Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADF6_LEIMA

TriTrypDb:

LmjF.27.1790 , LMJLV39_270024700 , LMJSD75_270024900

Length:

842

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.595
CLV_C14_Caspase3-7	752	756	PF00656	0.553
CLV_MEL_PAP_1	701	707	PF00089	0.372
CLV_NRD_NRD_1	300	302	PF00675	0.593
CLV_NRD_NRD_1	363	365	PF00675	0.622
CLV_NRD_NRD_1	406	408	PF00675	0.618
CLV_NRD_NRD_1	462	464	PF00675	0.602
CLV_NRD_NRD_1	478	480	PF00675	0.635
CLV_NRD_NRD_1	508	510	PF00675	0.717
CLV_NRD_NRD_1	552	554	PF00675	0.546
CLV_NRD_NRD_1	578	580	PF00675	0.547
CLV_NRD_NRD_1	614	616	PF00675	0.553
CLV_NRD_NRD_1	623	625	PF00675	0.457
CLV_NRD_NRD_1	757	759	PF00675	0.541
CLV_NRD_NRD_1	87	89	PF00675	0.448
CLV_PCSK_FUR_1	506	510	PF00082	0.698
CLV_PCSK_KEX2_1	300	302	PF00082	0.593
CLV_PCSK_KEX2_1	406	408	PF00082	0.618
CLV_PCSK_KEX2_1	462	464	PF00082	0.542
CLV_PCSK_KEX2_1	478	480	PF00082	0.635
CLV_PCSK_KEX2_1	508	510	PF00082	0.714
CLV_PCSK_KEX2_1	552	554	PF00082	0.546
CLV_PCSK_KEX2_1	578	580	PF00082	0.547
CLV_PCSK_KEX2_1	614	616	PF00082	0.495
CLV_PCSK_KEX2_1	623	625	PF00082	0.410
CLV_PCSK_KEX2_1	757	759	PF00082	0.541
CLV_PCSK_SKI1_1	195	199	PF00082	0.423
CLV_PCSK_SKI1_1	614	618	PF00082	0.524
CLV_PCSK_SKI1_1	624	628	PF00082	0.415
CLV_PCSK_SKI1_1	650	654	PF00082	0.362
CLV_PCSK_SKI1_1	685	689	PF00082	0.411
CLV_PCSK_SKI1_1	698	702	PF00082	0.419
CLV_PCSK_SKI1_1	80	84	PF00082	0.405
DEG_APCC_DBOX_1	134	142	PF00400	0.492
DEG_APCC_DBOX_1	660	668	PF00400	0.438
DEG_APCC_DBOX_1	809	817	PF00400	0.537
DEG_Nend_UBRbox_4	1	3	PF02207	0.547
DEG_SCF_TRCP1_1	549	554	PF00400	0.539
DEG_SPOP_SBC_1	241	245	PF00917	0.677
DEG_SPOP_SBC_1	408	412	PF00917	0.633
DEG_SPOP_SBC_1	555	559	PF00917	0.614
DOC_CKS1_1	140	145	PF01111	0.325
DOC_CYCLIN_RxL_1	682	692	PF00134	0.410
DOC_MAPK_FxFP_2	827	830	PF00069	0.671
DOC_MAPK_gen_1	375	384	PF00069	0.519
DOC_MAPK_gen_1	77	85	PF00069	0.387
DOC_MAPK_JIP1_4	836	842	PF00069	0.564
DOC_MAPK_MEF2A_6	698	705	PF00069	0.362
DOC_PP1_RVXF_1	683	690	PF00149	0.410
DOC_PP1_RVXF_1	700	706	PF00149	0.431
DOC_PP4_FxxP_1	140	143	PF00568	0.402
DOC_PP4_FxxP_1	401	404	PF00568	0.525
DOC_PP4_FxxP_1	827	830	PF00568	0.671
DOC_SPAK_OSR1_1	704	708	PF12202	0.475
DOC_USP7_MATH_1	173	177	PF00917	0.470
DOC_USP7_MATH_1	212	216	PF00917	0.434
DOC_USP7_MATH_1	275	279	PF00917	0.658
