Paraflagellar rod protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 5, putative

Species:

Leishmania major

UniProt:

E9ADG3_LEIMA

TriTrypDb:

LmjF.27.1850 , LMJLV39_270025600 , LMJSD75_270025600

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 26

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	30
GO:0005930	axoneme	2	2
GO:0031514	motile cilium	5	30
GO:0042995	cell projection	2	30
GO:0043226	organelle	2	30
GO:0043227	membrane-bounded organelle	3	30
GO:0110165	cellular anatomical entity	1	30
GO:0120025	plasma membrane bounded cell projection	3	30
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3

Expansion

Sequence features

E9ADG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADG3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	30
GO:0005515	protein binding	2	30
GO:0005516	calmodulin binding	3	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	550	554	PF00656	0.429
CLV_NRD_NRD_1	129	131	PF00675	0.453
CLV_NRD_NRD_1	245	247	PF00675	0.418
CLV_NRD_NRD_1	292	294	PF00675	0.278
CLV_NRD_NRD_1	342	344	PF00675	0.299
CLV_NRD_NRD_1	348	350	PF00675	0.351
CLV_NRD_NRD_1	359	361	PF00675	0.338
CLV_NRD_NRD_1	443	445	PF00675	0.270
CLV_NRD_NRD_1	447	449	PF00675	0.267
CLV_NRD_NRD_1	584	586	PF00675	0.598
CLV_NRD_NRD_1	88	90	PF00675	0.564
CLV_NRD_NRD_1	92	94	PF00675	0.616
CLV_PCSK_FUR_1	10	14	PF00082	0.460
CLV_PCSK_FUR_1	243	247	PF00082	0.448
CLV_PCSK_KEX2_1	12	14	PF00082	0.456
CLV_PCSK_KEX2_1	129	131	PF00082	0.440
CLV_PCSK_KEX2_1	211	213	PF00082	0.383
CLV_PCSK_KEX2_1	243	245	PF00082	0.476
CLV_PCSK_KEX2_1	294	296	PF00082	0.340
CLV_PCSK_KEX2_1	342	344	PF00082	0.309
CLV_PCSK_KEX2_1	348	350	PF00082	0.345
CLV_PCSK_KEX2_1	359	361	PF00082	0.325
CLV_PCSK_KEX2_1	429	431	PF00082	0.286
CLV_PCSK_KEX2_1	447	449	PF00082	0.428
CLV_PCSK_KEX2_1	584	586	PF00082	0.548
CLV_PCSK_KEX2_1	88	90	PF00082	0.449
CLV_PCSK_KEX2_1	92	94	PF00082	0.500
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.456
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.477
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.338
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.272
CLV_PCSK_PC7_1	239	245	PF00082	0.416
CLV_PCSK_PC7_1	355	361	PF00082	0.416
CLV_PCSK_PC7_1	580	586	PF00082	0.555
CLV_PCSK_PC7_1	88	94	PF00082	0.585
CLV_PCSK_SKI1_1	167	171	PF00082	0.515
CLV_PCSK_SKI1_1	222	226	PF00082	0.363
CLV_PCSK_SKI1_1	255	259	PF00082	0.331
CLV_PCSK_SKI1_1	320	324	PF00082	0.395
CLV_PCSK_SKI1_1	447	451	PF00082	0.377
CLV_PCSK_SKI1_1	463	467	PF00082	0.224
CLV_PCSK_SKI1_1	483	487	PF00082	0.165
CLV_PCSK_SKI1_1	507	511	PF00082	0.386
CLV_PCSK_SKI1_1	68	72	PF00082	0.634
CLV_Separin_Metazoa	418	422	PF03568	0.254
CLV_Separin_Metazoa	494	498	PF03568	0.225
DEG_APCC_DBOX_1	762	770	PF00400	0.254
DEG_SPOP_SBC_1	678	682	PF00917	0.524
DOC_CKS1_1	123	128	PF01111	0.497
DOC_MAPK_gen_1	729	738	PF00069	0.238
DOC_MAPK_gen_1	88	97	PF00069	0.424
DOC_PP1_RVXF_1	138	145	PF00149	0.409
DOC_PP1_RVXF_1	512	519	PF00149	0.270
DOC_PP4_FxxP_1	123	126	PF00568	0.438
DOC_USP7_MATH_1	24	28	PF00917	0.668
DOC_USP7_MATH_1	3	7	PF00917	0.434
DOC_USP7_MATH_1	625	629	PF00917	0.670
DOC_USP7_MATH_1	671	675	PF00917	0.666
DOC_USP7_MATH_1	701	705	PF00917	0.760
DOC_WW_Pin1_4	122	127	PF00397	0.456
DOC_WW_Pin1_4	181	186	PF00397	0.365
DOC_WW_Pin1_4	507	512	PF00397	0.398
DOC_WW_Pin1_4	621	626	PF00397	0.694
DOC_WW_Pin1_4	667	672	PF00397	0.544
DOC_WW_Pin1_4	775	780	PF00397	0.546
LIG_14-3-3_CanoR_1	222	231	PF00244	0.376
LIG_14-3-3_CanoR_1	239	247	PF00244	0.514
LIG_14-3-3_CanoR_1	320	325	PF00244	0.411
LIG_14-3-3_CanoR_1	33	39	PF00244	0.374
LIG_14-3-3_CanoR_1	430	436	PF00244	0.286
LIG_14-3-3_CanoR_1	447	456	PF00244	0.309
LIG_14-3-3_CanoR_1	457	462	PF00244	0.330
LIG_14-3-3_CanoR_1	537	542	PF00244	0.269
LIG_APCC_ABBA_1	322	327	PF00400	0.292
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_BRCT_BRCA1_1	119	123	PF00533	0.567
LIG_BRCT_BRCA1_1	140	144	PF00533	0.477
LIG_BRCT_BRCA1_1	27	31	PF00533	0.402
LIG_BRCT_BRCA1_1	302	306	PF00533	0.227
LIG_BRCT_BRCA1_1	514	518	PF00533	0.269
LIG_FHA_1	151	157	PF00498	0.503
LIG_FHA_1	164	170	PF00498	0.449
LIG_FHA_1	2	8	PF00498	0.437
LIG_FHA_1	256	262	PF00498	0.320
LIG_FHA_1	508	514	PF00498	0.393
LIG_FHA_1	560	566	PF00498	0.649
LIG_FHA_1	679	685	PF00498	0.532
LIG_FHA_2	448	454	PF00498	0.183
LIG_FHA_2	538	544	PF00498	0.318
LIG_FHA_2	713	719	PF00498	0.736
LIG_Integrin_RGD_1	569	571	PF01839	0.389
LIG_LIR_Apic_2	120	126	PF02991	0.565
LIG_LIR_Gen_1	215	224	PF02991	0.401
LIG_LIR_Gen_1	316	325	PF02991	0.372
LIG_LIR_Gen_1	536	544	PF02991	0.400
LIG_LIR_Gen_1	721	730	PF02991	0.384
LIG_LIR_Nem_3	215	220	PF02991	0.386
LIG_LIR_Nem_3	225	231	PF02991	0.385
LIG_LIR_Nem_3	316	321	PF02991	0.339
LIG_LIR_Nem_3	323	328	PF02991	0.332
LIG_LIR_Nem_3	515	521	PF02991	0.254
LIG_LIR_Nem_3	543	547	PF02991	0.283
LIG_LIR_Nem_3	721	725	PF02991	0.502
LIG_LIR_Nem_3	753	759	PF02991	0.277
LIG_LYPXL_yS_3	228	231	PF13949	0.371
LIG_PCNA_yPIPBox_3	408	420	PF02747	0.270
LIG_PDZ_Class_3	777	782	PF00595	0.497
LIG_Pex14_1	318	322	PF04695	0.254
LIG_Pex14_2	31	35	PF04695	0.430
LIG_Pex14_2	722	726	PF04695	0.386
LIG_PTB_Apo_2	316	323	PF02174	0.269
LIG_RPA_C_Fungi	338	350	PF08784	0.235
LIG_SH2_CRK	544	548	PF00017	0.211
LIG_SH2_PTP2	523	526	PF00017	0.254
LIG_SH2_SRC	217	220	PF00017	0.420
LIG_SH2_SRC	477	480	PF00017	0.292
LIG_SH2_SRC	523	526	PF00017	0.254
LIG_SH2_STAP1	217	221	PF00017	0.318
LIG_SH2_STAT3	234	237	PF00017	0.386
LIG_SH2_STAT3	409	412	PF00017	0.270
LIG_SH2_STAT5	15	18	PF00017	0.450
LIG_SH2_STAT5	435	438	PF00017	0.323
LIG_SH2_STAT5	441	444	PF00017	0.319
LIG_SH2_STAT5	477	480	PF00017	0.386
LIG_SH2_STAT5	523	526	PF00017	0.254
LIG_SH2_STAT5	771	774	PF00017	0.274
LIG_SH3_3	140	146	PF00018	0.524
LIG_SH3_3	61	67	PF00018	0.590
LIG_SH3_3	704	710	PF00018	0.708
LIG_SUMO_SIM_par_1	3	9	PF11976	0.428
LIG_TRAF2_1	179	182	PF00917	0.488
LIG_TRAF2_1	270	273	PF00917	0.286
LIG_TRAF2_1	750	753	PF00917	0.255
LIG_TYR_ITIM	542	547	PF00017	0.211
LIG_ULM_U2AF65_1	243	248	PF00076	0.431
LIG_WRC_WIRS_1	32	37	PF05994	0.517
MOD_CDC14_SPxK_1	624	627	PF00782	0.484
MOD_CDK_SPK_2	122	127	PF00069	0.456
MOD_CDK_SPxK_1	621	627	PF00069	0.486
MOD_CDK_SPxxK_3	122	129	PF00069	0.447
MOD_CDK_SPxxK_3	507	514	PF00069	0.386
MOD_CK1_1	122	128	PF00069	0.526
MOD_CK1_1	238	244	PF00069	0.429
MOD_CK1_1	536	542	PF00069	0.375
MOD_CK1_1	600	606	PF00069	0.725
MOD_CK1_1	618	624	PF00069	0.540
MOD_CK1_1	657	663	PF00069	0.739
MOD_CK1_1	670	676	PF00069	0.524
MOD_CK1_1	687	693	PF00069	0.639
MOD_CK2_1	3	9	PF00069	0.591
MOD_CK2_1	358	364	PF00069	0.270
MOD_CK2_1	712	718	PF00069	0.580
MOD_CK2_1	771	777	PF00069	0.364
MOD_Cter_Amidation	357	360	PF01082	0.254
MOD_DYRK1A_RPxSP_1	507	511	PF00069	0.386
MOD_GlcNHglycan	360	363	PF01048	0.254
MOD_GlcNHglycan	605	608	PF01048	0.699
MOD_GlcNHglycan	647	650	PF01048	0.748
MOD_GlcNHglycan	651	654	PF01048	0.703
MOD_GlcNHglycan	694	697	PF01048	0.727
MOD_GlcNHglycan	703	706	PF01048	0.647
MOD_GSK3_1	111	118	PF00069	0.495
MOD_GSK3_1	280	287	PF00069	0.383
MOD_GSK3_1	330	337	PF00069	0.389
MOD_GSK3_1	358	365	PF00069	0.292
MOD_GSK3_1	533	540	PF00069	0.343
MOD_GSK3_1	543	550	PF00069	0.255
MOD_GSK3_1	571	578	PF00069	0.539
MOD_GSK3_1	596	603	PF00069	0.655
MOD_GSK3_1	616	623	PF00069	0.668
MOD_GSK3_1	645	652	PF00069	0.644
MOD_GSK3_1	653	660	PF00069	0.589
MOD_GSK3_1	666	673	PF00069	0.662
MOD_GSK3_1	687	694	PF00069	0.608
MOD_GSK3_1	771	778	PF00069	0.364
MOD_LATS_1	427	433	PF00433	0.238
MOD_N-GLC_1	533	538	PF02516	0.317
MOD_N-GLC_1	654	659	PF02516	0.679
MOD_N-GLC_1	687	692	PF02516	0.670
MOD_NEK2_1	1	6	PF00069	0.625
MOD_NEK2_1	111	116	PF00069	0.417
MOD_NEK2_1	193	198	PF00069	0.375
MOD_NEK2_1	31	36	PF00069	0.417
MOD_NEK2_1	377	382	PF00069	0.380
MOD_NEK2_1	39	44	PF00069	0.368
MOD_NEK2_1	533	538	PF00069	0.403
MOD_NEK2_1	598	603	PF00069	0.774
MOD_NEK2_1	71	76	PF00069	0.500
MOD_NEK2_2	171	176	PF00069	0.345
MOD_NEK2_2	3	8	PF00069	0.501
MOD_NEK2_2	771	776	PF00069	0.348
MOD_PIKK_1	41	47	PF00454	0.510
MOD_PIKK_1	447	453	PF00454	0.197
MOD_PIKK_1	571	577	PF00454	0.522
MOD_PK_1	313	319	PF00069	0.282
MOD_PKA_1	429	435	PF00069	0.240
MOD_PKA_1	447	453	PF00069	0.346
MOD_PKA_2	238	244	PF00069	0.423
MOD_PKA_2	358	364	PF00069	0.263
MOD_PKA_2	429	435	PF00069	0.262
