BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flabarin, putative

Species:

Leishmania major

UniProt:

E9ADF0_LEIMA

TriTrypDb:

LmjF.27.1730 , LMJLV39_270023900 , LMJSD75_270024000

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9ADF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADF0

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.541
CLV_NRD_NRD_1	246	248	PF00675	0.583
CLV_NRD_NRD_1	249	251	PF00675	0.591
CLV_NRD_NRD_1	68	70	PF00675	0.466
CLV_PCSK_FUR_1	247	251	PF00082	0.461
CLV_PCSK_KEX2_1	160	162	PF00082	0.542
CLV_PCSK_KEX2_1	246	248	PF00082	0.583
CLV_PCSK_KEX2_1	249	251	PF00082	0.591
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.474
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.463

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	26%	100%
A0A0N1PG41	Leptomonas seymouri	57%	100%
A0A1X0NY72	Trypanosomatidae	26%	92%
A0A3Q8IKU7	Leishmania donovani	27%	100%
A0A3S5H792	Leishmania donovani	21%	100%
A0A3S5H7I1	Leishmania donovani	93%	100%
A4HBK0	Leishmania braziliensis	21%	100%
A4HFU7	Leishmania braziliensis	73%	100%
A4HZL5	Leishmania infantum	21%	100%
A4HZL6	Leishmania infantum	28%	100%

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