Phosphoenolpyruvate carboxykinase (ATP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphoenolpyruvate carboxykinase [ATP], glycosomal

Species:

Leishmania major

UniProt:

E9ADF9_LEIMA

TriTrypDb:

LmjF.27.1810 , LMJLV39_000016500 , LMJSD75_270025200

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	3
GO:0005773	vacuole	5	3
GO:0005777	peroxisome	6	3
GO:0005829	cytosol	2	3
GO:0005929	cilium	4	3
GO:0012506	vesicle membrane	4	3
GO:0016020	membrane	2	3
GO:0020015	glycosome	7	3
GO:0031090	organelle membrane	3	3
GO:0031410	cytoplasmic vesicle	6	3
GO:0031514	motile cilium	5	3
GO:0031982	vesicle	4	3
GO:0042579	microbody	5	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0097708	intracellular vesicle	5	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

E9ADF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADF9

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	16
GO:0005996	monosaccharide metabolic process	3	16
GO:0006006	glucose metabolic process	5	16
GO:0006094	gluconeogenesis	6	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0008152	metabolic process	1	16
GO:0009058	biosynthetic process	2	16
GO:0009987	cellular process	1	16
GO:0016051	carbohydrate biosynthetic process	4	16
GO:0016310	phosphorylation	5	16
GO:0019318	hexose metabolic process	4	16
GO:0019319	hexose biosynthetic process	5	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046364	monosaccharide biosynthetic process	4	16
GO:0071704	organic substance metabolic process	2	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	16
GO:0004612	phosphoenolpyruvate carboxykinase (ATP) activity	6	16
GO:0005488	binding	1	16
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0016829	lyase activity	2	16
GO:0016830	carbon-carbon lyase activity	3	16
GO:0016831	carboxy-lyase activity	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	475	477	PF00675	0.391
CLV_PCSK_FUR_1	46	50	PF00082	0.359
CLV_PCSK_KEX2_1	427	429	PF00082	0.280
CLV_PCSK_KEX2_1	48	50	PF00082	0.288
CLV_PCSK_KEX2_1	502	504	PF00082	0.542
CLV_PCSK_KEX2_1	79	81	PF00082	0.371
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.280
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.288
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.542
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.371
CLV_PCSK_SKI1_1	109	113	PF00082	0.305
CLV_PCSK_SKI1_1	186	190	PF00082	0.280
CLV_PCSK_SKI1_1	249	253	PF00082	0.283
CLV_PCSK_SKI1_1	30	34	PF00082	0.291
CLV_PCSK_SKI1_1	376	380	PF00082	0.292
CLV_PCSK_SKI1_1	390	394	PF00082	0.295
CLV_PCSK_SKI1_1	401	405	PF00082	0.346
CLV_PCSK_SKI1_1	424	428	PF00082	0.280
CLV_PCSK_SKI1_1	480	484	PF00082	0.487
CLV_PCSK_SKI1_1	7	11	PF00082	0.299
DEG_APCC_DBOX_1	29	37	PF00400	0.512
DEG_APCC_DBOX_1	87	95	PF00400	0.507
DEG_SPOP_SBC_1	158	162	PF00917	0.488
DOC_MAPK_gen_1	103	110	PF00069	0.496
DOC_MAPK_gen_1	185	193	PF00069	0.531
DOC_MAPK_gen_1	212	220	PF00069	0.515
DOC_MAPK_gen_1	421	431	PF00069	0.500
DOC_MAPK_gen_1	76	84	PF00069	0.549
DOC_MAPK_MEF2A_6	103	110	PF00069	0.496
DOC_MAPK_MEF2A_6	185	193	PF00069	0.480
DOC_MAPK_MEF2A_6	212	220	PF00069	0.480
DOC_MAPK_MEF2A_6	424	433	PF00069	0.480
DOC_PP2B_LxvP_1	459	462	PF13499	0.480
DOC_PP2B_LxvP_1	9	12	PF13499	0.549