DOC_USP7_MATH_1	281	285	PF00917	0.597
DOC_USP7_MATH_1	311	315	PF00917	0.653
DOC_USP7_MATH_1	330	334	PF00917	0.539
DOC_USP7_MATH_1	346	350	PF00917	0.622
DOC_USP7_MATH_1	395	399	PF00917	0.531
DOC_USP7_MATH_1	571	575	PF00917	0.537
DOC_USP7_MATH_1	753	757	PF00917	0.523
DOC_USP7_MATH_1	781	785	PF00917	0.634
DOC_USP7_MATH_1	823	827	PF00917	0.624
DOC_USP7_MATH_2	482	488	PF00917	0.654
DOC_WW_Pin1_4	139	144	PF00397	0.499
DOC_WW_Pin1_4	179	184	PF00397	0.578
DOC_WW_Pin1_4	226	231	PF00397	0.619
DOC_WW_Pin1_4	242	247	PF00397	0.629
DOC_WW_Pin1_4	260	265	PF00397	0.671
DOC_WW_Pin1_4	270	275	PF00397	0.623
DOC_WW_Pin1_4	277	282	PF00397	0.647
DOC_WW_Pin1_4	336	341	PF00397	0.667
DOC_WW_Pin1_4	342	347	PF00397	0.697
DOC_WW_Pin1_4	400	405	PF00397	0.617
DOC_WW_Pin1_4	435	440	PF00397	0.590
DOC_WW_Pin1_4	536	541	PF00397	0.524
DOC_WW_Pin1_4	551	556	PF00397	0.620
DOC_WW_Pin1_4	558	563	PF00397	0.725
DOC_WW_Pin1_4	59	64	PF00397	0.448
DOC_WW_Pin1_4	709	714	PF00397	0.615
DOC_WW_Pin1_4	804	809	PF00397	0.802
DOC_WW_Pin1_4	818	823	PF00397	0.595
LIG_14-3-3_CanoR_1	135	141	PF00244	0.423
LIG_14-3-3_CanoR_1	213	223	PF00244	0.559
LIG_14-3-3_CanoR_1	276	280	PF00244	0.699
LIG_14-3-3_CanoR_1	406	416	PF00244	0.523
LIG_14-3-3_CanoR_1	435	439	PF00244	0.637
LIG_14-3-3_CanoR_1	462	466	PF00244	0.535
LIG_14-3-3_CanoR_1	655	661	PF00244	0.492
LIG_14-3-3_CanoR_1	66	73	PF00244	0.404
LIG_14-3-3_CanoR_1	724	734	PF00244	0.636
LIG_14-3-3_CanoR_1	797	803	PF00244	0.620
LIG_14-3-3_CanoR_1	836	841	PF00244	0.604
LIG_APCC_ABBAyCdc20_2	685	691	PF00400	0.411
LIG_BRCT_BRCA1_1	397	401	PF00533	0.526
LIG_BRCT_BRCA1_1	685	689	PF00533	0.411
LIG_BRCT_BRCA1_1	823	827	PF00533	0.677
LIG_CSL_BTD_1	710	713	PF09270	0.615
LIG_CtBP_PxDLS_1	340	344	PF00389	0.694
LIG_FHA_1	140	146	PF00498	0.318
LIG_FHA_1	37	43	PF00498	0.389
LIG_FHA_1	392	398	PF00498	0.673
LIG_FHA_1	537	543	PF00498	0.637
LIG_FHA_1	60	66	PF00498	0.458
LIG_FHA_1	607	613	PF00498	0.493
LIG_FHA_1	651	657	PF00498	0.459
LIG_FHA_2	11	17	PF00498	0.511
LIG_FHA_2	585	591	PF00498	0.617
LIG_FHA_2	641	647	PF00498	0.493
LIG_FHA_2	733	739	PF00498	0.605
LIG_FHA_2	783	789	PF00498	0.825
LIG_Integrin_isoDGR_2	355	357	PF01839	0.541
LIG_Integrin_isoDGR_2	504	506	PF01839	0.619
LIG_LIR_Apic_2	139	143	PF02991	0.405
LIG_LIR_Apic_2	398	404	PF02991	0.521
