Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inner dynein arm I1 intermediate chain, axonemal

Species:

Leishmania major

UniProt:

E9ADE2_LEIMA

TriTrypDb:

LmjF.27.1630 , LMJLV39_270022700 , LMJSD75_270022800

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005858	axonemal dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0036156	inner dynein arm	5	2
GO:0110165	cellular anatomical entity	1	3
GO:1902494	catalytic complex	2	2
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ADE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADE2

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0003341	cilium movement	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0036159	inner dynein arm assembly	7	2
GO:0043933	protein-containing complex organization	4	2
GO:0048870	cell motility	2	2
GO:0060285	cilium-dependent cell motility	4	2
GO:0060294	cilium movement involved in cell motility	5	2
GO:0065003	protein-containing complex assembly	5	2
GO:0070286	axonemal dynein complex assembly	6	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045503	dynein light chain binding	3	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.570
CLV_C14_Caspase3-7	511	515	PF00656	0.555
CLV_C14_Caspase3-7	604	608	PF00656	0.481
CLV_C14_Caspase3-7	799	803	PF00656	0.631
CLV_C14_Caspase3-7	85	89	PF00656	0.628
CLV_NRD_NRD_1	159	161	PF00675	0.598
CLV_NRD_NRD_1	171	173	PF00675	0.453
CLV_NRD_NRD_1	260	262	PF00675	0.543
CLV_NRD_NRD_1	271	273	PF00675	0.544
CLV_NRD_NRD_1	296	298	PF00675	0.597
CLV_NRD_NRD_1	486	488	PF00675	0.491
CLV_NRD_NRD_1	559	561	PF00675	0.586
CLV_NRD_NRD_1	690	692	PF00675	0.593
CLV_NRD_NRD_1	721	723	PF00675	0.492
CLV_NRD_NRD_1	734	736	PF00675	0.363
CLV_NRD_NRD_1	794	796	PF00675	0.738
CLV_NRD_NRD_1	81	83	PF00675	0.697
CLV_PCSK_KEX2_1	159	161	PF00082	0.668
CLV_PCSK_KEX2_1	171	173	PF00082	0.639
CLV_PCSK_KEX2_1	273	275	PF00082	0.550
CLV_PCSK_KEX2_1	296	298	PF00082	0.510
CLV_PCSK_KEX2_1	559	561	PF00082	0.586
CLV_PCSK_KEX2_1	690	692	PF00082	0.573
CLV_PCSK_KEX2_1	734	736	PF00082	0.425
CLV_PCSK_KEX2_1	794	796	PF00082	0.738
CLV_PCSK_KEX2_1	83	85	PF00082	0.678
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.512
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.676
CLV_PCSK_PC7_1	269	275	PF00082	0.528
CLV_PCSK_SKI1_1	211	215	PF00082	0.543
CLV_PCSK_SKI1_1	230	234	PF00082	0.332
CLV_PCSK_SKI1_1	315	319	PF00082	0.396
CLV_PCSK_SKI1_1	487	491	PF00082	0.512
CLV_PCSK_SKI1_1	523	527	PF00082	0.521
