Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADH3_LEIMA

TriTrypDb:

LmjF.27.1945 , LMJLV39_270026600 , LMJSD75_270026600

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.662
CLV_NRD_NRD_1	156	158	PF00675	0.530
CLV_NRD_NRD_1	166	168	PF00675	0.429
CLV_NRD_NRD_1	19	21	PF00675	0.609
CLV_NRD_NRD_1	190	192	PF00675	0.538
CLV_PCSK_FUR_1	119	123	PF00082	0.670
CLV_PCSK_KEX2_1	121	123	PF00082	0.662
CLV_PCSK_KEX2_1	156	158	PF00082	0.530
CLV_PCSK_KEX2_1	166	168	PF00082	0.429
CLV_PCSK_KEX2_1	190	192	PF00082	0.547
CLV_PCSK_PC7_1	152	158	PF00082	0.477
CLV_PCSK_SKI1_1	157	161	PF00082	0.419
CLV_PCSK_SKI1_1	169	173	PF00082	0.458
DEG_Nend_Nbox_1	1	3	PF02207	0.583
DEG_SPOP_SBC_1	81	85	PF00917	0.642
DOC_USP7_MATH_1	53	57	PF00917	0.685
DOC_USP7_MATH_1	71	75	PF00917	0.502
DOC_USP7_MATH_1	81	85	PF00917	0.634
DOC_USP7_MATH_1	97	101	PF00917	0.654
DOC_WW_Pin1_4	67	72	PF00397	0.797
DOC_WW_Pin1_4	77	82	PF00397	0.621
LIG_14-3-3_CanoR_1	227	235	PF00244	0.471
LIG_14-3-3_CanoR_1	244	254	PF00244	0.604
LIG_14-3-3_CanoR_1	52	62	PF00244	0.602
LIG_14-3-3_CanoR_1	64	71	PF00244	0.590
LIG_FHA_1	253	259	PF00498	0.648
LIG_LIR_Apic_2	65	71	PF02991	0.563
LIG_LIR_Gen_1	248	258	PF02991	0.607
LIG_LIR_Nem_3	248	254	PF02991	0.609
LIG_SH2_CRK	16	20	PF00017	0.620
LIG_SH2_CRK	251	255	PF00017	0.514
LIG_SH2_SRC	33	36	PF00017	0.497
LIG_SH2_STAP1	216	220	PF00017	0.588
LIG_SH2_STAT5	216	219	PF00017	0.590
LIG_SH2_STAT5	68	71	PF00017	0.544
LIG_SH3_1	33	39	PF00018	0.651
LIG_SH3_3	102	108	PF00018	0.717
LIG_SH3_3	33	39	PF00018	0.651
LIG_TRFH_1	9	13	PF08558	0.650
LIG_TYR_ITIM	14	19	PF00017	0.673
LIG_WW_1	30	33	PF00397	0.556
MOD_CK1_1	46	52	PF00069	0.618
MOD_CK1_1	54	60	PF00069	0.605
MOD_CK1_1	70	76	PF00069	0.600
MOD_CK1_1	77	83	PF00069	0.584
MOD_CK1_1	84	90	PF00069	0.611
MOD_CK2_1	198	204	PF00069	0.626
MOD_CK2_1	41	47	PF00069	0.643
MOD_GlcNHglycan	123	126	PF01048	0.794
MOD_GlcNHglycan	43	46	PF01048	0.672
MOD_GlcNHglycan	53	56	PF01048	0.580
MOD_GlcNHglycan	65	68	PF01048	0.551
MOD_GlcNHglycan	76	79	PF01048	0.574
MOD_GlcNHglycan	99	102	PF01048	0.668
MOD_GSK3_1	173	180	PF00069	0.496
MOD_GSK3_1	226	233	PF00069	0.480
MOD_GSK3_1	51	58	PF00069	0.682
MOD_GSK3_1	63	70	PF00069	0.674
MOD_GSK3_1	76	83	PF00069	0.603
MOD_N-GLC_1	246	251	PF02516	0.601
MOD_NEK2_1	177	182	PF00069	0.548
MOD_NEK2_1	62	67	PF00069	0.706
MOD_PKA_1	121	127	PF00069	0.656
MOD_PKA_2	121	127	PF00069	0.656
MOD_PKA_2	226	232	PF00069	0.647
MOD_PKA_2	51	57	PF00069	0.634
MOD_PKA_2	63	69	PF00069	0.555
MOD_PKB_1	119	127	PF00069	0.662
MOD_Plk_1	173	179	PF00069	0.520
MOD_Plk_1	46	52	PF00069	0.705
MOD_ProDKin_1	67	73	PF00069	0.798
MOD_ProDKin_1	77	83	PF00069	0.621
TRG_DiLeu_BaEn_1	155	160	PF01217	0.396
TRG_DiLeu_BaEn_1	219	224	PF01217	0.522
TRG_ENDOCYTIC_2	16	19	PF00928	0.761
TRG_ENDOCYTIC_2	251	254	PF00928	0.521
TRG_ER_diArg_1	118	121	PF00400	0.673
TRG_ER_diArg_1	190	192	PF00400	0.606
TRG_ER_diArg_1	238	241	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NR64	Trypanosomatidae	29%	100%
A0A3S7X0W4	Leishmania donovani	93%	100%
A4HFW8	Leishmania braziliensis	73%	100%
A4I301	Leishmania infantum	92%	100%
E9AZ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%