TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADG8_LEIMA

TriTrypDb:

LmjF.27.1895 , LMJLV39_270026100 , LMJSD75_270026100

Length:

1177

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADG8

PDB structure(s): 7ane_ab

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1013	1017	PF00656	0.483
CLV_C14_Caspase3-7	202	206	PF00656	0.570
CLV_C14_Caspase3-7	828	832	PF00656	0.365
CLV_C14_Caspase3-7	849	853	PF00656	0.379
CLV_NRD_NRD_1	1026	1028	PF00675	0.393
CLV_NRD_NRD_1	330	332	PF00675	0.580
CLV_NRD_NRD_1	341	343	PF00675	0.495
CLV_NRD_NRD_1	362	364	PF00675	0.608
CLV_NRD_NRD_1	386	388	PF00675	0.408
CLV_NRD_NRD_1	399	401	PF00675	0.413
CLV_NRD_NRD_1	418	420	PF00675	0.405
CLV_NRD_NRD_1	511	513	PF00675	0.362
CLV_NRD_NRD_1	534	536	PF00675	0.358
CLV_NRD_NRD_1	690	692	PF00675	0.397
CLV_NRD_NRD_1	864	866	PF00675	0.406
CLV_NRD_NRD_1	926	928	PF00675	0.372
CLV_NRD_NRD_1	940	942	PF00675	0.397
CLV_NRD_NRD_1	948	950	PF00675	0.398
CLV_NRD_NRD_1	95	97	PF00675	0.462
CLV_PCSK_FUR_1	688	692	PF00082	0.432
CLV_PCSK_FUR_1	861	865	PF00082	0.362
CLV_PCSK_KEX2_1	1026	1028	PF00082	0.394
CLV_PCSK_KEX2_1	330	332	PF00082	0.592
CLV_PCSK_KEX2_1	362	364	PF00082	0.479
CLV_PCSK_KEX2_1	386	388	PF00082	0.528
CLV_PCSK_KEX2_1	399	401	PF00082	0.440
CLV_PCSK_KEX2_1	418	420	PF00082	0.405
CLV_PCSK_KEX2_1	511	513	PF00082	0.360
CLV_PCSK_KEX2_1	534	536	PF00082	0.358
CLV_PCSK_KEX2_1	690	692	PF00082	0.381
CLV_PCSK_KEX2_1	772	774	PF00082	0.423
CLV_PCSK_KEX2_1	863	865	PF00082	0.383
CLV_PCSK_KEX2_1	926	928	PF00082	0.378
CLV_PCSK_KEX2_1	940	942	PF00082	0.410
CLV_PCSK_KEX2_1	948	950	PF00082	0.388
CLV_PCSK_KEX2_1	95	97	PF00082	0.460
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.512
CLV_PCSK_SKI1_1	1093	1097	PF00082	0.395
CLV_PCSK_SKI1_1	1156	1160	PF00082	0.438
CLV_PCSK_SKI1_1	126	130	PF00082	0.562
CLV_PCSK_SKI1_1	140	144	PF00082	0.603
CLV_PCSK_SKI1_1	363	367	PF00082	0.481
CLV_PCSK_SKI1_1	387	391	PF00082	0.535
CLV_PCSK_SKI1_1	535	539	PF00082	0.473
CLV_PCSK_SKI1_1	620	624	PF00082	0.339
CLV_PCSK_SKI1_1	633	637	PF00082	0.369
CLV_PCSK_SKI1_1	773	777	PF00082	0.447
CLV_PCSK_SKI1_1	901	905	PF00082	0.333
CLV_PCSK_SKI1_1	999	1003	PF00082	0.385
DEG_APCC_DBOX_1	1092	1100	PF00400	0.489
DEG_APCC_DBOX_1	510	518	PF00400	0.418
DEG_APCC_DBOX_1	534	542	PF00400	0.350
DEG_SPOP_SBC_1	12	16	PF00917	0.619
DEG_SPOP_SBC_1	178	182	PF00917	0.480
DOC_CYCLIN_RxL_1	531	540	PF00134	0.511
DOC_CYCLIN_RxL_1	616	625	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.524
