ABC transporter domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADE9_LEIMA

TriTrypDb:

LmjF.27.1700 , LMJLV39_270023500 , LMJSD75_270023700

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ADE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADE9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005215	transporter activity	1	4
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0015399	primary active transmembrane transporter activity	4	4
GO:0017076	purine nucleotide binding	4	9
GO:0022804	active transmembrane transporter activity	3	4
GO:0022857	transmembrane transporter activity	2	4
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0042626	ATPase-coupled transmembrane transporter activity	2	4
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140657	ATP-dependent activity	1	4
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0140359	ABC-type transporter activity	3	2
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.546
CLV_C14_Caspase3-7	175	179	PF00656	0.531
CLV_C14_Caspase3-7	296	300	PF00656	0.483
CLV_NRD_NRD_1	106	108	PF00675	0.396
CLV_NRD_NRD_1	168	170	PF00675	0.313
CLV_NRD_NRD_1	209	211	PF00675	0.378
CLV_NRD_NRD_1	233	235	PF00675	0.385
CLV_NRD_NRD_1	49	51	PF00675	0.549
CLV_NRD_NRD_1	97	99	PF00675	0.382
CLV_PCSK_FUR_1	166	170	PF00082	0.386
CLV_PCSK_KEX2_1	105	107	PF00082	0.441
CLV_PCSK_KEX2_1	168	170	PF00082	0.311
CLV_PCSK_KEX2_1	233	235	PF00082	0.385
CLV_PCSK_KEX2_1	49	51	PF00082	0.416
CLV_PCSK_KEX2_1	97	99	PF00082	0.391
CLV_PCSK_SKI1_1	107	111	PF00082	0.356
CLV_PCSK_SKI1_1	136	140	PF00082	0.283
CLV_PCSK_SKI1_1	234	238	PF00082	0.352
CLV_PCSK_SKI1_1	415	419	PF00082	0.282
CLV_PCSK_SKI1_1	450	454	PF00082	0.456
DEG_APCC_DBOX_1	135	143	PF00400	0.481
DEG_APCC_DBOX_1	232	240	PF00400	0.561
DEG_APCC_DBOX_1	449	457	PF00400	0.356
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.536
DOC_MAPK_gen_1	210	218	PF00069	0.561
DOC_MAPK_gen_1	233	239	PF00069	0.538
DOC_MAPK_gen_1	395	404	PF00069	0.581
DOC_MAPK_MEF2A_6	233	241	PF00069	0.532
DOC_MAPK_MEF2A_6	499	507	PF00069	0.381
DOC_MAPK_MEF2A_6	521	529	PF00069	0.325
DOC_MAPK_NFAT4_5	234	242	PF00069	0.573
DOC_PP1_RVXF_1	396	402	PF00149	0.543
DOC_PP1_RVXF_1	502	508	PF00149	0.358
DOC_PP1_SILK_1	585	590	PF00149	0.382
DOC_PP2B_LxvP_1	117	120	PF13499	0.604
DOC_PP2B_LxvP_1	330	333	PF13499	0.632
DOC_SPAK_OSR1_1	197	201	PF12202	0.554
DOC_USP7_MATH_1	120	124	PF00917	0.502
DOC_USP7_MATH_1	13	17	PF00917	0.765
DOC_USP7_MATH_1	35	39	PF00917	0.713
DOC_USP7_MATH_1	523	527	PF00917	0.351
DOC_USP7_MATH_1	532	536	PF00917	0.280
