PrgI family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PrgI family protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADI9_LEIMA

TriTrypDb:

LmjF.27.2090 , LMJLV39_270028400 , LMJSD75_270028300

Length:

148

Annotations

LeishMANIAdb annotations

Relatively conserved in Kinetoplastids but not seen beyond.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ADI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.348
CLV_NRD_NRD_1	26	28	PF00675	0.417
CLV_NRD_NRD_1	43	45	PF00675	0.280
CLV_NRD_NRD_1	68	70	PF00675	0.565
CLV_PCSK_FUR_1	40	44	PF00082	0.391
CLV_PCSK_KEX2_1	111	113	PF00082	0.348
CLV_PCSK_KEX2_1	26	28	PF00082	0.425
CLV_PCSK_KEX2_1	42	44	PF00082	0.298
CLV_PCSK_KEX2_1	67	69	PF00082	0.572
CLV_PCSK_SKI1_1	44	48	PF00082	0.304
DEG_Nend_UBRbox_3	1	3	PF02207	0.761
DOC_CYCLIN_RxL_1	40	51	PF00134	0.567
DOC_MAPK_gen_1	40	48	PF00069	0.569
DOC_MAPK_gen_1	67	76	PF00069	0.366
DOC_PP1_RVXF_1	109	116	PF00149	0.547
DOC_PP1_RVXF_1	42	49	PF00149	0.562
DOC_USP7_MATH_1	3	7	PF00917	0.695
DOC_USP7_UBL2_3	117	121	PF12436	0.565
LIG_14-3-3_CanoR_1	132	138	PF00244	0.685
LIG_14-3-3_CanoR_1	43	49	PF00244	0.467
LIG_14-3-3_CanoR_1	67	73	PF00244	0.417
LIG_FHA_1	45	51	PF00498	0.496
LIG_FHA_1	69	75	PF00498	0.326
LIG_LIR_Gen_1	124	131	PF02991	0.613
LIG_LIR_Gen_1	71	79	PF02991	0.296
LIG_LIR_Gen_1	80	89	PF02991	0.342
LIG_LIR_Nem_3	124	128	PF02991	0.617
LIG_LIR_Nem_3	61	65	PF02991	0.349
LIG_LIR_Nem_3	71	76	PF02991	0.241
LIG_LIR_Nem_3	77	82	PF02991	0.231
LIG_Pex14_1	133	137	PF04695	0.593
LIG_Pex14_1	35	39	PF04695	0.609
LIG_SH2_CRK	125	129	PF00017	0.627
LIG_SH2_NCK_1	125	129	PF00017	0.627
LIG_SH2_STAT5	63	66	PF00017	0.393
LIG_SH2_STAT5	72	75	PF00017	0.273
LIG_WRC_WIRS_1	76	81	PF05994	0.330
MOD_CK1_1	53	59	PF00069	0.390
MOD_CK1_1	77	83	PF00069	0.376
MOD_GlcNHglycan	52	55	PF01048	0.390
MOD_GlcNHglycan	79	82	PF01048	0.410
MOD_GSK3_1	44	51	PF00069	0.483
MOD_GSK3_1	54	61	PF00069	0.317
MOD_N-GLC_1	3	8	PF02516	0.544
MOD_NEK2_1	48	53	PF00069	0.357
MOD_NEK2_1	58	63	PF00069	0.348
MOD_NEK2_1	75	80	PF00069	0.249
MOD_PIKK_1	123	129	PF00454	0.585
MOD_PKA_1	68	74	PF00069	0.365
MOD_PKA_2	68	74	PF00069	0.382
MOD_PKB_1	42	50	PF00069	0.541
MOD_Plk_1	105	111	PF00069	0.536
MOD_Plk_1	123	129	PF00069	0.585
MOD_Plk_4	105	111	PF00069	0.545
MOD_Plk_4	54	60	PF00069	0.330
MOD_Plk_4	68	74	PF00069	0.316
TRG_ENDOCYTIC_2	125	128	PF00928	0.601
TRG_ENDOCYTIC_2	63	66	PF00928	0.446
TRG_ENDOCYTIC_2	72	75	PF00928	0.304
TRG_ER_diArg_1	110	112	PF00400	0.543
TRG_ER_diArg_1	25	27	PF00400	0.631
TRG_ER_diArg_1	39	42	PF00400	0.493
TRG_ER_diArg_1	66	69	PF00400	0.416
TRG_ER_diLys_1	145	148	PF00400	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ2	Leptomonas seymouri	82%	100%
A0A0S4IJ67	Bodo saltans	51%	100%
A0A1X0NST1	Trypanosomatidae	74%	100%
A0A3S5IQM8	Trypanosoma rangeli	67%	100%
A0A3S7X0X5	Leishmania donovani	95%	100%
A4HFY6	Leishmania braziliensis	91%	100%
A4I2X9	Leishmania infantum	95%	100%
C9ZJG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	98%
E9AZB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%