TAP-C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADE7_LEIMA

TriTrypDb:

LmjF.27.1680 , LMJLV39_270023300 , LMJSD75_270023500

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005929	cilium	4	19
GO:0042995	cell projection	2	19
GO:0043226	organelle	2	19
GO:0043227	membrane-bounded organelle	3	19
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	19
GO:0120025	plasma membrane bounded cell projection	3	19
GO:0005643	nuclear pore	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9ADE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADE7

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	3
GO:0006406	mRNA export from nucleus	6	3
GO:0006810	transport	3	4
GO:0006913	nucleocytoplasmic transport	5	3
GO:0009987	cellular process	1	3
GO:0015931	nucleobase-containing compound transport	5	4
GO:0016973	poly(A)+ mRNA export from nucleus	7	3
GO:0046907	intracellular transport	3	3
GO:0050657	nucleic acid transport	6	4
GO:0050658	RNA transport	4	4
GO:0051028	mRNA transport	5	4
GO:0051168	nuclear export	6	3
GO:0051169	nuclear transport	4	3
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0051236	establishment of RNA localization	3	4
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.492
CLV_C14_Caspase3-7	64	68	PF00656	0.705
CLV_NRD_NRD_1	484	486	PF00675	0.485
CLV_PCSK_KEX2_1	119	121	PF00082	0.586
CLV_PCSK_KEX2_1	193	195	PF00082	0.509
CLV_PCSK_KEX2_1	483	485	PF00082	0.496
CLV_PCSK_KEX2_1	534	536	PF00082	0.451
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.580
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.524
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.447
CLV_PCSK_SKI1_1	155	159	PF00082	0.451
CLV_PCSK_SKI1_1	171	175	PF00082	0.510
CLV_PCSK_SKI1_1	235	239	PF00082	0.584
CLV_PCSK_SKI1_1	431	435	PF00082	0.397
CLV_PCSK_SKI1_1	534	538	PF00082	0.601
CLV_PCSK_SKI1_1	81	85	PF00082	0.440
CLV_Separin_Metazoa	134	138	PF03568	0.512
DOC_CYCLIN_RxL_1	139	153	PF00134	0.519
DOC_CYCLIN_RxL_1	78	85	PF00134	0.546
DOC_CYCLIN_yClb1_LxF_4	183	189	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.416
DOC_MAPK_DCC_7	217	227	PF00069	0.406
DOC_MAPK_gen_1	137	146	PF00069	0.482
DOC_MAPK_MEF2A_6	220	227	PF00069	0.470
DOC_MAPK_MEF2A_6	365	373	PF00069	0.552
DOC_MAPK_MEF2A_6	509	517	PF00069	0.599
DOC_MAPK_MEF2A_6	81	88	PF00069	0.519
DOC_MAPK_NFAT4_5	81	89	PF00069	0.532
DOC_PP2B_LxvP_1	238	241	PF13499	0.566
DOC_PP2B_LxvP_1	516	519	PF13499	0.576
DOC_USP7_MATH_1	243	247	PF00917	0.587
DOC_USP7_MATH_1	321	325	PF00917	0.636
DOC_USP7_MATH_1	336	340	PF00917	0.606
DOC_USP7_MATH_1	501	505	PF00917	0.576
DOC_USP7_MATH_1	525	529	PF00917	0.601
DOC_USP7_MATH_1	68	72	PF00917	0.807
DOC_USP7_MATH_2	350	356	PF00917	0.407
DOC_WW_Pin1_4	108	113	PF00397	0.513
DOC_WW_Pin1_4	462	467	PF00397	0.524
DOC_WW_Pin1_4	472	477	PF00397	0.591
LIG_14-3-3_CanoR_1	224	228	PF00244	0.488