DOC_PP4_FxxP_1	136	139	PF00568	0.490
DOC_PP4_FxxP_1	383	386	PF00568	0.490
DOC_USP7_MATH_1	151	155	PF00917	0.519
DOC_USP7_MATH_1	506	510	PF00917	0.467
DOC_USP7_MATH_1	511	515	PF00917	0.432
DOC_WW_Pin1_4	345	350	PF00397	0.551
DOC_WW_Pin1_4	369	374	PF00397	0.582
DOC_WW_Pin1_4	41	46	PF00397	0.488
LIG_14-3-3_CanoR_1	109	116	PF00244	0.490
LIG_14-3-3_CanoR_1	390	395	PF00244	0.571
LIG_14-3-3_CanoR_1	7	12	PF00244	0.547
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BIR_III_4	336	340	PF00653	0.480
LIG_BRCT_BRCA1_1	164	168	PF00533	0.577
LIG_BRCT_BRCA1_1	379	383	PF00533	0.480
LIG_Clathr_ClatBox_1	91	95	PF01394	0.482
LIG_deltaCOP1_diTrp_1	241	252	PF00928	0.480
LIG_FHA_1	159	165	PF00498	0.507
LIG_FHA_1	290	296	PF00498	0.479
LIG_FHA_1	318	324	PF00498	0.577
LIG_FHA_1	359	365	PF00498	0.480
LIG_FHA_1	432	438	PF00498	0.480
LIG_FHA_1	487	493	PF00498	0.472
LIG_FHA_1	51	57	PF00498	0.488
LIG_FHA_2	127	133	PF00498	0.515
LIG_FHA_2	168	174	PF00498	0.577
LIG_FHA_2	267	273	PF00498	0.480
LIG_FHA_2	486	492	PF00498	0.402
LIG_FHA_2	8	14	PF00498	0.512
LIG_LIR_Apic_2	134	139	PF02991	0.534
LIG_LIR_Apic_2	380	386	PF02991	0.490
LIG_LIR_Gen_1	113	124	PF02991	0.454
LIG_LIR_Gen_1	190	197	PF02991	0.480
LIG_LIR_Gen_1	271	282	PF02991	0.483
LIG_LIR_Gen_1	71	82	PF02991	0.521
LIG_LIR_Nem_3	113	119	PF02991	0.454
LIG_LIR_Nem_3	138	144	PF02991	0.490
LIG_LIR_Nem_3	217	222	PF02991	0.480
LIG_LIR_Nem_3	271	277	PF02991	0.483
LIG_LIR_Nem_3	449	454	PF02991	0.492
LIG_LIR_Nem_3	61	65	PF02991	0.488
LIG_LIR_Nem_3	71	77	PF02991	0.488
LIG_OCRL_FandH_1	386	398	PF00620	0.515
LIG_Pex14_2	379	383	PF04695	0.480
LIG_Pex14_2	496	500	PF04695	0.386
LIG_PTB_Apo_2	332	339	PF02174	0.480
LIG_PTB_Apo_2	411	418	PF02174	0.480
LIG_PTB_Phospho_1	411	417	PF10480	0.480
LIG_SH2_CRK	116	120	PF00017	0.490
LIG_SH2_CRK	122	126	PF00017	0.490
LIG_SH2_CRK	274	278	PF00017	0.501
LIG_SH2_STAP1	259	263	PF00017	0.480
LIG_SH2_STAP1	360	364	PF00017	0.480
LIG_SH2_STAT3	395	398	PF00017	0.480
LIG_SH2_STAT5	141	144	PF00017	0.490
LIG_SH2_STAT5	360	363	PF00017	0.480
LIG_SH2_STAT5	451	454	PF00017	0.595
LIG_SH2_STAT5	519	522	PF00017	0.429
LIG_SH3_3	150	156	PF00018	0.502
LIG_SH3_3	305	311	PF00018	0.480
LIG_SH3_3	337	343	PF00018	0.480
LIG_SH3_3	371	377	PF00018	0.527
LIG_TRAF2_1	129	132	PF00917	0.508
LIG_TRAF2_1	170	173	PF00917	0.577
LIG_TRAF2_1	269	272	PF00917	0.577
LIG_TRAF2_2	469	474	PF00917	0.623
LIG_TRFH_1	193	197	PF08558	0.328
LIG_WRC_WIRS_1	133	138	PF05994	0.346
MOD_CDK_SPK_2	41	46	PF00069	0.391
MOD_CDK_SPxxK_3	369	376	PF00069	0.394
MOD_CDK_SPxxK_3	41	48	PF00069	0.339
MOD_CK1_1	160	166	PF00069	0.428
MOD_CK1_1	70	76	PF00069	0.373
MOD_CK2_1	126	132	PF00069	0.377
MOD_CK2_1	167	173	PF00069	0.464
MOD_CK2_1	266	272	PF00069	0.358
MOD_CK2_1	485	491	PF00069	0.389
MOD_CK2_1	7	13	PF00069	0.354
MOD_Cter_Amidation	210	213	PF01082	0.399
MOD_GlcNHglycan	148	152	PF01048	0.316
MOD_GlcNHglycan	206	209	PF01048	0.328
MOD_GlcNHglycan	222	225	PF01048	0.328
MOD_GlcNHglycan	230	233	PF01048	0.341
MOD_GlcNHglycan	27	30	PF01048	0.458
MOD_GlcNHglycan	513	516	PF01048	0.441
MOD_GSK3_1	147	154	PF00069	0.447
MOD_GSK3_1	156	163	PF00069	0.411
MOD_GSK3_1	222	229	PF00069	0.337
MOD_GSK3_1	34	41	PF00069	0.333
