Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADI7_LEIMA

TriTrypDb:

LmjF.27.2070 , LMJLV39_270028200 , LMJSD75_270028100

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ADI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.413
CLV_C14_Caspase3-7	34	38	PF00656	0.796
CLV_C14_Caspase3-7	461	465	PF00656	0.814
CLV_C14_Caspase3-7	814	818	PF00656	0.567
CLV_NRD_NRD_1	289	291	PF00675	0.700
CLV_NRD_NRD_1	355	357	PF00675	0.656
CLV_NRD_NRD_1	499	501	PF00675	0.627
CLV_NRD_NRD_1	603	605	PF00675	0.625
CLV_NRD_NRD_1	666	668	PF00675	0.633
CLV_NRD_NRD_1	720	722	PF00675	0.547
CLV_NRD_NRD_1	815	817	PF00675	0.680
CLV_PCSK_FUR_1	664	668	PF00082	0.629
CLV_PCSK_KEX2_1	289	291	PF00082	0.700
CLV_PCSK_KEX2_1	355	357	PF00082	0.656
CLV_PCSK_KEX2_1	498	500	PF00082	0.634
CLV_PCSK_KEX2_1	603	605	PF00082	0.625
CLV_PCSK_KEX2_1	666	668	PF00082	0.633
CLV_PCSK_KEX2_1	710	712	PF00082	0.542
CLV_PCSK_KEX2_1	722	724	PF00082	0.403
CLV_PCSK_KEX2_1	815	817	PF00082	0.680
CLV_PCSK_KEX2_1	93	95	PF00082	0.600
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.542
CLV_PCSK_PC1ET2_1	722	724	PF00082	0.403
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.600
CLV_PCSK_PC7_1	89	95	PF00082	0.601
CLV_PCSK_SKI1_1	101	105	PF00082	0.619
CLV_PCSK_SKI1_1	289	293	PF00082	0.502
CLV_PCSK_SKI1_1	769	773	PF00082	0.641
CLV_PCSK_SKI1_1	799	803	PF00082	0.760
DEG_APCC_DBOX_1	288	296	PF00400	0.302
DEG_APCC_DBOX_1	798	806	PF00400	0.560
DEG_Nend_UBRbox_3	1	3	PF02207	0.716
DEG_SPOP_SBC_1	457	461	PF00917	0.790
DEG_SPOP_SBC_1	560	564	PF00917	0.699
DOC_CYCLIN_RxL_1	721	734	PF00134	0.750
DOC_MAPK_gen_1	166	175	PF00069	0.687
DOC_MAPK_gen_1	196	205	PF00069	0.687
DOC_MAPK_gen_1	319	329	PF00069	0.635
DOC_MAPK_gen_1	721	730	PF00069	0.756
DOC_MAPK_HePTP_8	205	217	PF00069	0.635
DOC_MAPK_MEF2A_6	208	217	PF00069	0.529
DOC_MAPK_MEF2A_6	322	331	PF00069	0.635
DOC_PP1_RVXF_1	724	731	PF00149	0.749
DOC_PP2B_LxvP_1	139	142	PF13499	0.772
DOC_PP2B_LxvP_1	582	585	PF13499	0.804
DOC_PP4_FxxP_1	772	775	PF00568	0.483
DOC_SPAK_OSR1_1	208	212	PF12202	0.529
DOC_USP7_MATH_1	152	156	PF00917	0.765
DOC_USP7_MATH_1	320	324	PF00917	0.706
DOC_USP7_MATH_1	445	449	PF00917	0.689
DOC_USP7_MATH_1	50	54	PF00917	0.738
DOC_USP7_MATH_1	515	519	PF00917	0.746
DOC_USP7_MATH_1	609	613	PF00917	0.683
DOC_USP7_MATH_1	67	71	PF00917	0.713
DOC_USP7_MATH_1	674	678	PF00917	0.702
DOC_USP7_MATH_1	694	698	PF00917	0.713
DOC_USP7_MATH_1	72	76	PF00917	0.758
DOC_USP7_MATH_1	784	788	PF00917	0.538
DOC_USP7_MATH_1	809	813	PF00917	0.577
DOC_USP7_MATH_1	88	92	PF00917	0.666
DOC_USP7_UBL2_3	722	726	PF12436	0.744
DOC_WW_Pin1_4	108	113	PF00397	0.700
DOC_WW_Pin1_4	561	566	PF00397	0.698
