D-lactate dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-lactate dehydrogenase-like protein

Species:

Leishmania major

UniProt:

E9ADI2_LEIMA

TriTrypDb:

LmjF.27.2020 , LMJLV39_270027600 , LMJSD75_270027500

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ADI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADI2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006089	lactate metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009987	cellular process	1	3
GO:0016054	organic acid catabolic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044248	cellular catabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044282	small molecule catabolic process	3	3
GO:0046395	carboxylic acid catabolic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072329	monocarboxylic acid catabolic process	6	3
GO:1901575	organic substance catabolic process	3	3
GO:1901615	organic hydroxy compound metabolic process	3	3
GO:1901616	organic hydroxy compound catabolic process	4	3
GO:1903457	lactate catabolic process	5	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004457	lactate dehydrogenase activity	4	3
GO:0004458	D-lactate dehydrogenase (cytochrome) activity	5	3
GO:0005488	binding	1	13
GO:0008720	D-lactate dehydrogenase activity	5	3
GO:0016491	oxidoreductase activity	2	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0016898	oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor	4	3
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0050660	flavin adenine dinucleotide binding	4	13
GO:0071949	FAD binding	5	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.389
CLV_NRD_NRD_1	133	135	PF00675	0.446
CLV_NRD_NRD_1	201	203	PF00675	0.493
CLV_NRD_NRD_1	29	31	PF00675	0.413
CLV_NRD_NRD_1	345	347	PF00675	0.337
CLV_PCSK_KEX2_1	310	312	PF00082	0.405
CLV_PCSK_KEX2_1	345	347	PF00082	0.337
CLV_PCSK_KEX2_1	427	429	PF00082	0.351
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.331
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.395
CLV_PCSK_SKI1_1	135	139	PF00082	0.406
CLV_PCSK_SKI1_1	145	149	PF00082	0.434
CLV_PCSK_SKI1_1	18	22	PF00082	0.409
CLV_PCSK_SKI1_1	186	190	PF00082	0.341
CLV_PCSK_SKI1_1	286	290	PF00082	0.315
CLV_PCSK_SKI1_1	30	34	PF00082	0.400
CLV_PCSK_SKI1_1	318	322	PF00082	0.371
CLV_PCSK_SKI1_1	424	428	PF00082	0.436
CLV_PCSK_SKI1_1	466	470	PF00082	0.301
DEG_SIAH_1	61	69	PF03145	0.337
DOC_CKS1_1	187	192	PF01111	0.337
DOC_CKS1_1	87	92	PF01111	0.337
DOC_MAPK_gen_1	202	210	PF00069	0.464
DOC_MAPK_gen_1	424	432	PF00069	0.455
DOC_MAPK_MEF2A_6	179	187	PF00069	0.337
DOC_PP2B_LxvP_1	405	408	PF13499	0.389
DOC_USP7_MATH_1	244	248	PF00917	0.424
DOC_USP7_MATH_1	251	255	PF00917	0.362
DOC_USP7_MATH_1	280	284	PF00917	0.454
DOC_USP7_MATH_1	352	356	PF00917	0.376
DOC_USP7_UBL2_3	321	325	PF12436	0.430
DOC_USP7_UBL2_3	34	38	PF12436	0.442
DOC_USP7_UBL2_3	387	391	PF12436	0.393
DOC_WW_Pin1_4	186	191	PF00397	0.337
DOC_WW_Pin1_4	86	91	PF00397	0.337
LIG_14-3-3_CanoR_1	140	149	PF00244	0.389
LIG_14-3-3_CanoR_1	202	210	PF00244	0.464
LIG_14-3-3_CanoR_1	345	353	PF00244	0.453