MOD_N-GLC_1	284	289	PF02516	0.458
MOD_N-GLC_1	485	490	PF02516	0.398
MOD_N-GLC_1	7	12	PF02516	0.354
MOD_NEK2_1	204	209	PF00069	0.328
MOD_NEK2_1	220	225	PF00069	0.328
MOD_NEK2_1	358	363	PF00069	0.377
MOD_NEK2_1	412	417	PF00069	0.328
MOD_NEK2_1	431	436	PF00069	0.328
MOD_NEK2_1	485	490	PF00069	0.377
MOD_NEK2_1	496	501	PF00069	0.411
MOD_NEK2_2	139	144	PF00069	0.428
MOD_NEK2_2	214	219	PF00069	0.339
MOD_PKA_1	401	407	PF00069	0.484
MOD_PKA_2	126	132	PF00069	0.484
MOD_Plk_1	139	145	PF00069	0.403
MOD_Plk_1	214	220	PF00069	0.328
MOD_Plk_1	284	290	PF00069	0.398
MOD_Plk_1	298	304	PF00069	0.259
MOD_Plk_1	70	76	PF00069	0.339
MOD_Plk_2-3	132	138	PF00069	0.346
MOD_Plk_2-3	284	290	PF00069	0.458
MOD_Plk_4	139	145	PF00069	0.416
MOD_Plk_4	187	193	PF00069	0.328
MOD_Plk_4	214	220	PF00069	0.328
MOD_Plk_4	390	396	PF00069	0.399
MOD_ProDKin_1	345	351	PF00069	0.428
MOD_ProDKin_1	369	375	PF00069	0.471
MOD_ProDKin_1	41	47	PF00069	0.339
MOD_SUMO_for_1	19	22	PF00179	0.339
MOD_SUMO_for_1	267	270	PF00179	0.342
MOD_SUMO_rev_2	22	28	PF00179	0.456
TRG_ENDOCYTIC_2	116	119	PF00928	0.342
TRG_ENDOCYTIC_2	122	125	PF00928	0.342
TRG_ENDOCYTIC_2	274	277	PF00928	0.342
TRG_NLS_MonoExtC_3	77	83	PF00514	0.422
TRG_NLS_MonoExtN_4	76	82	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.328
TRG_PTS1	522	525	PF00515	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSM3	Leptomonas seymouri	89%	100%
A0A0S4JLJ3	Bodo saltans	73%	100%
A0A1X0NR81	Trypanosomatidae	82%	100%
A0A3Q8IHQ3	Leishmania donovani	98%	100%
A0A3R7K1T3	Trypanosoma rangeli	83%	100%
A0A3S7X0U3	Leishmania donovani	97%	100%
A0A422MS16	Trypanosoma rangeli	83%	76%
A0KRH2	Shewanella sp. (strain ANA-3)	42%	100%
A0LXJ9	Gramella forsetii (strain KT0803)	43%	99%
A0RJZ8	Bacillus thuringiensis (strain Al Hakam)	46%	99%
A1AGS9	Escherichia coli O1:K1 / APEC	44%	97%
A1AV24	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	47%	99%
A1B5Z2	Paracoccus denitrificans (strain Pd 1222)	44%	99%
A1JSE7	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	44%	97%
A1RPC2	Shewanella sp. (strain W3-18-1)	42%	100%
A1S1X0	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	42%	100%
A1U754	Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8)	40%	100%
A1VZR5	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)	45%	100%
A3DAB2	Shewanella baltica (strain OS155 / ATCC BAA-1091)	42%	100%
A3N0G0	Actinobacillus pleuropneumoniae serotype 5b (strain L20)	41%	98%
A3PGG3	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	46%	99%
A3QJ41	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	41%	100%
A4HFV1	Leishmania braziliensis	92%	100%
A4I2Y7	Leishmania infantum	98%	100%
A4IRZ2	Geobacillus thermodenitrificans (strain NG80-2)	46%	99%
A4TGS8	Yersinia pestis (strain Pestoides F)	43%	97%
A4WFJ1	Enterobacter sp. (strain 638)	44%	98%
A4WVP0	Cereibacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)	46%	99%
A4XP75	Pseudomonas mendocina (strain ymp)	40%	100%
A4YBE7	Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)	42%	100%
A4YL90	Bradyrhizobium sp. (strain ORS 278)	46%	98%
A5EST5	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	46%	98%
A5F4Q4	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	42%	97%
