C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mRNA export factor MEX67

Species:

Leishmania major

UniProt:

E9ADE8_LEIMA

TriTrypDb:

LmjF.27.1690 , LMJLV39_270023400 , LMJSD75_270023600

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005643	nuclear pore	3	2
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	20
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	20
GO:0043226	organelle	2	20
GO:0043227	membrane-bounded organelle	3	20
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	20
GO:0120025	plasma membrane bounded cell projection	3	20
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9ADE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADE8

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	3
GO:0006406	mRNA export from nucleus	6	3
GO:0006810	transport	3	4
GO:0006913	nucleocytoplasmic transport	5	3
GO:0009987	cellular process	1	3
GO:0015931	nucleobase-containing compound transport	5	4
GO:0016973	poly(A)+ mRNA export from nucleus	7	3
GO:0046907	intracellular transport	3	3
GO:0050657	nucleic acid transport	6	4
GO:0050658	RNA transport	4	4
GO:0051028	mRNA transport	5	4
GO:0051168	nuclear export	6	3
GO:0051169	nuclear transport	4	3
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0051236	establishment of RNA localization	3	4
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.519
CLV_C14_Caspase3-7	422	426	PF00656	0.635
CLV_MEL_PAP_1	585	591	PF00089	0.432
CLV_NRD_NRD_1	528	530	PF00675	0.442
CLV_NRD_NRD_1	601	603	PF00675	0.421
CLV_PCSK_KEX2_1	441	443	PF00082	0.406
CLV_PCSK_KEX2_1	45	47	PF00082	0.645
CLV_PCSK_KEX2_1	521	523	PF00082	0.487
CLV_PCSK_KEX2_1	528	530	PF00082	0.456
CLV_PCSK_KEX2_1	601	603	PF00082	0.454
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.501
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.485
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.435
CLV_PCSK_SKI1_1	22	26	PF00082	0.533
CLV_PCSK_SKI1_1	259	263	PF00082	0.411
CLV_PCSK_SKI1_1	446	450	PF00082	0.394
CLV_PCSK_SKI1_1	70	74	PF00082	0.409
DEG_SCF_FBW7_1	309	315	PF00400	0.547
DOC_CKS1_1	309	314	PF01111	0.549
DOC_CKS1_1	496	501	PF01111	0.568
DOC_CYCLIN_RxL_1	256	266	PF00134	0.300
DOC_MAPK_gen_1	257	264	PF00069	0.299
DOC_MAPK_MEF2A_6	531	539	PF00069	0.376
DOC_PP1_RVXF_1	198	204	PF00149	0.561
DOC_PP1_RVXF_1	68	74	PF00149	0.382
DOC_PP2B_LxvP_1	223	226	PF13499	0.569
DOC_PP4_FxxP_1	230	233	PF00568	0.634
DOC_USP7_MATH_1	307	311	PF00917	0.491
DOC_USP7_MATH_1	490	494	PF00917	0.769
DOC_USP7_MATH_1	576	580	PF00917	0.466
DOC_USP7_UBL2_3	200	204	PF12436	0.558
DOC_WW_Pin1_4	123	128	PF00397	0.496
DOC_WW_Pin1_4	308	313	PF00397	0.505
DOC_WW_Pin1_4	380	385	PF00397	0.557
DOC_WW_Pin1_4	495	500	PF00397	0.680
DOC_WW_Pin1_4	512	517	PF00397	0.501
LIG_14-3-3_CanoR_1	159	164	PF00244	0.377
LIG_14-3-3_CanoR_1	335	345	PF00244	0.452
LIG_14-3-3_CanoR_1	358	362	PF00244	0.407
LIG_14-3-3_CanoR_1	40	45	PF00244	0.702
LIG_14-3-3_CanoR_1	446	451	PF00244	0.375
