Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ADG4_LEIMA

TriTrypDb:

LmjF.27.1860 , LMJLV39_270025700 , LMJSD75_270025700

Length:

864

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.693
CLV_C14_Caspase3-7	226	230	PF00656	0.713
CLV_C14_Caspase3-7	380	384	PF00656	0.641
CLV_NRD_NRD_1	103	105	PF00675	0.755
CLV_NRD_NRD_1	141	143	PF00675	0.773
CLV_NRD_NRD_1	16	18	PF00675	0.769
CLV_NRD_NRD_1	203	205	PF00675	0.807
CLV_NRD_NRD_1	24	26	PF00675	0.718
CLV_NRD_NRD_1	284	286	PF00675	0.622
CLV_NRD_NRD_1	393	395	PF00675	0.702
CLV_NRD_NRD_1	806	808	PF00675	0.752
CLV_PCSK_FUR_1	139	143	PF00082	0.776
CLV_PCSK_KEX2_1	103	105	PF00082	0.680
CLV_PCSK_KEX2_1	141	143	PF00082	0.773
CLV_PCSK_KEX2_1	16	18	PF00082	0.769
CLV_PCSK_KEX2_1	203	205	PF00082	0.787
CLV_PCSK_KEX2_1	234	236	PF00082	0.562
CLV_PCSK_KEX2_1	24	26	PF00082	0.718
CLV_PCSK_KEX2_1	271	273	PF00082	0.519
CLV_PCSK_KEX2_1	277	279	PF00082	0.563
CLV_PCSK_KEX2_1	284	286	PF00082	0.614
CLV_PCSK_KEX2_1	806	808	PF00082	0.826
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.562
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.519
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.580
CLV_PCSK_SKI1_1	103	107	PF00082	0.853
CLV_PCSK_SKI1_1	142	146	PF00082	0.722
CLV_PCSK_SKI1_1	17	21	PF00082	0.691
CLV_PCSK_SKI1_1	181	185	PF00082	0.710
CLV_Separin_Metazoa	363	367	PF03568	0.670
CLV_Separin_Metazoa	580	584	PF03568	0.809
CLV_Separin_Metazoa	738	742	PF03568	0.593
DEG_SCF_FBW7_1	323	330	PF00400	0.842
DEG_SCF_FBW7_1	36	43	PF00400	0.712
DEG_SCF_FBW7_1	659	666	PF00400	0.758
DEG_SCF_TRCP1_1	715	720	PF00400	0.625
DEG_SPOP_SBC_1	347	351	PF00917	0.686
DEG_SPOP_SBC_1	740	744	PF00917	0.730
DEG_SPOP_SBC_1	798	802	PF00917	0.710
DOC_ANK_TNKS_1	319	326	PF00023	0.688
DOC_CKS1_1	37	42	PF01111	0.710
DOC_CKS1_1	481	486	PF01111	0.729
DOC_CKS1_1	660	665	PF01111	0.760
DOC_CKS1_1	92	97	PF01111	0.749
DOC_CYCLIN_yCln2_LP_2	334	340	PF00134	0.598
DOC_MAPK_gen_1	234	240	PF00069	0.529
DOC_MAPK_gen_1	281	291	PF00069	0.643
DOC_MAPK_MEF2A_6	284	291	PF00069	0.558
DOC_PP2B_LxvP_1	168	171	PF13499	0.738
DOC_PP2B_LxvP_1	334	337	PF13499	0.606
DOC_PP2B_LxvP_1	90	93	PF13499	0.751
DOC_USP7_MATH_1	120	124	PF00917	0.859
DOC_USP7_MATH_1	137	141	PF00917	0.525
DOC_USP7_MATH_1	194	198	PF00917	0.832
DOC_USP7_MATH_1	266	270	PF00917	0.585
