Protein UL78

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein UL78

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ADH2_LEIMA

TriTrypDb:

LmjF.27.1930 , LMJLV39_270026500 , LMJSD75_270026500

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ADH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	202	204	PF00675	0.461
CLV_NRD_NRD_1	22	24	PF00675	0.411
CLV_NRD_NRD_1	281	283	PF00675	0.457
CLV_NRD_NRD_1	61	63	PF00675	0.430
CLV_NRD_NRD_1	93	95	PF00675	0.643
CLV_PCSK_FUR_1	200	204	PF00082	0.471
CLV_PCSK_KEX2_1	202	204	PF00082	0.461
CLV_PCSK_KEX2_1	22	24	PF00082	0.411
CLV_PCSK_KEX2_1	281	283	PF00082	0.457
CLV_PCSK_KEX2_1	60	62	PF00082	0.443
CLV_PCSK_SKI1_1	157	161	PF00082	0.475
CLV_PCSK_SKI1_1	22	26	PF00082	0.464
CLV_PCSK_SKI1_1	243	247	PF00082	0.589
CLV_PCSK_SKI1_1	61	65	PF00082	0.469
DEG_APCC_DBOX_1	60	68	PF00400	0.664
DOC_CDC14_PxL_1	52	60	PF14671	0.659
DOC_CKS1_1	84	89	PF01111	0.562
DOC_CYCLIN_RxL_1	154	161	PF00134	0.656
DOC_MAPK_MEF2A_6	33	40	PF00069	0.675
DOC_MAPK_MEF2A_6	7	16	PF00069	0.589
DOC_MAPK_RevD_3	79	95	PF00069	0.510
DOC_PP2B_PxIxI_1	86	92	PF00149	0.428
DOC_USP7_MATH_1	148	152	PF00917	0.692
DOC_USP7_MATH_1	238	242	PF00917	0.468
DOC_USP7_MATH_1	292	296	PF00917	0.651
DOC_WW_Pin1_4	83	88	PF00397	0.556
LIG_14-3-3_CanoR_1	147	155	PF00244	0.723
LIG_14-3-3_CanoR_1	172	180	PF00244	0.665
LIG_14-3-3_CanoR_1	22	27	PF00244	0.722
LIG_BIR_II_1	1	5	PF00653	0.740
LIG_deltaCOP1_diTrp_1	185	195	PF00928	0.662
LIG_FHA_1	49	55	PF00498	0.647
LIG_FHA_1	84	90	PF00498	0.597
LIG_FHA_2	68	74	PF00498	0.256
LIG_GBD_Chelix_1	258	266	PF00786	0.339
LIG_LIR_Gen_1	254	263	PF02991	0.366
LIG_LIR_Gen_1	43	52	PF02991	0.663
LIG_LIR_LC3C_4	43	48	PF02991	0.654
LIG_LIR_Nem_3	254	259	PF02991	0.366
LIG_LIR_Nem_3	43	48	PF02991	0.654
LIG_NRBOX	67	73	PF00104	0.423
LIG_NRBOX	77	83	PF00104	0.311
LIG_Pex14_2	252	256	PF04695	0.318
LIG_Pex14_2	263	267	PF04695	0.298
LIG_PTB_Apo_2	246	253	PF02174	0.350
LIG_SH2_CRK	103	107	PF00017	0.405
LIG_SH2_GRB2like	247	250	PF00017	0.349
LIG_SH2_NCK_1	329	333	PF00017	0.666
LIG_SH2_NCK_1	52	56	PF00017	0.661
LIG_SH2_SRC	247	250	PF00017	0.349
LIG_SH2_STAP1	235	239	PF00017	0.354
LIG_SH2_STAT3	163	166	PF00017	0.632
LIG_SH2_STAT5	268	271	PF00017	0.475
LIG_SH2_STAT5	45	48	PF00017	0.703
LIG_SH2_STAT5	96	99	PF00017	0.445
LIG_SH3_3	13	19	PF00018	0.704
LIG_SH3_3	321	327	PF00018	0.701
LIG_SH3_3	44	50	PF00018	0.659
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.368
LIG_SUMO_SIM_par_1	132	137	PF11976	0.256
LIG_TRFH_1	52	56	PF08558	0.701
LIG_Vh1_VBS_1	251	269	PF01044	0.240
MOD_CK1_1	201	207	PF00069	0.673
MOD_CK1_1	241	247	PF00069	0.446
MOD_CK1_1	345	351	PF00069	0.750
MOD_CK2_1	306	312	PF00069	0.692
MOD_CK2_1	67	73	PF00069	0.256
MOD_GlcNHglycan	1	4	PF01048	0.484
MOD_GlcNHglycan	174	177	PF01048	0.488
MOD_GlcNHglycan	240	243	PF01048	0.664
MOD_GlcNHglycan	292	295	PF01048	0.409
MOD_GlcNHglycan	301	304	PF01048	0.514
MOD_GlcNHglycan	320	323	PF01048	0.490
MOD_GlcNHglycan	329	332	PF01048	0.450
MOD_GlcNHglycan	344	347	PF01048	0.476
MOD_GSK3_1	234	241	PF00069	0.416
MOD_GSK3_1	318	325	PF00069	0.789
MOD_GSK3_1	342	349	PF00069	0.742
MOD_N-GLC_2	351	353	PF02516	0.429
MOD_NEK2_1	132	137	PF00069	0.412
MOD_NEK2_1	234	239	PF00069	0.447
MOD_NEK2_1	251	256	PF00069	0.409
MOD_OFUCOSY	347	353	PF10250	0.414
MOD_PKA_1	22	28	PF00069	0.600
MOD_PKA_2	201	207	PF00069	0.666
MOD_PKA_2	22	28	PF00069	0.657
MOD_PKA_2	290	296	PF00069	0.609
MOD_PKA_2	327	333	PF00069	0.725
MOD_Plk_4	118	124	PF00069	0.354
MOD_Plk_4	178	184	PF00069	0.645
MOD_Plk_4	251	257	PF00069	0.319
MOD_Plk_4	67	73	PF00069	0.357
MOD_ProDKin_1	83	89	PF00069	0.563
MOD_SUMO_for_1	183	186	PF00179	0.714
TRG_DiLeu_BaEn_2	247	253	PF01217	0.347
TRG_DiLeu_BaEn_2	72	78	PF01217	0.423
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.385
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.558
TRG_ENDOCYTIC_2	268	271	PF00928	0.487
TRG_ENDOCYTIC_2	277	280	PF00928	0.683
TRG_ENDOCYTIC_2	329	332	PF00928	0.647
TRG_ENDOCYTIC_2	45	48	PF00928	0.713
TRG_ENDOCYTIC_2	96	99	PF00928	0.445
TRG_ER_diArg_1	200	203	PF00400	0.669
TRG_ER_diArg_1	21	23	PF00400	0.601
TRG_ER_diArg_1	280	282	PF00400	0.689
TRG_ER_diArg_1	59	62	PF00400	0.639
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQ36	Leishmania donovani	82%	100%
A4HFW7	Leishmania braziliensis	47%	100%
A4I300	Leishmania infantum	82%	100%
E9AZ96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%