Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ADD9_LEIMA

TriTrypDb:

LmjF.27.1600 , LMJLV39_270022300 , LMJSD75_270022500

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ADD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ADD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.675
CLV_NRD_NRD_1	137	139	PF00675	0.527
CLV_NRD_NRD_1	245	247	PF00675	0.522
CLV_PCSK_FUR_1	243	247	PF00082	0.536
CLV_PCSK_KEX2_1	137	139	PF00082	0.527
CLV_PCSK_KEX2_1	245	247	PF00082	0.522
CLV_PCSK_SKI1_1	199	203	PF00082	0.492
CLV_PCSK_SKI1_1	256	260	PF00082	0.580
DEG_APCC_DBOX_1	255	263	PF00400	0.602
DEG_Nend_UBRbox_1	1	4	PF02207	0.489
DOC_CKS1_1	127	132	PF01111	0.648
DOC_CYCLIN_RxL_1	195	205	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.533
DOC_MAPK_MEF2A_6	199	206	PF00069	0.521
DOC_PP2B_LxvP_1	79	82	PF13499	0.542
DOC_PP4_FxxP_1	6	9	PF00568	0.489
DOC_USP7_MATH_1	151	155	PF00917	0.683
DOC_USP7_MATH_1	50	54	PF00917	0.668
DOC_USP7_MATH_1	72	76	PF00917	0.632
DOC_USP7_UBL2_3	195	199	PF12436	0.376
DOC_WW_Pin1_4	126	131	PF00397	0.633
LIG_14-3-3_CanoR_1	184	193	PF00244	0.518
LIG_14-3-3_CanoR_1	2	7	PF00244	0.487
LIG_14-3-3_CanoR_1	41	47	PF00244	0.496
LIG_BRCT_BRCA1_1	108	112	PF00533	0.555
LIG_BRCT_BRCA1_1	30	34	PF00533	0.490
LIG_BRCT_BRCA1_1	85	89	PF00533	0.544
LIG_FHA_1	120	126	PF00498	0.555
LIG_FHA_1	78	84	PF00498	0.531
LIG_FHA_2	255	261	PF00498	0.654
LIG_LIR_Apic_2	5	9	PF02991	0.485
LIG_LIR_Gen_1	98	106	PF02991	0.527
LIG_LIR_Nem_3	188	193	PF02991	0.589
LIG_LIR_Nem_3	58	63	PF02991	0.655
LIG_LIR_Nem_3	88	94	PF02991	0.568
LIG_LIR_Nem_3	98	102	PF02991	0.340
LIG_NRBOX	197	203	PF00104	0.483
LIG_PCNA_yPIPBox_3	245	259	PF02747	0.546
LIG_Pex14_2	85	89	PF04695	0.505
LIG_SH2_STAT5	186	189	PF00017	0.445
LIG_SH3_3	124	130	PF00018	0.580
LIG_SH3_3	255	261	PF00018	0.582
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.591
LIG_WRC_WIRS_1	12	17	PF05994	0.450
LIG_WRC_WIRS_1	3	8	PF05994	0.486
LIG_WRC_WIRS_1	99	104	PF05994	0.494
MOD_CK1_1	101	107	PF00069	0.509
MOD_CK1_1	118	124	PF00069	0.442
MOD_CK1_1	154	160	PF00069	0.639
MOD_CK1_1	223	229	PF00069	0.770
MOD_CK1_1	49	55	PF00069	0.740
MOD_GlcNHglycan	131	134	PF01048	0.591
MOD_GlcNHglycan	151	154	PF01048	0.710
MOD_GlcNHglycan	48	51	PF01048	0.676
MOD_GlcNHglycan	52	55	PF01048	0.669
MOD_GlcNHglycan	75	78	PF01048	0.515
MOD_GSK3_1	115	122	PF00069	0.529
MOD_GSK3_1	149	156	PF00069	0.610
MOD_GSK3_1	223	230	PF00069	0.750
MOD_GSK3_1	23	30	PF00069	0.486
MOD_GSK3_1	42	49	PF00069	0.561
MOD_GSK3_1	73	80	PF00069	0.531
MOD_GSK3_1	81	88	PF00069	0.443
MOD_GSK3_1	98	105	PF00069	0.573
MOD_NEK2_1	102	107	PF00069	0.558
MOD_NEK2_1	149	154	PF00069	0.534
MOD_NEK2_1	202	207	PF00069	0.514
MOD_NEK2_1	23	28	PF00069	0.487
MOD_NEK2_1	254	259	PF00069	0.560
MOD_NEK2_1	40	45	PF00069	0.614
MOD_NEK2_1	46	51	PF00069	0.720
MOD_NEK2_1	85	90	PF00069	0.450
MOD_NEK2_2	29	34	PF00069	0.487
MOD_PKA_1	137	143	PF00069	0.506
MOD_PKA_2	137	143	PF00069	0.739
MOD_PKA_2	23	29	PF00069	0.485
MOD_PKA_2	40	46	PF00069	0.432
MOD_Plk_1	118	124	PF00069	0.557
MOD_Plk_1	231	237	PF00069	0.554
MOD_Plk_2-3	227	233	PF00069	0.762
MOD_Plk_4	121	127	PF00069	0.516
MOD_Plk_4	202	208	PF00069	0.490
MOD_Plk_4	29	35	PF00069	0.489
MOD_Plk_4	98	104	PF00069	0.529
MOD_ProDKin_1	126	132	PF00069	0.639
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.693
TRG_ER_diArg_1	242	245	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S5	Leptomonas seymouri	36%	100%
A0A1X0P489	Trypanosomatidae	29%	100%
A0A3S7X0S9	Leishmania donovani	87%	100%
A4HFT6	Leishmania braziliensis	69%	100%
A4I2V3	Leishmania infantum	87%	100%
E9AZ63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%