Golgi apparatus membrane protein TVP23 homolog

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF846), putative

Species:

Leishmania major

UniProt:

E9ADG9_LEIMA

TriTrypDb:

LmjF.27.1900 , LMJLV39_270026200 , LMJSD75_270026200

Length:

245

Annotations

LeishMANIAdb annotations

Homologous to Golgi proteins of other Eukaryotes

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ADG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADG9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0008104	protein localization	4	2
GO:0009306	protein secretion	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0032940	secretion by cell	3	2
GO:0033036	macromolecule localization	2	2
GO:0035592	establishment of protein localization to extracellular region	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046903	secretion	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071692	protein localization to extracellular region	5	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0140352	export from cell	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.351
CLV_PCSK_KEX2_1	196	198	PF00082	0.351
CLV_PCSK_SKI1_1	106	110	PF00082	0.244
CLV_PCSK_SKI1_1	86	90	PF00082	0.294
DEG_Nend_UBRbox_3	1	3	PF02207	0.594
DOC_MAPK_MEF2A_6	70	78	PF00069	0.331
DOC_MAPK_MEF2A_6	86	95	PF00069	0.294
DOC_MAPK_NFAT4_5	86	94	PF00069	0.294
DOC_USP7_MATH_1	37	41	PF00917	0.686
DOC_WW_Pin1_4	132	137	PF00397	0.425
DOC_WW_Pin1_4	32	37	PF00397	0.675
LIG_14-3-3_CanoR_1	111	117	PF00244	0.445
LIG_Actin_WH2_2	71	88	PF00022	0.294
LIG_deltaCOP1_diTrp_1	146	151	PF00928	0.402
LIG_FHA_1	103	109	PF00498	0.183
LIG_FHA_1	126	132	PF00498	0.444
LIG_FHA_1	158	164	PF00498	0.247
LIG_FHA_1	92	98	PF00498	0.331
LIG_GBD_Chelix_1	71	79	PF00786	0.303
LIG_LIR_Gen_1	160	169	PF02991	0.247
LIG_LIR_Nem_3	146	152	PF02991	0.408
LIG_LIR_Nem_3	160	164	PF02991	0.367
LIG_LIR_Nem_3	171	177	PF02991	0.244
LIG_NRBOX	74	80	PF00104	0.369
LIG_PCNA_yPIPBox_3	194	207	PF02747	0.517
LIG_Pex14_2	189	193	PF04695	0.294
LIG_Pex14_2	65	69	PF04695	0.245
LIG_PTB_Apo_2	144	151	PF02174	0.444
LIG_PTB_Apo_2	26	33	PF02174	0.559
LIG_PTB_Phospho_1	26	32	PF10480	0.557
LIG_SH2_CRK	55	59	PF00017	0.478
LIG_SH2_GRB2like	145	148	PF00017	0.444
LIG_SH2_PTP2	87	90	PF00017	0.294
LIG_SH2_SRC	174	177	PF00017	0.327
LIG_SH2_STAP1	145	149	PF00017	0.486
LIG_SH2_STAT5	10	13	PF00017	0.622
LIG_SH2_STAT5	174	177	PF00017	0.327
LIG_SH2_STAT5	192	195	PF00017	0.492
LIG_SH2_STAT5	32	35	PF00017	0.695
LIG_SH2_STAT5	87	90	PF00017	0.319
LIG_SUMO_SIM_anti_2	160	166	PF11976	0.247
LIG_SUMO_SIM_anti_2	94	99	PF11976	0.352
LIG_SUMO_SIM_par_1	88	94	PF11976	0.352
LIG_TYR_ITIM	85	90	PF00017	0.267
LIG_Vh1_VBS_1	64	82	PF01044	0.294
LIG_WRC_WIRS_1	169	174	PF05994	0.244
LIG_WRC_WIRS_1	203	208	PF05994	0.577
LIG_WRC_WIRS_1	221	226	PF05994	0.620
MOD_CK1_1	12	18	PF00069	0.633
MOD_CK2_1	131	137	PF00069	0.504
MOD_CMANNOS	148	151	PF00535	0.236
MOD_GlcNHglycan	14	17	PF01048	0.447
MOD_GlcNHglycan	184	187	PF01048	0.294
MOD_GSK3_1	102	109	PF00069	0.248
MOD_GSK3_1	202	209	PF00069	0.602
MOD_GSK3_1	229	236	PF00069	0.665
MOD_GSK3_1	37	44	PF00069	0.638
MOD_N-GLC_1	106	111	PF02516	0.202
MOD_N-GLC_1	30	35	PF02516	0.518
MOD_N-GLC_1	47	52	PF02516	0.459
MOD_NEK2_1	102	107	PF00069	0.260
MOD_NEK2_1	150	155	PF00069	0.259
MOD_NEK2_1	206	211	PF00069	0.535
MOD_NEK2_1	91	96	PF00069	0.311
MOD_PIKK_1	125	131	PF00454	0.471
MOD_PIKK_1	206	212	PF00454	0.523
MOD_Plk_4	157	163	PF00069	0.247
MOD_Plk_4	202	208	PF00069	0.575
MOD_Plk_4	220	226	PF00069	0.621
MOD_Plk_4	91	97	PF00069	0.221
MOD_ProDKin_1	132	138	PF00069	0.425
MOD_ProDKin_1	32	38	PF00069	0.674
TRG_ENDOCYTIC_2	174	177	PF00928	0.327
TRG_ENDOCYTIC_2	55	58	PF00928	0.479
TRG_ENDOCYTIC_2	87	90	PF00928	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK7	Leptomonas seymouri	61%	99%
A0A1X0NSV4	Trypanosomatidae	60%	99%
A0A3R7KD75	Trypanosoma rangeli	56%	100%
A0A3S7X0W9	Leishmania donovani	94%	100%
A4I2Z7	Leishmania infantum	95%	100%
A6NH52	Homo sapiens	38%	100%
A8N1Z1	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	36%	96%
C9ZJE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AIS7	Leishmania braziliensis	86%	100%
Q0UV43	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	36%	100%
Q18449	Caenorhabditis elegans	32%	100%
Q54LC9	Dictyostelium discoideum	39%	94%
Q5APA2	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	92%
Q6BVH1	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	100%
Q7SGB6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	100%
Q8IQC1	Drosophila melanogaster	37%	100%
Q8LEK2	Arabidopsis thaliana	37%	100%