DOC_USP7_MATH_1	40	44	PF00917	0.718
DOC_USP7_MATH_1	45	49	PF00917	0.671
DOC_USP7_MATH_1	53	57	PF00917	0.796
DOC_USP7_MATH_1	533	537	PF00917	0.751
DOC_USP7_MATH_1	574	578	PF00917	0.707
DOC_USP7_MATH_1	630	634	PF00917	0.837
DOC_USP7_MATH_1	663	667	PF00917	0.804
DOC_USP7_MATH_1	669	673	PF00917	0.676
DOC_USP7_MATH_1	679	683	PF00917	0.580
DOC_USP7_MATH_1	7	11	PF00917	0.794
DOC_USP7_MATH_1	708	712	PF00917	0.711
DOC_USP7_MATH_1	778	782	PF00917	0.675
DOC_USP7_MATH_1	798	802	PF00917	0.772
DOC_WW_Pin1_4	166	171	PF00397	0.804
DOC_WW_Pin1_4	175	180	PF00397	0.725
DOC_WW_Pin1_4	18	23	PF00397	0.791
DOC_WW_Pin1_4	181	186	PF00397	0.608
DOC_WW_Pin1_4	198	203	PF00397	0.595
DOC_WW_Pin1_4	32	37	PF00397	0.599
DOC_WW_Pin1_4	323	328	PF00397	0.680
DOC_WW_Pin1_4	348	353	PF00397	0.797
DOC_WW_Pin1_4	480	485	PF00397	0.795
DOC_WW_Pin1_4	503	508	PF00397	0.723
DOC_WW_Pin1_4	529	534	PF00397	0.741
DOC_WW_Pin1_4	555	560	PF00397	0.733
DOC_WW_Pin1_4	659	664	PF00397	0.791
DOC_WW_Pin1_4	691	696	PF00397	0.756
DOC_WW_Pin1_4	703	708	PF00397	0.628
DOC_WW_Pin1_4	741	746	PF00397	0.764
DOC_WW_Pin1_4	76	81	PF00397	0.765
DOC_WW_Pin1_4	800	805	PF00397	0.837
DOC_WW_Pin1_4	91	96	PF00397	0.617
LIG_14-3-3_CanoR_1	141	150	PF00244	0.721
LIG_14-3-3_CanoR_1	222	228	PF00244	0.702
LIG_14-3-3_CanoR_1	284	288	PF00244	0.636
LIG_14-3-3_CanoR_1	354	359	PF00244	0.586
LIG_14-3-3_CanoR_1	649	654	PF00244	0.660
LIG_14-3-3_CanoR_1	741	745	PF00244	0.619
LIG_AP2alpha_1	792	796	PF02296	0.740
LIG_AP2alpha_2	69	71	PF02296	0.748
LIG_deltaCOP1_diTrp_1	783	786	PF00928	0.729
LIG_FHA_1	184	190	PF00498	0.827
LIG_FHA_1	204	210	PF00498	0.455
LIG_FHA_1	548	554	PF00498	0.710
LIG_FHA_1	590	596	PF00498	0.769
LIG_FHA_1	84	90	PF00498	0.756
LIG_FHA_2	224	230	PF00498	0.712
LIG_FHA_2	314	320	PF00498	0.832
LIG_FHA_2	341	347	PF00498	0.693
LIG_FHA_2	556	562	PF00498	0.668
LIG_FHA_2	624	630	PF00498	0.795
LIG_FHA_2	722	728	PF00498	0.604
LIG_FHA_2	825	831	PF00498	0.769
LIG_FHA_2	848	854	PF00498	0.649
LIG_LIR_Apic_2	43	47	PF02991	0.662
LIG_LIR_Gen_1	239	249	PF02991	0.657
LIG_LIR_Gen_1	439	449	PF02991	0.578
LIG_LIR_Gen_1	755	761	PF02991	0.684
LIG_LIR_Gen_1	781	792	PF02991	0.806
LIG_LIR_Nem_3	239	244	PF02991	0.664
LIG_LIR_Nem_3	39	44	PF02991	0.806
LIG_LIR_Nem_3	439	445	PF02991	0.587
LIG_LIR_Nem_3	755	759	PF02991	0.683