CLV_PCSK_SKI1_1	54	58	PF00082	0.575
CLV_PCSK_SKI1_1	726	730	PF00082	0.417
CLV_Separin_Metazoa	395	399	PF03568	0.714
DEG_APCC_DBOX_1	639	647	PF00400	0.459
DEG_COP1_1	558	568	PF00400	0.676
DEG_ODPH_VHL_1	10	23	PF01847	0.495
DEG_SPOP_SBC_1	254	258	PF00917	0.486
DOC_CYCLIN_RxL_1	207	217	PF00134	0.550
DOC_CYCLIN_RxL_1	312	322	PF00134	0.510
DOC_CYCLIN_RxL_1	51	61	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	308	314	PF00134	0.468
DOC_MAPK_gen_1	272	280	PF00069	0.418
DOC_MAPK_gen_1	296	304	PF00069	0.453
DOC_MAPK_gen_1	559	565	PF00069	0.670
DOC_MAPK_gen_1	575	583	PF00069	0.520
DOC_MAPK_gen_1	611	621	PF00069	0.482
DOC_MAPK_gen_1	690	698	PF00069	0.528
DOC_MAPK_MEF2A_6	98	105	PF00069	0.584
DOC_PP2B_LxvP_1	191	194	PF13499	0.456
DOC_PP2B_LxvP_1	318	321	PF13499	0.402
DOC_PP2B_LxvP_1	617	620	PF13499	0.524
DOC_USP7_MATH_1	338	342	PF00917	0.514
DOC_USP7_MATH_1	37	41	PF00917	0.729
DOC_USP7_MATH_1	540	544	PF00917	0.402
DOC_USP7_MATH_1	675	679	PF00917	0.468
DOC_USP7_MATH_1	770	774	PF00917	0.599
DOC_USP7_MATH_1	776	780	PF00917	0.578
DOC_USP7_MATH_1	800	804	PF00917	0.508
DOC_USP7_MATH_1	94	98	PF00917	0.647
DOC_USP7_UBL2_3	367	371	PF12436	0.656
DOC_USP7_UBL2_3	79	83	PF12436	0.622
DOC_USP7_UBL2_3	826	830	PF12436	0.566
DOC_WW_Pin1_4	634	639	PF00397	0.419
LIG_14-3-3_CanoR_1	114	124	PF00244	0.588
LIG_14-3-3_CanoR_1	159	163	PF00244	0.623
LIG_14-3-3_CanoR_1	230	239	PF00244	0.580
LIG_14-3-3_CanoR_1	559	566	PF00244	0.694
LIG_14-3-3_CanoR_1	575	581	PF00244	0.353
LIG_14-3-3_CanoR_1	690	698	PF00244	0.471
LIG_14-3-3_CanoR_1	716	724	PF00244	0.524
LIG_14-3-3_CanoR_1	742	750	PF00244	0.519
LIG_14-3-3_CanoR_1	82	90	PF00244	0.683
LIG_14-3-3_CanoR_1	98	104	PF00244	0.557
LIG_Actin_WH2_2	389	406	PF00022	0.706
LIG_Actin_WH2_2	49	66	PF00022	0.555
LIG_APCC_ABBA_1	101	106	PF00400	0.711
LIG_APCC_ABBA_1	222	227	PF00400	0.445
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_BIR_III_4	88	92	PF00653	0.660
LIG_BRCT_BRCA1_1	18	22	PF00533	0.705
LIG_BRCT_BRCA1_1	443	447	PF00533	0.333
LIG_BRCT_BRCA1_1	677	681	PF00533	0.473
LIG_Clathr_ClatBox_1	245	249	PF01394	0.524
LIG_CSL_BTD_1	501	504	PF09270	0.397
LIG_CSL_BTD_1	635	638	PF09270	0.459
LIG_CtBP_PxDLS_1	48	52	PF00389	0.642
LIG_deltaCOP1_diTrp_1	437	447	PF00928	0.516
LIG_deltaCOP1_diTrp_1	740	743	PF00928	0.552
LIG_eIF4E_1	692	698	PF01652	0.475
LIG_FHA_1	468	474	PF00498	0.493
LIG_FHA_1	51	57	PF00498	0.576
LIG_FHA_1	572	578	PF00498	0.478
LIG_FHA_1	666	672	PF00498	0.510