LIG_14-3-3_CanoR_1	356	363	PF00244	0.292
LIG_BRCT_BRCA1_1	116	120	PF00533	0.315
LIG_FHA_1	110	116	PF00498	0.337
LIG_FHA_1	195	201	PF00498	0.421
LIG_FHA_1	218	224	PF00498	0.350
LIG_FHA_1	357	363	PF00498	0.372
LIG_FHA_1	373	379	PF00498	0.354
LIG_FHA_1	421	427	PF00498	0.389
LIG_FHA_2	12	18	PF00498	0.478
LIG_FHA_2	175	181	PF00498	0.339
LIG_FHA_2	298	304	PF00498	0.329
LIG_FHA_2	379	385	PF00498	0.381
LIG_FHA_2	434	440	PF00498	0.315
LIG_FHA_2	93	99	PF00498	0.373
LIG_Integrin_RGD_1	191	193	PF01839	0.315
LIG_LIR_Gen_1	312	320	PF02991	0.280
LIG_LIR_Gen_1	400	409	PF02991	0.412
LIG_LIR_LC3C_4	37	42	PF02991	0.390
LIG_LIR_Nem_3	226	232	PF02991	0.453
LIG_LIR_Nem_3	312	316	PF02991	0.337
LIG_LIR_Nem_3	317	323	PF02991	0.337
LIG_LIR_Nem_3	400	406	PF02991	0.422
LIG_SH2_NCK_1	380	384	PF00017	0.331
LIG_SH2_SRC	313	316	PF00017	0.299
LIG_SH2_STAP1	22	26	PF00017	0.392
LIG_SH2_STAT3	481	484	PF00017	0.402
LIG_SH2_STAT5	214	217	PF00017	0.359
LIG_SH2_STAT5	284	287	PF00017	0.369
LIG_SH2_STAT5	315	318	PF00017	0.486
LIG_SH2_STAT5	331	334	PF00017	0.397
LIG_SH2_STAT5	380	383	PF00017	0.389
LIG_SH3_3	184	190	PF00018	0.337
LIG_SH3_3	364	370	PF00018	0.372
LIG_SH3_3	84	90	PF00018	0.337
LIG_SUMO_SIM_anti_2	72	79	PF11976	0.348
LIG_SUMO_SIM_par_1	293	298	PF11976	0.297
LIG_SUMO_SIM_par_1	43	51	PF11976	0.597
LIG_TRAF2_1	14	17	PF00917	0.510
LIG_TRAF2_1	70	73	PF00917	0.389
LIG_TRFH_1	229	233	PF08558	0.416
LIG_UBA3_1	46	52	PF00899	0.393
MOD_CDK_SPK_2	186	191	PF00069	0.331
MOD_CDK_SPK_2	86	91	PF00069	0.372
MOD_CK1_1	155	161	PF00069	0.343
MOD_CK1_1	168	174	PF00069	0.245
MOD_CK1_1	217	223	PF00069	0.351
MOD_CK1_1	372	378	PF00069	0.338
MOD_CK2_1	11	17	PF00069	0.495
MOD_CK2_1	174	180	PF00069	0.337
MOD_CK2_1	203	209	PF00069	0.455
MOD_CK2_1	331	337	PF00069	0.403
MOD_CK2_1	378	384	PF00069	0.340
MOD_CK2_1	433	439	PF00069	0.315
MOD_CK2_1	48	54	PF00069	0.462
MOD_CK2_1	66	72	PF00069	0.266
MOD_CK2_1	92	98	PF00069	0.337
MOD_DYRK1A_RPxSP_1	186	190	PF00069	0.372
MOD_GlcNHglycan	165	168	PF01048	0.347
MOD_GlcNHglycan	205	208	PF01048	0.486
MOD_GlcNHglycan	237	240	PF01048	0.371
MOD_GlcNHglycan	333	336	PF01048	0.403
MOD_GlcNHglycan	350	353	PF01048	0.512
MOD_GlcNHglycan	436	439	PF01048	0.340
MOD_GSK3_1	109	116	PF00069	0.434
MOD_GSK3_1	161	168	PF00069	0.330
MOD_GSK3_1	231	238	PF00069	0.381
MOD_GSK3_1	280	287	PF00069	0.382
MOD_GSK3_1	340	347	PF00069	0.443
MOD_GSK3_1	348	355	PF00069	0.389
MOD_GSK3_1	48	55	PF00069	0.400
MOD_LATS_1	354	360	PF00433	0.226
MOD_N-GLC_2	124	126	PF02516	0.372
MOD_NEK2_1	162	167	PF00069	0.366
MOD_NEK2_1	208	213	PF00069	0.420
MOD_NEK2_1	297	302	PF00069	0.367
MOD_NEK2_1	432	437	PF00069	0.429
MOD_NEK2_2	169	174	PF00069	0.337
MOD_NEK2_2	344	349	PF00069	0.449
MOD_PIKK_1	208	214	PF00454	0.412
MOD_PKA_1	202	208	PF00069	0.475
MOD_PKA_2	201	207	PF00069	0.469
MOD_PKA_2	344	350	PF00069	0.454
MOD_Plk_1	208	214	PF00069	0.412
MOD_Plk_4	263	269	PF00069	0.364
MOD_ProDKin_1	186	192	PF00069	0.337
MOD_ProDKin_1	86	92	PF00069	0.337
MOD_SUMO_rev_2	417	426	PF00179	0.373
TRG_ENDOCYTIC_2	242	245	PF00928	0.389