LIG_LIR_Nem_3	781	787	PF02991	0.807
LIG_MYND_1	166	170	PF01753	0.746
LIG_MYND_1	659	663	PF01753	0.831
LIG_MYND_1	688	692	PF01753	0.769
LIG_NRBOX	208	214	PF00104	0.674
LIG_NRBOX	577	583	PF00104	0.803
LIG_Pex14_2	14	18	PF04695	0.745
LIG_Pex14_2	792	796	PF04695	0.740
LIG_SH2_CRK	241	245	PF00017	0.658
LIG_SH2_CRK	44	48	PF00017	0.764
LIG_SH2_NCK_1	44	48	PF00017	0.764
LIG_SH2_STAP1	453	457	PF00017	0.722
LIG_SH2_STAT5	293	296	PF00017	0.644
LIG_SH2_STAT5	845	848	PF00017	0.675
LIG_SH3_2	199	204	PF14604	0.608
LIG_SH3_2	692	697	PF14604	0.718
LIG_SH3_3	168	174	PF00018	0.689
LIG_SH3_3	196	202	PF00018	0.697
LIG_SH3_3	325	331	PF00018	0.795
LIG_SH3_3	34	40	PF00018	0.709
LIG_SH3_3	349	355	PF00018	0.806
LIG_SH3_3	426	432	PF00018	0.716
LIG_SH3_3	657	663	PF00018	0.646
LIG_SH3_3	678	684	PF00018	0.693
LIG_SH3_3	689	695	PF00018	0.648
LIG_SH3_3	86	92	PF00018	0.754
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.637
LIG_SUMO_SIM_anti_2	577	584	PF11976	0.803
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.754
LIG_SUMO_SIM_par_1	342	351	PF11976	0.766
LIG_SUMO_SIM_par_1	732	738	PF11976	0.738
LIG_SxIP_EBH_1	661	670	PF03271	0.769
LIG_TRFH_1	18	22	PF08558	0.729
LIG_WRC_WIRS_1	747	752	PF05994	0.590
LIG_WW_3	694	698	PF00397	0.709
MOD_CDC14_SPxK_1	178	181	PF00782	0.801
MOD_CDC14_SPxK_1	201	204	PF00782	0.735
MOD_CDC14_SPxK_1	21	24	PF00782	0.728
MOD_CDC14_SPxK_1	35	38	PF00782	0.575
MOD_CDC14_SPxK_1	351	354	PF00782	0.660
MOD_CDC14_SPxK_1	694	697	PF00782	0.713
MOD_CDC14_SPxK_1	79	82	PF00782	0.741
MOD_CDC14_SPxK_1	803	806	PF00782	0.843
MOD_CDK_SPK_2	198	203	PF00069	0.610
MOD_CDK_SPxK_1	175	181	PF00069	0.812
MOD_CDK_SPxK_1	18	24	PF00069	0.731
MOD_CDK_SPxK_1	198	204	PF00069	0.737
MOD_CDK_SPxK_1	32	38	PF00069	0.581
MOD_CDK_SPxK_1	348	354	PF00069	0.662
MOD_CDK_SPxK_1	691	697	PF00069	0.719
MOD_CDK_SPxK_1	76	82	PF00069	0.747
MOD_CDK_SPxK_1	800	806	PF00069	0.840
MOD_CDK_SPxxK_3	18	25	PF00069	0.794
MOD_CDK_SPxxK_3	480	487	PF00069	0.761
MOD_CDK_SPxxK_3	503	510	PF00069	0.621
MOD_CDK_SPxxK_3	800	807	PF00069	0.718
MOD_CK1_1	169	175	PF00069	0.731
MOD_CK1_1	315	321	PF00069	0.754
MOD_CK1_1	359	365	PF00069	0.740
MOD_CK1_1	503	509	PF00069	0.804
MOD_CK1_1	532	538	PF00069	0.778
MOD_CK1_1	56	62	PF00069	0.774
MOD_CK1_1	584	590	PF00069	0.786
