Putative eukaryotic translation initiation factor eIF-4E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-1

Species:

Leishmania major

UniProt:

E9ADE1_LEIMA

TriTrypDb:

LmjF.27.1620 , LMJLV39_270022500 , LMJSD75_270022700

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	2
GO:0005737	cytoplasm	2	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0097165	nuclear stress granule	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ADE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADE1

PDB structure(s): 5wb5_A

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	2
GO:0000340	RNA 7-methylguanosine cap binding	6	2
GO:0000342	RNA cap 4 binding	6	2
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.487
CLV_NRD_NRD_1	166	168	PF00675	0.261
CLV_PCSK_KEX2_1	166	168	PF00082	0.257
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.270
CLV_PCSK_SKI1_1	190	194	PF00082	0.362
CLV_PCSK_SKI1_1	58	62	PF00082	0.339
DOC_MAPK_gen_1	166	175	PF00069	0.461
DOC_MAPK_gen_1	89	100	PF00069	0.515
DOC_MAPK_MEF2A_6	168	177	PF00069	0.460
DOC_MAPK_MEF2A_6	89	98	PF00069	0.475
DOC_USP7_MATH_1	118	122	PF00917	0.568
DOC_USP7_MATH_1	201	205	PF00917	0.545
DOC_USP7_UBL2_3	191	195	PF12436	0.475
DOC_USP7_UBL2_3	89	93	PF12436	0.461
DOC_WW_Pin1_4	150	155	PF00397	0.398
DOC_WW_Pin1_4	25	30	PF00397	0.518
LIG_14-3-3_CanoR_1	20	25	PF00244	0.492
LIG_14-3-3_CanoR_1	67	75	PF00244	0.461
LIG_Actin_WH2_2	53	69	PF00022	0.541
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_BRCT_BRCA1_1	203	207	PF00533	0.533
LIG_BRCT_BRCA1_2	203	209	PF00533	0.527
LIG_CaM_NSCaTE_8	133	140	PF13499	0.541
LIG_FHA_1	158	164	PF00498	0.541
LIG_FHA_1	181	187	PF00498	0.541
LIG_FHA_2	125	131	PF00498	0.472
LIG_FHA_2	138	144	PF00498	0.438
LIG_FHA_2	151	157	PF00498	0.375
LIG_Integrin_isoDGR_2	104	106	PF01839	0.364
LIG_LIR_Apic_2	23	29	PF02991	0.541
LIG_LIR_Gen_1	130	141	PF02991	0.476
LIG_LIR_Gen_1	51	62	PF02991	0.461
LIG_LIR_Gen_1	69	79	PF02991	0.461
LIG_LIR_Nem_3	130	136	PF02991	0.475
LIG_LIR_Nem_3	51	57	PF02991	0.450
LIG_LIR_Nem_3	69	75	PF02991	0.461
LIG_PCNA_PIPBox_1	138	147	PF02747	0.475
LIG_Pex14_1	22	26	PF04695	0.461
LIG_SH2_CRK	26	30	PF00017	0.461
LIG_SH2_CRK	59	63	PF00017	0.461
LIG_SH2_GRB2like	169	172	PF00017	0.475
LIG_SH2_NCK_1	26	30	PF00017	0.475
LIG_SH2_STAT5	144	147	PF00017	0.461
LIG_SH3_1	151	157	PF00018	0.398
LIG_SH3_3	151	157	PF00018	0.485
LIG_TRAF2_1	49	52	PF00917	0.513
LIG_UBA3_1	56	61	PF00899	0.541
MOD_CK1_1	113	119	PF00069	0.471
MOD_CK1_1	178	184	PF00069	0.541
MOD_CK1_1	2	8	PF00069	0.677
MOD_CK1_1	28	34	PF00069	0.467
MOD_CK2_1	118	124	PF00069	0.505
MOD_CK2_1	137	143	PF00069	0.351
MOD_CK2_1	150	156	PF00069	0.375
MOD_CK2_1	46	52	PF00069	0.497
MOD_CMANNOS	22	25	PF00535	0.261
MOD_GlcNHglycan	1	4	PF01048	0.697
MOD_GlcNHglycan	101	104	PF01048	0.299
MOD_GlcNHglycan	112	115	PF01048	0.307
MOD_GlcNHglycan	119	123	PF01048	0.317
MOD_GlcNHglycan	179	183	PF01048	0.292
MOD_GSK3_1	105	112	PF00069	0.508
MOD_GSK3_1	191	198	PF00069	0.525
MOD_GSK3_1	201	208	PF00069	0.410
MOD_GSK3_1	27	34	PF00069	0.475
MOD_N-GLC_1	109	114	PF02516	0.264
MOD_NEK2_1	137	142	PF00069	0.556
MOD_NEK2_1	205	210	PF00069	0.439
MOD_NEK2_1	66	71	PF00069	0.458
MOD_NEK2_1	98	103	PF00069	0.564
MOD_NEK2_2	43	48	PF00069	0.521
MOD_PIKK_1	67	73	PF00454	0.535
MOD_PKA_2	105	111	PF00069	0.541
MOD_PKA_2	66	72	PF00069	0.461
MOD_Plk_1	195	201	PF00069	0.564
