Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

E9ADJ0_LEIMA

TriTrypDb:

LmjF.27.2100 , LMJLV39_270028500 , LMJSD75_270028400

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016604	nuclear body	2	2
GO:0016607	nuclear speck	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADJ0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.657
CLV_C14_Caspase3-7	99	103	PF00656	0.705
CLV_NRD_NRD_1	127	129	PF00675	0.629
CLV_NRD_NRD_1	219	221	PF00675	0.747
CLV_NRD_NRD_1	224	226	PF00675	0.799
CLV_NRD_NRD_1	237	239	PF00675	0.408
CLV_NRD_NRD_1	318	320	PF00675	0.490
CLV_NRD_NRD_1	339	341	PF00675	0.677
CLV_NRD_NRD_1	348	350	PF00675	0.637
CLV_NRD_NRD_1	363	365	PF00675	0.493
CLV_NRD_NRD_1	373	375	PF00675	0.678
CLV_NRD_NRD_1	383	385	PF00675	0.520
CLV_NRD_NRD_1	395	397	PF00675	0.649
CLV_NRD_NRD_1	405	407	PF00675	0.668
CLV_NRD_NRD_1	417	419	PF00675	0.508
CLV_PCSK_FUR_1	344	348	PF00082	0.753
CLV_PCSK_FUR_1	357	361	PF00082	0.543
CLV_PCSK_FUR_1	370	374	PF00082	0.653
CLV_PCSK_FUR_1	380	384	PF00082	0.627
CLV_PCSK_FUR_1	392	396	PF00082	0.574
CLV_PCSK_FUR_1	415	419	PF00082	0.775
CLV_PCSK_KEX2_1	127	129	PF00082	0.583
CLV_PCSK_KEX2_1	219	221	PF00082	0.681
CLV_PCSK_KEX2_1	224	226	PF00082	0.738
CLV_PCSK_KEX2_1	237	239	PF00082	0.408
CLV_PCSK_KEX2_1	292	294	PF00082	0.383
CLV_PCSK_KEX2_1	318	320	PF00082	0.490
CLV_PCSK_KEX2_1	338	340	PF00082	0.691
CLV_PCSK_KEX2_1	344	346	PF00082	0.636
CLV_PCSK_KEX2_1	347	349	PF00082	0.625
CLV_PCSK_KEX2_1	359	361	PF00082	0.504
CLV_PCSK_KEX2_1	362	364	PF00082	0.440
CLV_PCSK_KEX2_1	372	374	PF00082	0.601
CLV_PCSK_KEX2_1	382	384	PF00082	0.536
CLV_PCSK_KEX2_1	394	396	PF00082	0.617
CLV_PCSK_KEX2_1	405	407	PF00082	0.679
CLV_PCSK_KEX2_1	415	417	PF00082	0.565
CLV_PCSK_KEX2_1	437	439	PF00082	0.682
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.284
CLV_PCSK_PC7_1	220	226	PF00082	0.613
CLV_PCSK_PC7_1	340	346	PF00082	0.748
CLV_PCSK_PC7_1	357	363	PF00082	0.483
CLV_PCSK_PC7_1	390	396	PF00082	0.607
CLV_PCSK_PC7_1	401	407	PF00082	0.640
CLV_PCSK_PC7_1	411	417	PF00082	0.649
CLV_PCSK_PC7_1	433	439	PF00082	0.657
CLV_PCSK_SKI1_1	155	159	PF00082	0.283
CLV_PCSK_SKI1_1	188	192	PF00082	0.328
CLV_PCSK_SKI1_1	220	224	PF00082	0.596
CLV_PCSK_SKI1_1	255	259	PF00082	0.237
DEG_APCC_DBOX_1	150	158	PF00400	0.452
DOC_ANK_TNKS_1	209	216	PF00023	0.500
DOC_CYCLIN_RxL_1	185	193	PF00134	0.523
DOC_MAPK_gen_1	134	142	PF00069	0.464
DOC_MAPK_gen_1	237	244	PF00069	0.505
DOC_MAPK_gen_1	306	315	PF00069	0.649
DOC_MAPK_MEF2A_6	237	246	PF00069	0.488
DOC_MAPK_MEF2A_6	275	282	PF00069	0.523
DOC_PP2B_PxIxI_1	275	281	PF00149	0.484