MOD_CK1_1	603	609	PF00069	0.556
MOD_CK1_1	633	639	PF00069	0.835
MOD_CK1_1	651	657	PF00069	0.552
MOD_CK1_1	664	670	PF00069	0.610
MOD_CK1_1	686	692	PF00069	0.824
MOD_CK1_1	702	708	PF00069	0.598
MOD_CK1_1	711	717	PF00069	0.753
MOD_CK1_1	749	755	PF00069	0.632
MOD_CK1_1	799	805	PF00069	0.783
MOD_CK1_1	820	826	PF00069	0.769
MOD_CK2_1	313	319	PF00069	0.741
MOD_CK2_1	574	580	PF00069	0.792
MOD_CK2_1	623	629	PF00069	0.712
MOD_CK2_1	721	727	PF00069	0.607
MOD_CK2_1	847	853	PF00069	0.654
MOD_Cter_Amidation	232	235	PF01082	0.587
MOD_DYRK1A_RPxSP_1	198	202	PF00069	0.589
MOD_GlcNHglycan	117	120	PF01048	0.844
MOD_GlcNHglycan	121	125	PF01048	0.806
MOD_GlcNHglycan	268	271	PF01048	0.583
MOD_GlcNHglycan	358	361	PF01048	0.758
MOD_GlcNHglycan	379	382	PF01048	0.812
MOD_GlcNHglycan	454	458	PF01048	0.664
MOD_GlcNHglycan	48	51	PF01048	0.623
MOD_GlcNHglycan	495	498	PF01048	0.820
MOD_GlcNHglycan	572	575	PF01048	0.714
MOD_GlcNHglycan	654	657	PF01048	0.753
MOD_GlcNHglycan	672	675	PF01048	0.547
MOD_GlcNHglycan	715	718	PF01048	0.859
MOD_GlcNHglycan	74	77	PF01048	0.773
MOD_GlcNHglycan	861	864	PF01048	0.792
MOD_GSK3_1	166	173	PF00069	0.797
MOD_GSK3_1	175	182	PF00069	0.749
MOD_GSK3_1	194	201	PF00069	0.630
MOD_GSK3_1	309	316	PF00069	0.748
MOD_GSK3_1	32	39	PF00069	0.814
MOD_GSK3_1	323	330	PF00069	0.549
MOD_GSK3_1	365	372	PF00069	0.603
MOD_GSK3_1	377	384	PF00069	0.616
MOD_GSK3_1	522	529	PF00069	0.691
MOD_GSK3_1	547	554	PF00069	0.812
MOD_GSK3_1	570	577	PF00069	0.799
MOD_GSK3_1	581	588	PF00069	0.637
MOD_GSK3_1	599	606	PF00069	0.535
MOD_GSK3_1	628	635	PF00069	0.857
MOD_GSK3_1	648	655	PF00069	0.497
MOD_GSK3_1	659	666	PF00069	0.687
MOD_GSK3_1	679	686	PF00069	0.593
MOD_GSK3_1	699	706	PF00069	0.602
MOD_GSK3_1	711	718	PF00069	0.668
MOD_GSK3_1	72	79	PF00069	0.778
MOD_GSK3_1	748	755	PF00069	0.623
MOD_GSK3_1	796	803	PF00069	0.753
MOD_GSK3_1	817	824	PF00069	0.773
MOD_GSK3_1	843	850	PF00069	0.665
MOD_LATS_1	763	769	PF00433	0.844
MOD_N-GLC_1	824	829	PF02516	0.681
MOD_NEK2_1	192	197	PF00069	0.650
MOD_NEK2_1	369	374	PF00069	0.783
MOD_NEK2_1	526	531	PF00069	0.698
MOD_NEK2_1	599	604	PF00069	0.752
MOD_NEK2_1	739	744	PF00069	0.731
MOD_NEK2_1	748	753	PF00069	0.663
MOD_NEK2_1	777	782	PF00069	0.699
MOD_NEK2_1	786	791	PF00069	0.645
MOD_NEK2_1	796	801	PF00069	0.727
MOD_NEK2_1	808	813	PF00069	0.585