A5FK68	Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101)	45%	98%
A5GBF9	Geotalea uraniireducens (strain Rf4)	46%	99%
A5ITV7	Staphylococcus aureus (strain JH9)	43%	99%
A5UDR5	Haemophilus influenzae (strain PittEE)	43%	98%
A5UHW1	Haemophilus influenzae (strain PittGG)	43%	98%
A5VX32	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	40%	100%
A6LFQ4	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	44%	98%
A6Q102	Nitratiruptor sp. (strain SB155-2)	44%	100%
A6QHX1	Staphylococcus aureus (strain Newman)	43%	99%
A6U2Q2	Staphylococcus aureus (strain JH1)	43%	99%
A6UEJ7	Sinorhizobium medicae (strain WSM419)	44%	98%
A6VDW7	Pseudomonas aeruginosa (strain PA7)	40%	100%
A6VKV4	Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z)	41%	98%
A6WHM7	Shewanella baltica (strain OS185)	42%	100%
A6WX47	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	45%	98%
A7FNU8	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	43%	97%
A7GU41	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	45%	99%
A7H3B9	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	44%	100%
A7HP99	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	43%	98%
A7MGC5	Cronobacter sakazakii (strain ATCC BAA-894)	44%	97%
A7MZB2	Vibrio campbellii (strain ATCC BAA-1116)	42%	97%
A7X3N3	Staphylococcus aureus (strain Mu3 / ATCC 700698)	43%	99%
A7Z7Z0	Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)	45%	100%
A7ZST1	Escherichia coli O139:H28 (strain E24377A / ETEC)	44%	97%
A8A5L1	Escherichia coli O9:H4 (strain HS)	44%	97%
A8AQV7	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	45%	97%
A8FGH8	Bacillus pumilus (strain SAFR-032)	45%	99%
A8FLY1	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	45%	100%
A8G1J1	Shewanella sediminis (strain HAW-EB3)	41%	100%
A8GYT2	Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)	40%	100%
A8ILP8	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571)	45%	98%
A8LLF2	Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)	46%	99%
A8MEV2	Alkaliphilus oremlandii (strain OhILAs)	43%	100%
A8Z4L3	Staphylococcus aureus (strain USA300 / TCH1516)	43%	99%
A9KDE5	Coxiella burnetii (strain Dugway 5J108-111)	41%	100%
A9KVC7	Shewanella baltica (strain OS195)	42%	100%
A9M9S3	Brucella canis (strain ATCC 23365 / NCTC 10854)	45%	98%
A9MMC5	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	44%	97%
A9MT72	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	45%	97%
A9NBT9	Coxiella burnetii (strain RSA 331 / Henzerling II)	40%	100%
A9R4C2	Yersinia pestis bv. Antiqua (strain Angola)	43%	97%
A9VLC7	Bacillus mycoides (strain KBAB4)	45%	99%
A9W382	Methylorubrum extorquens (strain PA1)	43%	97%
B0BP80	Actinobacillus pleuropneumoniae serotype 3 (strain JL03)	41%	98%
B0KI05	Pseudomonas putida (strain GB-1)	40%	100%
B0SFJ3	Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)	44%	99%
B0SPF0	Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)	44%	99%
B0TMY0	Shewanella halifaxensis (strain HAW-EB4)	40%	100%
B0UFE2	Methylobacterium sp. (strain 4-46)	45%	98%
B0UWS7	Histophilus somni (strain 2336)	42%	98%
B1HXZ6	Lysinibacillus sphaericus (strain C3-41)	46%	99%
B1IP62	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	44%	97%