DOC_MAPK_DCC_7	772	780	PF00069	0.377
DOC_MAPK_gen_1	772	780	PF00069	0.398
DOC_MAPK_MEF2A_6	773	782	PF00069	0.382
DOC_PP1_RVXF_1	618	625	PF00149	0.482
DOC_PP4_FxxP_1	1126	1129	PF00568	0.434
DOC_PP4_FxxP_1	766	769	PF00568	0.539
DOC_PP4_FxxP_1	895	898	PF00568	0.369
DOC_USP7_MATH_1	107	111	PF00917	0.440
DOC_USP7_MATH_1	12	16	PF00917	0.732
DOC_USP7_MATH_1	178	182	PF00917	0.581
DOC_USP7_MATH_1	188	192	PF00917	0.579
DOC_USP7_MATH_1	744	748	PF00917	0.563
DOC_USP7_MATH_1	85	89	PF00917	0.560
DOC_USP7_MATH_1	963	967	PF00917	0.688
DOC_USP7_UBL2_3	1106	1110	PF12436	0.398
DOC_USP7_UBL2_3	1150	1154	PF12436	0.461
DOC_USP7_UBL2_3	728	732	PF12436	0.545
DOC_WW_Pin1_4	1036	1041	PF00397	0.351
DOC_WW_Pin1_4	1100	1105	PF00397	0.407
DOC_WW_Pin1_4	35	40	PF00397	0.600
DOC_WW_Pin1_4	542	547	PF00397	0.362
DOC_WW_Pin1_4	574	579	PF00397	0.308
DOC_WW_Pin1_4	773	778	PF00397	0.444
DOC_WW_Pin1_4	843	848	PF00397	0.371
DOC_WW_Pin1_4	959	964	PF00397	0.697
LIG_14-3-3_CanoR_1	1135	1142	PF00244	0.403
LIG_14-3-3_CanoR_1	114	120	PF00244	0.518
LIG_14-3-3_CanoR_1	362	366	PF00244	0.529
LIG_14-3-3_CanoR_1	386	396	PF00244	0.488
LIG_14-3-3_CanoR_1	399	406	PF00244	0.412
LIG_14-3-3_CanoR_1	433	437	PF00244	0.542
LIG_14-3-3_CanoR_1	901	906	PF00244	0.420
LIG_14-3-3_CanoR_1	985	991	PF00244	0.468
LIG_14-3-3_CanoR_1	994	1001	PF00244	0.394
LIG_ActinCP_TwfCPI_2	1126	1135	PF01115	0.434
LIG_APCC_ABBA_1	465	470	PF00400	0.439
LIG_APCC_ABBA_1	477	482	PF00400	0.414
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_BRCT_BRCA1_1	104	108	PF00533	0.439
LIG_BRCT_BRCA1_1	1065	1069	PF00533	0.415
LIG_Clathr_ClatBox_1	621	625	PF01394	0.378
LIG_deltaCOP1_diTrp_1	1005	1010	PF00928	0.439
LIG_deltaCOP1_diTrp_1	497	501	PF00928	0.315
LIG_eIF4E_1	617	623	PF01652	0.364
LIG_FHA_1	1058	1064	PF00498	0.560
LIG_FHA_1	1150	1156	PF00498	0.512
LIG_FHA_1	241	247	PF00498	0.517
LIG_FHA_1	318	324	PF00498	0.418
LIG_FHA_1	634	640	PF00498	0.470
LIG_FHA_1	717	723	PF00498	0.432
LIG_FHA_1	789	795	PF00498	0.430
LIG_FHA_1	985	991	PF00498	0.507
LIG_FHA_1	996	1002	PF00498	0.388
LIG_FHA_2	1000	1006	PF00498	0.405
LIG_FHA_2	1037	1043	PF00498	0.355
LIG_FHA_2	1111	1117	PF00498	0.413
LIG_FHA_2	306	312	PF00498	0.481
LIG_FHA_2	367	373	PF00498	0.459
LIG_FHA_2	386	392	PF00498	0.295
LIG_FHA_2	525	531	PF00498	0.380
LIG_FHA_2	543	549	PF00498	0.365
LIG_FHA_2	577	583	PF00498	0.351
LIG_FHA_2	847	853	PF00498	0.382
LIG_FHA_2	932	938	PF00498	0.391
LIG_LIR_Apic_2	435	441	PF02991	0.501
LIG_LIR_Apic_2	463	467	PF02991	0.361
LIG_LIR_Apic_2	50	55	PF02991	0.389
