Intraflagellar transport protein 43

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Intraflagellar transport protein 43, putative

Species:

Leishmania major

UniProt:

E9ADH6_LEIMA

TriTrypDb:

LmjF.27.1960 , LMJLV39_270026900 , LMJSD75_270026900

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	3
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3
GO:0031514	motile cilium	5	1

Expansion

Sequence features

E9ADH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.620
CLV_C14_Caspase3-7	257	261	PF00656	0.576
CLV_NRD_NRD_1	129	131	PF00675	0.799
CLV_NRD_NRD_1	132	134	PF00675	0.749
CLV_NRD_NRD_1	291	293	PF00675	0.699
CLV_NRD_NRD_1	342	344	PF00675	0.665
CLV_NRD_NRD_1	377	379	PF00675	0.653
CLV_PCSK_FUR_1	130	134	PF00082	0.729
CLV_PCSK_KEX2_1	123	125	PF00082	0.794
CLV_PCSK_KEX2_1	129	131	PF00082	0.781
CLV_PCSK_KEX2_1	132	134	PF00082	0.731
CLV_PCSK_KEX2_1	290	292	PF00082	0.704
CLV_PCSK_KEX2_1	295	297	PF00082	0.675
CLV_PCSK_KEX2_1	379	381	PF00082	0.677
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.578
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.690
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.677
CLV_PCSK_PC7_1	291	297	PF00082	0.570
CLV_PCSK_SKI1_1	144	148	PF00082	0.539
DEG_SPOP_SBC_1	36	40	PF00917	0.647
DEG_SPOP_SBC_1	366	370	PF00917	0.647
DEG_SPOP_SBC_1	372	376	PF00917	0.597
DEG_SPOP_SBC_1	400	404	PF00917	0.644
DOC_CDC14_PxL_1	28	36	PF14671	0.550
DOC_USP7_MATH_1	12	16	PF00917	0.681
DOC_USP7_MATH_1	27	31	PF00917	0.617
DOC_USP7_MATH_1	336	340	PF00917	0.662
DOC_USP7_MATH_1	353	357	PF00917	0.541
DOC_USP7_MATH_1	367	371	PF00917	0.575
DOC_USP7_MATH_1	372	376	PF00917	0.536
DOC_USP7_MATH_1	382	386	PF00917	0.650
DOC_USP7_MATH_1	400	404	PF00917	0.531
DOC_USP7_MATH_1	423	427	PF00917	0.601
DOC_USP7_MATH_1	50	54	PF00917	0.780
DOC_USP7_MATH_1	83	87	PF00917	0.785
DOC_USP7_MATH_1	91	95	PF00917	0.705
DOC_USP7_UBL2_3	320	324	PF12436	0.728
DOC_USP7_UBL2_3	340	344	PF12436	0.664
DOC_USP7_UBL2_3	427	431	PF12436	0.667
DOC_WW_Pin1_4	15	20	PF00397	0.710
DOC_WW_Pin1_4	192	197	PF00397	0.582
DOC_WW_Pin1_4	326	331	PF00397	0.720
DOC_WW_Pin1_4	37	42	PF00397	0.696
DOC_WW_Pin1_4	72	77	PF00397	0.719
LIG_14-3-3_CanoR_1	190	199	PF00244	0.494
LIG_14-3-3_CanoR_1	220	228	PF00244	0.552
LIG_14-3-3_CanoR_1	296	306	PF00244	0.676
LIG_14-3-3_CanoR_1	343	350	PF00244	0.662
LIG_14-3-3_CanoR_1	43	48	PF00244	0.738
LIG_14-3-3_CanoR_1	92	96	PF00244	0.726
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BRCT_BRCA1_1	136	140	PF00533	0.685
LIG_BRCT_BRCA1_1	425	429	PF00533	0.620
LIG_BRCT_BRCA1_2	425	431	PF00533	0.620
LIG_FHA_1	230	236	PF00498	0.591
LIG_FHA_2	282	288	PF00498	0.691
LIG_FHA_2	312	318	PF00498	0.660
LIG_FHA_2	344	350	PF00498	0.659
LIG_LIR_Gen_1	212	222	PF02991	0.563