B1JET1	Pseudomonas putida (strain W619)	39%	100%
B1JI04	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	43%	97%
B1KN33	Shewanella woodyi (strain ATCC 51908 / MS32)	41%	100%
B1LHK1	Escherichia coli (strain SMS-3-5 / SECEC)	44%	97%
B1M6N5	Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1)	43%	97%
B1X750	Escherichia coli (strain K12 / DH10B)	44%	97%
B1ZG99	Methylorubrum populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)	43%	97%
B2K5U8	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	43%	97%
B2RHV8	Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)	43%	98%
B2U3L1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	44%	97%
B2VJU9	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	43%	97%
B3ET45	Amoebophilus asiaticus (strain 5a2)	41%	100%
B3H1D9	Actinobacillus pleuropneumoniae serotype 7 (strain AP76)	41%	98%
B3PWH4	Rhizobium etli (strain CIAT 652)	44%	98%
B3Q999	Rhodopseudomonas palustris (strain TIE-1)	47%	98%
B4F025	Proteus mirabilis (strain HI4320)	43%	97%
B4SVK3	Salmonella newport (strain SL254)	45%	97%
B4TKS6	Salmonella heidelberg (strain SL476)	45%	97%
B4TY59	Salmonella schwarzengrund (strain CVM19633)	45%	97%
B5BHF8	Salmonella paratyphi A (strain AKU_12601)	45%	97%
B5F8L6	Salmonella agona (strain SL483)	45%	97%
B5FCE7	Aliivibrio fischeri (strain MJ11)	42%	97%
B5FJS1	Salmonella dublin (strain CT_02021853)	45%	97%
B5R360	Salmonella enteritidis PT4 (strain P125109)	45%	97%
B5R7L4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	45%	97%
B5X574	Arabidopsis thaliana	49%	78%
B5YTV3	Escherichia coli O157:H7 (strain EC4115 / EHEC)	44%	97%
B5ZV86	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	44%	98%
B6EGP7	Aliivibrio salmonicida (strain LFI1238)	42%	97%
B6I2W3	Escherichia coli (strain SE11)	44%	97%
B6J3V5	Coxiella burnetii (strain CbuG_Q212)	40%	100%
B6J6M2	Coxiella burnetii (strain CbuK_Q154)	41%	100%
B6JJT0	Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)	46%	98%
B6YRN4	Azobacteroides pseudotrichonymphae genomovar. CFP2	42%	99%
B7H9C8	Bacillus cereus (strain B4264)	46%	99%
B7HSV7	Bacillus cereus (strain AH187)	46%	99%
B7IL29	Bacillus cereus (strain G9842)	45%	99%
B7JT33	Bacillus cereus (strain AH820)	46%	99%
B7KVW8	Methylorubrum extorquens (strain CM4 / NCIMB 13688)	43%	97%
B7L4T1	Escherichia coli (strain 55989 / EAEC)	44%	97%
B7LSA4	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	45%	97%
B7M1V7	Escherichia coli O8 (strain IAI1)	44%	97%
B7MDM9	Escherichia coli O45:K1 (strain S88 / ExPEC)	44%	97%
B7N136	Escherichia coli O81 (strain ED1a)	44%	97%
B7NE08	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	44%	97%
B7NMG6	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	44%	97%
B7UKA7	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	44%	97%
B7V3T9	Pseudomonas aeruginosa (strain LESB58)	40%	100%
B7VHF2	Vibrio atlanticus (strain LGP32)	43%	97%
B8CH32	Shewanella piezotolerans (strain WP3 / JCM 13877)	40%	100%
B8E3X7	Shewanella baltica (strain OS223)	42%	100%
B8F4W1	Glaesserella parasuis serovar 5 (strain SH0165)	42%	98%
B8IMT2	Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)	45%	98%
B9DN20	Staphylococcus carnosus (strain TM300)	44%	99%
