Adenylyltransferase and sulfurtransferase MOCS3 homolog

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

molybdopterin synthase sulphurylase-like protein, putative

Species:

Leishmania major

UniProt:

E9ADE6_LEIMA

TriTrypDb:

LmjF.27.1670 , LMJLV39_270023100 , LMJSD75_270023200

Length:

463

Annotations

LeishMANIAdb annotations

Homlogous to mammalian MOCS3. Non-TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	4

Expansion

Sequence features

E9ADE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADE6

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	10
GO:0002098	tRNA wobble uridine modification	8	10
GO:0002143	tRNA wobble position uridine thiolation	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006400	tRNA modification	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034227	tRNA thio-modification	7	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004792	thiosulfate sulfurtransferase activity	5	10
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0016782	transferase activity, transferring sulphur-containing groups	3	10
GO:0016783	sulfurtransferase activity	4	10
GO:0016874	ligase activity	2	12
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042292	URM1 activating enzyme activity	3	2
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.217
CLV_C14_Caspase3-7	205	209	PF00656	0.259
CLV_NRD_NRD_1	324	326	PF00675	0.404
CLV_NRD_NRD_1	406	408	PF00675	0.247
CLV_PCSK_KEX2_1	324	326	PF00082	0.357
CLV_PCSK_KEX2_1	356	358	PF00082	0.360
CLV_PCSK_KEX2_1	406	408	PF00082	0.247
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.375
CLV_PCSK_SKI1_1	191	195	PF00082	0.435
CLV_PCSK_SKI1_1	229	233	PF00082	0.478
CLV_PCSK_SKI1_1	241	245	PF00082	0.238
CLV_PCSK_SKI1_1	253	257	PF00082	0.224
CLV_PCSK_SKI1_1	32	36	PF00082	0.259
CLV_PCSK_SKI1_1	324	328	PF00082	0.375
CLV_PCSK_SKI1_1	413	417	PF00082	0.296
CLV_PCSK_SKI1_1	419	423	PF00082	0.326
CLV_PCSK_SKI1_1	439	443	PF00082	0.364
DEG_Nend_UBRbox_3	1	3	PF02207	0.599
DOC_MAPK_gen_1	324	332	PF00069	0.566
DOC_MAPK_MEF2A_6	324	332	PF00069	0.553
DOC_PP4_FxxP_1	194	197	PF00568	0.207
DOC_PP4_MxPP_1	373	376	PF00568	0.497
DOC_USP7_MATH_1	108	112	PF00917	0.259
DOC_USP7_MATH_1	14	18	PF00917	0.523
DOC_USP7_MATH_1	166	170	PF00917	0.207
DOC_USP7_MATH_1	265	269	PF00917	0.482
DOC_USP7_MATH_1	295	299	PF00917	0.642
DOC_USP7_MATH_1	303	307	PF00917	0.529
DOC_USP7_MATH_1	316	320	PF00917	0.603
DOC_USP7_MATH_1	348	352	PF00917	0.513
DOC_USP7_MATH_1	388	392	PF00917	0.689
DOC_WW_Pin1_4	126	131	PF00397	0.300
DOC_WW_Pin1_4	273	278	PF00397	0.603
DOC_WW_Pin1_4	298	303	PF00397	0.674
DOC_WW_Pin1_4	376	381	PF00397	0.608
LIG_14-3-3_CanoR_1	135	144	PF00244	0.343
LIG_14-3-3_CanoR_1	249	257	PF00244	0.476
LIG_14-3-3_CanoR_1	324	329	PF00244	0.566
LIG_14-3-3_CanoR_1	407	413	PF00244	0.482
LIG_Actin_WH2_2	215	231	PF00022	0.259
LIG_Actin_WH2_2	235	251	PF00022	0.116
LIG_EVH1_1	194	198	PF00568	0.207
LIG_FHA_1	137	143	PF00498	0.280
LIG_FHA_1	145	151	PF00498	0.204
LIG_FHA_1	325	331	PF00498	0.509