LIG_LIR_Gen_1	1005	1015	PF02991	0.430
LIG_LIR_Gen_1	1039	1049	PF02991	0.405
LIG_LIR_Gen_1	484	493	PF02991	0.354
LIG_LIR_Gen_1	497	506	PF02991	0.315
LIG_LIR_Nem_3	1005	1010	PF02991	0.413
LIG_LIR_Nem_3	1039	1044	PF02991	0.376
LIG_LIR_Nem_3	1066	1071	PF02991	0.430
LIG_LIR_Nem_3	1113	1117	PF02991	0.493
LIG_LIR_Nem_3	463	468	PF02991	0.404
LIG_LIR_Nem_3	484	489	PF02991	0.506
LIG_LIR_Nem_3	497	501	PF02991	0.315
LIG_LIR_Nem_3	681	686	PF02991	0.514
LIG_LIR_Nem_3	697	702	PF02991	0.558
LIG_LIR_Nem_3	792	798	PF02991	0.417
LIG_LYPXL_yS_3	76	79	PF13949	0.541
LIG_MAD2	886	894	PF02301	0.511
LIG_MLH1_MIPbox_1	1065	1069	PF16413	0.415
LIG_PCNA_yPIPBox_3	443	457	PF02747	0.365
LIG_PDZ_Class_2	1172	1177	PF00595	0.417
LIG_Pex14_1	569	573	PF04695	0.323
LIG_Pex14_1	631	635	PF04695	0.483
LIG_Pex14_1	924	928	PF04695	0.362
LIG_Pex14_2	627	631	PF04695	0.448
LIG_SH2_CRK	438	442	PF00017	0.492
LIG_SH2_CRK	650	654	PF00017	0.470
LIG_SH2_CRK	707	711	PF00017	0.546
LIG_SH2_CRK	891	895	PF00017	0.416
LIG_SH2_GRB2like	1088	1091	PF00017	0.455
LIG_SH2_GRB2like	617	620	PF00017	0.291
LIG_SH2_NCK_1	192	196	PF00017	0.521
LIG_SH2_NCK_1	650	654	PF00017	0.463
LIG_SH2_NCK_1	89	93	PF00017	0.402
LIG_SH2_NCK_1	942	946	PF00017	0.483
LIG_SH2_PTP2	573	576	PF00017	0.445
LIG_SH2_PTP2	950	953	PF00017	0.400
LIG_SH2_SRC	908	911	PF00017	0.396
LIG_SH2_SRC	950	953	PF00017	0.385
LIG_SH2_STAP1	1088	1092	PF00017	0.518
LIG_SH2_STAP1	211	215	PF00017	0.444
LIG_SH2_STAP1	89	93	PF00017	0.450
LIG_SH2_STAT3	1029	1032	PF00017	0.493
LIG_SH2_STAT3	59	62	PF00017	0.387
LIG_SH2_STAT3	671	674	PF00017	0.472
LIG_SH2_STAT3	890	893	PF00017	0.371
LIG_SH2_STAT5	1029	1032	PF00017	0.399
LIG_SH2_STAT5	1034	1037	PF00017	0.350
LIG_SH2_STAT5	1038	1041	PF00017	0.347
LIG_SH2_STAT5	1067	1070	PF00017	0.412
LIG_SH2_STAT5	1084	1087	PF00017	0.363
LIG_SH2_STAT5	192	195	PF00017	0.640
LIG_SH2_STAT5	397	400	PF00017	0.424
LIG_SH2_STAT5	464	467	PF00017	0.360
LIG_SH2_STAT5	573	576	PF00017	0.395
LIG_SH2_STAT5	659	662	PF00017	0.456
LIG_SH2_STAT5	671	674	PF00017	0.333
LIG_SH2_STAT5	692	695	PF00017	0.458
LIG_SH2_STAT5	765	768	PF00017	0.510
LIG_SH2_STAT5	826	829	PF00017	0.317
LIG_SH2_STAT5	950	953	PF00017	0.385
LIG_SH3_2	546	551	PF14604	0.491
LIG_SH3_2	856	861	PF14604	0.504
LIG_SH3_3	18	24	PF00018	0.748
LIG_SH3_3	269	275	PF00018	0.589
LIG_SH3_3	36	42	PF00018	0.435
LIG_SH3_3	543	549	PF00018	0.472
LIG_SH3_3	6	12	PF00018	0.627
LIG_SH3_3	853	859	PF00018	0.424
LIG_SH3_3	950	956	PF00018	0.402
LIG_SUMO_SIM_anti_2	513	518	PF11976	0.498