B9J266	Bacillus cereus (strain Q1)	46%	99%
B9JG59	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)	46%	98%
B9JXX4	Agrobacterium vitis (strain S4 / ATCC BAA-846)	43%	98%
B9KD79	Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)	45%	100%
C0Q0H5	Salmonella paratyphi C (strain RKS4594)	45%	97%
C0ZL09	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)	46%	100%
C1EW38	Bacillus cereus (strain 03BB102)	46%	99%
C3K4J5	Pseudomonas fluorescens (strain SBW25)	40%	100%
C3LSG5	Vibrio cholerae serotype O1 (strain M66-2)	42%	97%
C3PCC6	Bacillus anthracis (strain A0248)	46%	99%
C4K3J5	Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)	42%	97%
C4Z0Q6	Lachnospira eligens (strain ATCC 27750 / DSM 3376 / VPI C15-48 / C15-B4)	43%	98%
C4ZBL1	Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990)	42%	98%
C4ZUQ8	Escherichia coli (strain K12 / MC4100 / BW2952)	44%	97%
C5BGS4	Edwardsiella ictaluri (strain 93-146)	41%	97%
C6DGE8	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	44%	97%
C6E0Y2	Geobacter sp. (strain M21)	44%	99%
C9ZJD2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9ADF8	Leishmania major	100%	100%
E9AZ81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AZ83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O09460	Anaerobiospirillum succiniciproducens	41%	99%
O13434	Candida albicans	52%	95%
O43112	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	55%	97%
O83023	Selenomonas ruminantium	42%	97%
P0A0B3	Staphylococcus aureus (strain Mu50 / ATCC 700699)	43%	99%
P0C1S4	Staphylococcus aureus	43%	99%
P10963	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	96%
P13735	Trypanosoma brucei brucei	82%	100%
P22259	Escherichia coli (strain K12)	44%	97%
P41033	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	45%	98%
P42066	Cucumis sativus	48%	78%
P43085	Rhizobium meliloti (strain 1021)	45%	98%
P43086	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	44%	98%
P43923	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	43%	98%
P49292	Urochloa panicoides	50%	84%
P51058	Trypanosoma cruzi	82%	100%
P54418	Bacillus subtilis (strain 168)	44%	100%
P99128	Staphylococcus aureus (strain N315)	43%	99%
Q02EH2	Pseudomonas aeruginosa (strain UCBPP-PA14)	39%	100%
Q07TF9	Rhodopseudomonas palustris (strain BisA53)	47%	98%
Q089V1	Shewanella frigidimarina (strain NCIMB 400)	41%	100%
Q0AQP4	Maricaulis maris (strain MCS10)	42%	98%
Q0HNY4	Shewanella sp. (strain MR-4)	42%	100%
Q0I0F2	Shewanella sp. (strain MR-7)	42%	100%
Q0I554	Haemophilus somnus (strain 129Pt)	42%	98%
Q0SZR5	Shigella flexneri serotype 5b (strain 8401)	44%	97%
Q0TC64	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	44%	97%
Q11CK2	Chelativorans sp. (strain BNC1)	45%	98%
Q12T12	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	43%	100%
Q13E86	Rhodopseudomonas palustris (strain BisB5)	46%	98%
Q16AH6	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	45%	99%
Q1AY78	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)	43%	99%
Q1C2M9	Yersinia pestis bv. Antiqua (strain Antiqua)	43%	97%
Q1CCM6	Yersinia pestis bv. Antiqua (strain Nepal516)	43%	97%
Q1GDU2	Ruegeria sp. (strain TM1040)	45%	99%
Q1IGK1	Pseudomonas entomophila (strain L48)	40%	100%