MOD_NEK2_2	522	527	PF00069	0.705
MOD_PIKK_1	313	319	PF00454	0.824
MOD_PIKK_1	609	615	PF00454	0.620
MOD_PIKK_1	847	853	PF00454	0.654
MOD_PK_1	765	771	PF00069	0.803
MOD_PKA_1	203	209	PF00069	0.571
MOD_PKA_2	203	209	PF00069	0.637
MOD_PKA_2	283	289	PF00069	0.604
MOD_PKA_2	365	371	PF00069	0.710
MOD_PKA_2	500	506	PF00069	0.803
MOD_PKA_2	509	515	PF00069	0.645
MOD_PKA_2	584	590	PF00069	0.815
MOD_PKA_2	603	609	PF00069	0.713
MOD_PKA_2	648	654	PF00069	0.627
MOD_PKA_2	669	675	PF00069	0.858
MOD_PKA_2	711	717	PF00069	0.630
MOD_PKA_2	740	746	PF00069	0.620
MOD_PKB_1	583	591	PF00069	0.827
MOD_Plk_1	765	771	PF00069	0.601
MOD_Plk_1	83	89	PF00069	0.650
MOD_Plk_2-3	830	836	PF00069	0.686
MOD_Plk_4	340	346	PF00069	0.690
MOD_Plk_4	533	539	PF00069	0.695
MOD_Plk_4	574	580	PF00069	0.775
MOD_Plk_4	85	91	PF00069	0.659
MOD_ProDKin_1	166	172	PF00069	0.806
MOD_ProDKin_1	175	181	PF00069	0.725
MOD_ProDKin_1	18	24	PF00069	0.793
MOD_ProDKin_1	198	204	PF00069	0.681
MOD_ProDKin_1	32	38	PF00069	0.600
MOD_ProDKin_1	323	329	PF00069	0.683
MOD_ProDKin_1	348	354	PF00069	0.800
MOD_ProDKin_1	480	486	PF00069	0.793
MOD_ProDKin_1	503	509	PF00069	0.724
MOD_ProDKin_1	529	535	PF00069	0.742
MOD_ProDKin_1	555	561	PF00069	0.735
MOD_ProDKin_1	659	665	PF00069	0.796
MOD_ProDKin_1	691	697	PF00069	0.758
MOD_ProDKin_1	703	709	PF00069	0.628
MOD_ProDKin_1	741	747	PF00069	0.764
MOD_ProDKin_1	76	82	PF00069	0.768
MOD_ProDKin_1	800	806	PF00069	0.840
MOD_ProDKin_1	91	97	PF00069	0.619
MOD_SUMO_for_1	270	273	PF00179	0.676
MOD_SUMO_for_1	81	84	PF00179	0.653
MOD_SUMO_rev_2	823	833	PF00179	0.623
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.762
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.716
TRG_ENDOCYTIC_2	241	244	PF00928	0.657
TRG_ER_diArg_1	103	105	PF00400	0.751
TRG_ER_diArg_1	138	141	PF00400	0.778
TRG_ER_diArg_1	16	18	PF00400	0.704
TRG_ER_diArg_1	202	204	PF00400	0.758
TRG_ER_diArg_1	283	285	PF00400	0.600
TRG_ER_diArg_1	582	585	PF00400	0.814
TRG_ER_diArg_1	806	808	PF00400	0.752
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	806	810	PF00026	0.848

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDF6	Leishmania donovani	86%	100%
A4HFW0	Leishmania braziliensis	55%	94%
A4I2Z2	Leishmania infantum	86%	100%
E9AZ88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%