LIG_SUMO_SIM_par_1	1019	1024	PF11976	0.378
LIG_SUMO_SIM_par_1	721	727	PF11976	0.461
LIG_SUMO_SIM_par_1	798	803	PF11976	0.299
LIG_TRAF2_1	1045	1048	PF00917	0.364
LIG_TRAF2_1	278	281	PF00917	0.480
LIG_TRAF2_1	309	312	PF00917	0.519
LIG_TRAF2_1	839	842	PF00917	0.479
LIG_TRAF2_2	247	252	PF00917	0.407
LIG_WRPW_2	465	468	PF00400	0.388
MOD_CDK_SPxK_1	1100	1106	PF00069	0.421
MOD_CK1_1	181	187	PF00069	0.697
MOD_CK1_1	3	9	PF00069	0.780
MOD_CK1_1	747	753	PF00069	0.620
MOD_CK1_1	771	777	PF00069	0.543
MOD_CK1_1	784	790	PF00069	0.496
MOD_CK1_1	846	852	PF00069	0.382
MOD_CK1_1	962	968	PF00069	0.664
MOD_CK2_1	1036	1042	PF00069	0.367
MOD_CK2_1	1110	1116	PF00069	0.411
MOD_CK2_1	119	125	PF00069	0.510
MOD_CK2_1	196	202	PF00069	0.573
MOD_CK2_1	274	280	PF00069	0.466
MOD_CK2_1	305	311	PF00069	0.511
MOD_CK2_1	366	372	PF00069	0.447
MOD_CK2_1	442	448	PF00069	0.384
MOD_CK2_1	524	530	PF00069	0.381
MOD_CK2_1	576	582	PF00069	0.344
MOD_Cter_Amidation	688	691	PF01082	0.465
MOD_GlcNHglycan	1136	1139	PF01048	0.546
MOD_GlcNHglycan	140	143	PF01048	0.601
MOD_GlcNHglycan	157	160	PF01048	0.360
MOD_GlcNHglycan	198	201	PF01048	0.585
MOD_GlcNHglycan	2	5	PF01048	0.780
MOD_GlcNHglycan	332	335	PF01048	0.544
MOD_GlcNHglycan	731	735	PF01048	0.572
MOD_GlcNHglycan	783	786	PF01048	0.437
MOD_GlcNHglycan	795	798	PF01048	0.360
MOD_GlcNHglycan	801	805	PF01048	0.328
MOD_GlcNHglycan	81	84	PF01048	0.574
MOD_GlcNHglycan	965	968	PF01048	0.609
MOD_GSK3_1	1063	1070	PF00069	0.399
MOD_GSK3_1	155	162	PF00069	0.481
MOD_GSK3_1	177	184	PF00069	0.576
MOD_GSK3_1	428	435	PF00069	0.456
MOD_GSK3_1	576	583	PF00069	0.545
MOD_GSK3_1	744	751	PF00069	0.712
MOD_GSK3_1	784	791	PF00069	0.534
MOD_GSK3_1	81	88	PF00069	0.636
MOD_GSK3_1	959	966	PF00069	0.627
MOD_GSK3_1	986	993	PF00069	0.469
MOD_GSK3_1	995	1002	PF00069	0.395
MOD_LATS_1	328	334	PF00433	0.505
MOD_N-GLC_1	1071	1076	PF02516	0.507
MOD_N-GLC_1	145	150	PF02516	0.475
MOD_N-GLC_1	306	311	PF02516	0.547
MOD_N-GLC_1	524	529	PF02516	0.425
MOD_NEK2_1	1010	1015	PF00069	0.426
MOD_NEK2_1	1021	1026	PF00069	0.362
MOD_NEK2_1	1071	1076	PF00069	0.507
MOD_NEK2_1	155	160	PF00069	0.498
MOD_NEK2_1	240	245	PF00069	0.499
MOD_NEK2_1	449	454	PF00069	0.497
MOD_NEK2_1	723	728	PF00069	0.463
MOD_NEK2_1	79	84	PF00069	0.554
MOD_NEK2_1	800	805	PF00069	0.469
MOD_NEK2_1	986	991	PF00069	0.415
MOD_PIKK_1	107	113	PF00454	0.460
MOD_PIKK_1	127	133	PF00454	0.540
MOD_PIKK_1	826	832	PF00454	0.324
MOD_PK_1	1019	1025	PF00069	0.381
MOD_PKA_1	330	336	PF00069	0.507
MOD_PKA_1	366	372	PF00069	0.447