LIG_LIR_Apic_2	475	480	PF02991	0.613
LIG_LIR_Apic_2	824	830	PF02991	0.672
LIG_LIR_Gen_1	464	473	PF02991	0.510
LIG_LIR_Nem_3	121	127	PF02991	0.451
LIG_LIR_Nem_3	464	469	PF02991	0.557
LIG_LIR_Nem_3	471	477	PF02991	0.516
LIG_LIR_Nem_3	78	82	PF02991	0.392
LIG_MAD2	259	267	PF02301	0.531
LIG_NRBOX	149	155	PF00104	0.385
LIG_NRBOX	156	162	PF00104	0.392
LIG_PDZ_Class_2	837	842	PF00595	0.584
LIG_REV1ctd_RIR_1	19	28	PF16727	0.471
LIG_RPA_C_Fungi	208	220	PF08784	0.455
LIG_RPA_C_Fungi	650	662	PF08784	0.518
LIG_SH2_CRK	239	243	PF00017	0.580
LIG_SH2_CRK	477	481	PF00017	0.633
LIG_SH2_CRK	79	83	PF00017	0.356
LIG_SH2_GRB2like	72	75	PF00017	0.368
LIG_SH2_NCK_1	239	243	PF00017	0.580
LIG_SH2_SRC	72	75	PF00017	0.368
LIG_SH2_SRC	730	733	PF00017	0.636
LIG_SH2_STAT5	416	419	PF00017	0.612
LIG_SH2_STAT5	531	534	PF00017	0.497
LIG_SH2_STAT5	72	75	PF00017	0.414
LIG_SH2_STAT5	730	733	PF00017	0.776
LIG_SH3_1	714	720	PF00018	0.508
LIG_SH3_2	267	272	PF14604	0.620
LIG_SH3_3	12	18	PF00018	0.473
LIG_SH3_3	186	192	PF00018	0.458
LIG_SH3_3	220	226	PF00018	0.624
LIG_SH3_3	258	264	PF00018	0.662
LIG_SH3_3	293	299	PF00018	0.640
LIG_SH3_3	394	400	PF00018	0.679
LIG_SH3_3	714	720	PF00018	0.542
LIG_SH3_3	819	825	PF00018	0.620
LIG_SUMO_SIM_par_1	32	39	PF11976	0.393
LIG_TRAF2_1	119	122	PF00917	0.599
LIG_TRAF2_1	144	147	PF00917	0.472
LIG_TRAF2_1	285	288	PF00917	0.516
LIG_TRAF2_1	785	788	PF00917	0.576
LIG_UBA3_1	82	89	PF00899	0.382
LIG_WW_3	273	277	PF00397	0.621
LIG_WW_3	403	407	PF00397	0.524
LIG_WW_3	575	579	PF00397	0.521
MOD_CDC14_SPxK_1	273	276	PF00782	0.646
MOD_CDC14_SPxK_1	345	348	PF00782	0.632
MOD_CDC14_SPxK_1	403	406	PF00782	0.520
MOD_CDC14_SPxK_1	807	810	PF00782	0.653
MOD_CDK_SPK_2	226	231	PF00069	0.677
MOD_CDK_SPK_2	260	265	PF00069	0.623
MOD_CDK_SPK_2	709	714	PF00069	0.615
MOD_CDK_SPxK_1	270	276	PF00069	0.648
MOD_CDK_SPxK_1	342	348	PF00069	0.635
MOD_CDK_SPxK_1	400	406	PF00069	0.520
MOD_CDK_SPxK_1	804	810	PF00069	0.659
MOD_CDK_SPxxK_3	400	407	PF00069	0.668
MOD_CDK_SPxxK_3	59	66	PF00069	0.450
MOD_CK1_1	178	184	PF00069	0.459
MOD_CK1_1	211	217	PF00069	0.586
MOD_CK1_1	218	224	PF00069	0.666
MOD_CK1_1	229	235	PF00069	0.567
MOD_CK1_1	263	269	PF00069	0.708
MOD_CK1_1	277	283	PF00069	0.615
MOD_CK1_1	32	38	PF00069	0.381
MOD_CK1_1	487	493	PF00069	0.583
MOD_CK1_1	561	567	PF00069	0.753