LIG_14-3-3_CanoR_1	46	53	PF00244	0.732
LIG_14-3-3_CanoR_1	588	592	PF00244	0.344
LIG_APCC_ABBA_1	69	74	PF00400	0.507
LIG_BRCT_BRCA1_1	104	108	PF00533	0.388
LIG_deltaCOP1_diTrp_1	224	231	PF00928	0.683
LIG_EH1_1	458	466	PF00400	0.365
LIG_FHA_1	110	116	PF00498	0.365
LIG_FHA_1	297	303	PF00498	0.427
LIG_FHA_1	351	357	PF00498	0.516
LIG_FHA_1	59	65	PF00498	0.515
LIG_FHA_1	75	81	PF00498	0.433
LIG_FHA_1	83	89	PF00498	0.419
LIG_FHA_2	167	173	PF00498	0.512
LIG_FHA_2	281	287	PF00498	0.522
LIG_FHA_2	568	574	PF00498	0.501
LIG_FHA_2	92	98	PF00498	0.562
LIG_LIR_Apic_2	14	20	PF02991	0.496
LIG_LIR_Gen_1	297	308	PF02991	0.540
LIG_LIR_Gen_1	606	614	PF02991	0.346
LIG_LIR_Gen_1	94	103	PF02991	0.466
LIG_LIR_Nem_3	224	230	PF02991	0.568
LIG_LIR_Nem_3	297	303	PF02991	0.494
LIG_LIR_Nem_3	606	610	PF02991	0.526
LIG_LIR_Nem_3	94	99	PF02991	0.445
LIG_PCNA_PIPBox_1	65	74	PF02747	0.393
LIG_PCNA_yPIPBox_3	252	265	PF02747	0.549
LIG_PCNA_yPIPBox_3	372	380	PF02747	0.441
LIG_Pex14_1	227	231	PF04695	0.682
LIG_PTB_Apo_2	388	395	PF02174	0.627
LIG_REV1ctd_RIR_1	21	30	PF16727	0.539
LIG_REV1ctd_RIR_1	70	79	PF16727	0.530
LIG_SH2_CRK	17	21	PF00017	0.471
LIG_SH2_CRK	510	514	PF00017	0.627
LIG_SH2_CRK	530	534	PF00017	0.205
LIG_SH2_SRC	36	39	PF00017	0.515
LIG_SH2_STAP1	292	296	PF00017	0.351
LIG_SH2_STAP1	510	514	PF00017	0.627
LIG_SH2_STAP1	565	569	PF00017	0.440
LIG_SH2_STAT5	36	39	PF00017	0.515
LIG_SH2_STAT5	379	382	PF00017	0.508
LIG_SH2_STAT5	459	462	PF00017	0.375
LIG_SH3_3	122	128	PF00018	0.441
LIG_SH3_3	186	192	PF00018	0.475
LIG_SH3_3	266	272	PF00018	0.486
LIG_SH3_3	306	312	PF00018	0.485
LIG_SH3_3	365	371	PF00018	0.477
LIG_SH3_3	493	499	PF00018	0.753
LIG_SH3_3	529	535	PF00018	0.565
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.565
LIG_SUMO_SIM_anti_2	595	601	PF11976	0.409
LIG_SUMO_SIM_par_1	404	410	PF11976	0.417
LIG_SUMO_SIM_par_1	445	454	PF11976	0.492
LIG_SUMO_SIM_par_1	558	566	PF11976	0.483
LIG_TRAF2_1	148	151	PF00917	0.471
LIG_UBA3_1	346	350	PF00899	0.637
LIG_UBA3_1	68	75	PF00899	0.410
LIG_WRC_WIRS_1	540	545	PF05994	0.369
LIG_WRC_WIRS_1	93	98	PF05994	0.483
MOD_CDK_SPxK_1	308	314	PF00069	0.494
MOD_CK1_1	301	307	PF00069	0.465
MOD_CK1_1	310	316	PF00069	0.522
MOD_CK1_1	407	413	PF00069	0.485
MOD_CK1_1	515	521	PF00069	0.535
MOD_CK1_1	91	97	PF00069	0.495
MOD_CK2_1	46	52	PF00069	0.547
MOD_CK2_1	494	500	PF00069	0.709
MOD_CK2_1	543	549	PF00069	0.534
MOD_CK2_1	567	573	PF00069	0.493
MOD_GlcNHglycan	266	269	PF01048	0.460
MOD_GlcNHglycan	278	281	PF01048	0.488
MOD_GlcNHglycan	396	399	PF01048	0.609
MOD_GlcNHglycan	421	424	PF01048	0.462
MOD_GlcNHglycan	473	476	PF01048	0.579
MOD_GlcNHglycan	486	489	PF01048	0.717
MOD_GlcNHglycan	606	610	PF01048	0.520
MOD_GSK3_1	11	18	PF00069	0.656
MOD_GSK3_1	123	130	PF00069	0.406
MOD_GSK3_1	276	283	PF00069	0.622
MOD_GSK3_1	294	301	PF00069	0.336
MOD_GSK3_1	308	315	PF00069	0.438
MOD_GSK3_1	40	47	PF00069	0.666
MOD_GSK3_1	442	449	PF00069	0.400
MOD_GSK3_1	480	487	PF00069	0.653
MOD_GSK3_1	490	497	PF00069	0.733
