Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADG6_LEIMA

TriTrypDb:

LmjF.27.1880 , LMJLV39_270025900 , LMJSD75_270025900

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ADG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.705
CLV_NRD_NRD_1	134	136	PF00675	0.592
CLV_NRD_NRD_1	191	193	PF00675	0.582
CLV_NRD_NRD_1	320	322	PF00675	0.559
CLV_NRD_NRD_1	464	466	PF00675	0.662
CLV_NRD_NRD_1	57	59	PF00675	0.635
CLV_NRD_NRD_1	68	70	PF00675	0.574
CLV_PCSK_FUR_1	83	87	PF00082	0.523
CLV_PCSK_KEX2_1	134	136	PF00082	0.588
CLV_PCSK_KEX2_1	191	193	PF00082	0.508
CLV_PCSK_KEX2_1	320	322	PF00082	0.559
CLV_PCSK_KEX2_1	411	413	PF00082	0.525
CLV_PCSK_KEX2_1	85	87	PF00082	0.609
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.530
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.582
CLV_PCSK_PC7_1	130	136	PF00082	0.481
CLV_PCSK_SKI1_1	266	270	PF00082	0.357
CLV_PCSK_SKI1_1	320	324	PF00082	0.555
CLV_PCSK_SKI1_1	346	350	PF00082	0.383
CLV_PCSK_SKI1_1	353	357	PF00082	0.361
CLV_PCSK_SKI1_1	371	375	PF00082	0.432
CLV_PCSK_SKI1_1	389	393	PF00082	0.570
CLV_PCSK_SKI1_1	400	404	PF00082	0.505
CLV_PCSK_SKI1_1	424	428	PF00082	0.615
CLV_PCSK_SKI1_1	442	446	PF00082	0.409
DEG_APCC_DBOX_1	319	327	PF00400	0.534
DEG_APCC_DBOX_1	441	449	PF00400	0.572
DOC_CKS1_1	210	215	PF01111	0.456
DOC_CYCLIN_RxL_1	397	406	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.666
DOC_MAPK_DCC_7	99	107	PF00069	0.588
DOC_MAPK_gen_1	83	93	PF00069	0.422
DOC_MAPK_MEF2A_6	353	361	PF00069	0.465
DOC_PP2B_LxvP_1	145	148	PF13499	0.479
DOC_PP2B_LxvP_1	396	399	PF13499	0.505
DOC_PP2B_LxvP_1	472	475	PF13499	0.662
DOC_PP4_FxxP_1	107	110	PF00568	0.601
DOC_PP4_FxxP_1	140	143	PF00568	0.705
DOC_PP4_FxxP_1	3	6	PF00568	0.616
DOC_USP7_MATH_1	15	19	PF00917	0.519
DOC_USP7_MATH_1	278	282	PF00917	0.600
DOC_USP7_MATH_1	287	291	PF00917	0.563
DOC_USP7_MATH_1	48	52	PF00917	0.530
DOC_USP7_MATH_1	493	497	PF00917	0.782
DOC_USP7_MATH_1	519	523	PF00917	0.615
DOC_WW_Pin1_4	106	111	PF00397	0.594
DOC_WW_Pin1_4	209	214	PF00397	0.459
LIG_14-3-3_CanoR_1	209	213	PF00244	0.489
LIG_14-3-3_CanoR_1	353	358	PF00244	0.446
LIG_14-3-3_CanoR_1	465	472	PF00244	0.615
LIG_Actin_WH2_1	412	430	PF00022	0.601
LIG_BIR_III_2	497	501	PF00653	0.565
LIG_BRCT_BRCA1_1	12	16	PF00533	0.423
LIG_BRCT_BRCA1_1	180	184	PF00533	0.560
LIG_CtBP_PxDLS_1	179	183	PF00389	0.469
LIG_CtBP_PxDLS_1	95	99	PF00389	0.504
LIG_eIF4E_1	360	366	PF01652	0.396
LIG_FHA_1	198	204	PF00498	0.424
LIG_FHA_1	209	215	PF00498	0.457
LIG_FHA_1	354	360	PF00498	0.469
LIG_FHA_2	465	471	PF00498	0.630
LIG_FHA_2	47	53	PF00498	0.521
LIG_FHA_2	506	512	PF00498	0.496
LIG_LIR_Apic_2	137	143	PF02991	0.640
LIG_LIR_Apic_2	2	6	PF02991	0.626
LIG_LIR_Apic_2	358	363	PF02991	0.367
LIG_LIR_Apic_2	375	381	PF02991	0.484
LIG_LIR_Gen_1	117	126	PF02991	0.581
LIG_LIR_Gen_1	127	136	PF02991	0.406
LIG_LIR_Gen_1	290	301	PF02991	0.423
LIG_LIR_Gen_1	87	96	PF02991	0.452
LIG_LIR_Nem_3	117	121	PF02991	0.634
LIG_LIR_Nem_3	127	131	PF02991	0.629
LIG_LIR_Nem_3	263	268	PF02991	0.381
LIG_LIR_Nem_3	29	35	PF02991	0.533
LIG_LIR_Nem_3	290	296	PF02991	0.435
LIG_LIR_Nem_3	390	396	PF02991	0.554
LIG_LIR_Nem_3	479	483	PF02991	0.708
LIG_LIR_Nem_3	87	91	PF02991	0.439
LIG_LYPXL_S_1	392	396	PF13949	0.536
LIG_LYPXL_yS_3	393	396	PF13949	0.537
LIG_MYND_1	394	398	PF01753	0.526
LIG_Pex14_2	12	16	PF04695	0.515
LIG_Pex14_2	369	373	PF04695	0.387
LIG_PTB_Apo_2	264	271	PF02174	0.334
LIG_PTB_Apo_2	349	356	PF02174	0.356
LIG_PTB_Phospho_1	264	270	PF10480	0.333
