C-CAP/cofactor C-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin cofactor C domain-containing protein 1, putative

Species:

Leishmania major

UniProt:

E9ADF3_LEIMA

TriTrypDb:

LmjF.27.1760 , LMJLV39_270024300 , LMJSD75_270024500

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ADF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.385
CLV_C14_Caspase3-7	512	516	PF00656	0.582
CLV_NRD_NRD_1	177	179	PF00675	0.557
CLV_NRD_NRD_1	3	5	PF00675	0.705
CLV_NRD_NRD_1	505	507	PF00675	0.444
CLV_PCSK_KEX2_1	179	181	PF00082	0.599
CLV_PCSK_KEX2_1	3	5	PF00082	0.705
CLV_PCSK_KEX2_1	505	507	PF00082	0.444
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.582
CLV_PCSK_SKI1_1	137	141	PF00082	0.408
DEG_APCC_DBOX_1	136	144	PF00400	0.405
DEG_SCF_FBW7_1	114	121	PF00400	0.519
DOC_CKS1_1	115	120	PF01111	0.553
DOC_CKS1_1	389	394	PF01111	0.425
DOC_MAPK_DCC_7	159	168	PF00069	0.337
DOC_MAPK_gen_1	83	91	PF00069	0.490
DOC_MAPK_MEF2A_6	159	168	PF00069	0.337
DOC_MAPK_RevD_3	166	180	PF00069	0.492
DOC_PP2B_LxvP_1	495	498	PF13499	0.546
DOC_PP2B_LxvP_1	55	58	PF13499	0.491
DOC_USP7_MATH_1	153	157	PF00917	0.405
DOC_USP7_MATH_1	20	24	PF00917	0.706
DOC_USP7_MATH_1	30	34	PF00917	0.693
DOC_USP7_MATH_1	397	401	PF00917	0.604
DOC_USP7_MATH_1	431	435	PF00917	0.371
DOC_USP7_MATH_1	5	9	PF00917	0.712
DOC_USP7_MATH_1	516	520	PF00917	0.525
DOC_USP7_MATH_2	468	474	PF00917	0.542
DOC_WW_Pin1_4	114	119	PF00397	0.529
DOC_WW_Pin1_4	300	305	PF00397	0.512
DOC_WW_Pin1_4	388	393	PF00397	0.298
DOC_WW_Pin1_4	446	451	PF00397	0.464
LIG_14-3-3_CanoR_1	125	129	PF00244	0.596
LIG_14-3-3_CanoR_1	159	164	PF00244	0.364
LIG_14-3-3_CanoR_1	214	218	PF00244	0.435
LIG_14-3-3_CanoR_1	314	322	PF00244	0.425
LIG_14-3-3_CanoR_1	414	421	PF00244	0.517
LIG_14-3-3_CanoR_1	539	547	PF00244	0.500
LIG_Actin_WH2_2	510	527	PF00022	0.563
LIG_Actin_WH2_2	533	551	PF00022	0.451
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	240	244	PF00533	0.385
LIG_BRCT_BRCA1_1	472	476	PF00533	0.547
LIG_BRCT_BRCA1_1	5	9	PF00533	0.709
LIG_EVH1_2	467	471	PF00568	0.411
LIG_FHA_1	250	256	PF00498	0.379
LIG_FHA_1	277	283	PF00498	0.668
LIG_FHA_1	297	303	PF00498	0.301
LIG_FHA_1	346	352	PF00498	0.376
LIG_FHA_1	382	388	PF00498	0.308
LIG_FHA_1	389	395	PF00498	0.314
LIG_FHA_1	519	525	PF00498	0.538
LIG_FHA_1	61	67	PF00498	0.398
LIG_FHA_2	214	220	PF00498	0.382
LIG_FHA_2	549	555	PF00498	0.557
LIG_IRF3_LxIS_1	316	323	PF10401	0.437
LIG_LIR_Gen_1	259	266	PF02991	0.499
LIG_LIR_Gen_1	285	296	PF02991	0.622
LIG_LIR_Gen_1	303	312	PF02991	0.572
LIG_LIR_Gen_1	384	394	PF02991	0.425
LIG_LIR_Gen_1	469	478	PF02991	0.558
LIG_LIR_Gen_1	479	487	PF02991	0.639
LIG_LIR_Gen_1	97	108	PF02991	0.371