MOD_Plk_1	37	43	PF00069	0.461
MOD_Plk_2-3	124	130	PF00069	0.473
MOD_Plk_4	201	207	PF00069	0.556
MOD_Plk_4	37	43	PF00069	0.460
MOD_ProDKin_1	150	156	PF00069	0.398
MOD_ProDKin_1	25	31	PF00069	0.518
MOD_SUMO_rev_2	119	127	PF00179	0.476
MOD_SUMO_rev_2	143	153	PF00179	0.564
TRG_DiLeu_BaEn_3	51	57	PF01217	0.513
TRG_ENDOCYTIC_2	72	75	PF00928	0.461
TRG_NLS_Bipartite_1	150	170	PF00514	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A075QQ08	Nicotiana tabacum	27%	96%
A0A0N0P8F2	Leptomonas seymouri	82%	100%
A0A0S4KG92	Bodo saltans	23%	73%
A0A1D8EJF9	Solanum pimpinellifolium	25%	93%
A0A1U8F5V2	Capsicum annuum	30%	100%
A0A1U8GR65	Capsicum annuum	23%	94%
A0A1X0P494	Trypanosomatidae	48%	83%
A0A2J6L8Y7	Lactuca sativa	27%	91%
A0A3Q7FGP1	Solanum lycopersicum	26%	97%
A0A3Q7I7R4	Solanum lycopersicum	29%	100%
A0A3Q8IE78	Leishmania donovani	97%	100%
A0A3R7N8L4	Trypanosoma rangeli	48%	81%
A0A445AGS0	Arachis hypogaea	30%	100%
A3RCV9	Triticum aestivum	28%	92%
A4HA98	Leishmania braziliensis	26%	77%
A4HFT8	Leishmania braziliensis	92%	100%
A4HHZ6	Leishmania braziliensis	28%	70%
A4I2V4	Leishmania infantum	97%	100%
A6NMX2	Homo sapiens	22%	88%
A7KWF8	Cucumis zeyherii	27%	91%
C6ZJZ3	Glycine max	29%	90%
C7SG33	Citrullus lanatus	28%	91%
D0A633	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	92%
D3UW26	Solanum tuberosum	25%	93%
E9AZ65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
K0P2S0	Arachis hypogaea	27%	93%
M1J8U6	Prunus domestica	30%	100%
M1JJT8	Prunus domestica	27%	92%
O04663	Arabidopsis thaliana	30%	100%
O23252	Arabidopsis thaliana	27%	91%
O45551	Caenorhabditis elegans	27%	100%
O60573	Homo sapiens	27%	87%
O61955	Caenorhabditis elegans	27%	85%
O74743	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	88%
O77210	Aplysia californica	25%	100%
O81481	Zea mays	28%	98%
O81482	Zea mays	29%	99%
P06730	Homo sapiens	23%	99%
P07260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P29338	Oryctolagus cuniculus	24%	99%
P29557	Triticum aestivum	28%	100%
P48597	Xenopus laevis	23%	100%
P48598	Drosophila melanogaster	27%	83%
P48599	Oryza sativa subsp. japonica	27%	94%
P48600	Oryza sativa subsp. japonica	29%	100%
P56570	Caenorhabditis elegans	23%	100%
P63073	Mus musculus	24%	99%
P63074	Rattus norvegicus	24%	99%
P78954	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	98%
Q00LS8	Cucumis melo	27%	91%
Q03389	Triticum aestivum	31%	100%
Q0GRC4	Pisum sativum	25%	94%
Q10NQ9	Oryza sativa subsp. japonica	26%	94%
Q21693	Caenorhabditis elegans	29%	94%
Q22888	Caenorhabditis elegans	26%	100%
Q3UTA9	Mus musculus	26%	88%
Q4QXS7	Hordeum vulgare subsp. vulgare	28%	100%
Q4VQY1	Solanum habrochaites	24%	93%
Q4VQY3	Solanum lycopersicum	25%	93%
Q55FE0	Dictyostelium discoideum	28%	86%
Q66HY7	Danio rerio	27%	96%
Q66UV4	Nicotiana tabacum	28%	96%
Q66WU1	Nicotiana tabacum	29%	100%
Q75AV8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
Q8BMB3	Mus musculus	27%	87%
Q9C7P2	Arabidopsis thaliana	26%	89%
Q9C7P6	Arabidopsis thaliana	26%	89%
Q9DFS6	Danio rerio	25%	100%
Q9FK59	Arabidopsis thaliana	24%	97%
Q9N0T5	Bos taurus	23%	99%
Q9P974	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	31%	100%
Q9P975	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	100%
Q9PW28	Danio rerio	21%	100%
R4HYA4	Solanum etuberosum	23%	93%
V5B0X7	Trypanosoma cruzi	48%	82%
V7BSD0	Phaseolus vulgaris	27%	93%