Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADH1_LEIMA

TriTrypDb:

LmjF.27.1920 , LMJLV39_270026400 , LMJSD75_270026400

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ADH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.334
CLV_NRD_NRD_1	170	172	PF00675	0.564
CLV_NRD_NRD_1	265	267	PF00675	0.360
CLV_NRD_NRD_1	336	338	PF00675	0.354
CLV_NRD_NRD_1	366	368	PF00675	0.656
CLV_NRD_NRD_1	389	391	PF00675	0.592
CLV_NRD_NRD_1	428	430	PF00675	0.661
CLV_NRD_NRD_1	437	439	PF00675	0.647
CLV_NRD_NRD_1	482	484	PF00675	0.633
CLV_NRD_NRD_1	525	527	PF00675	0.556
CLV_NRD_NRD_1	571	573	PF00675	0.333
CLV_NRD_NRD_1	601	603	PF00675	0.463
CLV_NRD_NRD_1	613	615	PF00675	0.434
CLV_NRD_NRD_1	630	632	PF00675	0.405
CLV_PCSK_FUR_1	426	430	PF00082	0.642
CLV_PCSK_FUR_1	599	603	PF00082	0.458
CLV_PCSK_FUR_1	611	615	PF00082	0.421
CLV_PCSK_KEX2_1	170	172	PF00082	0.564
CLV_PCSK_KEX2_1	265	267	PF00082	0.360
CLV_PCSK_KEX2_1	336	338	PF00082	0.351
CLV_PCSK_KEX2_1	428	430	PF00082	0.661
CLV_PCSK_KEX2_1	437	439	PF00082	0.647
CLV_PCSK_KEX2_1	482	484	PF00082	0.633
CLV_PCSK_KEX2_1	525	527	PF00082	0.556
CLV_PCSK_KEX2_1	571	573	PF00082	0.330
CLV_PCSK_KEX2_1	601	603	PF00082	0.584
CLV_PCSK_KEX2_1	613	615	PF00082	0.428
CLV_PCSK_KEX2_1	630	632	PF00082	0.406
CLV_PCSK_SKI1_1	294	298	PF00082	0.208
CLV_PCSK_SKI1_1	315	319	PF00082	0.480
CLV_PCSK_SKI1_1	476	480	PF00082	0.640
CLV_PCSK_SKI1_1	562	566	PF00082	0.292
DEG_APCC_DBOX_1	279	287	PF00400	0.549
DEG_APCC_DBOX_1	389	397	PF00400	0.352
DEG_APCC_DBOX_1	561	569	PF00400	0.319
DEG_Nend_UBRbox_3	1	3	PF02207	0.657
DOC_CDC14_PxL_1	329	337	PF14671	0.428
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	464	470	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.608
DOC_MAPK_gen_1	140	149	PF00069	0.532
DOC_MAPK_gen_1	278	285	PF00069	0.540
DOC_MAPK_MEF2A_6	143	151	PF00069	0.480
DOC_MAPK_MEF2A_6	53	62	PF00069	0.559
DOC_MAPK_MEF2A_6	544	553	PF00069	0.263
DOC_MAPK_RevD_3	469	483	PF00069	0.440
DOC_PP2B_LxvP_1	24	27	PF13499	0.584
DOC_PP2B_LxvP_1	471	474	PF13499	0.452
DOC_PP4_FxxP_1	184	187	PF00568	0.459
DOC_PP4_FxxP_1	330	333	PF00568	0.319
DOC_USP7_MATH_1	18	22	PF00917	0.706
DOC_USP7_MATH_1	225	229	PF00917	0.413
DOC_USP7_MATH_1	243	247	PF00917	0.218
DOC_USP7_MATH_1	379	383	PF00917	0.307
DOC_USP7_MATH_1	410	414	PF00917	0.411
DOC_USP7_MATH_1	458	462	PF00917	0.454
DOC_USP7_MATH_1	472	476	PF00917	0.403
DOC_USP7_MATH_1	632	636	PF00917	0.685
DOC_WW_Pin1_4	178	183	PF00397	0.445
DOC_WW_Pin1_4	252	257	PF00397	0.398
DOC_WW_Pin1_4	37	42	PF00397	0.609
DOC_WW_Pin1_4	375	380	PF00397	0.416
DOC_WW_Pin1_4	438	443	PF00397	0.453
