PF11976	0.494
LIG_TRAF2_1	277	280	PF00917	0.492
LIG_TRAF2_1	767	770	PF00917	0.704
LIG_TRFH_1	437	441	PF08558	0.375
LIG_TYR_ITIM	483	488	PF00017	0.356
LIG_UBA3_1	265	270	PF00899	0.543
LIG_UBA3_1	737	741	PF00899	0.518
LIG_WRC_WIRS_1	322	327	PF05994	0.405
LIG_WRC_WIRS_1	329	334	PF05994	0.333
MOD_CDC14_SPxK_1	396	399	PF00782	0.332
MOD_CDK_SPxK_1	393	399	PF00069	0.332
MOD_CDK_SPxxK_3	194	201	PF00069	0.653
MOD_CDK_SPxxK_3	393	400	PF00069	0.378
MOD_CK1_1	24	30	PF00069	0.690
MOD_CK1_1	256	262	PF00069	0.543
MOD_CK1_1	283	289	PF00069	0.545
MOD_CK1_1	303	309	PF00069	0.367
MOD_CK1_1	32	38	PF00069	0.605
MOD_CK1_1	48	54	PF00069	0.527
MOD_CK1_1	55	61	PF00069	0.448
MOD_CK1_1	672	678	PF00069	0.640
MOD_CK1_1	685	691	PF00069	0.666
MOD_CK2_1	139	145	PF00069	0.590
MOD_CK2_1	269	275	PF00069	0.615
MOD_CK2_1	284	290	PF00069	0.417
MOD_CK2_1	381	387	PF00069	0.356
MOD_CK2_1	410	416	PF00069	0.380
MOD_CK2_1	658	664	PF00069	0.716
MOD_CK2_1	685	691	PF00069	0.686
MOD_CK2_1	752	758	PF00069	0.548
MOD_CK2_1	764	770	PF00069	0.501
MOD_Cter_Amidation	528	531	PF01082	0.260
MOD_GlcNHglycan	214	217	PF01048	0.559
MOD_GlcNHglycan	23	26	PF01048	0.714
MOD_GlcNHglycan	271	274	PF01048	0.640
MOD_GlcNHglycan	282	285	PF01048	0.500
MOD_GlcNHglycan	293	296	PF01048	0.455
MOD_GlcNHglycan	31	34	PF01048	0.615
MOD_GlcNHglycan	36	39	PF01048	0.575
MOD_GlcNHglycan	410	413	PF01048	0.394
MOD_GlcNHglycan	50	53	PF01048	0.448
MOD_GlcNHglycan	536	539	PF01048	0.477
MOD_GlcNHglycan	57	60	PF01048	0.427
MOD_GlcNHglycan	578	581	PF01048	0.638
MOD_GlcNHglycan	583	586	PF01048	0.602
MOD_GlcNHglycan	612	615	PF01048	0.638
MOD_GlcNHglycan	674	677	PF01048	0.650
MOD_GlcNHglycan	70	74	PF01048	0.462
MOD_GlcNHglycan	752	755	PF01048	0.524
MOD_GSK3_1	128	135	PF00069	0.454
MOD_GSK3_1	156	163	PF00069	0.646
MOD_GSK3_1	16	23	PF00069	0.699
MOD_GSK3_1	24	31	PF00069	0.625
MOD_GSK3_1	253	260	PF00069	0.514
MOD_GSK3_1	265	272	PF00069	0.494
MOD_GSK3_1	280	287	PF00069	0.460
MOD_GSK3_1	296	303	PF00069	0.403
MOD_GSK3_1	321	328	PF00069	0.395
MOD_GSK3_1	39	46	PF00069	0.541
MOD_GSK3_1	406	413	PF00069	0.359
MOD_GSK3_1	460	467	PF00069	0.380
MOD_GSK3_1	48	55	PF00069	0.541
MOD_GSK3_1	576	583	PF00069	0.625
MOD_GSK3_1	668	675	PF00069	0.658
MOD_GSK3_1	678	685	PF00069	0.691
MOD_GSK3_1	748	755	PF00069	0.514