DOC_PP4_FxxP_1	261	264	PF00568	0.523
DOC_PP4_FxxP_1	273	276	PF00568	0.523
DOC_PP4_FxxP_1	54	57	PF00568	0.523
DOC_USP7_MATH_1	114	118	PF00917	0.664
DOC_USP7_MATH_1	284	288	PF00917	0.485
DOC_WW_Pin1_4	156	161	PF00397	0.452
DOC_WW_Pin1_4	260	265	PF00397	0.484
DOC_WW_Pin1_4	399	404	PF00397	0.627
DOC_WW_Pin1_4	409	414	PF00397	0.581
DOC_WW_Pin1_4	419	424	PF00397	0.596
DOC_WW_Pin1_4	425	430	PF00397	0.595
DOC_WW_Pin1_4	431	436	PF00397	0.582
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BIR_III_4	102	106	PF00653	0.683
LIG_BIR_III_4	212	216	PF00653	0.511
LIG_FHA_1	3	9	PF00498	0.269
LIG_FHA_2	14	20	PF00498	0.442
LIG_FHA_2	179	185	PF00498	0.507
LIG_FHA_2	284	290	PF00498	0.538
LIG_FHA_2	97	103	PF00498	0.653
LIG_LIR_Apic_2	270	276	PF02991	0.523
LIG_LIR_Apic_2	51	57	PF02991	0.484
LIG_LIR_Gen_1	166	175	PF02991	0.534
LIG_LIR_Gen_1	18	27	PF02991	0.453
LIG_LIR_Nem_3	166	170	PF02991	0.560
LIG_LIR_Nem_3	18	24	PF02991	0.453
LIG_MAD2	139	147	PF02301	0.391
LIG_NRP_CendR_1	437	439	PF00754	0.683
LIG_REV1ctd_RIR_1	21	30	PF16727	0.440
LIG_SH2_STAT5	180	183	PF00017	0.537
LIG_SH2_STAT5	7	10	PF00017	0.443
LIG_SH2_STAT5	78	81	PF00017	0.468
LIG_SH3_3	154	160	PF00018	0.452
LIG_SH3_3	200	206	PF00018	0.590
LIG_SH3_3	30	36	PF00018	0.523
LIG_TRAF2_1	181	184	PF00917	0.452
LIG_TRFH_1	167	171	PF08558	0.440
LIG_WW_3	207	211	PF00397	0.580
LIG_WW_3	412	416	PF00397	0.744
LIG_WW_3	422	426	PF00397	0.549
LIG_WW_3	428	432	PF00397	0.625
LIG_WW_3	434	438	PF00397	0.568
MOD_CDC14_SPxK_1	402	405	PF00782	0.615
MOD_CDC14_SPxK_1	412	415	PF00782	0.580
MOD_CDC14_SPxK_1	422	425	PF00782	0.592
MOD_CDC14_SPxK_1	428	431	PF00782	0.591
MOD_CDC14_SPxK_1	434	437	PF00782	0.554
MOD_CDK_SPxK_1	399	405	PF00069	0.619
MOD_CDK_SPxK_1	409	415	PF00069	0.582
MOD_CDK_SPxK_1	419	425	PF00069	0.599
MOD_CDK_SPxK_1	431	437	PF00069	0.585
MOD_CDK_SPxxK_3	399	406	PF00069	0.754
MOD_CDK_SPxxK_3	409	416	PF00069	0.654
MOD_CDK_SPxxK_3	431	438	PF00069	0.658
MOD_CK1_1	2	8	PF00069	0.502
MOD_CK1_1	233	239	PF00069	0.538
MOD_CK1_1	251	257	PF00069	0.564
MOD_CK1_1	334	340	PF00069	0.610
MOD_CK1_1	350	356	PF00069	0.550
MOD_CK1_1	62	68	PF00069	0.520
MOD_CK2_1	11	17	PF00069	0.526
MOD_CK2_1	178	184	PF00069	0.458
MOD_CK2_1	283	289	PF00069	0.513
MOD_DYRK1A_RPxSP_1	399	403	PF00069	0.625
MOD_DYRK1A_RPxSP_1	409	413	PF00069	0.585
MOD_DYRK1A_RPxSP_1	425	429	PF00069	0.604
MOD_DYRK1A_RPxSP_1	431	435	PF00069	0.611
MOD_GlcNHglycan	1	4	PF01048	0.562
MOD_GlcNHglycan	116	119	PF01048	0.681
MOD_GlcNHglycan	128	131	PF01048	0.732
MOD_GlcNHglycan	13	16	PF01048	0.328
MOD_GlcNHglycan	232	235	PF01048	0.647
MOD_GlcNHglycan	286	289	PF01048	0.273