LIG_14-3-3_CanoR_1	327	335	PF00244	0.511
LIG_14-3-3_CanoR_1	431	436	PF00244	0.376
LIG_Actin_WH2_2	312	329	PF00022	0.474
LIG_APCC_ABBAyCdc20_2	457	463	PF00400	0.638
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BRCT_BRCA1_1	124	128	PF00533	0.415
LIG_BRCT_BRCA1_1	328	332	PF00533	0.448
LIG_BRCT_BRCA1_1	425	429	PF00533	0.477
LIG_BRCT_BRCA1_1	467	471	PF00533	0.606
LIG_BRCT_BRCA1_1	84	88	PF00533	0.482
LIG_BRCT_BRCA1_1	92	96	PF00533	0.471
LIG_BRCT_BRCA1_2	124	130	PF00533	0.439
LIG_BRCT_BRCA1_2	84	90	PF00533	0.530
LIG_FHA_1	306	312	PF00498	0.500
LIG_FHA_1	430	436	PF00498	0.352
LIG_FHA_1	489	495	PF00498	0.517
LIG_FHA_2	425	431	PF00498	0.496
LIG_FHA_2	500	506	PF00498	0.579
LIG_IRF3_LxIS_1	284	290	PF10401	0.533
LIG_LIR_Gen_1	122	131	PF02991	0.425
LIG_LIR_Gen_1	263	273	PF02991	0.556
LIG_LIR_Gen_1	282	289	PF02991	0.542
LIG_LIR_Gen_1	89	99	PF02991	0.548
LIG_LIR_Nem_3	122	126	PF02991	0.430
LIG_LIR_Nem_3	270	276	PF02991	0.493
LIG_LIR_Nem_3	282	287	PF02991	0.522
LIG_LIR_Nem_3	329	335	PF02991	0.510
LIG_LIR_Nem_3	89	95	PF02991	0.537
LIG_LRP6_Inhibitor_1	149	155	PF00058	0.399
LIG_MLH1_MIPbox_1	425	429	PF16413	0.475
LIG_MYND_1	112	116	PF01753	0.468
LIG_NRBOX	197	203	PF00104	0.406
LIG_NRBOX	82	88	PF00104	0.419
LIG_PCNA_PIPBox_1	253	262	PF02747	0.507
LIG_Pex14_2	373	377	PF04695	0.584
LIG_PTB_Apo_2	371	378	PF02174	0.573
LIG_REV1ctd_RIR_1	426	435	PF16727	0.407
LIG_SH2_CRK	123	127	PF00017	0.528
LIG_SH2_CRK	195	199	PF00017	0.518
LIG_SH2_CRK	273	277	PF00017	0.474
LIG_SH2_CRK	92	96	PF00017	0.526
LIG_SH2_NCK_1	123	127	PF00017	0.528
LIG_SH2_NCK_1	273	277	PF00017	0.378
LIG_SH2_NCK_1	92	96	PF00017	0.503
LIG_SH2_SRC	278	281	PF00017	0.378
LIG_SH2_STAP1	214	218	PF00017	0.419
LIG_SH2_STAP1	92	96	PF00017	0.555
LIG_SH2_STAT3	259	262	PF00017	0.550
LIG_SH2_STAT3	280	283	PF00017	0.555
LIG_SH2_STAT5	259	262	PF00017	0.470
LIG_SH2_STAT5	278	281	PF00017	0.483
LIG_SH2_STAT5	403	406	PF00017	0.383
LIG_SH3_3	404	410	PF00018	0.416
LIG_SH3_3	412	418	PF00018	0.394
LIG_SH3_3	463	469	PF00018	0.641
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.475
LIG_SUMO_SIM_par_1	430	436	PF11976	0.482
LIG_TRAF2_1	504	507	PF00917	0.471
LIG_TYR_ITIM	121	126	PF00017	0.523
LIG_UBA3_1	83	90	PF00899	0.415
LIG_WRC_WIRS_1	425	430	PF05994	0.523
MOD_CDK_SPxK_1	472	478	PF00069	0.632
MOD_CK1_1	187	193	PF00069	0.471
MOD_CK1_1	267	273	PF00069	0.512
MOD_CK1_1	282	288	PF00069	0.492
MOD_CK1_1	339	345	PF00069	0.603
MOD_CK1_1	71	77	PF00069	0.591
MOD_CK2_1	474	480	PF00069	0.452
MOD_CK2_1	500	506	PF00069	0.624
MOD_CK2_1	525	531	PF00069	0.549
MOD_Cter_Amidation	5	8	PF01082	0.617
MOD_GlcNHglycan	15	18	PF01048	0.733
MOD_GlcNHglycan	176	179	PF01048	0.388
MOD_GlcNHglycan	189	192	PF01048	0.380
MOD_GlcNHglycan	19	22	PF01048	0.768
MOD_GlcNHglycan	245	248	PF01048	0.683
MOD_GlcNHglycan	284	287	PF01048	0.494