DOC_WW_Pin1_4	670	675	PF00397	0.747
DOC_WW_Pin1_4	788	793	PF00397	0.522
DOC_WW_Pin1_4	805	810	PF00397	0.410
DOC_WW_Pin1_4	84	89	PF00397	0.822
LIG_14-3-3_CanoR_1	101	110	PF00244	0.812
LIG_14-3-3_CanoR_1	168	174	PF00244	0.695
LIG_14-3-3_CanoR_1	181	185	PF00244	0.558
LIG_14-3-3_CanoR_1	257	263	PF00244	0.477
LIG_14-3-3_CanoR_1	282	288	PF00244	0.322
LIG_14-3-3_CanoR_1	355	363	PF00244	0.489
LIG_14-3-3_CanoR_1	404	411	PF00244	0.712
LIG_14-3-3_CanoR_1	417	427	PF00244	0.595
LIG_14-3-3_CanoR_1	451	455	PF00244	0.788
LIG_14-3-3_CanoR_1	64	70	PF00244	0.690
LIG_14-3-3_CanoR_1	647	652	PF00244	0.805
LIG_APCC_ABBA_1	192	197	PF00400	0.690
LIG_APCC_ABBA_1	327	332	PF00400	0.467
LIG_BIR_III_4	443	447	PF00653	0.765
LIG_BRCT_BRCA1_1	283	287	PF00533	0.484
LIG_Clathr_ClatBox_1	328	332	PF01394	0.529
LIG_Clathr_ClatBox_1	829	833	PF01394	0.571
LIG_EH1_1	208	216	PF00400	0.529
LIG_FHA_1	229	235	PF00498	0.567
LIG_FHA_1	295	301	PF00498	0.519
LIG_FHA_1	341	347	PF00498	0.393
LIG_FHA_1	349	355	PF00498	0.336
LIG_FHA_1	426	432	PF00498	0.665
LIG_FHA_1	435	441	PF00498	0.743
LIG_FHA_1	458	464	PF00498	0.813
LIG_FHA_1	481	487	PF00498	0.753
LIG_FHA_1	751	757	PF00498	0.616
LIG_FHA_1	833	839	PF00498	0.477
LIG_FHA_2	143	149	PF00498	0.783
LIG_FHA_2	586	592	PF00498	0.800
LIG_FHA_2	739	745	PF00498	0.529
LIG_FHA_2	838	844	PF00498	0.599
LIG_Integrin_RGD_1	500	502	PF01839	0.556
LIG_LIR_Gen_1	197	206	PF02991	0.683
LIG_LIR_Gen_1	218	226	PF02991	0.525
LIG_LIR_Gen_1	230	240	PF02991	0.333
LIG_LIR_Gen_1	241	249	PF02991	0.363
LIG_LIR_Gen_1	268	275	PF02991	0.489
LIG_LIR_Nem_3	190	195	PF02991	0.665
LIG_LIR_Nem_3	197	203	PF02991	0.579
LIG_LIR_Nem_3	218	222	PF02991	0.525
LIG_LIR_Nem_3	230	236	PF02991	0.317
LIG_LIR_Nem_3	240	245	PF02991	0.341
LIG_LIR_Nem_3	268	272	PF02991	0.487
LIG_LIR_Nem_3	580	584	PF02991	0.810
LIG_LIR_Nem_3	591	597	PF02991	0.711
LIG_LIR_Nem_3	761	767	PF02991	0.490
LIG_Pex14_2	287	291	PF04695	0.491
LIG_Pex14_2	727	731	PF04695	0.797
LIG_PTB_Apo_2	366	373	PF02174	0.352
LIG_PTB_Apo_2	729	736	PF02174	0.751
LIG_PTB_Phospho_1	366	372	PF10480	0.353
LIG_PTB_Phospho_1	729	735	PF10480	0.755
LIG_REV1ctd_RIR_1	246	256	PF16727	0.495
LIG_REV1ctd_RIR_1	728	737	PF16727	0.794
LIG_SH2_CRK	135	139	PF00017	0.658
LIG_SH2_CRK	200	204	PF00017	0.680
LIG_SH2_GRB2like	780	783	PF00017	0.490
LIG_SH2_NCK_1	200	204	PF00017	0.680
LIG_SH2_STAP1	350	354	PF00017	0.460
LIG_SH2_STAP1	427	431	PF00017	0.574
LIG_SH2_STAP1	735	739	PF00017	0.561
LIG_SH2_STAT3	195	198	PF00017	0.693
LIG_SH2_STAT5	350	353	PF00017	0.461
LIG_SH2_STAT5	379	382	PF00017	0.411
LIG_SH2_STAT5	399	402	PF00017	0.367
LIG_SH2_STAT5	427	430	PF00017	0.694
LIG_SH2_STAT5	739	742	PF00017	0.529