MOD_CK1_1	602	608	PF00069	0.556
MOD_CK1_1	712	718	PF00069	0.645
MOD_CK1_1	760	766	PF00069	0.604
MOD_CK1_1	828	834	PF00069	0.767
MOD_CK1_1	99	105	PF00069	0.516
MOD_CK2_1	10	16	PF00069	0.521
MOD_CK2_1	141	147	PF00069	0.462
MOD_CK2_1	229	235	PF00069	0.620
MOD_CK2_1	281	287	PF00069	0.525
MOD_CK2_1	336	342	PF00069	0.696
MOD_CK2_1	491	497	PF00069	0.669
MOD_CK2_1	584	590	PF00069	0.622
MOD_CK2_1	733	739	PF00069	0.643
MOD_CK2_1	781	787	PF00069	0.672
MOD_CK2_1	803	809	PF00069	0.699
MOD_CK2_1	99	105	PF00069	0.362
MOD_Cter_Amidation	362	365	PF01082	0.644
MOD_Cter_Amidation	460	463	PF01082	0.534
MOD_Cter_Amidation	550	553	PF01082	0.540
MOD_GlcNHglycan	210	213	PF01048	0.478
MOD_GlcNHglycan	214	217	PF01048	0.511
MOD_GlcNHglycan	281	284	PF01048	0.592
MOD_GlcNHglycan	371	374	PF01048	0.778
MOD_GlcNHglycan	378	381	PF01048	0.637
MOD_GlcNHglycan	411	414	PF01048	0.670
MOD_GlcNHglycan	420	423	PF01048	0.593
MOD_GlcNHglycan	494	497	PF01048	0.658
MOD_GlcNHglycan	549	552	PF01048	0.537
MOD_GlcNHglycan	691	696	PF01048	0.392
MOD_GlcNHglycan	721	724	PF01048	0.681
MOD_GlcNHglycan	727	730	PF01048	0.769
MOD_GSK3_1	175	182	PF00069	0.573
MOD_GSK3_1	208	215	PF00069	0.476
MOD_GSK3_1	242	249	PF00069	0.700
MOD_GSK3_1	270	277	PF00069	0.668
MOD_GSK3_1	311	318	PF00069	0.643
MOD_GSK3_1	32	39	PF00069	0.423
MOD_GSK3_1	332	339	PF00069	0.664
MOD_GSK3_1	342	349	PF00069	0.693
MOD_GSK3_1	367	374	PF00069	0.713
MOD_GSK3_1	391	398	PF00069	0.616
MOD_GSK3_1	435	442	PF00069	0.562
MOD_GSK3_1	484	491	PF00069	0.642
MOD_GSK3_1	547	554	PF00069	0.634
MOD_GSK3_1	578	585	PF00069	0.680
MOD_GSK3_1	599	606	PF00069	0.566
MOD_GSK3_1	753	760	PF00069	0.590
MOD_GSK3_1	821	828	PF00069	0.684
MOD_GSK3_1	96	103	PF00069	0.510
MOD_N-GLC_2	443	445	PF02516	0.525
MOD_N-GLC_2	680	682	PF02516	0.403
MOD_NEK2_1	36	41	PF00069	0.395
MOD_NEK2_1	630	635	PF00069	0.440
MOD_NEK2_1	640	645	PF00069	0.536
MOD_NEK2_1	656	661	PF00069	0.378
MOD_NEK2_1	683	688	PF00069	0.410
MOD_NEK2_1	803	808	PF00069	0.544
MOD_PIKK_1	148	154	PF00454	0.536
MOD_PIKK_1	175	181	PF00454	0.580
MOD_PIKK_1	184	190	PF00454	0.402
MOD_PIKK_1	324	330	PF00454	0.651
MOD_PIKK_1	484	490	PF00454	0.618
MOD_PIKK_1	49	55	PF00454	0.486
MOD_PIKK_1	582	588	PF00454	0.671
MOD_PIKK_1	630	636	PF00454	0.360
MOD_PIKK_1	712	718	PF00454	0.728
MOD_PK_1	96	102	PF00069	0.468