LIG_LIR_Nem_3	104	109	PF02991	0.336
LIG_LIR_Nem_3	259	264	PF02991	0.503
LIG_LIR_Nem_3	285	291	PF02991	0.655
LIG_LIR_Nem_3	303	308	PF02991	0.560
LIG_LIR_Nem_3	384	389	PF02991	0.403
LIG_LIR_Nem_3	469	474	PF02991	0.399
LIG_LIR_Nem_3	479	484	PF02991	0.501
LIG_LIR_Nem_3	97	103	PF02991	0.378
LIG_LYPXL_S_1	435	439	PF13949	0.503
LIG_LYPXL_yS_3	436	439	PF13949	0.495
LIG_MYND_1	393	397	PF01753	0.347
LIG_MYND_2	392	396	PF01753	0.347
LIG_NRBOX	166	172	PF00104	0.454
LIG_NRBOX	222	228	PF00104	0.358
LIG_Pex14_2	103	107	PF04695	0.465
LIG_Pex14_2	244	248	PF04695	0.537
LIG_PTB_Apo_2	41	48	PF02174	0.406
LIG_SH2_CRK	305	309	PF00017	0.600
LIG_SH2_PTP2	386	389	PF00017	0.408
LIG_SH2_SRC	331	334	PF00017	0.425
LIG_SH2_STAT3	195	198	PF00017	0.472
LIG_SH2_STAT5	195	198	PF00017	0.396
LIG_SH2_STAT5	225	228	PF00017	0.479
LIG_SH2_STAT5	261	264	PF00017	0.504
LIG_SH2_STAT5	386	389	PF00017	0.425
LIG_SH3_3	158	164	PF00018	0.372
LIG_SH3_3	231	237	PF00018	0.409
LIG_SH3_3	386	392	PF00018	0.425
LIG_SH3_3	454	460	PF00018	0.391
LIG_SH3_3	471	477	PF00018	0.415
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.355
LIG_TRAF2_1	551	554	PF00917	0.523
LIG_TRFH_1	305	309	PF08558	0.600
LIG_TYR_ITSM	382	389	PF00017	0.425
LIG_UBA3_1	170	179	PF00899	0.480
LIG_WRC_WIRS_1	432	437	PF05994	0.494
MOD_CK1_1	14	20	PF00069	0.738
MOD_CK1_1	213	219	PF00069	0.518
MOD_CK1_1	318	324	PF00069	0.304
MOD_CK1_1	342	348	PF00069	0.455
MOD_CK1_1	378	384	PF00069	0.403
MOD_CK1_1	408	414	PF00069	0.694
MOD_CK1_1	417	423	PF00069	0.585
MOD_CK1_1	446	452	PF00069	0.430
MOD_CK1_1	485	491	PF00069	0.595
MOD_CK1_1	59	65	PF00069	0.447
MOD_CK1_1	75	81	PF00069	0.370
MOD_CK2_1	118	124	PF00069	0.656
MOD_CK2_1	265	271	PF00069	0.431
MOD_CK2_1	548	554	PF00069	0.510
MOD_GlcNHglycan	109	112	PF01048	0.492
MOD_GlcNHglycan	120	123	PF01048	0.577
MOD_GlcNHglycan	13	16	PF01048	0.637
MOD_GlcNHglycan	204	207	PF01048	0.471
MOD_GlcNHglycan	22	25	PF01048	0.557
MOD_GlcNHglycan	276	279	PF01048	0.619
MOD_GlcNHglycan	354	357	PF01048	0.366
MOD_GlcNHglycan	368	371	PF01048	0.298
MOD_GlcNHglycan	407	410	PF01048	0.716
MOD_GlcNHglycan	416	419	PF01048	0.747
MOD_GlcNHglycan	445	448	PF01048	0.375
MOD_GlcNHglycan	5	8	PF01048	0.634
MOD_GlcNHglycan	518	521	PF01048	0.492
MOD_GlcNHglycan	58	61	PF01048	0.465
MOD_GSK3_1	114	121	PF00069	0.618
MOD_GSK3_1	14	21	PF00069	0.610
MOD_GSK3_1	274	281	PF00069	0.580
MOD_GSK3_1	296	303	PF00069	0.510
MOD_GSK3_1	310	317	PF00069	0.397
MOD_GSK3_1	336	343	PF00069	0.342
MOD_GSK3_1	352	359	PF00069	0.425
MOD_GSK3_1	405	412	PF00069	0.694
MOD_GSK3_1	416	423	PF00069	0.644
MOD_GSK3_1	442	449	PF00069	0.467
MOD_GSK3_1	466	473	PF00069	0.494
MOD_GSK3_1	5	12	PF00069	0.665
MOD_GSK3_1	56	63	PF00069	0.442