LIG_SH2_STAT5	804	807	PF00017	0.562
LIG_SH3_3	172	178	PF00018	0.674
LIG_SH3_3	488	494	PF00018	0.850
LIG_SH3_3	523	529	PF00018	0.807
LIG_SH3_3	78	84	PF00018	0.717
LIG_SUMO_SIM_anti_2	828	837	PF11976	0.558
LIG_SUMO_SIM_par_1	212	218	PF11976	0.488
LIG_SUMO_SIM_par_1	342	348	PF11976	0.479
LIG_SUMO_SIM_par_1	390	395	PF11976	0.354
LIG_TRAF2_1	146	149	PF00917	0.785
LIG_TRAF2_1	787	790	PF00917	0.522
LIG_WRC_WIRS_1	216	221	PF05994	0.488
LIG_WRC_WIRS_1	764	769	PF05994	0.496
MOD_CDC14_SPxK_1	111	114	PF00782	0.664
MOD_CDK_SPK_2	84	89	PF00069	0.822
MOD_CDK_SPxK_1	108	114	PF00069	0.671
MOD_CK1_1	241	247	PF00069	0.402
MOD_CK1_1	261	267	PF00069	0.375
MOD_CK1_1	434	440	PF00069	0.654
MOD_CK1_1	477	483	PF00069	0.690
MOD_CK1_1	610	616	PF00069	0.859
MOD_CK1_1	697	703	PF00069	0.856
MOD_CK1_1	8	14	PF00069	0.809
MOD_CK1_1	808	814	PF00069	0.579
MOD_CK1_1	837	843	PF00069	0.505
MOD_CK2_1	142	148	PF00069	0.781
MOD_CK2_1	738	744	PF00069	0.529
MOD_CK2_1	784	790	PF00069	0.531
MOD_CMANNOS	266	269	PF00535	0.675
MOD_GlcNHglycan	101	104	PF01048	0.532
MOD_GlcNHglycan	119	122	PF01048	0.426
MOD_GlcNHglycan	154	157	PF01048	0.556
MOD_GlcNHglycan	2	5	PF01048	0.618
MOD_GlcNHglycan	21	24	PF01048	0.440
MOD_GlcNHglycan	263	266	PF01048	0.700
MOD_GlcNHglycan	283	286	PF01048	0.488
MOD_GlcNHglycan	322	325	PF01048	0.504
MOD_GlcNHglycan	363	366	PF01048	0.590
MOD_GlcNHglycan	420	423	PF01048	0.474
MOD_GlcNHglycan	480	483	PF01048	0.573
MOD_GlcNHglycan	544	547	PF01048	0.643
MOD_GlcNHglycan	549	552	PF01048	0.555
MOD_GlcNHglycan	597	600	PF01048	0.562
MOD_GlcNHglycan	686	689	PF01048	0.666
MOD_GlcNHglycan	69	72	PF01048	0.513
MOD_GlcNHglycan	7	10	PF01048	0.580
MOD_GlcNHglycan	847	850	PF01048	0.795
MOD_GlcNHglycan	90	93	PF01048	0.615
MOD_GSK3_1	101	108	PF00069	0.677
MOD_GSK3_1	122	129	PF00069	0.693
MOD_GSK3_1	17	24	PF00069	0.790
MOD_GSK3_1	228	235	PF00069	0.554
MOD_GSK3_1	257	264	PF00069	0.439
MOD_GSK3_1	33	40	PF00069	0.695
MOD_GSK3_1	431	438	PF00069	0.631
MOD_GSK3_1	445	452	PF00069	0.716
MOD_GSK3_1	466	473	PF00069	0.732
MOD_GSK3_1	474	481	PF00069	0.693
MOD_GSK3_1	515	522	PF00069	0.780
MOD_GSK3_1	555	562	PF00069	0.744
MOD_GSK3_1	595	602	PF00069	0.814
MOD_GSK3_1	623	630	PF00069	0.786
MOD_GSK3_1	633	640	PF00069	0.791
MOD_GSK3_1	670	677	PF00069	0.847
MOD_GSK3_1	694	701	PF00069	0.726
MOD_GSK3_1	734	741	PF00069	0.605
MOD_GSK3_1	784	791	PF00069	0.530
MOD_GSK3_1	805	812	PF00069	0.568
MOD_GSK3_1	821	828	PF00069	0.438
MOD_GSK3_1	833	840	PF00069	0.480
MOD_GSK3_1	84	91	PF00069	0.799
MOD_N-GLC_1	238	243	PF02516	0.659
MOD_N-GLC_1	273	278	PF02516	0.649
MOD_N-GLC_1	432	437	PF02516	0.506
MOD_N-GLC_1	465	470	PF02516	0.578
MOD_N-GLC_1	65	70	PF02516	0.487