Q1IZ41	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	47%	99%
Q1LU72	Baumannia cicadellinicola subsp. Homalodisca coagulata	40%	98%
Q1MNG2	Rhizobium leguminosarum bv. viciae (strain 3841)	44%	98%
Q1QR12	Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)	46%	98%
Q21BR2	Rhodopseudomonas palustris (strain BisB18)	47%	98%
Q2FFV5	Staphylococcus aureus (strain USA300)	43%	99%
Q2G1W2	Staphylococcus aureus (strain NCTC 8325 / PS 47)	43%	99%
Q2G480	Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)	45%	98%
Q2J2Y8	Rhodopseudomonas palustris (strain HaA2)	47%	98%
Q2KE66	Rhizobium etli (strain CFN 42 / ATCC 51251)	45%	98%
Q2NQI3	Sodalis glossinidius (strain morsitans)	43%	97%
Q2RH96	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	46%	100%
Q2RKS7	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	46%	100%
Q2S008	Salinibacter ruber (strain DSM 13855 / M31)	52%	99%
Q2S1I3	Salinibacter ruber (strain DSM 13855 / M31)	44%	98%
Q2SPF9	Hahella chejuensis (strain KCTC 2396)	40%	100%
Q2YTK0	Staphylococcus aureus (strain bovine RF122 / ET3-1)	43%	99%
Q30PV8	Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)	45%	99%
Q31VN1	Shigella boydii serotype 4 (strain Sb227)	44%	97%
Q32AL7	Shigella dysenteriae serotype 1 (strain Sd197)	44%	97%
Q39QU2	Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)	44%	99%
Q3ILP3	Pseudoalteromonas translucida (strain TAC 125)	42%	100%
Q3J5V6	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	46%	99%
Q3KJP4	Pseudomonas fluorescens (strain Pf0-1)	40%	100%
Q3SVS4	Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)	45%	98%
Q3YWM2	Shigella sonnei (strain Ss046)	44%	97%
Q47VD0	Colwellia psychrerythraea (strain 34H / ATCC BAA-681)	45%	98%
Q48BY7	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	41%	100%
Q49YL7	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	44%	99%
Q4KK03	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	40%	100%
Q4L7C9	Staphylococcus haemolyticus (strain JCSC1435)	44%	99%
Q4QM91	Haemophilus influenzae (strain 86-028NP)	43%	98%
Q500D1	Pseudomonas syringae pv. syringae (strain B728a)	41%	100%
Q57IX4	Salmonella choleraesuis (strain SC-B67)	45%	97%
Q5E1X3	Aliivibrio fischeri (strain ATCC 700601 / ES114)	42%	98%
Q5HEY8	Staphylococcus aureus (strain COL)	43%	99%
Q5HNB7	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	44%	99%
Q5HUM7	Campylobacter jejuni (strain RM1221)	45%	100%
Q5KW01	Geobacillus kaustophilus (strain HTA426)	47%	99%
Q5L7N5	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	44%	98%
Q5LVJ2	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	45%	99%
Q5PLX8	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	45%	97%
Q5QUN4	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	45%	98%
Q5SLL5	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	45%	99%
Q5WDZ7	Alkalihalobacillus clausii (strain KSM-K16)	43%	100%
Q632S4	Bacillus cereus (strain ZK / E33L)	46%	99%
Q64MV4	Bacteroides fragilis (strain YCH46)	44%	98%
Q65FV7	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	44%	100%
Q65Q60	Mannheimia succiniciproducens (strain MBEL55E)	43%	98%
Q664K7	Yersinia pseudotuberculosis serotype I (strain IP32953)	43%	97%