LIG_FHA_1	356	362	PF00498	0.534
LIG_FHA_1	61	67	PF00498	0.251
LIG_FHA_1	95	101	PF00498	0.248
LIG_FHA_2	21	27	PF00498	0.463
LIG_FHA_2	75	81	PF00498	0.259
LIG_FXI_DFP_1	78	82	PF00024	0.417
LIG_GBD_Chelix_1	361	369	PF00786	0.368
LIG_Integrin_isoDGR_2	239	241	PF01839	0.368
LIG_Integrin_RGD_1	428	430	PF01839	0.312
LIG_LIR_Gen_1	80	89	PF02991	0.228
LIG_LIR_Nem_3	288	292	PF02991	0.540
LIG_LIR_Nem_3	411	415	PF02991	0.455
LIG_LIR_Nem_3	457	463	PF02991	0.510
LIG_LIR_Nem_3	80	84	PF02991	0.234
LIG_SH2_CRK	190	194	PF00017	0.261
LIG_SH2_CRK	292	296	PF00017	0.640
LIG_SH2_CRK	349	353	PF00017	0.556
LIG_SH2_STAP1	312	316	PF00017	0.543
LIG_SH2_STAT5	154	157	PF00017	0.216
LIG_SH2_STAT5	289	292	PF00017	0.585
LIG_SH2_STAT5	402	405	PF00017	0.494
LIG_SH2_STAT5	440	443	PF00017	0.500
LIG_SH2_STAT5	67	70	PF00017	0.310
LIG_SH3_3	192	198	PF00018	0.207
LIG_SH3_3	208	214	PF00018	0.207
LIG_SH3_3	342	348	PF00018	0.469
LIG_TRAF2_1	198	201	PF00917	0.223
LIG_TYR_ITIM	347	352	PF00017	0.546
LIG_WRC_WIRS_1	409	414	PF05994	0.393
MOD_CDK_SPxK_1	376	382	PF00069	0.557
MOD_CK1_1	18	24	PF00069	0.627
MOD_CK1_1	298	304	PF00069	0.599
MOD_CK2_1	305	311	PF00069	0.553
MOD_GlcNHglycan	106	109	PF01048	0.413
MOD_GlcNHglycan	168	171	PF01048	0.407
MOD_GlcNHglycan	208	211	PF01048	0.529
MOD_GlcNHglycan	267	270	PF01048	0.367
MOD_GlcNHglycan	297	300	PF01048	0.384
MOD_GlcNHglycan	307	310	PF01048	0.334
MOD_GlcNHglycan	318	321	PF01048	0.372
MOD_GlcNHglycan	385	389	PF01048	0.574
MOD_GlcNHglycan	445	448	PF01048	0.301
MOD_GlcNHglycan	457	460	PF01048	0.237
MOD_GlcNHglycan	70	73	PF01048	0.368
MOD_GSK3_1	104	111	PF00069	0.258
MOD_GSK3_1	14	21	PF00069	0.552
MOD_GSK3_1	202	209	PF00069	0.209
MOD_GSK3_1	290	297	PF00069	0.646
MOD_GSK3_1	298	305	PF00069	0.570
MOD_GSK3_1	384	391	PF00069	0.746
MOD_N-GLC_1	206	211	PF02516	0.407
MOD_N-GLC_1	443	448	PF02516	0.299
MOD_NEK2_1	15	20	PF00069	0.553
MOD_NEK2_1	248	253	PF00069	0.524
MOD_NEK2_1	341	346	PF00069	0.570
MOD_NEK2_1	60	65	PF00069	0.243
MOD_NEK2_1	68	73	PF00069	0.243
MOD_NEK2_2	177	182	PF00069	0.207
MOD_NEK2_2	408	413	PF00069	0.506
MOD_PIKK_1	3	9	PF00454	0.517
MOD_PIKK_1	360	366	PF00454	0.475
MOD_PIKK_1	394	400	PF00454	0.467
MOD_PKA_1	324	330	PF00069	0.471
MOD_PKA_2	248	254	PF00069	0.496
MOD_PKA_2	316	322	PF00069	0.633
MOD_PKA_2	324	330	PF00069	0.471
MOD_PKA_2	74	80	PF00069	0.259
MOD_Plk_4	177	183	PF00069	0.215
MOD_Plk_4	348	354	PF00069	0.571
MOD_Plk_4	357	363	PF00069	0.600
MOD_Plk_4	413	419	PF00069	0.444
MOD_Plk_4	60	66	PF00069	0.337
MOD_Plk_4	74	80	PF00069	0.265
MOD_ProDKin_1	126	132	PF00069	0.300
MOD_ProDKin_1	273	279	PF00069	0.605
MOD_ProDKin_1	298	304	PF00069	0.671
MOD_ProDKin_1	376	382	PF00069	0.611
TRG_ENDOCYTIC_2	190	193	PF00928	0.261
TRG_ENDOCYTIC_2	349	352	PF00928	0.573
TRG_ER_diArg_1	257	260	PF00400	0.419
TRG_ER_diArg_1	324	326	PF00400	0.592
TRG_ER_diArg_1	330	333	PF00400	0.548
TRG_NES_CRM1_1	337	350	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E8	Leptomonas seymouri	66%	100%
A0A0S4JY12	Bodo saltans	47%	96%
A0A1X0P4G1	Trypanosomatidae	46%	86%