MOD_GlcNHglycan	297	300	PF01048	0.233
MOD_GlcNHglycan	36	39	PF01048	0.266
MOD_GlcNHglycan	43	46	PF01048	0.386
MOD_GlcNHglycan	61	64	PF01048	0.198
MOD_GlcNHglycan	66	69	PF01048	0.537
MOD_GlcNHglycan	79	82	PF01048	0.534
MOD_GSK3_1	2	9	PF00069	0.503
MOD_GSK3_1	226	233	PF00069	0.679
MOD_GSK3_1	334	341	PF00069	0.621
MOD_GSK3_1	347	354	PF00069	0.650
MOD_GSK3_1	395	402	PF00069	0.641
MOD_GSK3_1	405	412	PF00069	0.664
MOD_GSK3_1	419	426	PF00069	0.665
MOD_GSK3_1	62	69	PF00069	0.523
MOD_GSK3_1	82	89	PF00069	0.396
MOD_LATS_1	393	399	PF00433	0.588
MOD_N-GLC_1	226	231	PF02516	0.581
MOD_NEK2_1	302	307	PF00069	0.494
MOD_PKA_1	338	344	PF00069	0.579
MOD_PKA_1	347	353	PF00069	0.724
MOD_PKA_1	362	368	PF00069	0.498
MOD_PKA_1	372	378	PF00069	0.574
MOD_PKA_1	382	388	PF00069	0.505
MOD_PKA_1	395	401	PF00069	0.553
MOD_PKA_1	405	411	PF00069	0.658
MOD_PKA_1	417	423	PF00069	0.539
MOD_PKA_2	126	132	PF00069	0.616
MOD_PKA_2	133	139	PF00069	0.533
MOD_PKA_2	338	344	PF00069	0.669
MOD_PKA_2	347	353	PF00069	0.645
MOD_PKA_2	362	368	PF00069	0.498
MOD_PKA_2	372	378	PF00069	0.574
MOD_PKA_2	382	388	PF00069	0.505
MOD_PKA_2	395	401	PF00069	0.553
MOD_PKA_2	405	411	PF00069	0.658
MOD_PKA_2	417	423	PF00069	0.539
MOD_PKB_1	345	353	PF00069	0.736
MOD_PKB_1	360	368	PF00069	0.504
MOD_PKB_1	370	378	PF00069	0.571
MOD_PKB_1	380	388	PF00069	0.593
MOD_PKB_1	415	423	PF00069	0.647
MOD_Plk_4	141	147	PF00069	0.484
MOD_Plk_4	2	8	PF00069	0.502
MOD_ProDKin_1	156	162	PF00069	0.452
MOD_ProDKin_1	260	266	PF00069	0.484
MOD_ProDKin_1	399	405	PF00069	0.629
MOD_ProDKin_1	409	415	PF00069	0.582
MOD_ProDKin_1	419	425	PF00069	0.599
MOD_ProDKin_1	431	437	PF00069	0.585
MOD_SUMO_for_1	274	277	PF00179	0.523
MOD_SUMO_for_1	307	310	PF00179	0.396
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.507
TRG_ER_diArg_1	126	128	PF00400	0.615
TRG_ER_diArg_1	338	340	PF00400	0.725
TRG_ER_diArg_1	344	347	PF00400	0.667
TRG_ER_diArg_1	359	362	PF00400	0.570
TRG_ER_diArg_1	372	374	PF00400	0.592
TRG_ER_diArg_1	382	384	PF00400	0.506
TRG_ER_diArg_1	392	395	PF00400	0.587
TRG_ER_diArg_1	414	417	PF00400	0.711
TRG_ER_diArg_1	424	427	PF00400	0.516
TRG_ER_diArg_1	430	433	PF00400	0.618
TRG_ER_diArg_1	436	439	PF00400	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB5	Leptomonas seymouri	51%	100%
A0A1X0NSK5	Trypanosomatidae	29%	95%
A0A3R7LQ31	Trypanosoma rangeli	31%	100%
A0A3S7X0Y2	Leishmania donovani	98%	97%
A4HFY7	Leishmania braziliensis	81%	100%
A4I2Y0	Leishmania infantum	98%	98%
C9ZJH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AZB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%