Casein kinase I-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I-like protein

Species:

Leishmania major

UniProt:

E9ADF5_LEIMA

TriTrypDb:

LmjF.27.1780 , LMJLV39_270024500 , LMJSD75_270024700

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

E9ADF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADF5

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0007165	signal transduction	2	3
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016192	vesicle-mediated transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0004674	protein serine/threonine kinase activity	4	8
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.478
CLV_C14_Caspase3-7	410	414	PF00656	0.432
CLV_C14_Caspase3-7	486	490	PF00656	0.609
CLV_NRD_NRD_1	183	185	PF00675	0.369
CLV_NRD_NRD_1	294	296	PF00675	0.309
CLV_NRD_NRD_1	327	329	PF00675	0.360
CLV_PCSK_KEX2_1	183	185	PF00082	0.369
CLV_PCSK_KEX2_1	327	329	PF00082	0.367
CLV_PCSK_KEX2_1	361	363	PF00082	0.539
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.539

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKB0	Leptomonas seymouri	61%	99%
A0A0S4IVY6	Bodo saltans	29%	100%
A0A3Q8ISA0	Leishmania donovani	32%	100%
A0A3S7X0V1	Leishmania donovani	94%	99%
A4HFV0	Leishmania braziliensis	77%	100%
A4HIT6	Leishmania braziliensis	32%	100%
A4I2Y4	Leishmania infantum	94%	99%
A4I638	Leishmania infantum	32%	100%
E9AZ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%

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