MOD_GSK3_1	560	567	PF00069	0.589
MOD_LATS_1	537	543	PF00433	0.551
MOD_N-GLC_1	289	294	PF02516	0.516
MOD_N-GLC_1	31	36	PF02516	0.486
MOD_N-GLC_1	318	323	PF02516	0.356
MOD_N-GLC_1	345	350	PF02516	0.298
MOD_N-GLC_1	378	383	PF02516	0.363
MOD_N-GLC_1	397	402	PF02516	0.441
MOD_N-GLC_1	482	487	PF02516	0.642
MOD_NEK2_1	107	112	PF00069	0.325
MOD_NEK2_1	19	24	PF00069	0.648
MOD_NEK2_1	238	243	PF00069	0.343
MOD_NEK2_1	296	301	PF00069	0.396
MOD_NEK2_1	315	320	PF00069	0.290
MOD_NEK2_1	340	345	PF00069	0.352
MOD_NEK2_1	548	553	PF00069	0.503
MOD_NEK2_1	560	565	PF00069	0.602
MOD_NEK2_1	9	14	PF00069	0.718
MOD_NEK2_1	94	99	PF00069	0.416
MOD_NEK2_2	431	436	PF00069	0.486
MOD_PIKK_1	14	20	PF00454	0.634
MOD_PIKK_1	256	262	PF00454	0.361
MOD_PIKK_1	323	329	PF00454	0.313
MOD_PIKK_1	476	482	PF00454	0.567
MOD_PK_1	539	545	PF00069	0.355
MOD_PKA_1	3	9	PF00069	0.713
MOD_PKA_2	124	130	PF00069	0.608
MOD_PKA_2	210	216	PF00069	0.423
MOD_PKA_2	3	9	PF00069	0.713
MOD_PKA_2	405	411	PF00069	0.632
MOD_PKA_2	538	544	PF00069	0.526
MOD_PKA_2	94	100	PF00069	0.402
MOD_PKB_1	263	271	PF00069	0.537
MOD_Plk_1	123	129	PF00069	0.594
MOD_Plk_1	249	255	PF00069	0.392
MOD_Plk_1	289	295	PF00069	0.517
MOD_Plk_1	318	324	PF00069	0.376
MOD_Plk_1	345	351	PF00069	0.298
MOD_Plk_1	381	387	PF00069	0.383
MOD_Plk_1	397	403	PF00069	0.551
MOD_Plk_1	95	101	PF00069	0.512
MOD_Plk_4	331	337	PF00069	0.342
MOD_Plk_4	381	387	PF00069	0.342
MOD_Plk_4	431	437	PF00069	0.530
MOD_Plk_4	461	467	PF00069	0.522
MOD_Plk_4	539	545	PF00069	0.428
MOD_Plk_4	62	68	PF00069	0.514
MOD_Plk_4	87	93	PF00069	0.408
MOD_ProDKin_1	114	120	PF00069	0.533
MOD_ProDKin_1	300	306	PF00069	0.523
MOD_ProDKin_1	388	394	PF00069	0.298
MOD_ProDKin_1	446	452	PF00069	0.460
MOD_SUMO_rev_2	268	275	PF00179	0.494
TRG_DiLeu_BaEn_1	222	227	PF01217	0.358
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.585
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.501
TRG_ENDOCYTIC_2	100	103	PF00928	0.370
TRG_ENDOCYTIC_2	261	264	PF00928	0.504
TRG_ENDOCYTIC_2	305	308	PF00928	0.543
TRG_ENDOCYTIC_2	386	389	PF00928	0.403
TRG_ENDOCYTIC_2	432	435	PF00928	0.379
TRG_ENDOCYTIC_2	436	439	PF00928	0.353
TRG_ER_diArg_1	262	265	PF00400	0.383
TRG_ER_diArg_1	3	5	PF00400	0.688
TRG_ER_diArg_1	505	507	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E5	Leptomonas seymouri	76%	100%
A0A1X0P3V6	Trypanosomatidae	48%	100%
A0A3Q8IEG6	Leishmania donovani	97%	100%
A0A3R7M8R7	Trypanosoma rangeli	48%	100%
A4HFU9	Leishmania braziliensis	85%	100%
A4I2W6	Leishmania infantum	97%	100%
D0A651	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AZ76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BYH8	Trypanosoma cruzi	47%	100%