MOD_GSK3_1	539	546	PF00069	0.425
MOD_GSK3_1	88	95	PF00069	0.422
MOD_GSK3_1	97	104	PF00069	0.419
MOD_LATS_1	165	171	PF00433	0.350
MOD_LATS_1	38	44	PF00433	0.633
MOD_N-GLC_1	294	299	PF02516	0.499
MOD_N-GLC_1	40	45	PF02516	0.674
MOD_N-GLC_1	442	447	PF02516	0.392
MOD_N-GLC_1	58	63	PF02516	0.585
MOD_N-GLC_1	88	93	PF02516	0.429
MOD_NEK2_1	154	159	PF00069	0.396
MOD_NEK2_1	247	252	PF00069	0.706
MOD_NEK2_1	25	30	PF00069	0.568
MOD_NEK2_1	264	269	PF00069	0.459
MOD_NEK2_1	294	299	PF00069	0.411
MOD_NEK2_1	349	354	PF00069	0.527
MOD_NEK2_1	374	379	PF00069	0.344
MOD_NEK2_1	480	485	PF00069	0.787
MOD_NEK2_1	605	610	PF00069	0.547
MOD_NEK2_1	88	93	PF00069	0.450
MOD_NEK2_2	576	581	PF00069	0.477
MOD_NEK2_2	58	63	PF00069	0.504
MOD_OFUCOSY	114	120	PF10250	0.470
MOD_PIKK_1	74	80	PF00454	0.582
MOD_PIKK_1	88	94	PF00454	0.417
MOD_PKA_2	25	31	PF00069	0.526
MOD_PKA_2	336	342	PF00069	0.500
MOD_PKA_2	357	363	PF00069	0.508
MOD_PKA_2	419	425	PF00069	0.546
MOD_PKA_2	587	593	PF00069	0.386
MOD_Plk_1	294	300	PF00069	0.494
MOD_Plk_1	40	46	PF00069	0.693
MOD_Plk_1	442	448	PF00069	0.410
MOD_Plk_1	605	611	PF00069	0.495
MOD_Plk_1	88	94	PF00069	0.391
MOD_Plk_1	97	103	PF00069	0.414
MOD_Plk_4	127	133	PF00069	0.412
MOD_Plk_4	404	410	PF00069	0.415
MOD_Plk_4	429	435	PF00069	0.679
MOD_Plk_4	463	469	PF00069	0.401
MOD_Plk_4	539	545	PF00069	0.500
MOD_Plk_4	567	573	PF00069	0.415
MOD_Plk_4	576	582	PF00069	0.329
MOD_Plk_4	64	70	PF00069	0.442
MOD_ProDKin_1	123	129	PF00069	0.491
MOD_ProDKin_1	308	314	PF00069	0.508
MOD_ProDKin_1	380	386	PF00069	0.551
MOD_ProDKin_1	495	501	PF00069	0.676
MOD_ProDKin_1	512	518	PF00069	0.503
MOD_SUMO_for_1	363	366	PF00179	0.497
MOD_SUMO_rev_2	135	142	PF00179	0.531
MOD_SUMO_rev_2	195	201	PF00179	0.515
MOD_SUMO_rev_2	385	394	PF00179	0.601
MOD_SUMO_rev_2	515	523	PF00179	0.475
TRG_DiLeu_BaEn_1	595	600	PF01217	0.401
TRG_ENDOCYTIC_2	36	39	PF00928	0.515
TRG_ENDOCYTIC_2	510	513	PF00928	0.622
TRG_ER_diArg_1	334	337	PF00400	0.504
TRG_ER_diArg_1	528	530	PF00400	0.480
TRG_ER_diArg_1	600	602	PF00400	0.448
TRG_NLS_MonoExtC_3	5	11	PF00514	0.568
TRG_NLS_MonoExtN_4	3	10	PF00514	0.694
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	271	276	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E9	Leptomonas seymouri	68%	98%
A0A0N0P8S6	Leptomonas seymouri	25%	100%
A0A0S4IW66	Bodo saltans	31%	100%
A0A1X0P4A3	Trypanosomatidae	29%	100%
A0A1X0P4L1	Trypanosomatidae	44%	100%
A0A3R7NID6	Trypanosoma rangeli	45%	100%
A0A3S7X0T0	Leishmania donovani	25%	100%
A0A3S7X0T8	Leishmania donovani	95%	100%
A4HFU4	Leishmania braziliensis	84%	100%
A4I2W0	Leishmania infantum	25%	100%
A4I2W1	Leishmania infantum	95%	100%
D0A641	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A644	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADE7	Leishmania major	24%	100%
E9AZ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AZ72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B0W6	Trypanosoma cruzi	45%	100%
V5BQG4	Trypanosoma cruzi	28%	100%