MOD_LATS_1	149	155	PF00433	0.477
MOD_N-GLC_1	280	285	PF02516	0.469
MOD_NEK2_1	132	137	PF00069	0.498
MOD_NEK2_1	182	187	PF00069	0.645
MOD_NEK2_1	257	262	PF00069	0.548
MOD_NEK2_1	26	31	PF00069	0.633
MOD_NEK2_1	265	270	PF00069	0.509
MOD_NEK2_1	296	301	PF00069	0.480
MOD_NEK2_1	325	330	PF00069	0.405
MOD_NEK2_1	478	483	PF00069	0.436
MOD_NEK2_1	62	67	PF00069	0.534
MOD_NEK2_1	711	716	PF00069	0.507
MOD_NEK2_1	739	744	PF00069	0.538
MOD_NEK2_1	748	753	PF00069	0.372
MOD_NEK2_1	91	96	PF00069	0.454
MOD_NEK2_2	511	516	PF00069	0.405
MOD_OFUCOSY	515	521	PF10250	0.356
MOD_PIKK_1	300	306	PF00454	0.526
MOD_PIKK_1	339	345	PF00454	0.405
MOD_PKA_1	109	115	PF00069	0.544
MOD_PKA_1	253	259	PF00069	0.507
MOD_PKA_2	109	115	PF00069	0.544
MOD_PKA_2	253	259	PF00069	0.507
MOD_PKA_2	296	302	PF00069	0.434
MOD_PKA_2	325	331	PF00069	0.405
MOD_PKA_2	364	370	PF00069	0.405
MOD_Plk_1	132	138	PF00069	0.507
MOD_Plk_1	174	180	PF00069	0.562
MOD_Plk_1	280	286	PF00069	0.466
MOD_Plk_1	405	411	PF00069	0.332
MOD_Plk_1	650	656	PF00069	0.669
MOD_Plk_4	103	109	PF00069	0.454
MOD_Plk_4	174	180	PF00069	0.579
MOD_Plk_4	284	290	PF00069	0.584
MOD_Plk_4	357	363	PF00069	0.405
MOD_Plk_4	45	51	PF00069	0.604
MOD_Plk_4	460	466	PF00069	0.402
MOD_Plk_4	62	68	PF00069	0.460
MOD_Plk_4	739	745	PF00069	0.537
MOD_Plk_4	91	97	PF00069	0.479
MOD_ProDKin_1	100	106	PF00069	0.525
MOD_ProDKin_1	160	166	PF00069	0.645
MOD_ProDKin_1	194	200	PF00069	0.675
MOD_ProDKin_1	203	209	PF00069	0.597
MOD_ProDKin_1	390	396	PF00069	0.356
MOD_ProDKin_1	441	447	PF00069	0.477
MOD_ProDKin_1	712	718	PF00069	0.528
TRG_DiLeu_BaEn_4	405	411	PF01217	0.332
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.479
TRG_ENDOCYTIC_2	111	114	PF00928	0.422
TRG_ENDOCYTIC_2	248	251	PF00928	0.448
TRG_ENDOCYTIC_2	310	313	PF00928	0.439
TRG_ENDOCYTIC_2	462	465	PF00928	0.405
TRG_ENDOCYTIC_2	485	488	PF00928	0.356
TRG_ENDOCYTIC_2	89	92	PF00928	0.480
TRG_ENDOCYTIC_2	99	102	PF00928	0.428
TRG_ER_diArg_1	252	254	PF00400	0.481
TRG_ER_diArg_1	482	485	PF00400	0.269
TRG_NES_CRM1_1	736	746	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7I3	Leishmania donovani	91%	98%
A4HFY8	Leishmania braziliensis	66%	69%
A4I2Y1	Leishmania infantum	91%	70%
E9AZB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%