DOC_USP7_MATH_1	75	79	PF00917	0.746
DOC_WW_Pin1_4	227	232	PF00397	0.473
DOC_WW_Pin1_4	275	280	PF00397	0.478
DOC_WW_Pin1_4	487	492	PF00397	0.584
DOC_WW_Pin1_4	54	59	PF00397	0.774
DOC_WW_Pin1_4	628	633	PF00397	0.467
LIG_14-3-3_CanoR_1	14	21	PF00244	0.776
LIG_14-3-3_CanoR_1	225	229	PF00244	0.582
LIG_14-3-3_CanoR_1	601	606	PF00244	0.414
LIG_14-3-3_CanoR_1	620	630	PF00244	0.362
LIG_BRCT_BRCA1_1	354	358	PF00533	0.536
LIG_BRCT_BRCA1_1	601	605	PF00533	0.258
LIG_CaM_IQ_9	261	277	PF13499	0.541
LIG_EH1_1	424	432	PF00400	0.318
LIG_EH1_1	491	499	PF00400	0.507
LIG_FHA_1	160	166	PF00498	0.591
LIG_FHA_1	217	223	PF00498	0.543
LIG_FHA_1	346	352	PF00498	0.656
LIG_FHA_1	480	486	PF00498	0.567
LIG_FHA_1	528	534	PF00498	0.403
LIG_FHA_1	666	672	PF00498	0.404
LIG_FHA_2	108	114	PF00498	0.589
LIG_FHA_2	173	179	PF00498	0.522
LIG_FHA_2	183	189	PF00498	0.501
LIG_FHA_2	291	297	PF00498	0.562
LIG_FHA_2	342	348	PF00498	0.592
LIG_FHA_2	383	389	PF00498	0.637
LIG_FHA_2	436	442	PF00498	0.587
LIG_FHA_2	60	66	PF00498	0.800
LIG_GBD_Chelix_1	416	424	PF00786	0.361
LIG_GBD_Chelix_1	426	434	PF00786	0.338
LIG_HP1_1	247	251	PF01393	0.572
LIG_IRF3_LxIS_1	481	488	PF10401	0.600
LIG_LIR_Gen_1	185	193	PF02991	0.554
LIG_LIR_Gen_1	289	298	PF02991	0.563
LIG_LIR_Gen_1	326	337	PF02991	0.470
LIG_LIR_Nem_3	185	190	PF02991	0.552
LIG_LIR_Nem_3	219	224	PF02991	0.607
LIG_LIR_Nem_3	257	261	PF02991	0.539
LIG_LIR_Nem_3	289	295	PF02991	0.538
LIG_LIR_Nem_3	326	332	PF02991	0.471
LIG_LIR_Nem_3	81	87	PF02991	0.695
LIG_MYND_1	23	27	PF01753	0.678
LIG_NRBOX	452	458	PF00104	0.426
LIG_PCNA_yPIPBox_3	469	481	PF02747	0.522
LIG_Pex14_1	359	363	PF04695	0.435
LIG_Pex14_1	421	425	PF04695	0.279
LIG_Pex14_1	548	552	PF04695	0.619
LIG_PTAP_UEV_1	631	636	PF05743	0.317
LIG_PTB_Apo_2	186	193	PF02174	0.554
LIG_PTB_Apo_2	357	364	PF02174	0.597
LIG_PTB_Apo_2	556	563	PF02174	0.310
LIG_PTB_Phospho_1	357	363	PF10480	0.600
LIG_PTB_Phospho_1	556	562	PF10480	0.310
LIG_SH2_CRK	565	569	PF00017	0.327
LIG_SH2_CRK	592	596	PF00017	0.283
LIG_SH2_PTP2	486	489	PF00017	0.528
LIG_SH2_STAP1	134	138	PF00017	0.565
LIG_SH2_STAT3	167	170	PF00017	0.582
LIG_SH2_STAT3	363	366	PF00017	0.599
LIG_SH2_STAT3	637	640	PF00017	0.420
LIG_SH2_STAT5	173	176	PF00017	0.565
LIG_SH2_STAT5	221	224	PF00017	0.606
LIG_SH2_STAT5	312	315	PF00017	0.576
LIG_SH2_STAT5	356	359	PF00017	0.445
LIG_SH2_STAT5	396	399	PF00017	0.525
LIG_SH2_STAT5	486	489	PF00017	0.487
LIG_SH2_STAT5	492	495	PF00017	0.462
LIG_SH2_STAT5	554	557	PF00017	0.366
LIG_SH2_STAT5	565	568	PF00017	0.244
LIG_SH2_STAT5	637	640	PF00017	0.328