LIG_FHA_1	731	737	PF00498	0.519
LIG_FHA_2	180	186	PF00498	0.544
LIG_FHA_2	231	237	PF00498	0.510
LIG_FHA_2	239	245	PF00498	0.482
LIG_FHA_2	285	291	PF00498	0.550
LIG_FHA_2	462	468	PF00498	0.458
LIG_FHA_2	509	515	PF00498	0.587
LIG_FHA_2	528	534	PF00498	0.336
LIG_FHA_2	553	559	PF00498	0.547
LIG_FHA_2	595	601	PF00498	0.391
LIG_FHA_2	602	608	PF00498	0.348
LIG_IBAR_NPY_1	808	810	PF08397	0.711
LIG_LIR_Apic_2	217	223	PF02991	0.545
LIG_LIR_Gen_1	275	285	PF02991	0.442
LIG_LIR_Gen_1	459	468	PF02991	0.425
LIG_LIR_Gen_1	547	554	PF02991	0.489
LIG_LIR_Gen_1	654	663	PF02991	0.511
LIG_LIR_Gen_1	817	827	PF02991	0.623
LIG_LIR_Nem_3	226	232	PF02991	0.465
LIG_LIR_Nem_3	275	280	PF02991	0.450
LIG_LIR_Nem_3	387	393	PF02991	0.737
LIG_LIR_Nem_3	459	465	PF02991	0.421
LIG_LIR_Nem_3	499	505	PF02991	0.444
LIG_LIR_Nem_3	654	659	PF02991	0.479
LIG_LIR_Nem_3	678	684	PF02991	0.451
LIG_LIR_Nem_3	704	710	PF02991	0.341
LIG_MYND_1	417	421	PF01753	0.410
LIG_PCNA_yPIPBox_3	195	205	PF02747	0.605
LIG_PDZ_Class_1	836	841	PF00595	0.691
LIG_PTB_Apo_2	137	144	PF02174	0.634
LIG_PTB_Phospho_1	137	143	PF10480	0.633
LIG_SH2_CRK	220	224	PF00017	0.547
LIG_SH2_CRK	615	619	PF00017	0.519
LIG_SH2_NCK_1	622	626	PF00017	0.471
LIG_SH2_PTP2	708	711	PF00017	0.452
LIG_SH2_SRC	220	223	PF00017	0.541
LIG_SH2_SRC	253	256	PF00017	0.555
LIG_SH2_STAP1	225	229	PF00017	0.554
LIG_SH2_STAP1	537	541	PF00017	0.457
LIG_SH2_STAP1	692	696	PF00017	0.486
LIG_SH2_STAP1	739	743	PF00017	0.515
LIG_SH2_STAT3	480	483	PF00017	0.547
LIG_SH2_STAT3	590	593	PF00017	0.410
LIG_SH2_STAT3	692	695	PF00017	0.493
LIG_SH2_STAT5	123	126	PF00017	0.615
LIG_SH2_STAT5	225	228	PF00017	0.547
LIG_SH2_STAT5	253	256	PF00017	0.432
LIG_SH2_STAT5	316	319	PF00017	0.490
LIG_SH2_STAT5	480	483	PF00017	0.534
LIG_SH2_STAT5	570	573	PF00017	0.642
LIG_SH2_STAT5	602	605	PF00017	0.321
LIG_SH2_STAT5	708	711	PF00017	0.438
LIG_SH3_1	783	789	PF00018	0.574
LIG_SH3_2	93	98	PF14604	0.685
LIG_SH3_3	135	141	PF00018	0.705
LIG_SH3_3	308	314	PF00018	0.414
LIG_SH3_3	328	334	PF00018	0.232
LIG_SH3_3	394	400	PF00018	0.598
LIG_SH3_3	411	417	PF00018	0.341
LIG_SH3_3	42	48	PF00018	0.639
LIG_SH3_3	498	504	PF00018	0.463
LIG_SH3_3	6	12	PF00018	0.702
LIG_SH3_3	62	68	PF00018	0.641
LIG_SH3_3	635	641	PF00018	0.435
LIG_SH3_3	706	712	PF00018	0.338
LIG_SH3_3	783	789	PF00018	0.574
LIG_SH3_3	87	93	PF00018	0.705
LIG_SUMO_SIM_anti_2	243	249	PF11976	0.512
LIG_SUMO_SIM_anti_2	299	307	PF11976	0.464
LIG_SUMO_SIM_par_1	243	249	PF11976	0.461