TRG_ENDOCYTIC_2	313	316	PF00928	0.429
TRG_ENDOCYTIC_2	480	483	PF00928	0.301
TRG_ER_diArg_1	258	261	PF00400	0.389
TRG_PTS1	490	493	PF00515	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q0	Leptomonas seymouri	25%	95%
A0A0N1PE88	Leptomonas seymouri	75%	99%
A0A0N1PEY1	Leptomonas seymouri	24%	79%
A0A0S4IT80	Bodo saltans	24%	100%
A0A0S4JD99	Bodo saltans	54%	100%
A0A0S4JV88	Bodo saltans	24%	78%
A0A1X0NXE7	Trypanosomatidae	25%	95%
A0A1X0P026	Trypanosomatidae	66%	100%
A0A1X0P2J0	Trypanosomatidae	23%	80%
A0A3Q8IDH3	Leishmania donovani	61%	100%
A0A3Q8IDH5	Leishmania donovani	99%	100%
A0A3Q8IEJ5	Leishmania donovani	24%	95%
A0A3Q8IRN9	Leishmania donovani	22%	79%
A0A422N649	Trypanosoma rangeli	22%	80%
A0A422N8Z9	Trypanosoma rangeli	26%	95%
A1L258	Danio rerio	25%	92%
A4HCV1	Leishmania braziliensis	25%	94%
A4HFX9	Leishmania braziliensis	87%	100%
A4HHV7	Leishmania braziliensis	23%	79%
A4I0D2	Leishmania infantum	24%	95%
A4I309	Leishmania infantum	99%	100%
A4I481	Leishmania infantum	61%	100%
A4I507	Leishmania infantum	22%	79%
A4VGK4	Pseudomonas stutzeri (strain A1501)	27%	100%
B8B7X6	Oryza sativa subsp. indica	26%	88%
C9ZQF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	80%
D4MUV9	Anaerostipes hadrus	33%	100%
E9ADN0	Leishmania major	61%	100%
E9AM50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9AW96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	95%
E9AZA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B0D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	79%
F1QXM5	Danio rerio	34%	99%
H6LBS1	Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)	28%	100%
O23240	Arabidopsis thaliana	23%	88%
O29853	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	31%	100%
O45218	Caenorhabditis elegans	25%	83%
O96759	Dictyostelium discoideum	24%	81%
O97157	Trypanosoma brucei brucei	22%	80%
P0AEP9	Escherichia coli (strain K12)	30%	99%
P0AEQ0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	99%
P0DV35	Xanthomonas citri pv. viticola (strain LMG 965 / NCPPB 2475 / ICMP 3867 / CFBP 7660)	28%	100%
P32891	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	84%
P39976	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	99%
P46681	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	93%
P84850	Rattus norvegicus	24%	92%
P94535	Bacillus subtilis (strain 168)	31%	100%
P9WIT0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WIT1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q12627	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	86%
Q1JPD3	Bos taurus	25%	91%
Q46911	Escherichia coli (strain K12)	25%	100%
Q4QB82	Leishmania major	23%	95%
Q7TNG8	Mus musculus	35%	100%
Q7XI14	Oryza sativa subsp. japonica	26%	88%
Q7YWB6	Leishmania major	22%	79%
Q86WU2	Homo sapiens	34%	97%
Q8CIM3	Mus musculus	24%	92%
Q8N465	Homo sapiens	25%	95%
Q8X7S0	Escherichia coli O157:H7	25%	100%
Q94AX4	Arabidopsis thaliana	33%	87%
Q9C1X2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	94%
V5BCB2	Trypanosoma cruzi	23%	80%
V5D7M3	Trypanosoma cruzi	24%	98%