DOC_WW_Pin1_4	463	468	PF00397	0.460
DOC_WW_Pin1_4	625	630	PF00397	0.696
DOC_WW_Pin1_4	640	645	PF00397	0.620
LIG_14-3-3_CanoR_1	174	183	PF00244	0.430
LIG_14-3-3_CanoR_1	280	286	PF00244	0.550
LIG_14-3-3_CanoR_1	294	302	PF00244	0.221
LIG_14-3-3_CanoR_1	371	376	PF00244	0.429
LIG_14-3-3_CanoR_1	418	422	PF00244	0.438
LIG_14-3-3_CanoR_1	459	467	PF00244	0.443
LIG_14-3-3_CanoR_1	631	640	PF00244	0.703
LIG_14-3-3_CanoR_1	663	672	PF00244	0.579
LIG_Actin_RPEL_3	332	351	PF02755	0.292
LIG_Actin_WH2_2	466	484	PF00022	0.379
LIG_ActinCP_TwfCPI_2	184	193	PF01115	0.461
LIG_APCC_ABBA_1	402	407	PF00400	0.352
LIG_BRCT_BRCA1_1	180	184	PF00533	0.456
LIG_BRCT_BRCA1_1	465	469	PF00533	0.386
LIG_CtBP_PxDLS_1	114	118	PF00389	0.270
LIG_EH1_1	545	553	PF00400	0.280
LIG_eIF4E_1	141	147	PF01652	0.510
LIG_eIF4E_1	546	552	PF01652	0.280
LIG_eIF4E_1	72	78	PF01652	0.319
LIG_EVH1_1	42	46	PF00568	0.661
LIG_FHA_1	208	214	PF00498	0.377
LIG_FHA_1	248	254	PF00498	0.230
LIG_FHA_1	302	308	PF00498	0.379
LIG_FHA_1	314	320	PF00498	0.217
LIG_FHA_1	322	328	PF00498	0.180
LIG_FHA_1	384	390	PF00498	0.357
LIG_FHA_1	508	514	PF00498	0.375
LIG_FHA_1	543	549	PF00498	0.326
LIG_FHA_1	578	584	PF00498	0.505
LIG_FHA_1	645	651	PF00498	0.652
LIG_FHA_1	77	83	PF00498	0.328
LIG_FHA_2	602	608	PF00498	0.590
LIG_GBD_Chelix_1	117	125	PF00786	0.292
LIG_LIR_Apic_2	181	187	PF02991	0.457
LIG_LIR_Gen_1	116	126	PF02991	0.319
LIG_LIR_Gen_1	355	366	PF02991	0.395
LIG_LIR_Gen_1	545	554	PF02991	0.280
LIG_LIR_Nem_3	116	122	PF02991	0.319
LIG_LIR_Nem_3	261	267	PF02991	0.630
LIG_LIR_Nem_3	338	344	PF02991	0.536
LIG_LIR_Nem_3	355	361	PF02991	0.247
LIG_LIR_Nem_3	465	471	PF02991	0.382
LIG_LIR_Nem_3	494	498	PF02991	0.376
LIG_LIR_Nem_3	500	504	PF02991	0.300
LIG_LIR_Nem_3	541	546	PF02991	0.332
LIG_MLH1_MIPbox_1	465	469	PF16413	0.382
LIG_PDZ_Class_1	667	672	PF00595	0.646
LIG_PTB_Apo_2	124	131	PF02174	0.279
LIG_REV1ctd_RIR_1	520	530	PF16727	0.353
LIG_SH2_CRK	358	362	PF00017	0.283
LIG_SH2_CRK	546	550	PF00017	0.280
LIG_SH2_CRK	67	71	PF00017	0.208
LIG_SH2_PTP2	72	75	PF00017	0.292
LIG_SH2_SRC	394	397	PF00017	0.403
LIG_SH2_STAP1	134	138	PF00017	0.367
LIG_SH2_STAP1	358	362	PF00017	0.283
LIG_SH2_STAP1	385	389	PF00017	0.337
LIG_SH2_STAP1	394	398	PF00017	0.308
LIG_SH2_STAP1	546	550	PF00017	0.280
LIG_SH2_STAT3	597	600	PF00017	0.606
LIG_SH2_STAT3	603	606	PF00017	0.647
LIG_SH2_STAT5	163	166	PF00017	0.279
LIG_SH2_STAT5	301	304	PF00017	0.319
LIG_SH2_STAT5	329	332	PF00017	0.319
LIG_SH2_STAT5	385	388	PF00017	0.366
LIG_SH2_STAT5	491	494	PF00017	0.364
LIG_SH2_STAT5	501	504	PF00017	0.321
LIG_SH2_STAT5	597	600	PF00017	0.564