MOD_GlcNHglycan	302	305	PF01048	0.437
MOD_GlcNHglycan	338	341	PF01048	0.671
MOD_GlcNHglycan	70	73	PF01048	0.688
MOD_GSK3_1	13	20	PF00069	0.751
MOD_GSK3_1	212	219	PF00069	0.594
MOD_GSK3_1	243	250	PF00069	0.591
MOD_GSK3_1	260	267	PF00069	0.418
MOD_GSK3_1	321	328	PF00069	0.559
MOD_GSK3_1	352	359	PF00069	0.334
MOD_GSK3_1	409	416	PF00069	0.558
MOD_GSK3_1	429	436	PF00069	0.409
MOD_GSK3_1	438	445	PF00069	0.468
MOD_N-GLC_1	103	108	PF02516	0.458
MOD_N-GLC_1	13	18	PF02516	0.568
MOD_N-GLC_1	179	184	PF02516	0.584
MOD_N-GLC_1	33	38	PF02516	0.539
MOD_N-GLC_1	499	504	PF02516	0.607
MOD_N-GLC_1	61	66	PF02516	0.743
MOD_N-GLC_1	68	73	PF02516	0.683
MOD_NEK2_1	103	108	PF00069	0.474
MOD_NEK2_1	260	265	PF00069	0.443
MOD_NEK2_1	279	284	PF00069	0.476
MOD_NEK2_1	287	292	PF00069	0.420
MOD_NEK2_1	382	387	PF00069	0.518
MOD_NEK2_1	424	429	PF00069	0.391
MOD_NEK2_1	88	93	PF00069	0.449
MOD_NEK2_2	393	398	PF00069	0.378
MOD_PIKK_1	247	253	PF00454	0.509
MOD_PIKK_1	279	285	PF00454	0.583
MOD_PIKK_1	326	332	PF00454	0.587
MOD_PIKK_1	409	415	PF00454	0.530
MOD_PIKK_1	90	96	PF00454	0.588
MOD_PK_1	179	185	PF00069	0.360
MOD_PKA_2	216	222	PF00069	0.576
MOD_PKA_2	223	229	PF00069	0.447
MOD_PKA_2	326	332	PF00069	0.509
MOD_Plk_1	150	156	PF00069	0.440
MOD_Plk_1	179	185	PF00069	0.519
MOD_Plk_1	260	266	PF00069	0.537
MOD_Plk_1	363	369	PF00069	0.626
MOD_Plk_1	382	388	PF00069	0.443
MOD_Plk_1	429	435	PF00069	0.408
MOD_Plk_1	88	94	PF00069	0.514
MOD_Plk_4	184	190	PF00069	0.475
MOD_Plk_4	223	229	PF00069	0.375
MOD_Plk_4	252	258	PF00069	0.510
MOD_Plk_4	260	266	PF00069	0.398
MOD_Plk_4	424	430	PF00069	0.483
MOD_Plk_4	508	514	PF00069	0.612
MOD_Plk_4	82	88	PF00069	0.431
MOD_ProDKin_1	108	114	PF00069	0.506
MOD_ProDKin_1	462	468	PF00069	0.524
MOD_ProDKin_1	472	478	PF00069	0.584
MOD_SUMO_rev_2	503	511	PF00179	0.606
TRG_DiLeu_BaEn_1	98	103	PF01217	0.384
TRG_ENDOCYTIC_2	123	126	PF00928	0.526
TRG_ENDOCYTIC_2	195	198	PF00928	0.430
TRG_ENDOCYTIC_2	273	276	PF00928	0.478
TRG_ENDOCYTIC_2	92	95	PF00928	0.556
TRG_ER_diArg_1	143	146	PF00400	0.542
TRG_ER_diArg_1	482	485	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E9	Leptomonas seymouri	24%	86%
A0A0N0P8S6	Leptomonas seymouri	74%	100%
A0A0S4IW66	Bodo saltans	29%	100%
A0A1X0P4A3	Trypanosomatidae	45%	100%
A0A1X0P4L1	Trypanosomatidae	26%	92%
A0A3R7NID6	Trypanosoma rangeli	26%	93%
A0A3S7X0T0	Leishmania donovani	97%	100%
A4HFU3	Leishmania braziliensis	88%	99%
A4HFU4	Leishmania braziliensis	25%	88%
A4I2W0	Leishmania infantum	96%	100%
D0A641	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A644	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ADE8	Leishmania major	24%	100%
E9AZ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	98%
E9AZ72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
V5B0W6	Trypanosoma cruzi	26%	93%
V5BQG4	Trypanosoma cruzi	44%	100%