Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADI1_LEIMA

TriTrypDb:

LmjF.27.2010 , LMJLV39_270027500 , LMJSD75_270027400

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	128	132	PF00082	0.509
CLV_PCSK_KEX2_1	130	132	PF00082	0.614
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.510
CLV_PCSK_SKI1_1	130	134	PF00082	0.507
CLV_PCSK_SKI1_1	176	180	PF00082	0.419
CLV_PCSK_SKI1_1	50	54	PF00082	0.660
DEG_APCC_DBOX_1	163	171	PF00400	0.505
DOC_PP2B_LxvP_1	15	18	PF13499	0.614
DOC_USP7_MATH_1	178	182	PF00917	0.580
DOC_USP7_MATH_1	2	6	PF00917	0.626
DOC_USP7_MATH_1	20	24	PF00917	0.482
DOC_USP7_MATH_1	206	210	PF00917	0.596
DOC_USP7_MATH_1	61	65	PF00917	0.656
DOC_USP7_MATH_1	89	93	PF00917	0.748
DOC_WW_Pin1_4	180	185	PF00397	0.494
DOC_WW_Pin1_4	59	64	PF00397	0.656
DOC_WW_Pin1_4	77	82	PF00397	0.511
DOC_WW_Pin1_4	8	13	PF00397	0.686
LIG_14-3-3_CanoR_1	123	132	PF00244	0.497
LIG_14-3-3_CanoR_1	176	185	PF00244	0.521
LIG_FHA_2	106	112	PF00498	0.481
LIG_FHA_2	42	48	PF00498	0.513
LIG_HCF-1_HBM_1	219	222	PF13415	0.645
LIG_LIR_Apic_2	219	225	PF02991	0.644
LIG_SH2_CRK	222	226	PF00017	0.646
LIG_SH2_STAP1	149	153	PF00017	0.492
LIG_SH2_STAT3	115	118	PF00017	0.468
LIG_SH2_STAT5	115	118	PF00017	0.468
LIG_SH2_STAT5	230	233	PF00017	0.800
LIG_SH2_STAT5	30	33	PF00017	0.609
LIG_SH2_STAT5	43	46	PF00017	0.540
LIG_SH3_3	226	232	PF00018	0.649
LIG_SH3_3	70	76	PF00018	0.658
MOD_CDK_SPxxK_3	180	187	PF00069	0.496
MOD_CDK_SPxxK_3	59	66	PF00069	0.660
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.563
MOD_GlcNHglycan	145	148	PF01048	0.489
MOD_GlcNHglycan	209	212	PF01048	0.631
MOD_GlcNHglycan	222	225	PF01048	0.665
MOD_GlcNHglycan	239	242	PF01048	0.513
MOD_GlcNHglycan	85	89	PF01048	0.785
MOD_GlcNHglycan	91	94	PF01048	0.700
MOD_GSK3_1	176	183	PF00069	0.546
MOD_GSK3_1	233	240	PF00069	0.714
MOD_GSK3_1	55	62	PF00069	0.659
MOD_N-GLC_1	176	181	PF02516	0.556
MOD_N-GLC_1	207	212	PF02516	0.537
MOD_N-GLC_1	41	46	PF02516	0.642
MOD_N-GLC_2	29	31	PF02516	0.524
MOD_NEK2_1	143	148	PF00069	0.362
MOD_NEK2_1	41	46	PF00069	0.642
MOD_PIKK_1	61	67	PF00454	0.659
MOD_PKA_1	130	136	PF00069	0.508
MOD_PKA_2	130	136	PF00069	0.596
MOD_PKA_2	206	212	PF00069	0.515
MOD_Plk_1	207	213	PF00069	0.533
MOD_Plk_2-3	105	111	PF00069	0.481
MOD_Plk_4	105	111	PF00069	0.481
MOD_ProDKin_1	180	186	PF00069	0.499
MOD_ProDKin_1	59	65	PF00069	0.658
MOD_ProDKin_1	77	83	PF00069	0.511
MOD_ProDKin_1	8	14	PF00069	0.684
TRG_DiLeu_BaEn_3	168	174	PF01217	0.378
TRG_ER_diArg_1	164	167	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0X1	Leishmania donovani	87%	100%
A4I308	Leishmania infantum	88%	100%
E9AZA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%