LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9ADI6_LEIMA
TriTrypDb:
LmjF.27.2060 , LMJLV39_270028100 , LMJSD75_270028000
Length:
382

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: bmtom@gate.sinica.edu.tw
Publication title: Identification of macrosialin (CD68) on the surface of host macrophages as the receptor for the intercellular adhesive molecule (ICAM-L) of Leishmania amazonensis
Publication 1st author(s): Ng
Publication Identifier(s): 19540239
Host organism: -1
Interaction detection method(s): anti bait coimmunoprecipitation
Interaction type: physical association
Identification method participant A: western blot
Identification method participant B: western blot
ID(s) interactor A: Q9NGK0
ID(s) interactor B: P31996
Taxid interactor A: Leishmania amazonensis
Taxid interactor B: Mus musculus
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: prey

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9ADI6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADI6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 104 108 PF00656 0.734
CLV_C14_Caspase3-7 231 235 PF00656 0.658
CLV_C14_Caspase3-7 36 40 PF00656 0.571
CLV_NRD_NRD_1 331 333 PF00675 0.762
CLV_NRD_NRD_1 348 350 PF00675 0.678
CLV_NRD_NRD_1 372 374 PF00675 0.784
CLV_NRD_NRD_1 376 378 PF00675 0.789
CLV_PCSK_KEX2_1 247 249 PF00082 0.627
CLV_PCSK_KEX2_1 329 331 PF00082 0.710
CLV_PCSK_KEX2_1 348 350 PF00082 0.681
CLV_PCSK_KEX2_1 359 361 PF00082 0.746
CLV_PCSK_KEX2_1 378 380 PF00082 0.727
CLV_PCSK_PC1ET2_1 247 249 PF00082 0.627
CLV_PCSK_PC1ET2_1 329 331 PF00082 0.710
CLV_PCSK_PC1ET2_1 359 361 PF00082 0.746
CLV_PCSK_PC1ET2_1 378 380 PF00082 0.727
CLV_PCSK_SKI1_1 59 63 PF00082 0.480
CLV_PCSK_SKI1_1 68 72 PF00082 0.419
DEG_SPOP_SBC_1 111 115 PF00917 0.735
DOC_CYCLIN_yCln2_LP_2 71 77 PF00134 0.590
DOC_MAPK_MEF2A_6 142 151 PF00069 0.549
DOC_MAPK_MEF2A_6 45 53 PF00069 0.505
DOC_PP2B_LxvP_1 109 112 PF13499 0.531
DOC_USP7_MATH_1 112 116 PF00917 0.660
DOC_USP7_MATH_1 164 168 PF00917 0.476
DOC_USP7_MATH_1 17 21 PF00917 0.677
DOC_USP7_MATH_1 171 175 PF00917 0.471
DOC_USP7_MATH_1 191 195 PF00917 0.339
DOC_USP7_MATH_1 224 228 PF00917 0.727
DOC_USP7_MATH_1 235 239 PF00917 0.752
DOC_USP7_MATH_1 246 250 PF00917 0.516
DOC_USP7_MATH_1 331 335 PF00917 0.783
DOC_USP7_MATH_1 9 13 PF00917 0.757
DOC_USP7_UBL2_3 329 333 PF12436 0.776
DOC_USP7_UBL2_3 374 378 PF12436 0.779
DOC_WW_Pin1_4 116 121 PF00397 0.630
DOC_WW_Pin1_4 167 172 PF00397 0.583
DOC_WW_Pin1_4 342 347 PF00397 0.760
LIG_14-3-3_CanoR_1 192 201 PF00244 0.668
LIG_14-3-3_CanoR_1 261 267 PF00244 0.538
LIG_14-3-3_CterR_2 379 382 PF00244 0.742
LIG_BRCT_BRCA1_1 310 314 PF00533 0.550
LIG_EVH1_2 26 30 PF00568 0.641
LIG_FHA_1 117 123 PF00498 0.615
LIG_FHA_1 180 186 PF00498 0.448
LIG_FHA_1 198 204 PF00498 0.650
LIG_FHA_1 36 42 PF00498 0.452
LIG_FHA_1 62 68 PF00498 0.527
LIG_FHA_2 229 235 PF00498 0.568
LIG_FHA_2 34 40 PF00498 0.548
LIG_Integrin_RGD_1 142 144 PF01839 0.625
LIG_LIR_Gen_1 118 129 PF02991 0.579
LIG_LIR_Nem_3 118 124 PF02991 0.591
LIG_NRBOX 66 72 PF00104 0.522
LIG_SH2_PTP2 121 124 PF00017 0.554
LIG_SH2_SRC 121 124 PF00017 0.554