MOD_PKA_1	399	405	PF00069	0.459
MOD_PKA_2	113	119	PF00069	0.494
MOD_PKA_2	1134	1140	PF00069	0.414
MOD_PKA_2	155	161	PF00069	0.556
MOD_PKA_2	241	247	PF00069	0.460
MOD_PKA_2	330	336	PF00069	0.457
MOD_PKA_2	361	367	PF00069	0.535
MOD_PKA_2	385	391	PF00069	0.467
MOD_PKA_2	398	404	PF00069	0.409
MOD_PKA_2	432	438	PF00069	0.481
MOD_PKA_2	984	990	PF00069	0.511
MOD_PKA_2	995	1001	PF00069	0.388
MOD_Plk_1	1071	1077	PF00069	0.509
MOD_Plk_1	145	151	PF00069	0.476
MOD_Plk_1	931	937	PF00069	0.407
MOD_Plk_4	1063	1069	PF00069	0.419
MOD_Plk_4	576	582	PF00069	0.344
MOD_Plk_4	753	759	PF00069	0.553
MOD_ProDKin_1	1036	1042	PF00069	0.352
MOD_ProDKin_1	1100	1106	PF00069	0.406
MOD_ProDKin_1	35	41	PF00069	0.600
MOD_ProDKin_1	542	548	PF00069	0.364
MOD_ProDKin_1	574	580	PF00069	0.308
MOD_ProDKin_1	773	779	PF00069	0.447
MOD_ProDKin_1	843	849	PF00069	0.375
MOD_ProDKin_1	959	965	PF00069	0.704
MOD_SUMO_rev_2	1143	1152	PF00179	0.446
MOD_SUMO_rev_2	158	166	PF00179	0.557
MOD_SUMO_rev_2	233	240	PF00179	0.543
MOD_SUMO_rev_2	310	315	PF00179	0.602
TRG_DiLeu_BaEn_1	484	489	PF01217	0.336
TRG_DiLeu_BaEn_2	103	109	PF01217	0.338
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.518
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.264
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.381
TRG_ENDOCYTIC_2	1114	1117	PF00928	0.408
TRG_ENDOCYTIC_2	480	483	PF00928	0.351
TRG_ENDOCYTIC_2	699	702	PF00928	0.396
TRG_ENDOCYTIC_2	76	79	PF00928	0.541
TRG_ENDOCYTIC_2	765	768	PF00928	0.460
TRG_ENDOCYTIC_2	950	953	PF00928	0.407
TRG_ER_diArg_1	330	332	PF00400	0.460
TRG_ER_diArg_1	385	387	PF00400	0.538
TRG_ER_diArg_1	398	400	PF00400	0.449
TRG_ER_diArg_1	534	536	PF00400	0.417
TRG_ER_diArg_1	688	691	PF00400	0.376
TRG_ER_diArg_1	860	863	PF00400	0.349
TRG_ER_diArg_1	864	866	PF00400	0.404
TRG_ER_diArg_1	884	887	PF00400	0.488
TRG_ER_diArg_1	926	928	PF00400	0.378
TRG_ER_diArg_1	940	942	PF00400	0.410
TRG_ER_diArg_1	947	949	PF00400	0.376
TRG_NLS_Bipartite_1	330	346	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	620	625	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K9	Leptomonas seymouri	75%	94%
A0A0S4JLH0	Bodo saltans	46%	100%
A0A1X0NRH4	Trypanosomatidae	58%	98%
A0A3S7X0V6	Leishmania donovani	95%	100%
A0A422NJT2	Trypanosoma rangeli	60%	100%
A4HFW4	Leishmania braziliensis	88%	100%
A4I2Z6	Leishmania infantum	95%	89%
C9ZJE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AZ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BN80	Trypanosoma cruzi	61%	100%