Putative branched-chain amino acid aminotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

branched-chain amino acid aminotransferase, putative

Species:

Leishmania major

UniProt:

E9ADI3_LEIMA

TriTrypDb:

LmjF.27.2030 , LMJLV39_270027800 , LMJSD75_270027600

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADI3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009081	branched-chain amino acid metabolic process	4	13
GO:0009987	cellular process	1	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044281	small molecule metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009082	branched-chain amino acid biosynthetic process	5	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004084	branched-chain-amino-acid transaminase activity	5	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0052654	L-leucine transaminase activity	6	9
GO:0052655	L-valine transaminase activity	6	9
GO:0052656	L-isoleucine transaminase activity	6	9
GO:0050048	L-leucine:2-oxoglutarate aminotransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.378
CLV_NRD_NRD_1	226	228	PF00675	0.225
CLV_NRD_NRD_1	377	379	PF00675	0.436
CLV_PCSK_KEX2_1	226	228	PF00082	0.223
CLV_PCSK_KEX2_1	377	379	PF00082	0.436
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.326
CLV_PCSK_SKI1_1	149	153	PF00082	0.299
CLV_PCSK_SKI1_1	217	221	PF00082	0.291
CLV_PCSK_SKI1_1	377	381	PF00082	0.322
DEG_APCC_DBOX_1	376	384	PF00400	0.426
DEG_Nend_Nbox_1	1	3	PF02207	0.630
DEG_SCF_FBW7_1	183	190	PF00400	0.464
DOC_ANK_TNKS_1	172	179	PF00023	0.431
DOC_MAPK_gen_1	112	120	PF00069	0.508
DOC_MAPK_gen_1	14	23	PF00069	0.616
DOC_MAPK_gen_1	362	370	PF00069	0.551
DOC_MAPK_MEF2A_6	14	23	PF00069	0.425
DOC_PP1_RVXF_1	133	140	PF00149	0.454
DOC_PP1_RVXF_1	41	48	PF00149	0.406
DOC_PP4_FxxP_1	76	79	PF00568	0.416
DOC_USP7_MATH_1	13	17	PF00917	0.566
DOC_USP7_MATH_1	185	189	PF00917	0.522
DOC_USP7_MATH_1	19	23	PF00917	0.569
DOC_USP7_MATH_1	351	355	PF00917	0.488
DOC_USP7_MATH_1	80	84	PF00917	0.400
DOC_USP7_MATH_2	206	212	PF00917	0.452
DOC_WW_Pin1_4	183	188	PF00397	0.485
DOC_WW_Pin1_4	195	200	PF00397	0.409
DOC_WW_Pin1_4	388	393	PF00397	0.418
DOC_WW_Pin1_4	49	54	PF00397	0.316
LIG_14-3-3_CanoR_1	129	135	PF00244	0.477
LIG_APCC_ABBA_1	95	100	PF00400	0.522
LIG_BRCT_BRCA1_1	135	139	PF00533	0.452
LIG_EH1_1	326	334	PF00400	0.424
LIG_eIF4E_1	244	250	PF01652	0.445
LIG_eIF4E_1	327	333	PF01652	0.531
LIG_FHA_1	150	156	PF00498	0.517
LIG_FHA_1	27	33	PF00498	0.475
LIG_FHA_1	288	294	PF00498	0.438
LIG_FHA_1	347	353	PF00498	0.420
LIG_FHA_1	80	86	PF00498	0.329
LIG_FHA_2	155	161	PF00498	0.514
LIG_FXI_DFP_1	139	143	PF00024	0.314
LIG_HCF-1_HBM_1	165	168	PF13415	0.445
LIG_LIR_Apic_2	169	174	PF02991	0.420
LIG_LIR_Apic_2	365	369	PF02991	0.395
LIG_LIR_Apic_2	62	68	PF02991	0.388
LIG_LIR_Gen_1	273	282	PF02991	0.542
LIG_LIR_Nem_3	136	142	PF02991	0.524
LIG_LIR_Nem_3	165	171	PF02991	0.455
LIG_LIR_Nem_3	273	279	PF02991	0.548
LIG_LIR_Nem_3	316	320	PF02991	0.522
LIG_MYND_1	37	41	PF01753	0.475
LIG_PDZ_Class_2	396	401	PF00595	0.443
LIG_Pex14_2	279	283	PF04695	0.447
LIG_Pex14_2	47	51	PF04695	0.333
LIG_SH2_CRK	244	248	PF00017	0.429
LIG_SH2_CRK	259	263	PF00017	0.393
