Casein kinase I-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I-like protein

Species:

Leishmania major

UniProt:

E9ADF5_LEIMA

TriTrypDb:

LmjF.27.1780 , LMJLV39_270024500 , LMJSD75_270024700

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ADF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADF5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0007165	signal transduction	2	3
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0018105	peptidyl-serine phosphorylation	6	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018209	peptidyl-serine modification	6	3
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0065007	biological regulation	1	3
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0004674	protein serine/threonine kinase activity	4	8
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.478
CLV_C14_Caspase3-7	410	414	PF00656	0.432
CLV_C14_Caspase3-7	486	490	PF00656	0.609
CLV_NRD_NRD_1	183	185	PF00675	0.369
CLV_NRD_NRD_1	294	296	PF00675	0.309
CLV_NRD_NRD_1	327	329	PF00675	0.360
CLV_PCSK_KEX2_1	183	185	PF00082	0.369
CLV_PCSK_KEX2_1	327	329	PF00082	0.367
CLV_PCSK_KEX2_1	361	363	PF00082	0.539
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.539
CLV_PCSK_SKI1_1	384	388	PF00082	0.441
CLV_TASPASE1	487	493	PF01112	0.606
DOC_CKS1_1	309	314	PF01111	0.388
DOC_PP4_FxxP_1	540	543	PF00568	0.634
DOC_USP7_MATH_1	138	142	PF00917	0.536
DOC_USP7_MATH_1	427	431	PF00917	0.754
DOC_USP7_MATH_1	47	51	PF00917	0.630
DOC_WW_Pin1_4	308	313	PF00397	0.388
DOC_WW_Pin1_4	526	531	PF00397	0.775
DOC_WW_Pin1_4	538	543	PF00397	0.561
DOC_WW_Pin1_4	550	555	PF00397	0.702
LIG_14-3-3_CanoR_1	130	138	PF00244	0.653
LIG_14-3-3_CanoR_1	236	240	PF00244	0.355
LIG_14-3-3_CanoR_1	313	318	PF00244	0.448
LIG_14-3-3_CanoR_1	352	356	PF00244	0.309
LIG_14-3-3_CanoR_1	97	101	PF00244	0.486
LIG_Actin_WH2_2	339	354	PF00022	0.309
LIG_Actin_WH2_2	399	414	PF00022	0.450
LIG_BIR_III_2	524	528	PF00653	0.649
LIG_BIR_III_4	511	515	PF00653	0.629
LIG_BRCT_BRCA1_1	105	109	PF00533	0.504
LIG_BRCT_BRCA1_1	140	144	PF00533	0.494
LIG_BRCT_BRCA1_1	288	292	PF00533	0.388
LIG_eIF4E_1	336	342	PF01652	0.388
LIG_FHA_1	132	138	PF00498	0.464
LIG_FHA_1	240	246	PF00498	0.380
LIG_FHA_1	437	443	PF00498	0.529
LIG_FHA_1	476	482	PF00498	0.595
LIG_FHA_2	466	472	PF00498	0.674
LIG_FHA_2	97	103	PF00498	0.492
LIG_Integrin_isoDGR_2	181	183	PF01839	0.309
LIG_IRF3_LxIS_1	347	354	PF10401	0.309
LIG_LIR_Gen_1	238	246	PF02991	0.388
LIG_LIR_Gen_1	311	321	PF02991	0.388
LIG_LIR_Gen_1	398	408	PF02991	0.385
LIG_LIR_Nem_3	106	112	PF02991	0.503
LIG_LIR_Nem_3	238	243	PF02991	0.388
LIG_LIR_Nem_3	311	317	PF02991	0.425
LIG_LIR_Nem_3	381	386	PF02991	0.391
LIG_LIR_Nem_3	398	404	PF02991	0.439
LIG_LYPXL_S_1	26	30	PF13949	0.630
LIG_LYPXL_yS_3	27	30	PF13949	0.630
LIG_MYND_1	24	28	PF01753	0.618
LIG_NRBOX	403	409	PF00104	0.446
LIG_NRP_CendR_1	557	560	PF00754	0.636
LIG_PCNA_yPIPBox_3	205	218	PF02747	0.348
LIG_Pex14_2	94	98	PF04695	0.534
LIG_PTB_Apo_2	302	309	PF02174	0.348
LIG_SH2_CRK	314	318	PF00017	0.388
LIG_SH2_CRK	401	405	PF00017	0.444
LIG_SH2_PTP2	336	339	PF00017	0.348
LIG_SH2_SRC	261	264	PF00017	0.388
LIG_SH2_STAP1	389	393	PF00017	0.495
LIG_SH2_STAT3	208	211	PF00017	0.348
LIG_SH2_STAT3	48	51	PF00017	0.672