MOD_PKA_1	578	584	PF00069	0.528
MOD_PKA_1	757	763	PF00069	0.529
MOD_PKA_2	212	218	PF00069	0.526
MOD_PKA_2	275	281	PF00069	0.692
MOD_PKA_2	347	353	PF00069	0.690
MOD_PKA_2	356	362	PF00069	0.605
MOD_PKA_2	376	382	PF00069	0.671
MOD_PKA_2	408	414	PF00069	0.634
MOD_PKA_2	434	440	PF00069	0.762
MOD_PKA_2	461	467	PF00069	0.497
MOD_PKA_2	521	527	PF00069	0.542
MOD_PKA_2	571	577	PF00069	0.569
MOD_PKA_2	578	584	PF00069	0.538
MOD_PKA_2	672	678	PF00069	0.413
MOD_PKA_2	757	763	PF00069	0.571
MOD_PKA_2	782	788	PF00069	0.623
MOD_PKA_2	796	802	PF00069	0.639
MOD_PKB_1	407	415	PF00069	0.607
MOD_Plk_1	173	179	PF00069	0.509
MOD_Plk_1	367	373	PF00069	0.643
MOD_Plk_1	691	697	PF00069	0.468
MOD_Plk_1	758	764	PF00069	0.654
MOD_Plk_2-3	603	609	PF00069	0.539
MOD_Plk_4	136	142	PF00069	0.374
MOD_Plk_4	29	35	PF00069	0.606
MOD_Plk_4	683	689	PF00069	0.427
MOD_ProDKin_1	139	145	PF00069	0.494
MOD_ProDKin_1	179	185	PF00069	0.569
MOD_ProDKin_1	226	232	PF00069	0.618
MOD_ProDKin_1	242	248	PF00069	0.631
MOD_ProDKin_1	260	266	PF00069	0.672
MOD_ProDKin_1	270	276	PF00069	0.625
MOD_ProDKin_1	277	283	PF00069	0.647
MOD_ProDKin_1	336	342	PF00069	0.669
MOD_ProDKin_1	400	406	PF00069	0.619
MOD_ProDKin_1	435	441	PF00069	0.589
MOD_ProDKin_1	536	542	PF00069	0.529
MOD_ProDKin_1	551	557	PF00069	0.624
MOD_ProDKin_1	558	564	PF00069	0.654
MOD_ProDKin_1	59	65	PF00069	0.444
MOD_ProDKin_1	709	715	PF00069	0.621
MOD_ProDKin_1	804	810	PF00069	0.803
MOD_ProDKin_1	818	824	PF00069	0.597
MOD_SUMO_rev_2	619	629	PF00179	0.504
MOD_SUMO_rev_2	784	791	PF00179	0.655
TRG_DiLeu_BaEn_1	194	199	PF01217	0.492
TRG_DiLeu_BaEn_1	78	83	PF01217	0.376
TRG_ENDOCYTIC_2	416	419	PF00928	0.550
TRG_ENDOCYTIC_2	79	82	PF00928	0.374
TRG_ER_diArg_1	299	301	PF00400	0.588
TRG_ER_diArg_1	405	407	PF00400	0.613
TRG_ER_diArg_1	477	479	PF00400	0.618
TRG_ER_diArg_1	506	509	PF00400	0.702
TRG_ER_diArg_1	577	579	PF00400	0.627
TRG_ER_diArg_1	614	616	PF00400	0.495
TRG_ER_diArg_1	622	624	PF00400	0.413
TRG_ER_diArg_1	701	704	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	615	619	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P552	Leptomonas seymouri	37%	87%
A0A3Q8IED4	Leishmania donovani	88%	100%
A4HFV2	Leishmania braziliensis	67%	100%
A4I2Y5	Leishmania infantum	88%	100%
E9AZ79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%