LIG_SH2_CRK	366	370	PF00017	0.375
LIG_SH2_NCK_1	98	102	PF00017	0.522
LIG_SH2_SRC	204	207	PF00017	0.452
LIG_SH2_SRC	98	101	PF00017	0.522
LIG_SH2_STAP1	168	172	PF00017	0.420
LIG_SH2_STAP1	375	379	PF00017	0.395
LIG_SH2_STAP1	98	102	PF00017	0.452
LIG_SH2_STAT3	87	90	PF00017	0.338
LIG_SH2_STAT5	161	164	PF00017	0.429
LIG_SH2_STAT5	171	174	PF00017	0.417
LIG_SH2_STAT5	204	207	PF00017	0.452
LIG_SH3_2	38	43	PF14604	0.471
LIG_SH3_3	196	202	PF00018	0.421
LIG_SH3_3	290	296	PF00018	0.487
LIG_SH3_3	30	36	PF00018	0.379
LIG_SUMO_SIM_par_1	246	253	PF11976	0.477
LIG_SUMO_SIM_par_1	54	59	PF11976	0.375
LIG_TRAF2_1	335	338	PF00917	0.485
LIG_TRFH_1	203	207	PF08558	0.452
LIG_TRFH_1	76	80	PF08558	0.476
LIG_TYR_ITIM	257	262	PF00017	0.452
LIG_WRC_WIRS_1	20	25	PF05994	0.422
LIG_WW_2	37	40	PF00397	0.391
MOD_CDK_SPxK_1	183	189	PF00069	0.464
MOD_CK1_1	133	139	PF00069	0.452
MOD_CK1_1	354	360	PF00069	0.425
MOD_CK1_1	371	377	PF00069	0.304
MOD_CK1_1	393	399	PF00069	0.473
MOD_CK2_1	264	270	PF00069	0.518
MOD_CK2_1	313	319	PF00069	0.478
MOD_GlcNHglycan	10	13	PF01048	0.659
MOD_GlcNHglycan	210	213	PF01048	0.249
MOD_GSK3_1	179	186	PF00069	0.443
MOD_GSK3_1	278	285	PF00069	0.522
MOD_GSK3_1	287	294	PF00069	0.522
MOD_GSK3_1	364	371	PF00069	0.388
MOD_N-GLC_1	74	79	PF02516	0.346
MOD_N-GLC_2	278	280	PF02516	0.312
MOD_NEK2_1	1	6	PF00069	0.627
MOD_NEK2_1	130	135	PF00069	0.420
MOD_NEK2_1	28	33	PF00069	0.472
MOD_NEK2_1	297	302	PF00069	0.441
MOD_NEK2_1	313	318	PF00069	0.420
MOD_NEK2_2	187	192	PF00069	0.522
MOD_NEK2_2	46	51	PF00069	0.433
MOD_PIKK_1	86	92	PF00454	0.394
MOD_PK_1	364	370	PF00069	0.421
MOD_PKA_2	13	19	PF00069	0.684
MOD_PKA_2	130	136	PF00069	0.572
MOD_PKA_2	306	312	PF00069	0.429
MOD_Plk_1	364	370	PF00069	0.449
MOD_Plk_1	74	80	PF00069	0.347
MOD_Plk_4	166	172	PF00069	0.420
MOD_Plk_4	217	223	PF00069	0.522
MOD_Plk_4	278	284	PF00069	0.533
MOD_Plk_4	28	34	PF00069	0.470
MOD_Plk_4	297	303	PF00069	0.420
MOD_Plk_4	306	312	PF00069	0.420
MOD_Plk_4	354	360	PF00069	0.445
MOD_Plk_4	46	52	PF00069	0.261
MOD_ProDKin_1	183	189	PF00069	0.485
MOD_ProDKin_1	195	201	PF00069	0.409
MOD_ProDKin_1	388	394	PF00069	0.426
MOD_ProDKin_1	49	55	PF00069	0.311
MOD_SUMO_for_1	397	400	PF00179	0.519
TRG_DiLeu_BaEn_4	252	258	PF01217	0.452
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.477
TRG_ENDOCYTIC_2	259	262	PF00928	0.445
TRG_ENDOCYTIC_2	98	101	PF00928	0.477
TRG_ER_diArg_1	377	379	PF00400	0.436
TRG_NLS_MonoExtN_4	226	231	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9J7	Leptomonas seymouri	73%	100%
A0A0S4IPR2	Bodo saltans	51%	100%
A0A179HME7	Purpureocillium lilacinum	25%	100%
A0A1W5T1Y5	Penicillium oxalicum	28%	100%
A0A1X0NR31	Trypanosomatidae	59%	100%
A0A3Q8IGG4	Leishmania donovani	97%	100%
A0A3R7K7G7	Trypanosoma rangeli	56%	100%
A0R066	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	36%	100%
A4HFY0	Leishmania braziliensis	81%	100%
A4I2W8	Leishmania infantum	98%	100%
A7SLW1	Nematostella vectensis	41%	99%
A9UZ24	Monosiga brevicollis	46%	100%
C9K7B6	Alternaria alternata	31%	100%
C9K7D8	Alternaria alternata	31%	100%
C9ZJG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
