Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane adaptor Erv26, putative

Species:

Leishmania major

UniProt:

E9ADI4_LEIMA

TriTrypDb:

LmjF.27.2040 , LMJLV39_270027900 , LMJSD75_270027800

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	9
GO:0016020	membrane	2	9

Expansion

Sequence features

E9ADI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADI4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	11
GO:0009987	cellular process	1	11
GO:0016192	vesicle-mediated transport	4	11
GO:0046907	intracellular transport	3	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11

Molecular functions
Term	Name	Level	Count
GO:0038024	cargo receptor activity	1	11
GO:0097020	COPII receptor activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.739
CLV_NRD_NRD_1	213	215	PF00675	0.410
CLV_PCSK_FUR_1	211	215	PF00082	0.486
CLV_PCSK_KEX2_1	211	213	PF00082	0.435
CLV_PCSK_KEX2_1	22	24	PF00082	0.674
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.697
CLV_PCSK_SKI1_1	214	218	PF00082	0.395
CLV_PCSK_SKI1_1	69	73	PF00082	0.256
CLV_PCSK_SKI1_1	96	100	PF00082	0.374
DEG_APCC_DBOX_1	213	221	PF00400	0.656
DEG_APCC_DBOX_1	95	103	PF00400	0.378
DOC_MAPK_MEF2A_6	32	41	PF00069	0.338
DOC_MAPK_MEF2A_6	96	105	PF00069	0.458
DOC_MAPK_NFAT4_5	96	104	PF00069	0.456
DOC_PP1_SILK_1	69	74	PF00149	0.395
DOC_USP7_MATH_1	115	119	PF00917	0.522
DOC_USP7_MATH_1	188	192	PF00917	0.645
DOC_WW_Pin1_4	119	124	PF00397	0.506
LIG_14-3-3_CanoR_1	109	115	PF00244	0.477
LIG_14-3-3_CanoR_1	32	38	PF00244	0.351
LIG_14-3-3_CanoR_1	96	102	PF00244	0.391
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_BRCT_BRCA1_1	112	116	PF00533	0.395
LIG_eIF4E_1	148	154	PF01652	0.362
LIG_FHA_1	148	154	PF00498	0.308
LIG_FHA_1	34	40	PF00498	0.338
LIG_FHA_1	66	72	PF00498	0.511
LIG_GBD_Chelix_1	102	110	PF00786	0.322
LIG_GBD_Chelix_1	126	134	PF00786	0.378
LIG_LIR_Apic_2	16	21	PF02991	0.424
LIG_LIR_Nem_3	113	117	PF02991	0.556
LIG_LIR_Nem_3	136	142	PF02991	0.322
LIG_LIR_Nem_3	93	98	PF02991	0.361
LIG_NRBOX	129	135	PF00104	0.378
LIG_NRBOX	97	103	PF00104	0.378
LIG_PCNA_PIPBox_1	152	161	PF02747	0.242
LIG_Pex14_2	159	163	PF04695	0.383
LIG_PTB_Apo_2	101	108	PF02174	0.331
LIG_PTB_Phospho_1	101	107	PF10480	0.331
LIG_SH2_STAP1	149	153	PF00017	0.308
LIG_SH2_STAT5	107	110	PF00017	0.306
LIG_SH2_STAT5	149	152	PF00017	0.296
LIG_SH3_2	27	32	PF14604	0.404
LIG_SH3_3	24	30	PF00018	0.418
LIG_SUMO_SIM_anti_2	128	136	PF11976	0.456
LIG_SUMO_SIM_anti_2	85	90	PF11976	0.421
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.322
LIG_SUMO_SIM_par_1	122	128	PF11976	0.425
LIG_SUMO_SIM_par_1	85	90	PF11976	0.346
LIG_TYR_ITIM	105	110	PF00017	0.354
LIG_WRPW_2	25	28	PF00400	0.431
MOD_CK1_1	97	103	PF00069	0.311
MOD_Cter_Amidation	209	212	PF01082	0.445
MOD_GlcNHglycan	117	120	PF01048	0.369
MOD_GlcNHglycan	135	138	PF01048	0.317
MOD_GlcNHglycan	194	197	PF01048	0.506
MOD_GlcNHglycan	201	204	PF01048	0.486
MOD_GSK3_1	115	122	PF00069	0.440
MOD_GSK3_1	188	195	PF00069	0.705
MOD_GSK3_1	90	97	PF00069	0.272
MOD_NEK2_1	110	115	PF00069	0.508
MOD_NEK2_1	133	138	PF00069	0.353
MOD_NEK2_1	147	152	PF00069	0.206
MOD_NEK2_1	169	174	PF00069	0.378
MOD_NEK2_1	33	38	PF00069	0.337
MOD_PKA_1	212	218	PF00069	0.603
MOD_PKA_2	212	218	PF00069	0.620
MOD_Plk_4	125	131	PF00069	0.348
MOD_Plk_4	13	19	PF00069	0.487
MOD_Plk_4	148	154	PF00069	0.271
MOD_Plk_4	33	39	PF00069	0.126
MOD_Plk_4	82	88	PF00069	0.356
MOD_Plk_4	90	96	PF00069	0.268
MOD_Plk_4	97	103	PF00069	0.243
MOD_ProDKin_1	119	125	PF00069	0.506
MOD_SUMO_rev_2	10	16	PF00179	0.437
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.314
TRG_ENDOCYTIC_2	107	110	PF00928	0.331
TRG_ENDOCYTIC_2	149	152	PF00928	0.279
TRG_ENDOCYTIC_2	25	28	PF00928	0.411
TRG_ER_diArg_1	211	214	PF00400	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBA4	Leptomonas seymouri	61%	100%
A0A0S4IJ23	Bodo saltans	35%	100%
A0A1X0NR52	Trypanosomatidae	36%	100%
A0A3Q8IDL3	Leishmania donovani	93%	100%
A0A3R7RES4	Trypanosoma rangeli	40%	100%
A4HFY1	Leishmania braziliensis	74%	100%
A4I2W9	Leishmania infantum	91%	100%
C9ZJG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AZB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q5BJW3	Rattus norvegicus	24%	100%
Q5RFE0	Pongo abelii	25%	100%
Q62302	Mus musculus	24%	100%
Q6UWH6	Homo sapiens	25%	100%