LIG_SUMO_SIM_par_1	47	53	PF11976	0.634
LIG_SUMO_SIM_par_1	642	648	PF11976	0.341
LIG_SUMO_SIM_par_1	651	657	PF11976	0.338
LIG_SUMO_SIM_par_1	787	793	PF11976	0.720
LIG_TRAF2_1	194	197	PF00917	0.626
LIG_TRAF2_1	320	323	PF00917	0.544
LIG_TRFH_1	708	712	PF08558	0.510
LIG_WRC_WIRS_1	356	361	PF05994	0.526
LIG_WRC_WIRS_1	565	570	PF05994	0.612
LIG_WRC_WIRS_1	702	707	PF05994	0.344
MOD_CDC14_SPxK_1	637	640	PF00782	0.425
MOD_CDK_SPxK_1	634	640	PF00069	0.389
MOD_CK1_1	129	135	PF00069	0.577
MOD_CK1_1	164	170	PF00069	0.617
MOD_CK1_1	264	270	PF00069	0.385
MOD_CK1_1	300	306	PF00069	0.515
MOD_CK1_1	35	41	PF00069	0.668
MOD_CK1_1	358	364	PF00069	0.563
MOD_CK1_1	527	533	PF00069	0.581
MOD_CK1_1	552	558	PF00069	0.495
MOD_CK1_1	715	721	PF00069	0.467
MOD_CK1_1	74	80	PF00069	0.555
MOD_CK2_1	238	244	PF00069	0.578
MOD_CK2_1	284	290	PF00069	0.478
MOD_CK2_1	422	428	PF00069	0.430
MOD_CK2_1	461	467	PF00069	0.471
MOD_CK2_1	527	533	PF00069	0.512
MOD_CK2_1	552	558	PF00069	0.510
MOD_CK2_1	715	721	PF00069	0.500
MOD_CK2_1	74	80	PF00069	0.555
MOD_CK2_1	776	782	PF00069	0.702
MOD_Cter_Amidation	259	262	PF01082	0.577
MOD_Cter_Amidation	270	273	PF01082	0.378
MOD_GlcNHglycan	1	4	PF01048	0.664
MOD_GlcNHglycan	117	120	PF01048	0.703
MOD_GlcNHglycan	263	266	PF01048	0.508
MOD_GlcNHglycan	269	272	PF01048	0.522
MOD_GlcNHglycan	34	37	PF01048	0.677
MOD_GlcNHglycan	361	364	PF01048	0.575
MOD_GlcNHglycan	39	42	PF01048	0.659
MOD_GlcNHglycan	494	497	PF01048	0.648
MOD_GlcNHglycan	526	529	PF01048	0.507
MOD_GlcNHglycan	542	545	PF01048	0.403
MOD_GlcNHglycan	718	721	PF01048	0.431
MOD_GlcNHglycan	772	775	PF01048	0.669
MOD_GlcNHglycan	778	781	PF01048	0.655
MOD_GlcNHglycan	838	841	PF01048	0.643
MOD_GSK3_1	122	129	PF00069	0.586
MOD_GSK3_1	158	165	PF00069	0.660
MOD_GSK3_1	25	32	PF00069	0.625
MOD_GSK3_1	355	362	PF00069	0.468
MOD_GSK3_1	463	470	PF00069	0.494
MOD_GSK3_1	564	571	PF00069	0.604
MOD_GSK3_1	686	693	PF00069	0.500
MOD_GSK3_1	697	704	PF00069	0.279
MOD_GSK3_1	712	719	PF00069	0.403
MOD_GSK3_1	741	748	PF00069	0.552
MOD_GSK3_1	762	769	PF00069	0.601
MOD_LATS_1	557	563	PF00433	0.660
MOD_N-GLC_1	230	235	PF02516	0.578
MOD_N-GLC_2	200	202	PF02516	0.377
MOD_NEK2_1	1	6	PF00069	0.668
MOD_NEK2_1	214	219	PF00069	0.537
MOD_NEK2_1	22	27	PF00069	0.566
MOD_NEK2_1	359	364	PF00069	0.615
MOD_NEK2_1	422	427	PF00069	0.539
MOD_NEK2_1	524	529	PF00069	0.521
MOD_NEK2_1	576	581	PF00069	0.497
MOD_NEK2_1	697	702	PF00069	0.439
MOD_NEK2_1	762	767	PF00069	0.561
MOD_PIKK_1	162	168	PF00454	0.528