LIG_SH2_STAT5	603	606	PF00017	0.586
LIG_SH2_STAT5	657	660	PF00017	0.622
LIG_SH2_STAT5	72	75	PF00017	0.292
LIG_SH3_3	109	115	PF00018	0.359
LIG_SH3_3	179	185	PF00018	0.434
LIG_SH3_3	20	26	PF00018	0.628
LIG_SH3_3	216	222	PF00018	0.450
LIG_SH3_3	226	232	PF00018	0.367
LIG_SH3_3	250	256	PF00018	0.319
LIG_SH3_3	38	44	PF00018	0.666
LIG_SH3_3	626	632	PF00018	0.673
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.253
LIG_SUMO_SIM_anti_2	81	86	PF11976	0.308
LIG_SUMO_SIM_par_1	315	321	PF11976	0.280
LIG_SUMO_SIM_par_1	350	355	PF11976	0.318
LIG_SUMO_SIM_par_1	54	59	PF11976	0.601
LIG_SUMO_SIM_par_1	552	559	PF11976	0.335
LIG_SUMO_SIM_par_1	74	79	PF11976	0.319
LIG_SUMO_SIM_par_1	80	86	PF11976	0.235
LIG_TRAF2_1	514	517	PF00917	0.476
LIG_TRAF2_1	604	607	PF00917	0.652
LIG_TRFH_1	329	333	PF08558	0.319
LIG_TYR_ITIM	327	332	PF00017	0.319
LIG_TYR_ITIM	70	75	PF00017	0.319
LIG_UBA3_1	56	65	PF00899	0.544
LIG_Vh1_VBS_1	62	80	PF01044	0.460
LIG_WRC_WIRS_1	259	264	PF05994	0.545
LIG_WRC_WIRS_1	322	327	PF05994	0.319
LIG_WRC_WIRS_1	87	92	PF05994	0.422
LIG_WW_2	43	46	PF00397	0.660
MOD_CDC14_SPxK_1	628	631	PF00782	0.696
MOD_CDK_SPK_2	625	630	PF00069	0.696
MOD_CDK_SPxK_1	625	631	PF00069	0.698
MOD_CK1_1	176	182	PF00069	0.425
MOD_CK1_1	199	205	PF00069	0.418
MOD_CK1_1	252	258	PF00069	0.340
MOD_CK1_1	374	380	PF00069	0.419
MOD_CK1_1	462	468	PF00069	0.450
MOD_CK1_1	93	99	PF00069	0.358
MOD_CK2_1	208	214	PF00069	0.437
MOD_CK2_1	601	607	PF00069	0.588
MOD_CK2_1	93	99	PF00069	0.350
MOD_CMANNOS	570	573	PF00535	0.356
MOD_GlcNHglycan	20	23	PF01048	0.489
MOD_GlcNHglycan	205	208	PF01048	0.616
MOD_GlcNHglycan	209	213	PF01048	0.616
MOD_GlcNHglycan	354	357	PF01048	0.319
MOD_GlcNHglycan	37	40	PF01048	0.421
MOD_GlcNHglycan	395	399	PF01048	0.572
MOD_GlcNHglycan	407	411	PF01048	0.535
MOD_GlcNHglycan	461	464	PF01048	0.644
MOD_GlcNHglycan	476	479	PF01048	0.586
MOD_GlcNHglycan	558	561	PF01048	0.319
MOD_GlcNHglycan	640	643	PF01048	0.503
MOD_GSK3_1	173	180	PF00069	0.407
MOD_GSK3_1	199	206	PF00069	0.456
MOD_GSK3_1	237	244	PF00069	0.317
MOD_GSK3_1	281	288	PF00069	0.544
MOD_GSK3_1	371	378	PF00069	0.425
MOD_GSK3_1	379	386	PF00069	0.374
MOD_GSK3_1	406	413	PF00069	0.444
MOD_GSK3_1	44	51	PF00069	0.586
MOD_GSK3_1	458	465	PF00069	0.453
MOD_GSK3_1	487	494	PF00069	0.343
MOD_GSK3_1	632	639	PF00069	0.650
MOD_GSK3_1	640	647	PF00069	0.650
MOD_GSK3_1	664	671	PF00069	0.649
MOD_GSK3_1	86	93	PF00069	0.450
MOD_N-GLC_1	485	490	PF02516	0.601
MOD_N-GLC_1	507	512	PF02516	0.593
MOD_N-GLC_1	90	95	PF02516	0.508
MOD_NEK2_1	117	122	PF00069	0.319
MOD_NEK2_1	234	239	PF00069	0.312
MOD_NEK2_1	247	252	PF00069	0.238