LIG_SH2_STAT5	642	645	PF00017	0.310
LIG_SH3_2	23	28	PF14604	0.713
LIG_SH3_3	1	7	PF00018	0.743
LIG_SH3_3	17	23	PF00018	0.797
LIG_SH3_3	241	247	PF00018	0.480
LIG_SH3_3	497	503	PF00018	0.356
LIG_SH3_3	629	635	PF00018	0.335
LIG_Sin3_3	138	145	PF02671	0.420
LIG_SUMO_SIM_anti_2	246	254	PF11976	0.559
LIG_SUMO_SIM_anti_2	299	307	PF11976	0.500
LIG_SUMO_SIM_anti_2	656	662	PF11976	0.356
LIG_SUMO_SIM_par_1	246	254	PF11976	0.496
LIG_SUMO_SIM_par_1	433	439	PF11976	0.464
LIG_SUMO_SIM_par_1	659	664	PF11976	0.331
LIG_SxIP_EBH_1	571	580	PF03271	0.527
LIG_TRAF2_1	64	67	PF00917	0.794
LIG_TYR_ITIM	590	595	PF00017	0.440
LIG_TYR_ITSM	217	224	PF00017	0.510
LIG_UBA3_1	477	483	PF00899	0.402
LIG_WRC_WIRS_1	533	538	PF05994	0.381
LIG_WW_1	393	396	PF00397	0.558
LIG_WW_3	25	29	PF00397	0.673
LIG_WW_3	392	396	PF00397	0.470
MOD_CDC14_SPxK_1	230	233	PF00782	0.264
MOD_CDK_SPxK_1	227	233	PF00069	0.271
MOD_CDK_SPxxK_3	227	234	PF00069	0.270
MOD_CK1_1	129	135	PF00069	0.448
MOD_CK1_1	16	22	PF00069	0.723
MOD_CK1_1	227	233	PF00069	0.271
MOD_CK1_1	257	263	PF00069	0.394
MOD_CK1_1	286	292	PF00069	0.391
MOD_CK1_1	38	44	PF00069	0.776
MOD_CK1_1	609	615	PF00069	0.576
MOD_CK1_1	624	630	PF00069	0.550
MOD_CK1_1	649	655	PF00069	0.443
MOD_CK1_1	679	685	PF00069	0.584
MOD_CK1_1	78	84	PF00069	0.589
MOD_CK1_1	8	14	PF00069	0.770
MOD_CK2_1	182	188	PF00069	0.432
MOD_CK2_1	435	441	PF00069	0.578
MOD_CK2_1	609	615	PF00069	0.660
MOD_GlcNHglycan	10	13	PF01048	0.761
MOD_GlcNHglycan	120	123	PF01048	0.331
MOD_GlcNHglycan	279	282	PF01048	0.480
MOD_GlcNHglycan	285	288	PF01048	0.382
MOD_GlcNHglycan	37	40	PF01048	0.721
MOD_GlcNHglycan	568	571	PF01048	0.351
MOD_GlcNHglycan	608	611	PF01048	0.633
MOD_GlcNHglycan	617	620	PF01048	0.624
MOD_GlcNHglycan	626	629	PF01048	0.624
MOD_GlcNHglycan	632	635	PF01048	0.619
MOD_GlcNHglycan	678	681	PF01048	0.526
MOD_GlcNHglycan	77	80	PF01048	0.656
MOD_GSK3_1	107	114	PF00069	0.501
MOD_GSK3_1	125	132	PF00069	0.274
MOD_GSK3_1	275	282	PF00069	0.495
MOD_GSK3_1	286	293	PF00069	0.442
MOD_GSK3_1	299	306	PF00069	0.363
MOD_GSK3_1	341	348	PF00069	0.549
MOD_GSK3_1	382	389	PF00069	0.471
MOD_GSK3_1	523	530	PF00069	0.302
MOD_GSK3_1	611	618	PF00069	0.635
MOD_GSK3_1	620	627	PF00069	0.583
MOD_GSK3_1	649	656	PF00069	0.416
MOD_GSK3_1	661	668	PF00069	0.298
MOD_GSK3_1	671	678	PF00069	0.446
MOD_GSK3_1	679	686	PF00069	0.525
MOD_GSK3_1	74	81	PF00069	0.735
MOD_GSK3_1	8	15	PF00069	0.767
MOD_NEK2_1	130	135	PF00069	0.506
MOD_NEK2_1	182	187	PF00069	0.390
MOD_NEK2_1	358	363	PF00069	0.365
MOD_NEK2_1	43	48	PF00069	0.768
MOD_NEK2_1	455	460	PF00069	0.337
