Putative small nuclear ribonucleoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein protein, putative

Species:

Leishmania major

UniProt:

E9ADH7_LEIMA

TriTrypDb:

LmjF.27.1970 , LMJLV39_270027000 , LMJSD75_270027000

Length:

111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005681	spliceosomal complex	3	2
GO:0005682	U5 snRNP	5	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005685	U1 snRNP	5	2
GO:0005686	U2 snRNP	5	2
GO:0005687	U4 snRNP	5	2
GO:0005737	cytoplasm	2	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	2
GO:0071004	U2-type prespliceosome	5	2
GO:0071010	prespliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0097526	spliceosomal tri-snRNP complex	5	2
GO:0110165	cellular anatomical entity	1	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

E9ADH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADH7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.624
CLV_PCSK_KEX2_1	106	108	PF00082	0.565
CLV_PCSK_KEX2_1	60	62	PF00082	0.355
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.580
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.355
CLV_PCSK_SKI1_1	22	26	PF00082	0.275
CLV_PCSK_SKI1_1	98	102	PF00082	0.678
DOC_CDC14_PxL_1	93	101	PF14671	0.469
DOC_CYCLIN_RxL_1	22	32	PF00134	0.511
DOC_MAPK_gen_1	60	68	PF00069	0.513
DOC_MAPK_HePTP_8	66	78	PF00069	0.494
DOC_MAPK_MEF2A_6	60	67	PF00069	0.560
DOC_MAPK_MEF2A_6	69	78	PF00069	0.480
DOC_MAPK_NFAT4_5	60	68	PF00069	0.560
DOC_PP1_RVXF_1	25	32	PF00149	0.511
LIG_Clathr_ClatBox_1	28	32	PF01394	0.532
LIG_FHA_1	23	29	PF00498	0.507
LIG_SH2_CRK	4	8	PF00017	0.566
LIG_SH2_STAT5	4	7	PF00017	0.532
LIG_SUMO_SIM_anti_2	75	83	PF11976	0.648
LIG_SUMO_SIM_par_1	71	77	PF11976	0.486
LIG_TRAF2_1	42	45	PF00917	0.560
LIG_UBA3_1	6	12	PF00899	0.518
MOD_GlcNHglycan	86	89	PF01048	0.622
MOD_Plk_4	2	8	PF00069	0.503
MOD_Plk_4	74	80	PF00069	0.501
TRG_ENDOCYTIC_2	4	7	PF00928	0.570
TRG_ER_diLys_1	106	111	PF00400	0.659
TRG_NLS_MonoCore_2	105	110	PF00514	0.722
TRG_NLS_MonoExtN_4	106	111	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y3	Leptomonas seymouri	79%	100%
A0A0S4J6U1	Bodo saltans	50%	100%
A0A1X0NSU4	Trypanosomatidae	58%	100%
A0A3Q8IEE4	Leishmania donovani	97%	100%
A0A3R7MNH5	Trypanosoma rangeli	58%	97%
A4HFX2	Leishmania braziliensis	92%	100%
A4I304	Leishmania infantum	97%	100%
C9ZJF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AZA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P91918	Caenorhabditis elegans	43%	69%
Q10163	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	76%
Q9BRA0	Homo sapiens	36%	89%
Q9D2U5	Mus musculus	36%	89%