C9ZJG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AZA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AZA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
I1R9B6	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	30%	100%
K0E3V3	Aspergillus rugulosus	28%	100%
K7QHS5	Humulus lupulus	31%	98%
K7QKH1	Humulus lupulus	32%	100%
O05970	Rickettsia prowazekii (strain Madrid E)	24%	100%
O14370	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	94%
O15382	Homo sapiens	43%	100%
O26004	Helicobacter pylori (strain ATCC 700392 / 26695)	30%	100%
O27481	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	100%
O31461	Bacillus subtilis (strain 168)	39%	100%
O32954	Mycobacterium leprae (strain TN)	37%	100%
O35854	Rattus norvegicus	44%	100%
O35855	Mus musculus	44%	100%
O86505	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	36%	100%
P0A1A5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	100%
P0A1A6	Salmonella typhi	27%	100%
P0AB80	Escherichia coli (strain K12)	27%	100%
P0AB81	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
P0AB82	Escherichia coli O157:H7	27%	100%
P24288	Mus musculus	42%	100%
P38891	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P39576	Bacillus subtilis (strain 168)	35%	100%
P47176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P54687	Homo sapiens	41%	100%
P54688	Caenorhabditis elegans	41%	97%
P54689	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P54690	Rattus norvegicus	40%	98%
P54691	Synechocystis sp. (strain PCC 6803 / Kazusa)	27%	100%
P63512	Staphylococcus aureus (strain Mu50 / ATCC 700699)	35%	100%
P63513	Staphylococcus aureus (strain MW2)	35%	100%
P99138	Staphylococcus aureus (strain N315)	35%	100%
P9WQ74	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	36%	100%
P9WQ75	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	36%	100%
Q1RIJ2	Rickettsia bellii (strain RML369-C)	23%	100%
Q4ULR3	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	24%	100%
Q54N47	Dictyostelium discoideum	47%	100%
Q5AV02	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	100%
Q5AV04	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q5EA40	Bos taurus	45%	100%
Q5HIC1	Staphylococcus aureus (strain COL)	35%	100%
Q5HRJ8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	36%	100%
Q5REP0	Pongo abelii	43%	100%
Q6GBT3	Staphylococcus aureus (strain MSSA476)	35%	100%
Q6GJB4	Staphylococcus aureus (strain MRSA252)	35%	100%
Q8CQ78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	36%	100%
Q92I26	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	24%	100%
Q93Y32	Arabidopsis thaliana	29%	100%
Q9AKE5	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	24%	100%
Q9FYA6	Arabidopsis thaliana	30%	97%
Q9GKM4	Ovis aries	42%	100%
Q9LE06	Arabidopsis thaliana	28%	100%
Q9LPM8	Arabidopsis thaliana	30%	100%
Q9LPM9	Arabidopsis thaliana	30%	100%
Q9M401	Arabidopsis thaliana	33%	97%
Q9M439	Arabidopsis thaliana	29%	100%
Q9Y885	Cochliobolus carbonum	26%	100%
Q9ZJF1	Helicobacter pylori (strain J99 / ATCC 700824)	30%	100%
S0DS11	Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)	25%	100%
S3DQP8	Glarea lozoyensis (strain ATCC 20868 / MF5171)	28%	100%
S7ZEI5	Penicillium oxalicum (strain 114-2 / CGMCC 5302)	28%	100%