LIG_SH2_STAP1 75 79 PF00017 0.548
LIG_SH2_STAT5 121 124 PF00017 0.500
LIG_SH2_STAT5 303 306 PF00017 0.652
LIG_SH3_3 175 181 PF00018 0.554
LIG_SH3_3 21 27 PF00018 0.640
LIG_SH3_3 268 274 PF00018 0.546
LIG_SH3_3 46 52 PF00018 0.409
LIG_Sin3_3 199 206 PF02671 0.686
LIG_SUMO_SIM_par_1 181 186 PF11976 0.521
LIG_SUMO_SIM_par_1 199 205 PF11976 0.641
LIG_SUMO_SIM_par_1 277 283 PF11976 0.529
LIG_SUMO_SIM_par_1 349 354 PF11976 0.722
LIG_TRAF2_1 88 91 PF00917 0.693
LIG_TYR_ITSM 117 124 PF00017 0.607
LIG_WW_3 293 297 PF00397 0.571
MOD_CDK_SPxK_1 342 348 PF00069 0.757
MOD_CDK_SPxxK_3 342 349 PF00069 0.755
MOD_CK1_1 114 120 PF00069 0.644
MOD_CK1_1 167 173 PF00069 0.553
MOD_CK1_1 238 244 PF00069 0.626
MOD_CK1_1 249 255 PF00069 0.401
MOD_CK1_1 334 340 PF00069 0.691
MOD_CK2_1 312 318 PF00069 0.765
MOD_CK2_1 85 91 PF00069 0.678
MOD_Cter_Amidation 5 8 PF01082 0.801
MOD_GlcNHglycan 103 106 PF01048 0.689
MOD_GlcNHglycan 127 130 PF01048 0.578
MOD_GlcNHglycan 185 188 PF01048 0.534
MOD_GlcNHglycan 19 22 PF01048 0.672
MOD_GlcNHglycan 225 229 PF01048 0.730
MOD_GlcNHglycan 237 240 PF01048 0.739
MOD_GlcNHglycan 310 313 PF01048 0.737
MOD_GlcNHglycan 315 318 PF01048 0.776
MOD_GlcNHglycan 336 339 PF01048 0.797
MOD_GlcNHglycan 76 80 PF01048 0.583
MOD_GSK3_1 110 117 PF00069 0.661
MOD_GSK3_1 167 174 PF00069 0.490
MOD_GSK3_1 179 186 PF00069 0.399
MOD_GSK3_1 224 231 PF00069 0.584
MOD_GSK3_1 233 240 PF00069 0.769
MOD_GSK3_1 298 305 PF00069 0.611
MOD_GSK3_1 308 315 PF00069 0.692
MOD_GSK3_1 334 341 PF00069 0.728
MOD_GSK3_1 41 48 PF00069 0.383
MOD_GSK3_1 85 92 PF00069 0.669
MOD_N-GLC_1 17 22 PF02516 0.757
MOD_N-GLC_1 212 217 PF02516 0.759
MOD_NEK2_1 233 238 PF00069 0.711
MOD_NEK2_1 260 265 PF00069 0.470
MOD_NEK2_1 304 309 PF00069 0.724
MOD_NEK2_1 62 67 PF00069 0.512
MOD_PIKK_1 212 218 PF00454 0.794
MOD_PIKK_1 305 311 PF00454 0.693
MOD_PIKK_1 85 91 PF00454 0.673
MOD_PK_1 349 355 PF00069 0.647
MOD_PK_1 45 51 PF00069 0.507
MOD_PKA_2 191 197 PF00069 0.648
MOD_PKA_2 260 266 PF00069 0.525
MOD_PKA_2 331 337 PF00069 0.753
MOD_Plk_1 233 239 PF00069 0.669
MOD_Plk_4 149 155 PF00069 0.455
MOD_Plk_4 197 203 PF00069 0.620
MOD_Plk_4 298 304 PF00069 0.488
MOD_Plk_4 62 68 PF00069 0.462
MOD_ProDKin_1 116 122 PF00069 0.616
MOD_ProDKin_1 167 173 PF00069 0.594
MOD_ProDKin_1 342 348 PF00069 0.757
MOD_SUMO_for_1 219 222 PF00179 0.722
MOD_SUMO_for_1 358 361 PF00179 0.760
MOD_SUMO_rev_2 215 224 PF00179 0.754
TRG_ENDOCYTIC_2 121 124 PF00928 0.500
TRG_ER_diArg_1 348 350 PF00400 0.681
TRG_ER_diArg_1 376 379 PF00400 0.725
TRG_NLS_Bipartite_1 359 381 PF00514 0.694
TRG_NLS_MonoExtC_3 327 332 PF00514 0.798
TRG_NLS_MonoExtN_4 326 333 PF00514 0.754
TRG_NLS_MonoExtN_4 374 381 PF00514 0.761
TRG_Pf-PMV_PEXEL_1 265 269 PF00026 0.560
TRG_Pf-PMV_PEXEL_1 54 58 PF00026 0.554

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMI6 Leptomonas seymouri 49% 100%
A0A0S4IML8 Bodo saltans 26% 100%
A0A1X0NRR0 Trypanosomatidae 33% 100%
A0A3S7X0X4 Leishmania donovani 93% 100%
A4HFY3 Leishmania braziliensis 74% 99%
A4I2X6 Leishmania infantum 93% 100%
E9AZB2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS