Putative GTP binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP binding protein, putative

Species:

Leishmania major

UniProt:

E9ADG1_LEIMA

TriTrypDb:

LmjF.27.1830 , LMJLV39_270025400 , LMJSD75_270025400

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADG1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.370
CLV_NRD_NRD_1	152	154	PF00675	0.425
CLV_NRD_NRD_1	3	5	PF00675	0.539
CLV_PCSK_KEX2_1	10	12	PF00082	0.421
CLV_PCSK_KEX2_1	150	152	PF00082	0.445
CLV_PCSK_KEX2_1	169	171	PF00082	0.515
CLV_PCSK_KEX2_1	3	5	PF00082	0.537
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.485
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.482
CLV_PCSK_SKI1_1	195	199	PF00082	0.416
CLV_PCSK_SKI1_1	218	222	PF00082	0.471
DEG_Nend_Nbox_1	1	3	PF02207	0.568
DOC_CKS1_1	124	129	PF01111	0.421
DOC_CYCLIN_RxL_1	189	202	PF00134	0.408
DOC_MAPK_gen_1	10	19	PF00069	0.275
DOC_MAPK_gen_1	238	246	PF00069	0.359
DOC_MAPK_MEF2A_6	238	246	PF00069	0.359
DOC_MAPK_MEF2A_6	72	80	PF00069	0.431
DOC_MAPK_RevD_3	135	151	PF00069	0.361
DOC_PP2B_PxIxI_1	207	213	PF00149	0.232
DOC_PP4_FxxP_1	124	127	PF00568	0.406
DOC_USP7_MATH_1	303	307	PF00917	0.335
DOC_USP7_MATH_1	49	53	PF00917	0.526
DOC_USP7_MATH_1	88	92	PF00917	0.500
DOC_USP7_UBL2_3	150	154	PF12436	0.373
DOC_WW_Pin1_4	123	128	PF00397	0.429
LIG_14-3-3_CanoR_1	241	245	PF00244	0.332
LIG_14-3-3_CanoR_1	298	303	PF00244	0.309
LIG_14-3-3_CanoR_1	3	7	PF00244	0.639
LIG_BRCT_BRCA1_1	24	28	PF00533	0.430
LIG_Clathr_ClatBox_1	260	264	PF01394	0.491
LIG_FHA_1	158	164	PF00498	0.382
LIG_FHA_1	237	243	PF00498	0.360
LIG_FHA_1	248	254	PF00498	0.388
LIG_FHA_1	49	55	PF00498	0.527
LIG_FHA_2	189	195	PF00498	0.448
LIG_FHA_2	347	353	PF00498	0.391
LIG_FHA_2	66	72	PF00498	0.542
LIG_LIR_Apic_2	122	127	PF02991	0.429
LIG_LIR_Gen_1	162	171	PF02991	0.481
LIG_LIR_Gen_1	200	209	PF02991	0.415
LIG_LIR_Gen_1	25	36	PF02991	0.525
LIG_LIR_Nem_3	162	168	PF02991	0.481
LIG_LIR_Nem_3	200	204	PF02991	0.419
LIG_LIR_Nem_3	25	31	PF02991	0.430
LIG_LIR_Nem_3	288	292	PF02991	0.284
LIG_PCNA_yPIPBox_3	272	281	PF02747	0.455
LIG_Pex14_2	319	323	PF04695	0.366
LIG_SH2_CRK	165	169	PF00017	0.471
LIG_SH2_CRK	201	205	PF00017	0.327
LIG_SH2_CRK	281	285	PF00017	0.357
LIG_SH2_STAT3	354	357	PF00017	0.366
LIG_SH2_STAT5	354	357	PF00017	0.349
LIG_SH3_3	14	20	PF00018	0.495
LIG_SH3_3	53	59	PF00018	0.485
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.453
LIG_SUMO_SIM_par_1	71	77	PF11976	0.417
LIG_TRAF2_1	245	248	PF00917	0.360
LIG_TRAF2_1	255	258	PF00917	0.401
LIG_TYR_ITIM	163	168	PF00017	0.402
LIG_WRC_WIRS_1	286	291	PF05994	0.275
MOD_CK1_1	288	294	PF00069	0.275
MOD_CK2_1	116	122	PF00069	0.485
MOD_CK2_1	140	146	PF00069	0.406
MOD_CK2_1	188	194	PF00069	0.423
MOD_CK2_1	252	258	PF00069	0.454
MOD_CK2_1	314	320	PF00069	0.300
MOD_CK2_1	65	71	PF00069	0.520
MOD_GlcNHglycan	179	182	PF01048	0.310
MOD_GlcNHglycan	341	344	PF01048	0.395
MOD_GSK3_1	236	243	PF00069	0.354
MOD_N-GLC_1	49	54	PF02516	0.273
MOD_NEK2_1	110	115	PF00069	0.473
MOD_NEK2_1	2	7	PF00069	0.606
MOD_NEK2_1	31	36	PF00069	0.443
MOD_NEK2_2	23	28	PF00069	0.430
MOD_NEK2_2	236	241	PF00069	0.386
MOD_PIKK_1	157	163	PF00454	0.372
MOD_PIKK_1	31	37	PF00454	0.441
MOD_PIKK_1	365	371	PF00454	0.586
MOD_PIKK_1	65	71	PF00454	0.473
MOD_PKA_2	2	8	PF00069	0.633
MOD_PKA_2	240	246	PF00069	0.343
MOD_Plk_1	163	169	PF00069	0.481
MOD_Plk_2-3	314	320	PF00069	0.290
MOD_Plk_4	163	169	PF00069	0.404
MOD_Plk_4	23	29	PF00069	0.432
MOD_Plk_4	285	291	PF00069	0.275
MOD_Plk_4	330	336	PF00069	0.380
MOD_ProDKin_1	123	129	PF00069	0.416
MOD_SUMO_rev_2	176	181	PF00179	0.374
TRG_DiLeu_BaEn_3	257	263	PF01217	0.388
TRG_ENDOCYTIC_2	165	168	PF00928	0.460
TRG_ENDOCYTIC_2	201	204	PF00928	0.331
TRG_ENDOCYTIC_2	206	209	PF00928	0.340
TRG_ENDOCYTIC_2	281	284	PF00928	0.356
TRG_ER_diArg_1	2	4	PF00400	0.547
TRG_ER_diArg_1	59	62	PF00400	0.445
TRG_ER_diArg_1	9	12	PF00400	0.430
TRG_NES_CRM1_1	131	146	PF08389	0.349
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD45	Leptomonas seymouri	79%	100%
A0A0N1PG70	Leptomonas seymouri	35%	95%
A0A0S4JQA1	Bodo saltans	31%	95%
A0A0S4JQX4	Bodo saltans	62%	100%
A0A1X0NR20	Trypanosomatidae	32%	94%
A0A1X0NSW3	Trypanosomatidae	64%	100%
A0A3R7MAR4	Trypanosoma rangeli	32%	94%
A0A3R7MNI8	Trypanosoma rangeli	66%	100%
A0A3S7X0V3	Leishmania donovani	95%	100%
A0A3S7X112	Leishmania donovani	34%	95%
A0JPJ7	Rattus norvegicus	35%	94%
A4HFV7	Leishmania braziliensis	86%	100%
A4HG11	Leishmania braziliensis	34%	95%
A4I2Y9	Leishmania infantum	95%	100%
A4I330	Leishmania infantum	34%	95%
B8BBN7	Oryza sativa subsp. indica	34%	94%
C9ZJD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZJK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	94%
E9ACV1	Leishmania major	34%	100%
E9AZ85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AZE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	95%
O13998	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	95%
O14078	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	91%
P0ABU2	Escherichia coli (strain K12)	40%	100%
P0ABU3	Escherichia coli O157:H7	40%	100%
P0ABU4	Shigella flexneri	40%	100%
P37518	Bacillus subtilis (strain 168)	41%	100%
P38219	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	94%
P38746	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	92%
P44681	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	42%	100%
P47270	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	37%	100%
P57288	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	36%	100%
P75088	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	35%	100%
P91917	Caenorhabditis elegans	34%	94%
Q2HJ33	Bos taurus	35%	94%
Q58728	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	94%
Q5R821	Pongo abelii	35%	94%
Q5ZM25	Gallus gallus	35%	94%
Q66JG0	Xenopus tropicalis	35%	94%
Q6Z1J6	Oryza sativa subsp. japonica	34%	94%
Q7VMI2	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	41%	100%
Q7ZU42	Danio rerio	35%	94%
Q7ZWM6	Xenopus laevis	35%	94%
Q89AR6	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	35%	100%
Q8K9V2	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	35%	100%
Q8SWU7	Drosophila melanogaster	32%	93%
Q9CP90	Pasteurella multocida (strain Pm70)	41%	100%
Q9CZ30	Mus musculus	35%	94%
Q9NTK5	Homo sapiens	35%	94%
Q9SA73	Arabidopsis thaliana	34%	94%
V5AYP1	Trypanosoma cruzi	62%	86%
V5B8C6	Trypanosoma cruzi	32%	94%