MOD_NEK2_1	307	312	PF00069	0.348
MOD_NEK2_1	318	323	PF00069	0.243
MOD_NEK2_1	335	340	PF00069	0.488
MOD_NEK2_1	417	422	PF00069	0.428
MOD_NEK2_1	555	560	PF00069	0.319
MOD_NEK2_1	78	83	PF00069	0.318
MOD_NEK2_1	90	95	PF00069	0.297
MOD_NEK2_2	243	248	PF00069	0.236
MOD_NEK2_2	301	306	PF00069	0.319
MOD_NEK2_2	432	437	PF00069	0.402
MOD_NEK2_2	507	512	PF00069	0.360
MOD_PIKK_1	623	629	PF00454	0.690
MOD_PIKK_1	644	650	PF00454	0.675
MOD_PK_1	371	377	PF00069	0.428
MOD_PKA_1	601	607	PF00069	0.588
MOD_PKA_2	173	179	PF00069	0.408
MOD_PKA_2	196	202	PF00069	0.457
MOD_PKA_2	281	287	PF00069	0.548
MOD_PKA_2	335	341	PF00069	0.550
MOD_PKA_2	417	423	PF00069	0.429
MOD_PKA_2	458	464	PF00069	0.447
MOD_PKA_2	601	607	PF00069	0.588
MOD_PKB_1	599	607	PF00069	0.585
MOD_Plk_1	406	412	PF00069	0.397
MOD_Plk_1	507	513	PF00069	0.365
MOD_Plk_1	577	583	PF00069	0.504
MOD_Plk_1	90	96	PF00069	0.301
MOD_Plk_4	199	205	PF00069	0.456
MOD_Plk_4	237	243	PF00069	0.252
MOD_Plk_4	249	255	PF00069	0.284
MOD_Plk_4	281	287	PF00069	0.558
MOD_Plk_4	301	307	PF00069	0.180
MOD_Plk_4	400	406	PF00069	0.330
MOD_Plk_4	487	493	PF00069	0.343
MOD_Plk_4	78	84	PF00069	0.319
MOD_ProDKin_1	178	184	PF00069	0.446
MOD_ProDKin_1	252	258	PF00069	0.391
MOD_ProDKin_1	37	43	PF00069	0.607
MOD_ProDKin_1	375	381	PF00069	0.415
MOD_ProDKin_1	438	444	PF00069	0.452
MOD_ProDKin_1	463	469	PF00069	0.461
MOD_ProDKin_1	625	631	PF00069	0.698
MOD_ProDKin_1	640	646	PF00069	0.619
TRG_DiLeu_BaEn_1	142	147	PF01217	0.504
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.480
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.609
TRG_ENDOCYTIC_2	163	166	PF00928	0.279
TRG_ENDOCYTIC_2	259	262	PF00928	0.506
TRG_ENDOCYTIC_2	329	332	PF00928	0.319
TRG_ENDOCYTIC_2	358	361	PF00928	0.283
TRG_ENDOCYTIC_2	501	504	PF00928	0.330
TRG_ENDOCYTIC_2	546	549	PF00928	0.345
TRG_ENDOCYTIC_2	67	70	PF00928	0.319
TRG_ENDOCYTIC_2	72	75	PF00928	0.285
TRG_ER_diArg_1	264	266	PF00400	0.556
TRG_ER_diArg_1	279	282	PF00400	0.482
TRG_ER_diArg_1	335	337	PF00400	0.571
TRG_ER_diArg_1	426	429	PF00400	0.449
TRG_ER_diArg_1	436	438	PF00400	0.445
TRG_ER_diArg_1	481	483	PF00400	0.441
TRG_ER_diArg_1	525	527	PF00400	0.356
TRG_ER_diArg_1	570	572	PF00400	0.533
TRG_ER_diArg_1	599	602	PF00400	0.655
TRG_ER_diArg_1	611	614	PF00400	0.632
TRG_ER_diArg_1	629	631	PF00400	0.597
TRG_ER_diArg_1	660	663	PF00400	0.551
TRG_NES_CRM1_1	281	293	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JPF7	Bodo saltans	21%	100%
A0A3S7X0W2	Leishmania donovani	90%	100%
A4I2Z9	Leishmania infantum	90%	100%
E9AZ95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%