MOD_N-GLC_1	845	850	PF02516	0.794
MOD_NEK2_1	169	174	PF00069	0.713
MOD_NEK2_1	215	220	PF00069	0.525
MOD_NEK2_1	247	252	PF00069	0.469
MOD_NEK2_1	255	260	PF00069	0.427
MOD_NEK2_1	333	338	PF00069	0.378
MOD_NEK2_1	392	397	PF00069	0.332
MOD_NEK2_1	432	437	PF00069	0.626
MOD_NEK2_1	577	582	PF00069	0.832
MOD_NEK2_1	597	602	PF00069	0.664
MOD_NEK2_1	831	836	PF00069	0.479
MOD_NEK2_2	381	386	PF00069	0.302
MOD_OFUCOSY	353	358	PF10250	0.672
MOD_PIKK_1	458	464	PF00454	0.798
MOD_PIKK_1	597	603	PF00454	0.694
MOD_PIKK_1	774	780	PF00454	0.497
MOD_PK_1	470	476	PF00069	0.802
MOD_PK_1	647	653	PF00069	0.762
MOD_PKA_1	815	821	PF00069	0.482
MOD_PKA_1	93	99	PF00069	0.801
MOD_PKA_2	105	111	PF00069	0.666
MOD_PKA_2	180	186	PF00069	0.709
MOD_PKA_2	281	287	PF00069	0.349
MOD_PKA_2	31	37	PF00069	0.714
MOD_PKA_2	318	324	PF00069	0.707
MOD_PKA_2	354	360	PF00069	0.478
MOD_PKA_2	403	409	PF00069	0.706
MOD_PKA_2	416	422	PF00069	0.599
MOD_PKA_2	450	456	PF00069	0.790
MOD_PKA_2	457	463	PF00069	0.818
MOD_PKA_2	466	472	PF00069	0.667
MOD_PKA_2	50	56	PF00069	0.715
MOD_PKA_2	547	553	PF00069	0.714
MOD_PKA_2	815	821	PF00069	0.482
MOD_PKA_2	88	94	PF00069	0.803
MOD_Plk_1	238	244	PF00069	0.453
MOD_Plk_1	425	431	PF00069	0.576
MOD_Plk_1	432	438	PF00069	0.567
MOD_Plk_1	519	525	PF00069	0.813
MOD_Plk_1	640	646	PF00069	0.850
MOD_Plk_1	65	71	PF00069	0.804
MOD_Plk_1	675	681	PF00069	0.835
MOD_Plk_1	695	701	PF00069	0.657
MOD_Plk_1	72	78	PF00069	0.742
MOD_Plk_1	825	831	PF00069	0.595
MOD_Plk_4	169	175	PF00069	0.714
MOD_Plk_4	238	244	PF00069	0.453
MOD_Plk_4	340	346	PF00069	0.467
MOD_Plk_4	470	476	PF00069	0.713
MOD_Plk_4	530	536	PF00069	0.684
MOD_Plk_4	577	583	PF00069	0.811
MOD_Plk_4	640	646	PF00069	0.850
MOD_Plk_4	825	831	PF00069	0.566
MOD_ProDKin_1	108	114	PF00069	0.700
MOD_ProDKin_1	561	567	PF00069	0.697
MOD_ProDKin_1	670	676	PF00069	0.748
MOD_ProDKin_1	788	794	PF00069	0.526
MOD_ProDKin_1	805	811	PF00069	0.411
MOD_ProDKin_1	84	90	PF00069	0.823
MOD_SUMO_rev_2	148	152	PF00179	0.691
TRG_DiLeu_BaEn_1	744	749	PF01217	0.467
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.776
TRG_ENDOCYTIC_2	200	203	PF00928	0.684
TRG_ENDOCYTIC_2	764	767	PF00928	0.438
TRG_ER_diArg_1	165	168	PF00400	0.690
TRG_ER_diArg_1	288	290	PF00400	0.493
TRG_ER_diArg_1	354	356	PF00400	0.448
TRG_ER_diArg_1	415	418	PF00400	0.668
TRG_ER_diArg_1	498	500	PF00400	0.726
TRG_ER_diArg_1	603	605	PF00400	0.806
TRG_ER_diArg_1	664	667	PF00400	0.828
TRG_NLS_Bipartite_1	710	725	PF00514	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQ50	Leishmania donovani	91%	100%
A4HFY4	Leishmania braziliensis	62%	100%
A4I2X7	Leishmania infantum	91%	100%
E9AZB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%