GMP_PDE_delta domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GMP-PDE, delta subunit, putative

Species:

Leishmania major

UniProt:

E9ADI0_LEIMA

TriTrypDb:

LmjF.27.2000 , LMJLV39_270027400 , LMJSD75_270027300

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	yes	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2

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Expansion

Sequence features

E9ADI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADI0

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0033036	macromolecule localization	2	2

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008289	lipid binding	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.605
CLV_NRD_NRD_1	93	95	PF00675	0.319
CLV_PCSK_SKI1_1	101	105	PF00082	0.317
CLV_PCSK_SKI1_1	124	128	PF00082	0.339
CLV_PCSK_SKI1_1	46	50	PF00082	0.315
DOC_CYCLIN_RxL_1	40	53	PF00134	0.569
DOC_PP1_RVXF_1	44	50	PF00149	0.499
DOC_PP1_RVXF_1	99	105	PF00149	0.518
DOC_PP4_FxxP_1	137	140	PF00568	0.504
DOC_PP4_FxxP_1	14	17	PF00568	0.447

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF99	Leptomonas seymouri	86%	100%
A0A0S4IN63	Bodo saltans	61%	92%
A0A1X0NR59	Trypanosomatidae	61%	100%
A0A3Q8IHR5	Leishmania donovani	97%	100%
A0A3R7R7R0	Trypanosoma rangeli	65%	100%
A4HFX7	Leishmania braziliensis	88%	100%
A4I307	Leishmania infantum	97%	100%
A6NIH7	Homo sapiens	47%	78%
C9ZJG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AZA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%

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