BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flabarin, putative

Species:

Leishmania major

UniProt:

E9ADF0_LEIMA

TriTrypDb:

LmjF.27.1730 , LMJLV39_270023900 , LMJSD75_270024000

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.541
CLV_NRD_NRD_1	246	248	PF00675	0.583
CLV_NRD_NRD_1	249	251	PF00675	0.591
CLV_NRD_NRD_1	68	70	PF00675	0.466
CLV_PCSK_FUR_1	247	251	PF00082	0.461
CLV_PCSK_KEX2_1	160	162	PF00082	0.542
CLV_PCSK_KEX2_1	246	248	PF00082	0.583
CLV_PCSK_KEX2_1	249	251	PF00082	0.591
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.474
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.463
CLV_PCSK_SKI1_1	111	115	PF00082	0.482
CLV_PCSK_SKI1_1	172	176	PF00082	0.548
CLV_PCSK_SKI1_1	187	191	PF00082	0.654
CLV_PCSK_SKI1_1	246	250	PF00082	0.550
CLV_PCSK_SKI1_1	27	31	PF00082	0.566
CLV_PCSK_SKI1_1	80	84	PF00082	0.507
DEG_SPOP_SBC_1	149	153	PF00917	0.435
DOC_MAPK_gen_1	111	122	PF00069	0.578
DOC_PP4_FxxP_1	301	304	PF00568	0.579
DOC_USP7_MATH_1	105	109	PF00917	0.495
DOC_USP7_MATH_1	113	117	PF00917	0.488
DOC_USP7_MATH_1	35	39	PF00917	0.616
DOC_USP7_UBL2_3	107	111	PF12436	0.485
DOC_USP7_UBL2_3	139	143	PF12436	0.638
DOC_USP7_UBL2_3	156	160	PF12436	0.643
DOC_USP7_UBL2_3	234	238	PF12436	0.487
LIG_14-3-3_CanoR_1	250	258	PF00244	0.507
LIG_Actin_WH2_2	96	113	PF00022	0.409
LIG_BRCT_BRCA1_1	223	227	PF00533	0.737
LIG_BRCT_BRCA1_1	254	258	PF00533	0.550
LIG_CaM_IQ_9	179	194	PF13499	0.413
LIG_EH_1	255	259	PF12763	0.555
LIG_FHA_1	15	21	PF00498	0.486
LIG_FHA_1	184	190	PF00498	0.561
LIG_FHA_1	288	294	PF00498	0.568
LIG_FHA_1	97	103	PF00498	0.463
LIG_FHA_2	164	170	PF00498	0.414
LIG_FHA_2	215	221	PF00498	0.652
LIG_FHA_2	258	264	PF00498	0.611
LIG_FHA_2	312	318	PF00498	0.649
LIG_FHA_2	46	52	PF00498	0.508
LIG_LIR_Apic_2	300	304	PF02991	0.580
LIG_LIR_Gen_1	126	134	PF02991	0.463
LIG_LIR_Gen_1	48	57	PF02991	0.424
LIG_LIR_Nem_3	126	130	PF02991	0.518
LIG_LIR_Nem_3	48	53	PF02991	0.421
LIG_PTB_Apo_2	295	302	PF02174	0.642
LIG_SH2_CRK	127	131	PF00017	0.466
LIG_SH2_CRK	43	47	PF00017	0.477
LIG_SH2_CRK	57	61	PF00017	0.490
LIG_SH2_GRB2like	43	46	PF00017	0.404
LIG_SH2_SRC	319	322	PF00017	0.615
LIG_SH2_STAT5	197	200	PF00017	0.512
LIG_SH2_STAT5	21	24	PF00017	0.473
LIG_SH3_3	65	71	PF00018	0.571
LIG_SH3_3	99	105	PF00018	0.518
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.420
LIG_SUMO_SIM_par_1	98	104	PF11976	0.404
LIG_WRC_WIRS_1	88	93	PF05994	0.501
MOD_CK1_1	252	258	PF00069	0.651
MOD_CK1_1	266	272	PF00069	0.655
MOD_CK2_1	311	317	PF00069	0.721
MOD_GlcNHglycan	33	36	PF01048	0.644
MOD_GSK3_1	150	157	PF00069	0.552
MOD_GSK3_1	164	171	PF00069	0.497
MOD_GSK3_1	221	228	PF00069	0.608
MOD_GSK3_1	262	269	PF00069	0.619
MOD_GSK3_1	283	290	PF00069	0.640
MOD_GSK3_1	3	10	PF00069	0.546
MOD_GSK3_1	31	38	PF00069	0.534
MOD_N-GLC_1	266	271	PF02516	0.710
MOD_N-GLC_1	30	35	PF02516	0.582
MOD_N-GLC_1	311	316	PF02516	0.608
MOD_NEK2_1	148	153	PF00069	0.611
MOD_NEK2_1	182	187	PF00069	0.600
MOD_NEK2_1	190	195	PF00069	0.551
MOD_NEK2_1	198	203	PF00069	0.520
MOD_NEK2_1	208	213	PF00069	0.474
MOD_NEK2_1	3	8	PF00069	0.580
MOD_NEK2_1	36	41	PF00069	0.429
MOD_NEK2_2	113	118	PF00069	0.408
MOD_PKA_1	249	255	PF00069	0.462
MOD_PKA_1	283	289	PF00069	0.629
MOD_PKA_2	249	255	PF00069	0.489
MOD_Plk_1	137	143	PF00069	0.531
MOD_Plk_1	208	214	PF00069	0.536
MOD_Plk_1	311	317	PF00069	0.658
MOD_Plk_2-3	311	317	PF00069	0.638
MOD_Plk_4	185	191	PF00069	0.500
MOD_Plk_4	283	289	PF00069	0.608
MOD_SUMO_rev_2	104	113	PF00179	0.585
TRG_DiLeu_BaEn_4	177	183	PF01217	0.398
TRG_ENDOCYTIC_2	127	130	PF00928	0.521
TRG_ENDOCYTIC_2	43	46	PF00928	0.466
TRG_ENDOCYTIC_2	57	60	PF00928	0.462
TRG_NLS_MonoExtC_3	142	147	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	26%	100%
A0A0N1PG41	Leptomonas seymouri	57%	100%
A0A1X0NY72	Trypanosomatidae	26%	92%
A0A3Q8IKU7	Leishmania donovani	27%	100%
A0A3S5H792	Leishmania donovani	21%	100%
A0A3S5H7I1	Leishmania donovani	93%	100%
A4HBK0	Leishmania braziliensis	21%	100%
A4HFU7	Leishmania braziliensis	73%	100%
A4HZL5	Leishmania infantum	21%	100%
A4HZL6	Leishmania infantum	28%	100%
A4I2W4	Leishmania infantum	93%	100%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCL3	Leishmania major	21%	100%
Q4QCL4	Leishmania major	27%	100%