MOD_PIKK_1	214	220	PF00454	0.538
MOD_PIKK_1	552	558	PF00454	0.544
MOD_PIKK_1	690	696	PF00454	0.519
MOD_PIKK_1	71	77	PF00454	0.643
MOD_PK_1	559	565	PF00069	0.670
MOD_PK_1	627	633	PF00069	0.458
MOD_PKA_1	261	267	PF00069	0.509
MOD_PKA_1	559	565	PF00069	0.670
MOD_PKA_1	690	696	PF00069	0.544
MOD_PKA_1	82	88	PF00069	0.690
MOD_PKA_2	115	121	PF00069	0.643
MOD_PKA_2	158	164	PF00069	0.664
MOD_PKA_2	558	564	PF00069	0.667
MOD_PKA_2	686	692	PF00069	0.548
MOD_PKA_2	715	721	PF00069	0.535
MOD_PKA_2	730	736	PF00069	0.375
MOD_PKA_2	741	747	PF00069	0.394
MOD_PKA_2	762	768	PF00069	0.593
MOD_Plk_1	298	304	PF00069	0.523
MOD_Plk_2-3	134	140	PF00069	0.711
MOD_Plk_2-3	745	751	PF00069	0.570
MOD_Plk_4	179	185	PF00069	0.513
MOD_Plk_4	300	306	PF00069	0.452
MOD_Plk_4	355	361	PF00069	0.522
MOD_Plk_4	451	457	PF00069	0.580
MOD_Plk_4	467	473	PF00069	0.500
MOD_Plk_4	549	555	PF00069	0.466
MOD_Plk_4	559	565	PF00069	0.604
MOD_Plk_4	627	633	PF00069	0.440
MOD_Plk_4	68	74	PF00069	0.632
MOD_ProDKin_1	634	640	PF00069	0.421
MOD_SUMO_for_1	194	197	PF00179	0.566
MOD_SUMO_rev_2	444	454	PF00179	0.450
MOD_SUMO_rev_2	715	725	PF00179	0.573
TRG_DiLeu_BaEn_1	654	659	PF01217	0.481
TRG_DiLeu_BaEn_2	457	463	PF01217	0.369
TRG_DiLeu_BaEn_3	818	824	PF01217	0.636
TRG_DiLeu_BaEn_4	196	202	PF01217	0.611
TRG_DiLeu_BaEn_4	322	328	PF01217	0.527
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.414
TRG_DiLeu_BaLyEn_6	786	791	PF01217	0.699
TRG_ENDOCYTIC_2	143	146	PF00928	0.601
TRG_ENDOCYTIC_2	615	618	PF00928	0.521
TRG_ER_diArg_1	113	116	PF00400	0.609
TRG_ER_diArg_1	158	160	PF00400	0.667
TRG_ER_diArg_1	171	173	PF00400	0.639
TRG_ER_diArg_1	690	692	PF00400	0.593
TRG_ER_diArg_1	734	736	PF00400	0.419
TRG_ER_diArg_1	794	796	PF00400	0.723
TRG_ER_diArg_1	81	84	PF00400	0.630
TRG_NES_CRM1_1	55	69	PF08389	0.605
TRG_NLS_MonoExtN_4	485	491	PF00514	0.493
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2KIZ8	Danio rerio	25%	87%
A0A0N1PF46	Leptomonas seymouri	69%	97%
A0A0S4JPP6	Bodo saltans	41%	100%
A0A1X0P495	Trypanosomatidae	47%	100%
A0A3Q8IEC3	Leishmania donovani	97%	100%
A0A422N9T1	Trypanosoma rangeli	47%	100%
A4HFT9	Leishmania braziliensis	86%	100%
A4HK88	Leishmania braziliensis	23%	100%
A4I2V5	Leishmania infantum	97%	100%
B2RY71	Mus musculus	24%	91%
D0A634	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AZ66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q8IWG1	Homo sapiens	23%	94%
Q95JP0	Macaca fascicularis	23%	94%
V5BGF1	Trypanosoma cruzi	46%	100%