A0A3Q8IDE2	Leishmania donovani	94%	100%
A0A422NC72	Trypanosoma rangeli	49%	94%
A1A4L8	Bos taurus	38%	100%
A1CAZ7	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	34%	94%
A1DED8	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	35%	96%
A2BDX3	Mus musculus	37%	100%
A2R3H4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	37%	96%
A3ACF3	Oryza sativa subsp. japonica	35%	100%
A3LQF9	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	33%	100%
A4HFU1	Leishmania braziliensis	77%	100%
A4I2V9	Leishmania infantum	94%	100%
A4RPM5	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	32%	94%
A5DMB6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	33%	100%
A5DSR2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	32%	100%
A5GFZ6	Sus scrofa	38%	100%
A6ZT19	Saccharomyces cerevisiae (strain YJM789)	31%	100%
A7F582	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	32%	100%
A7THV5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	31%	100%
A8WRE3	Caenorhabditis briggsae	35%	100%
B0W377	Culex quinquefasciatus	37%	100%
B0Y0P7	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	35%	94%
B3LSM6	Saccharomyces cerevisiae (strain RM11-1a)	31%	100%
B3MLX7	Drosophila ananassae	35%	100%
B4FAT0	Zea mays	38%	96%
B4GKQ3	Drosophila persimilis	34%	100%
B4HYP0	Drosophila sechellia	35%	100%
B4JBC4	Drosophila grimshawi	34%	100%
B4KI53	Drosophila mojavensis	33%	100%
B4LRB9	Drosophila virilis	34%	100%
B4N7R4	Drosophila willistoni	34%	100%
B4NXF7	Drosophila yakuba	35%	100%
B5DS72	Drosophila pseudoobscura pseudoobscura	34%	100%
B5VK45	Saccharomyces cerevisiae (strain AWRI1631)	31%	100%
B6TNK6	Zea mays	38%	99%
D0A640	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	92%
E9AZ70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O44510	Caenorhabditis elegans	34%	100%
O59954	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	96%
O95396	Homo sapiens	38%	100%
P38820	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P51335	Porphyra purpurea	30%	100%
Q09810	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q0CFD4	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	36%	96%
Q17CA7	Aedes aegypti	36%	100%
Q1XDF1	Neopyropia yezoensis	29%	100%
Q29PG5	Drosophila pseudoobscura pseudoobscura	34%	100%
Q2TWN3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	100%
Q4WV19	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	94%
Q55FS0	Dictyostelium discoideum	33%	100%
Q58E95	Xenopus laevis	34%	100%
Q59WH7	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	100%
Q6BHZ2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	33%	100%
Q6CBK1	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	100%
Q6CMC2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	100%
Q6FR35	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q756K6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q7PY41	Anopheles gambiae	37%	100%
Q8AWD2	Danio rerio	37%	100%
Q9VLJ8	Drosophila melanogaster	35%	100%
Q9ZNW0	Arabidopsis thaliana	37%	100%
V5B0X0	Trypanosoma cruzi	49%	94%