LIG_LIR_Nem_3	212	218	PF02991	0.574
LIG_LIR_Nem_3	270	275	PF02991	0.661
LIG_SH2_PTP2	272	275	PF00017	0.660
LIG_SH2_SRC	272	275	PF00017	0.660
LIG_SH2_STAT5	272	275	PF00017	0.660
LIG_SH3_2	61	66	PF14604	0.673
LIG_SH3_3	58	64	PF00018	0.672
MOD_CDC14_SPxK_1	18	21	PF00782	0.655
MOD_CDC14_SPxK_1	40	43	PF00782	0.646
MOD_CDK_SPxK_1	15	21	PF00069	0.662
MOD_CDK_SPxK_1	37	43	PF00069	0.649
MOD_CK1_1	15	21	PF00069	0.632
MOD_CK1_1	229	235	PF00069	0.589
MOD_CK1_1	297	303	PF00069	0.654
MOD_CK1_1	368	374	PF00069	0.698
MOD_CK1_1	37	43	PF00069	0.748
MOD_CK1_1	401	407	PF00069	0.672
MOD_CK1_1	415	421	PF00069	0.547
MOD_CK1_1	46	52	PF00069	0.735
MOD_CK1_1	53	59	PF00069	0.668
MOD_CK2_1	281	287	PF00069	0.683
MOD_CK2_1	311	317	PF00069	0.668
MOD_CK2_1	84	90	PF00069	0.603
MOD_Cter_Amidation	121	124	PF01082	0.677
MOD_Cter_Amidation	127	130	PF01082	0.675
MOD_GlcNHglycan	120	123	PF01048	0.704
MOD_GlcNHglycan	29	32	PF01048	0.769
MOD_GlcNHglycan	380	383	PF01048	0.729
MOD_GlcNHglycan	386	389	PF01048	0.670
MOD_GlcNHglycan	390	393	PF01048	0.630
MOD_GlcNHglycan	408	411	PF01048	0.545
MOD_GlcNHglycan	52	55	PF01048	0.637
MOD_GSK3_1	104	111	PF00069	0.653
MOD_GSK3_1	114	121	PF00069	0.552
MOD_GSK3_1	190	197	PF00069	0.643
MOD_GSK3_1	226	233	PF00069	0.615
MOD_GSK3_1	32	39	PF00069	0.703
MOD_GSK3_1	367	374	PF00069	0.711
MOD_GSK3_1	378	385	PF00069	0.619
MOD_GSK3_1	395	402	PF00069	0.554
MOD_GSK3_1	406	413	PF00069	0.654
MOD_GSK3_1	423	430	PF00069	0.489
MOD_GSK3_1	46	53	PF00069	0.719
MOD_N-GLC_1	108	113	PF02516	0.648
MOD_N-GLC_1	372	377	PF02516	0.697
MOD_N-GLC_1	395	400	PF02516	0.672
MOD_N-GLC_1	50	55	PF02516	0.596
MOD_NEK2_1	1	6	PF00069	0.717
MOD_NEK2_1	199	204	PF00069	0.693
MOD_NEK2_1	209	214	PF00069	0.527
MOD_NEK2_1	226	231	PF00069	0.413
MOD_NEK2_1	34	39	PF00069	0.727
MOD_PKA_1	295	301	PF00069	0.677
MOD_PKA_1	343	349	PF00069	0.665
MOD_PKA_1	378	384	PF00069	0.656
MOD_PKA_2	295	301	PF00069	0.677
MOD_PKA_2	360	366	PF00069	0.670
MOD_PKA_2	91	97	PF00069	0.722
MOD_PKA_2	98	104	PF00069	0.643
MOD_Plk_1	134	140	PF00069	0.543
MOD_Plk_1	226	232	PF00069	0.588
MOD_Plk_2-3	135	141	PF00069	0.635
MOD_Plk_4	135	141	PF00069	0.635
MOD_ProDKin_1	15	21	PF00069	0.710
MOD_ProDKin_1	192	198	PF00069	0.585
MOD_ProDKin_1	326	332	PF00069	0.716
MOD_ProDKin_1	37	43	PF00069	0.698
MOD_ProDKin_1	72	78	PF00069	0.721
MOD_SUMO_rev_2	3	13	PF00179	0.568
MOD_SUMO_rev_2	408	416	PF00179	0.661
TRG_ENDOCYTIC_2	272	275	PF00928	0.660
TRG_ER_diArg_1	129	132	PF00400	0.735
TRG_ER_diArg_1	290	292	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.743

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE97	Leishmania donovani	91%	100%
A4HFX1	Leishmania braziliensis	60%	98%
A4I303	Leishmania infantum	92%	100%
E9AZA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%