MOD_PKA_2	447	453	PF00069	0.304
MOD_PKA_2	536	542	PF00069	0.332
MOD_PKA_2	559	565	PF00069	0.532
MOD_PKA_2	603	609	PF00069	0.823
MOD_Plk_1	171	177	PF00069	0.496
MOD_Plk_1	194	200	PF00069	0.373
MOD_Plk_1	255	261	PF00069	0.302
MOD_Plk_1	39	45	PF00069	0.432
MOD_Plk_1	533	539	PF00069	0.463
MOD_Plk_1	654	660	PF00069	0.801
MOD_Plk_1	734	740	PF00069	0.254
MOD_Plk_2-3	734	740	PF00069	0.254
MOD_Plk_4	119	125	PF00069	0.518
MOD_Plk_4	138	144	PF00069	0.473
MOD_Plk_4	171	177	PF00069	0.489
MOD_Plk_4	3	9	PF00069	0.460
MOD_Plk_4	313	319	PF00069	0.298
MOD_Plk_4	34	40	PF00069	0.367
MOD_Plk_4	362	368	PF00069	0.314
MOD_Plk_4	537	543	PF00069	0.254
MOD_Plk_4	554	560	PF00069	0.507
MOD_Plk_4	687	693	PF00069	0.516
MOD_ProDKin_1	122	128	PF00069	0.450
MOD_ProDKin_1	181	187	PF00069	0.358
MOD_ProDKin_1	507	513	PF00069	0.398
MOD_ProDKin_1	621	627	PF00069	0.695
MOD_ProDKin_1	667	673	PF00069	0.545
MOD_ProDKin_1	775	781	PF00069	0.552
MOD_SUMO_rev_2	133	142	PF00179	0.410
MOD_SUMO_rev_2	17	22	PF00179	0.451
TRG_DiLeu_BaEn_1	145	150	PF01217	0.444
TRG_DiLeu_BaEn_1	418	423	PF01217	0.261
TRG_DiLeu_BaEn_2	301	307	PF01217	0.386
TRG_DiLeu_BaEn_4	17	23	PF01217	0.582
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.527
TRG_ENDOCYTIC_2	217	220	PF00928	0.326
TRG_ENDOCYTIC_2	228	231	PF00928	0.387
TRG_ENDOCYTIC_2	544	547	PF00928	0.309
TRG_ER_diArg_1	129	131	PF00400	0.455
TRG_ER_diArg_1	243	246	PF00400	0.429
TRG_ER_diArg_1	293	296	PF00400	0.282
TRG_ER_diArg_1	348	350	PF00400	0.328
TRG_ER_diArg_1	447	449	PF00400	0.263
TRG_ER_diArg_1	496	499	PF00400	0.255
TRG_ER_diArg_1	728	731	PF00400	0.363
TRG_ER_diArg_1	88	90	PF00400	0.564
TRG_ER_diArg_1	91	93	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J5	Leptomonas seymouri	72%	98%
A0A0N1IFZ5	Leptomonas seymouri	26%	100%
A0A0S4IZY8	Bodo saltans	24%	100%
A0A1X0NR57	Trypanosomatidae	56%	99%
A0A1X0NYU4	Trypanosomatidae	25%	100%
A0A381MH18	Leishmania infantum	25%	100%
A0A381MN58	Leishmania infantum	24%	100%
A0A3Q8IAP5	Leishmania donovani	25%	100%
A0A3Q8IEH2	Leishmania donovani	24%	100%
A0A3R7KDB9	Trypanosoma rangeli	25%	100%
A0A3S7X0V5	Leishmania donovani	95%	100%
A0A3S7X2K1	Leishmania donovani	25%	100%
A0A422NJR9	Trypanosoma rangeli	56%	100%
A4H8S1	Leishmania braziliensis	25%	100%
A4HFV9	Leishmania braziliensis	85%	100%
A4HIY0	Leishmania braziliensis	25%	100%
A4I2Z1	Leishmania infantum	95%	100%
C9ZJD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AE36	Leishmania major	25%	100%
E9AE37	Leishmania major	25%	100%
E9AHJ2	Leishmania infantum	25%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AZ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P22225	Trypanosoma brucei brucei	24%	100%
Q4QEM2	Leishmania major	25%	100%
V5BIN9	Trypanosoma cruzi	56%	100%