MOD_NEK2_1	485	490	PF00069	0.485
MOD_NEK2_1	493	498	PF00069	0.350
MOD_NEK2_1	527	532	PF00069	0.334
MOD_NEK2_1	661	666	PF00069	0.325
MOD_NEK2_1	671	676	PF00069	0.305
MOD_NEK2_1	74	79	PF00069	0.769
MOD_NEK2_2	120	125	PF00069	0.355
MOD_PIKK_1	107	113	PF00454	0.457
MOD_PIKK_1	191	197	PF00454	0.415
MOD_PIKK_1	6	12	PF00454	0.551
MOD_PIKK_1	67	73	PF00454	0.785
MOD_PKA_2	13	19	PF00069	0.769
MOD_PKA_2	224	230	PF00069	0.483
MOD_PKA_2	67	73	PF00069	0.787
MOD_PKB_1	105	113	PF00069	0.482
MOD_PKB_1	275	283	PF00069	0.457
MOD_Plk_1	182	188	PF00069	0.378
MOD_Plk_1	43	49	PF00069	0.721
MOD_Plk_1	649	655	PF00069	0.488
MOD_Plk_1	87	93	PF00069	0.439
MOD_Plk_4	16	22	PF00069	0.783
MOD_Plk_4	182	188	PF00069	0.454
MOD_Plk_4	224	230	PF00069	0.503
MOD_Plk_4	254	260	PF00069	0.428
MOD_Plk_4	279	285	PF00069	0.509
MOD_Plk_4	299	305	PF00069	0.152
MOD_Plk_4	352	358	PF00069	0.437
MOD_Plk_4	38	44	PF00069	0.665
MOD_Plk_4	462	468	PF00069	0.331
MOD_Plk_4	493	499	PF00069	0.308
MOD_Plk_4	583	589	PF00069	0.359
MOD_Plk_4	653	659	PF00069	0.288
MOD_Plk_4	679	685	PF00069	0.570
MOD_ProDKin_1	227	233	PF00069	0.333
MOD_ProDKin_1	275	281	PF00069	0.335
MOD_ProDKin_1	487	493	PF00069	0.489
MOD_ProDKin_1	54	60	PF00069	0.757
MOD_ProDKin_1	628	634	PF00069	0.598
MOD_SUMO_for_1	468	471	PF00179	0.510
TRG_DiLeu_BaEn_1	246	251	PF01217	0.478
TRG_DiLeu_BaEn_2	324	330	PF01217	0.488
TRG_ENDOCYTIC_2	221	224	PF00928	0.513
TRG_ENDOCYTIC_2	396	399	PF00928	0.501
TRG_ENDOCYTIC_2	486	489	PF00928	0.412
TRG_ENDOCYTIC_2	554	557	PF00928	0.373
TRG_ENDOCYTIC_2	565	568	PF00928	0.240
TRG_ENDOCYTIC_2	592	595	PF00928	0.346
TRG_ENDOCYTIC_2	642	645	PF00928	0.382
TRG_ENDOCYTIC_2	84	87	PF00928	0.637
TRG_ER_diArg_1	104	107	PF00400	0.551
TRG_ER_diArg_1	167	169	PF00400	0.398
TRG_ER_diArg_1	274	277	PF00400	0.451
TRG_ER_diArg_1	375	378	PF00400	0.491
TRG_ER_diArg_1	49	51	PF00400	0.659
TRG_ER_diArg_1	600	603	PF00400	0.512
TRG_ER_diArg_1	96	98	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I194	Leptomonas seymouri	54%	83%
A0A0S4IZ09	Bodo saltans	36%	100%
A0A1X0P4K0	Trypanosomatidae	32%	100%
A0A3Q8IDI3	Leishmania donovani	91%	100%
A0A3R7MIF6	Trypanosoma rangeli	32%	100%
A4HFU5	Leishmania braziliensis	75%	100%
A4I2W2	Leishmania infantum	91%	100%
P45843	Drosophila melanogaster	24%	100%
Q4GZT4	Bos taurus	21%	100%
Q5MB13	Macaca mulatta	22%	100%
Q7TMS5	Mus musculus	21%	100%
Q80W57	Rattus norvegicus	21%	100%
Q8MIB3	Sus scrofa	22%	100%
Q99P81	Mus musculus	23%	100%
Q9UNQ0	Homo sapiens	21%	100%
V5B0X3	Trypanosoma cruzi	35%	100%
V5BLN9	Trypanosoma cruzi	24%	99%