LIG_SH2_STAT5	261	264	PF00017	0.388
LIG_SH2_STAT5	282	285	PF00017	0.441
LIG_SH2_STAT5	336	339	PF00017	0.395
LIG_SH2_STAT5	340	343	PF00017	0.380
LIG_SH3_3	19	25	PF00018	0.690
LIG_SH3_3	306	312	PF00018	0.309
LIG_SH3_3	524	530	PF00018	0.622
LIG_SH3_3	536	542	PF00018	0.559
LIG_SH3_3	68	74	PF00018	0.665
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.450
LIG_SUMO_SIM_par_1	241	247	PF11976	0.324
LIG_TYR_ITIM	334	339	PF00017	0.337
LIG_UBA3_1	169	176	PF00899	0.474
LIG_WW_1	24	27	PF00397	0.675
MOD_CDK_SPK_2	308	313	PF00069	0.388
MOD_CDK_SPK_2	526	531	PF00069	0.612
MOD_CDK_SPxxK_3	550	557	PF00069	0.664
MOD_CK1_1	316	322	PF00069	0.388
MOD_CK1_1	420	426	PF00069	0.652
MOD_CK1_1	500	506	PF00069	0.731
MOD_CK2_1	411	417	PF00069	0.492
MOD_CK2_1	465	471	PF00069	0.663
MOD_Cter_Amidation	181	184	PF01082	0.309
MOD_GlcNHglycan	105	108	PF01048	0.515
MOD_GlcNHglycan	178	181	PF01048	0.339
MOD_GlcNHglycan	34	37	PF01048	0.716
MOD_GlcNHglycan	348	351	PF01048	0.362
MOD_GlcNHglycan	429	432	PF01048	0.747
MOD_GlcNHglycan	481	484	PF01048	0.651
MOD_GlcNHglycan	518	521	PF01048	0.723
MOD_GSK3_1	235	242	PF00069	0.353
MOD_GSK3_1	304	311	PF00069	0.455
MOD_GSK3_1	407	414	PF00069	0.438
MOD_GSK3_1	416	423	PF00069	0.529
MOD_GSK3_1	475	482	PF00069	0.681
MOD_GSK3_1	496	503	PF00069	0.631
MOD_GSK3_1	516	523	PF00069	0.597
MOD_N-GLC_1	304	309	PF02516	0.448
MOD_N-GLC_1	427	432	PF02516	0.603
MOD_N-GLC_1	442	447	PF02516	0.476
MOD_N-GLC_1	520	525	PF02516	0.653
MOD_NEK2_1	1	6	PF00069	0.658
MOD_NEK2_1	218	223	PF00069	0.388
MOD_NEK2_1	239	244	PF00069	0.365
MOD_NEK2_1	286	291	PF00069	0.328
MOD_NEK2_1	321	326	PF00069	0.356
MOD_NEK2_1	407	412	PF00069	0.461
MOD_NEK2_1	496	501	PF00069	0.771
MOD_NEK2_2	235	240	PF00069	0.365
MOD_OFUCOSY	409	415	PF10250	0.400
MOD_PIKK_1	47	53	PF00454	0.836
MOD_PKA_2	129	135	PF00069	0.504
MOD_PKA_2	235	241	PF00069	0.372
MOD_PKA_2	351	357	PF00069	0.321
MOD_PKA_2	411	417	PF00069	0.456
MOD_PKA_2	500	506	PF00069	0.630
MOD_PKA_2	96	102	PF00069	0.496
MOD_Plk_1	138	144	PF00069	0.514
MOD_Plk_1	304	310	PF00069	0.348
MOD_Plk_1	368	374	PF00069	0.398
MOD_Plk_4	138	144	PF00069	0.514
MOD_Plk_4	235	241	PF00069	0.344
MOD_Plk_4	304	310	PF00069	0.348
MOD_Plk_4	89	95	PF00069	0.538
MOD_ProDKin_1	308	314	PF00069	0.388
MOD_ProDKin_1	526	532	PF00069	0.773
MOD_ProDKin_1	538	544	PF00069	0.565
MOD_ProDKin_1	550	556	PF00069	0.703
MOD_SUMO_for_1	126	129	PF00179	0.465
MOD_SUMO_for_1	366	369	PF00179	0.392
MOD_SUMO_rev_2	141	150	PF00179	0.461
TRG_DiLeu_BaEn_1	117	122	PF01217	0.422
TRG_DiLeu_BaEn_1	279	284	PF01217	0.388
TRG_ENDOCYTIC_2	27	30	PF00928	0.630
TRG_ENDOCYTIC_2	314	317	PF00928	0.441
TRG_ENDOCYTIC_2	336	339	PF00928	0.337
TRG_ENDOCYTIC_2	401	404	PF00928	0.384
TRG_ER_diArg_1	342	345	PF00400	0.328
TRG_NES_CRM1_1	212	225	PF08389	0.309
TRG_NES_CRM1_1	279	294	PF08389	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKB0	Leptomonas seymouri	61%	99%
A0A0S4IVY6	Bodo saltans	29%	100%
A0A3Q8ISA0	Leishmania donovani	32%	100%
A0A3S7X0V1	Leishmania donovani	94%	99%
A4HFV0	Leishmania braziliensis	77%	100%
A4HIT6	Leishmania braziliensis	32%	100%
A4I2Y4	Leishmania infantum	94%	99%
A4I638	Leishmania infantum	32%	100%
E9AZ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q6U1	Leishmania major	31%	100%