Q6CZP5	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	43%	97%
Q6FRR0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	53%	97%
Q6G8E2	Staphylococcus aureus (strain MSSA476)	43%	99%
Q6GFR5	Staphylococcus aureus (strain MRSA252)	43%	99%
Q6HCB3	Bacillus thuringiensis subsp. konkukian (strain 97-27)	46%	99%
Q6LLS2	Photobacterium profundum (strain SS9)	41%	99%
Q72GY7	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	45%	99%
Q72VT0	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	44%	99%
Q72YV4	Bacillus cereus (strain ATCC 10987 / NRS 248)	46%	99%
Q753M0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	52%	97%
Q75JD5	Dictyostelium discoideum	51%	93%
Q7MQ03	Vibrio vulnificus (strain YJ016)	41%	97%
Q7MU78	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	43%	98%
Q7NA45	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	44%	97%
Q7RVS9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	51%	87%
Q7VLT3	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	43%	98%
Q816Q7	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	46%	99%
Q81KH8	Bacillus anthracis	46%	99%
Q83A19	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	40%	100%
Q83J96	Shigella flexneri	44%	97%
Q87TE1	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	43%	97%
Q88AZ4	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	41%	100%
Q89BK7	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	46%	98%
Q8A414	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	44%	98%
Q8CS25	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	44%	99%
Q8D1X9	Wigglesworthia glossinidia brevipalpis	40%	97%
Q8DDS6	Vibrio vulnificus (strain CMCP6)	41%	97%
Q8EKD3	Shewanella oneidensis (strain MR-1)	42%	100%
Q8EP04	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	45%	100%
Q8F9E4	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	44%	99%
Q8FCU4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	44%	97%
Q8FY05	Brucella suis biovar 1 (strain 1330)	45%	98%
Q8NVZ8	Staphylococcus aureus (strain MW2)	43%	99%
Q8R943	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	46%	100%
Q8REI2	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	41%	100%
Q8UJ94	Agrobacterium fabrum (strain C58 / ATCC 33970)	45%	98%
Q8X733	Escherichia coli O157:H7	44%	97%
Q8YE41	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	45%	98%
Q8Z216	Salmonella typhi	45%	97%
Q8ZJG9	Yersinia pestis	43%	97%
Q96UL8	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	50%	88%
Q98CL7	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	43%	98%
Q9CKR4	Pasteurella multocida (strain Pm70)	43%	98%
Q9HTZ7	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	39%	100%
Q9K7Q7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	47%	100%
Q9KNK0	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	42%	97%
Q9PP01	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	45%	100%
Q9RVP6	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	48%	100%
Q9SLZ0	Zea mays	49%	79%
Q9T074	Arabidopsis thaliana	49%	78%
Q9XFA2	Urochloa panicoides	50%	84%
Q9YG68	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	26%	100%
Q9ZNH4	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	47%	98%
V5BN69	Trypanosoma cruzi	81%	100%