LIG_SH2_CRK	265	269	PF00017	0.330
LIG_SH2_CRK	480	484	PF00017	0.697
LIG_SH2_PTP2	360	363	PF00017	0.361
LIG_SH2_SRC	360	363	PF00017	0.392
LIG_SH2_STAT5	186	189	PF00017	0.482
LIG_SH2_STAT5	360	363	PF00017	0.361
LIG_SH2_STAT5	507	510	PF00017	0.503
LIG_SH3_3	173	179	PF00018	0.694
LIG_SH3_3	210	216	PF00018	0.623
LIG_SH3_3	305	311	PF00018	0.388
LIG_SH3_3	497	503	PF00018	0.758
LIG_SH3_3	89	95	PF00018	0.415
LIG_SH3_3	98	104	PF00018	0.413
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.543
LIG_SUMO_SIM_par_1	33	38	PF11976	0.526
LIG_SUMO_SIM_par_1	89	94	PF11976	0.371
LIG_TRAF2_1	453	456	PF00917	0.671
LIG_TYR_ITIM	478	483	PF00017	0.449
LIG_WW_3	397	401	PF00397	0.495
MOD_CK1_1	218	224	PF00069	0.645
MOD_CK1_1	229	235	PF00069	0.446
MOD_CK1_1	280	286	PF00069	0.691
MOD_CK1_1	38	44	PF00069	0.530
MOD_CK2_1	398	404	PF00069	0.594
MOD_CK2_1	46	52	PF00069	0.531
MOD_CK2_1	464	470	PF00069	0.629
MOD_CK2_1	515	521	PF00069	0.707
MOD_Cter_Amidation	318	321	PF01082	0.555
MOD_Cter_Amidation	409	412	PF01082	0.538
MOD_GlcNHglycan	12	15	PF01048	0.562
MOD_GlcNHglycan	187	190	PF01048	0.375
MOD_GlcNHglycan	217	220	PF01048	0.479
MOD_GlcNHglycan	262	265	PF01048	0.416
MOD_GlcNHglycan	283	286	PF01048	0.695
MOD_GlcNHglycan	503	506	PF01048	0.793
MOD_GlcNHglycan	517	520	PF01048	0.552
MOD_GlcNHglycan	521	524	PF01048	0.486
MOD_GSK3_1	149	156	PF00069	0.700
MOD_GSK3_1	225	232	PF00069	0.549
MOD_GSK3_1	276	283	PF00069	0.601
MOD_GSK3_1	287	294	PF00069	0.705
MOD_GSK3_1	418	425	PF00069	0.511
MOD_GSK3_1	501	508	PF00069	0.594
MOD_GSK3_1	515	522	PF00069	0.652
MOD_N-GLC_1	351	356	PF02516	0.494
MOD_NEK2_1	184	189	PF00069	0.483
MOD_NEK2_1	226	231	PF00069	0.595
MOD_NEK2_1	291	296	PF00069	0.649
MOD_NEK2_1	351	356	PF00069	0.493
MOD_NEK2_1	476	481	PF00069	0.457
MOD_NEK2_2	287	292	PF00069	0.596
MOD_PIKK_1	23	29	PF00454	0.493
MOD_PIKK_1	294	300	PF00454	0.641
MOD_PIKK_1	418	424	PF00454	0.586
MOD_PKA_1	134	140	PF00069	0.532
MOD_PKA_2	134	140	PF00069	0.553
MOD_PKA_2	208	214	PF00069	0.491
MOD_PKA_2	291	297	PF00069	0.661
MOD_PKA_2	339	345	PF00069	0.412
MOD_PKA_2	464	470	PF00069	0.613
MOD_PKA_2	8	14	PF00069	0.560
MOD_Plk_1	198	204	PF00069	0.432
MOD_Plk_1	35	41	PF00069	0.552
MOD_Plk_1	351	357	PF00069	0.488
MOD_Plk_2-3	117	123	PF00069	0.649
MOD_Plk_4	198	204	PF00069	0.424
MOD_Plk_4	35	41	PF00069	0.564
MOD_Plk_4	422	428	PF00069	0.634
MOD_ProDKin_1	106	112	PF00069	0.592
MOD_ProDKin_1	209	215	PF00069	0.456
MOD_SUMO_rev_2	342	348	PF00179	0.408
MOD_SUMO_rev_2	462	468	PF00179	0.627
TRG_DiLeu_BaEn_3	455	461	PF01217	0.643
TRG_DiLeu_BaEn_4	440	446	PF01217	0.594
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.410
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.628
TRG_ENDOCYTIC_2	265	268	PF00928	0.353
TRG_ENDOCYTIC_2	270	273	PF00928	0.340
TRG_ENDOCYTIC_2	32	35	PF00928	0.530
TRG_ENDOCYTIC_2	393	396	PF00928	0.537
TRG_ENDOCYTIC_2	480	483	PF00928	0.696
TRG_ER_diArg_1	134	136	PF00400	0.522
TRG_ER_diArg_1	19	22	PF00400	0.441
TRG_ER_diArg_1	320	322	PF00400	0.580
TRG_ER_diArg_1	6	9	PF00400	0.608
TRG_NES_CRM1_1	231	246	PF08389	0.408
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J3	Leptomonas seymouri	65%	86%
A0A1X0NRT0	Trypanosomatidae	39%	100%
A0A3S7X0V2	Leishmania donovani	93%	98%
A0A422NJS3	Trypanosoma rangeli	37%	100%
A4HFW2	Leishmania braziliensis	82%	100%
A4I2Z4	Leishmania infantum	93%	98%
C9ZJE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AZ90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DEY5	Trypanosoma cruzi	45%	100%